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An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair

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Regenerative Biomaterials 2019年第6期6卷 335-347页

作者： Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector Jose Aguado Hernandez Matilde Alonso Rodrigo Angel Jose Alvarez Barcia ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena Jose Carlos Rodriguez-Cabello Technical Proteins Nanobiotechnology S.L. Paseo Belen 9AValladolid 47011Spain Departamento de traumatologıa Hospital Clınico de ValladolidAv.Ramon y Cajal 3Valladolid 47003Spain Bioforge University of Valladolid CIBER-BBNPaseo de Belen 19Valladolid 47011Spain SIBA-UVA:servicio investigacion y bienestar animal University of ValladolidC/Plaza de Santa Cruz 8Valladolid 47002Spain Instituto de Biologıa y Genetica Molecular(IBGM) Universidad de Valladolid y CSICCalle Sanz y Fores 3Valladolid 47003Spain Facultad de veterinaria Campus UniversitarioAvda.Carballo Calero s/nLugo 27002Spain

The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral *** the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand ***,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the *** both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline *** conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis.

关键词： biopolymer animal test cartilage bone

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Experimental Investigation of Solid Fuel Combustion Process in a Hybrid Porous Reactor

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Journal of Energy and Power Engineering 2017年第9期11卷 589-596页

作者： Vojislav Jovicic Nataliia Fedorova ana Zbogar-Rasic Mario Toledo Torres Antonio Delgado Institute of Fluid Mechanics (LSTM) Friedrich-Alexander University of Erlangen-Nuremberg Erlangen D-91058 Germany Erlangen Graduate School in Advanced Optical Technologies (SA OT) Erlangen D-91058 Germany Department of Mechanical Engineering Technical University Federico Santa Maria Valparaiso 05101 Chile

One of the most significant human-made methane emission sources is the MSW （municipal solid waste）, deposited on sanitary landfills and open dumps. Within this work, an alternative MSW treatment concept is presented, which could provide a relatively clean waste/biomass-to-energy transformation. The proposed procedure comprises of a combustion and a gasification （or pyrolysis） step, which are consecutively taking place in a two-stage hybrid porous reactor system. The core of the system is two packed bed reactors, in which solid fuel （waste or biomass） is mixed with inert ceramic particles of similar size. This paper overviews the initial experimental investigation of the combustion step of a hybrid mixture, composed of wood pellets （fuel） and alumina balls （inert ceramic particles） in a 250 ram-high batch reactor. The temperature profile along the reactor, the concentration of CO and the flame front propagation velocity were measured as a function of the ceramic particle size （11 and 20 mrn）, the inert-to-fuel mass ratio （0：1, 2：1, 3：1） and the airflow rate （30, 42, 60 1/min）. Experiments indicate that an increase of the mass ratio of inert-to-fuel material and a decrease of the inert ceramic particles size lead to a decrease of the maximum temperature of the packed hybrid bed. Measured CO concentrations showed strong dependence on the inert ceramic particle size, i.e. the particle size reduction from 20 to 11 mm resulted in a significant reduction of CO-emission peaks. The maximum flame front propagation velocity of 0.2 mm/sec was detected for the airflow of 42 1/min, the particle size of 20 mm and the mass ratio of 3：1.

关键词： Combustion allothermal gasification MSW hybrid filtration combustion packed bed.

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CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

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Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： Joana Vitallé Iñigo Terrén Ane Orrantia Raquel Pérez-Garay Francesc Vidal JoséA.Iribarren Carmen Rodríguez ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIV-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC

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Implementation of Quick HIV Tests in a Basic Health Unit in the Town of santa Cruz-RN:Experiment Experienced by the PRO/PET-Saude Students

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Health 2015年第13期7卷 1782-1787页

作者： ana Rafaela Dantas dos Santos ana Mayara Gomes de Sousa Fernanda Diniz de Sá Adriana Gomes Magalhaes Fábia Barbosa de Andrade Higo Luiz Amorim Belo Maia Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil

This article is about a report of the experiment of PRO/PET-Saúde students in the anti-HIV tests implementation in the town of santa Cruz-RN. The goal is to report the importance and discuss the aspects of the moment experienced above inside the basic health unit in the town of santa Cruz-RN. The experience occurred in the months from February to March 2014 and they were conducted within 8 hours per week. This way, it is observed that the period lived made possible great reflection about the making of the examination in the pre-natal appointment routines, cataloguing challenges which come up during their adequacy within the services. Lastly, the action developed aimed for the aggregation of an active learning process in the search for a critical sense in the experienced practice, allowing and prioritizing the basic health unit as a scope of reference and counter-reference in the public health service, increasing concrete answers and the needs of the population, guaranteeing an adequate service delivery and strengthening the SUS more and more. The insertion of students through the PRO/PET-Saúde-Rede Cegonha enables a reorientation of professional formation, from the integration between service and teaching.

