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Indicators of fatal outcome in severe Plasmodium falciparum malaria:a study in a tertiary-care hospital in Thailand

Asian Pacific Journal of Tropical Medicine 2010年第11期3卷 855-859页

作者： Noppadon Tangpukdee Khin Myat Wai sant muangnoicharoen Shigeyuki Kano Nanthaporn Phophak Janram Tiemprasert Srivicha Krudsood Polrat Wilairatana Critical Care Research Unit Department of Clinical Tropical MedicineFaculty of Tropical MedicineMahidol UniversityBangkokThailand Department of Tropical Medicine and Malaria Research InstituteNational Center for Global Health and Medicine(NCGM)TokyoJapan Hospital for Tropical Diseases Faculty of Tropical MedicineMahidol UniversityBangkokThailand Department of Tropical Hygiene Faculty of Tropical MedicineMahidol UniversityBangkokThailand WHO Collaborating Center for Clinical Management of MalariaFaculty of Tropical MedicineMahidol UniversityBangkokThailand WHO Collaborating Center for Clinical Management of Malaria Faculty of Tropical MedicineMahidol UniversityBangkokThailand

Objective:To illustrate the clinical features and investigate the indicators associated with a fatal outcome in adult patients with severe Plasmodium falciparum malaria admitted to the Hospital for Tropical Diseases,Bangkok,***:We studied 202 adult malaria patients admitted to the Intensive Care Unit.A total of 43 clinical variables were identified by univariate and logistic regression analyses,to eliminate confounding ***:Regarding the statistical methods,only 6 variables-jaundice,cerebral malaria,metabolic acidosis,body mass index,initial respiratory rate,and white blood cell count-were significant indicators of death, with adjusted odds ratios(95%CI) of 15.2(2.1-32.3).4.3(2.3-12.6),3.3(2.3-5.7),2.4(1.9-3.5),2.2 (1.5-2.6),and 1.7(1.2-3.1),***:Our study found that jaundice,cerebral malaria,metabolic acidosis,body mass index,initial respiratory rate and white blood cell count were indicators of fatal outcome in severe Plasmodium falciparum *** studies on the fatal indicators in severe malaria need to be compared with data from different geographical areas,to construct practical measures to address potentially fatal indicators in different settings.

关键词： Plasmodium falciparum Severe malaria Fatal indicator Tertiary care Thailand

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On the Semiprimitivity and Semiprimality Problems for Partial Smash Products

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Algebra Colloquium 2018年第1期25卷 1-30页

作者： Rafael Cavalheiro Alveri sant'Ana Instituto de Matemdtica Estatfstica e Fisica Universidade Federal do Rio Grande Brazil Instituto de Matemdtica Universidade Federal do Rio Grande do Sul Brazil

In this paper we discuss about the semiprimitivity and the semiprimality of partial smash products. Let H be a semisimple Hopf algebra over a field k and let A be a left partial H-module algebra. We study the H-prime and the H-Jacobson radicals of A and their relations with the prime and the Jacobson radicals of A#H, respectively. In particular, we prove that if A is H-semiprimitive, then A^fH is semiprimitive provided that all irreducible representations of A are finite-dimensional, or A is an affine PI-algebra over k and k is a perfect field, or A is locally finite. Moreover, we prove that A=#=H is semiprime provided that A is an H-semiprime PI-algebra, generalizing to the setting of partial actions the known results for global actions of Hopf algebras.

关键词： partial Hopf action partial smash product semiprimitivity semiprimality H-radical partial (A H)-module

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Are fat NKT cells born that way?