关键词： Pregnant Student Teaching-Service HIV Tests Vertical Transmissions

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Spatial analysis of Dengue through the reproduction numbers relating to socioeconomic features:Case studies on two Brazilian urban centers

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Infectious Disease Modelling 2024年第1期9卷 142-157页

作者： ana T.C.Silva Rejane C.Dorn Lívia R.Tomás Leonardo B.L.Santos Lacita M.Skalinski Suani T.R.Pinho Departamento de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil Centro Nacional de Monitoramento e Alertas de Desastres Naturais(CEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Universidade Estadual de santa Cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de Saúde Coletiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional de Ciência e Tecnologia-Sistemas Complexos Virtual InstitutionBrazil

The study of the propagation of infectious diseases in urban centers finds a close connection with their population's social characteristics and *** work performs a spatial analysis of dengue cases in urban centers based on the basic reproduction numbers,R0,and incidence by planning areas(PAs),as well as their correlations with the Human Development Index(HDI)and the number of *** analyzed dengue epidemics in 2002 at two Brazilian urban centers,Belo Horizonte(BH)and Rio de Janeiro(RJ),using PAs as spatial *** results reveal heterogeneous spatial scenarios for both cities,with very weak correlations between R0 and both the number of trips and the HDI;in BH,the values of R0 show a less spatial heterogeneous pattern than in *** BH,there are moderate correlations between incidence and both the number of trips and the HDI;meanwhile,they weakly correlate for ***,the absence of strong correlations between the considered measures indicates that the transmission process should be treated considering the city as a whole.

关键词： Dengue Mathematical mode lBasic reproduction number Urban mobility Urban indices

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Micro-computed tomography assessment of human femoral trabecular bone for two disease groups(fragility fracture and coxarthrosis):Age and gender related effects on the microstructure

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Journal of Biomedical Science and Engineering 2013年第2期6卷 175-184页

作者： ana Catarina Vale Manuel F.C.Pereira Antonio Maurício Bruno Vidal ana Rodrigues Joana Caetano-Lopes Ara Nazarian Joao E.Fonseca Helena Canhao Maria Fatima Vaz Institute of Materials and Surface Science and Engineering LisbonPortugal Rheumatology Research Unit Instituto de Medicina MolecularFaculdade de Medicina de LisboaLisbonPortugal Center of Petrology and Geochemistry Instituto Superior TécnicoUniversidade Técnica de LisboaLisbonPortugal Rheumatology and Metabolic Bone Diseases Department Hospital de Santa MariaLisbonPortugal Orthopedic Biomechanics Laboratory Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA Mechanical Engineering Department Instituto Superior TecnicoUniversidade Tecnica de LisboaLisbonPortugal

The aim of this study was to identify three-dimensional microstructural changes of trabecular bone with age and gender, using micro-computed tomography. Human trabecular bone from two disease groups, osteoporosis and osteoarthritis was analyzed. A prior analysis of the effects of some procedure variables on the micro-CT results was performed. Preliminary micro-CT scans were performed with three voxel resolutions and two acquisition conditions. On the reconstruction step, the image segmentation was performed with three different threshold values. Samples were collected from patients, with coxarthrosis (osteoarthritis) or fragility fracture (osteoporosis). The specimens of the coxarthrosis group include twenty females and fifteen males, while the fragility fracture group was composed by twenty three females and seven males. The mean age of the population was 69 ± 11 (females) and 67 ± 10 years (males), in the coxarthrosis group, while in the fragility fracture group was 81 ± 6 (females) and 78 ± 6 (males) years. The 30 μm voxel size provided lower percentage difference for the microarchitecture parameters. Acquisition conditions with 160 μA and 60 kV permit the evaluation of all the volume’s sample, with low average values of the coefficients of variation of the microstructural parameters. No statistically significant differences were found between the two diseases groups, neither between genders. However, with aging, there is a decrease of bone volume fraction, trabecular number and fractal dimension, and an increase of structural model index and trabecular separation, for both disease groups and genders. The parameters bone specific surface, trabecular thickness and degree of anisotropy have different behaviors with age, depending on the type of disease. While in coxarthrosis patients, trabecular thickness increases with age, in the fragility fracture group, there is a decrease of trabecular thickness with increasing age. Our findings indicate that disease, age and

关键词： Trabecular Bone Micro-Computed Tomography Coxarthrosis Fragility Fracture Age Gender

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Growth and phenotypic plasticity of two tropical tree species under low light availability

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Journal of Plant Ecology 2021年第2期14卷 270-279页

作者： Marúcia da Cunha Fagundes Ândrea Carla Dalmolin Luciana Santos Lobo ana Cristina Schilling Martielly santana dos Santos Marcelo Schramm Mielke Departamento de Ciências Biológicas Universidade Estadual de Santa CruzIlhéusBABrazil Centro de Formação em Ciências Agroflorestais Universidade Federal do Sul da BahiaIlhéusBABrazil Departamento de Ciências Exatas e Tecnológicas Universidade Estadual de Santa CruzIlhéusBABrazil

Aims Screening tree species in tropical rainforest according to their shade tolerance is important to efficiently manage the native trees of economic significance in secondary forest enrichment *** objective of this study was to determine the whole-plant light compensation point(WPLCP)and compare the phenotypic plasticity in relation to growth and carbon allocation of Cariniana legalis and Gallesia integrifolia seedlings under low light *** Seedlings were cultivated for 77 days under conditions of five photosynthetically active radiation(PAR)(0.02,1.1,2.3,4.5 and 5.9 mol photons m^(−2)day^(−1))in three *** and carbon allocation variables were *** Findings Growth rates of *** were higher and lower than those of *** under 1.1 and 5.9 mol photons m^(−2)day^(−1),*** WPLCP differed significantly between the two *** accordance with the criteria of the shade tolerance classification for these two tropical tree species,our results showed that *** had lower WPLCP and phenotypic plasticity in terms of higher growth rates and greater shade tolerance than *** a practical point of view,we demonstrated that the differential linkage between growth and changing PAR between the two species can become a useful tool for comparing and selecting tree species in forest enrichment projects.

关键词： Cariniana legalis Gallesia integrifolia rainforest tropical tree seedlings relative distance plasticity index whole-plant light compensation point

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Clinical outcomes of direct-acting antiviral therapy in patients with compensated hepatitis C virus-related cirrhosis

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Hepatoma Research 2017年第9期3卷 209-214页

作者： Estefania Berge ana Arencibia Elena Otón Luis Cejas Silvia Acosta Francisco Pérez Liver Unit Hospital Universitario Nuestra Senora de la Candelaria38010 Santa Cruz de TenerifeSpain.

Aim: The aim was to assess the clinical impact of direct-acting antiviral treatment in patients with compensated hepatitis C virus-related cirrhosis after one year of follow-up. Methods: An observational retrospective study was conducted on 129 consecutive patients with compensated cirrhosis treated in 2015, analyzing the evolution of liver function and the development of hepatocellular carcinoma and clinical decompensations. Results: The median follow-up time was 16 months. Most patients were males (73%), the mean age was 58.1 years and the most frequent genotype was 1b (52.2%). All participants were Child-Pugh A class at the start of the treatment and the median model for end-stage liver disease (MELD) score was 7. Four patients (4.4%) suffered a decompensation: three episodes of ascites and one acute on chronic liver failure. The incidence of de novo hepatocellular carcinoma during the follow-up was 3.6%. Seven patients (7.8%) improved MELD score more than one point and in 11 patients (12.2%) it worsened more than one point. There was a significant improvement in the mean platelets count [P < 0.001, 95% confidence interval (CI): -26,360, -12,096] and in the mean albumin levels (P < 0.001, 95% CI: -322, -130) after treatment. Conclusion:Direct-acting antiviral treatment is not associated in the short term with a decrease in the development of hepatic decompensation or hepatocellular carcinoma compared to what it was reported for untreated compensated cirrhotic patients. There is an improvement in pre and post-treatment platelet counts and albumin levels showing a probable improvement of the hepatic function.

关键词： Direct-acting antiviral therapy compensated cirrhosis hepatocellular carcinoma clinical decompensation

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Myoclonus and Recurrent Cardioinhibitory Vasovagal Syncope after Abdominal Surgery in a Critical Care Setting

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World Journal of Cardiovascular Diseases 2020年第5期10卷 274-277页

作者： ana Belén Fernández Elena Martín Ramsés Marrero David Viera Department of Anesthesiology and Postsurgical Intensive Care Unit Ntra Sra De Candelaria University Hospital Santa Cruz de Tenerife Spain

Letter to the

关键词： Vasovagal Reflex Syncope Cardioinhibitory Response Autonomic Failure Asystole

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Put Yourself in My Shoes: Perspectives of Adolescents about What Makes an Obesity Intervention Effective

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Health 2015年第14期7卷 1833-1840页

作者： ana Prioste Helena Fonseca Pedro Sousa Pedro Gaspar Rita Francisco Maria do Céu Machado Researcher at PTDC/DTP-PIC/0769/2012 Project Funded by Fundacao para a Ciência e Tecnologia Lisboa Portugal Department of Paediatrics Hospital de Santa Maria Lisboa Portugal Faculty of Medicine University of Lisbon Lisbon Portugal Instituto Politécnico de Leiria Leiria Portugal Faculdade de Psicologia Universidade de Lisboa Lisboa Portugal

Purpose: This study aims to investigate the adolescents’ perspectives about 1) the changing process promoted by a weight management program;2) the factors which may act as facilitators and barriers to obesity management;3) the strategies that should be included in order to design a successful weight management program. Methods: Data were collected by in-depth interviews and focus group discussions with 16 overweight adolescents, aged 12 - 18 years. Thematic analysis was used for analysing the data. Results: Findings suggest that attributions (internal and external), functions (barriers and facilitators) and perceptual changes (lifestyle and body and mind changes) play distinct roles in the changing process. Interactions recognized as high quality ones, acquisition of new knowledge and competencies and encouragement throughout the process, were identified as facilitators. Negative patterns of interaction, collection of anthropometric data and internal resistances, were identified as barriers. The relevance of developing systemic interventions including family and peers, and the use of Information and Communication Technologies were highlighted. Conclusion: This study aims to contribute for a deeper understanding of the factors and processes behind adherence to weight management. Implications for the design of future more effective strategies and implementation of appropriate interventions are discussed.

关键词： Adolescence Overweight Weight Management Adherence

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