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Cellular & Molecular Immunology 2017年第8期14卷 658-661页

作者： Joshua A Vieth Derek B sant'Angel Child Health Institute of New Jersey Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Graduate School of Biomedical Sciences Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Department of Pediatrics Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA

The role of natural killer T(NKT)cells in adipose tissue is a topic of much interest,as reports have suggested a correlation between depletion of the adipose-resident NKT(arNKT)cell population and chronic obesity.1 Fu... 详细信息

关键词： NKT killer obesity

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In vitro and in vivo evaluation of cerium oxide nanoparticles in respiratory syncytial virus infection

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Bioactive Materials 2023年第6期24卷 124-135页

作者： Akhil Patel Jessica Kosanovich Sameera Sansare Sricharani Balmuri Vinayak sant Kerry M.Empey Shilpa sant Department of Pharmaceutical Sciences School of PharmacyUniversity of PittsburghPittsburghPA15261USA Center for Clinical Pharmaceutical Sciences Department of Pharmacy and TherapeuticsSchool of PharmacyClinical and Translational Science InstituteDepartment of ImmunologySchool of MedicineUniversity of PittsburghPittsburghPA15261USA Department of Bioengineering Swanson School of EngineeringMcGowan Institute for Regenerative MedicineUPMC Hillman Cancer CenterUniversity of PittsburghPittsburghPA15261USA

Respiratory syncytial virus(RSV)is the most common cause of viral bronchiolitis among children worldwide,yet there is no vaccine for RSV *** study investigates the potential of cube and sphere-shaped cerium oxide nanoparticles(CNP)to modulate reactive oxygen(ROS)and nitrogen(RNS)species and immune cell phenotypes in the presence of RSV infection in vitro and in *** and sphere-shaped CNP were synthesized by hydrothermal and ultrasonication methods,***-chemical characterization confirmed the shape of sphere and cube CNP and effect of various parameters on their particle size distribution and zeta *** vitro results revealed that sphere and cube CNP differentially modulated ROS and RNS levels in J774 ***,cube CNP significantly reduced RSV-induced ROS levels without affecting RNS levels while sphere CNP increased RSV-induced RNS levels with minimal effect on ROS *** CNP drove an M1 phenotype in RSV-infected macrophages in vitro by increasing macrophage surface expression of CD80 and CD86 with a concomitant increase in TNFαand IL-12p70,while simultaneously decreasing M2 CD206 *** administration of sphere and cube-CNP were well-tolerated with no observed toxicity in BALB/c ***,cube CNP preferentially accumulated in murine alveolar macrophages and induced their activation,avoiding enhanced uptake and activation of other inflammatory cells such as neutrophils,which are associated with RSV-mediated *** conclusion,we report that sphere and cube CNP modulate macrophage polarization and innate cellular responses during RSV infection.

关键词： Cerium oxide nanoparticles Reactive oxygen species Respiratory syncytial virus Macrophage phenotypes Immunomodulation Nanoparticle shape Bioactive nanoparticles

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A Novel Green IoT-Based Pay-As-You-Go Smart Parking System

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Computers, Materials & Continua 2021年第6期67卷 3523-3544页

作者： Andrea sant Lalit Garg Peter Xuereb Chinmay Chakraborty Faculty of Information&Communication Technology University of MaltaMsidaMalta Birla Institute of Technology MesraJharkhand814142India

The better management of resources and the potential improvement in trafc congestion via reducing the orbiting time for parking spaces is crucial in a smart city,particularly those with an uneven correlation between the increase in vehicles and *** paper proposes and analyses a novel green IoT-based Pay-As-You-Go(PAYG)smart parking system by utilizing unused garage parking *** article also presents an intelligent system that offers the most favorable prices to its users by matching private garages’pricing portfolio with a garage’s current ***,the world’s fourth-most densely populated country,is considered as a case of a smart city for the implementation of the proposed *** results obtained conrm that apart from having a high potential system in such countries,the pricing generated correctly forecasts the demand for a particular garage at a specic time of the day and *** proposed PAYG smart parking system can effectively contribute to the macro solution to trafc congestion by encouraging potential users to use the system’s services and reducing the orbiting time for parking.

关键词： Smart parking garages smart city internet of things trafc congestion green IT

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PROGRESSING PRACTICES OF SUSTAINABLE SCHOOL DESIGN

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Journal of Green Building 2010年第2期5卷 147-157页

作者： sant Chansomsak Brenda Vale Faculty of Architecture Naresuan UniversityPhitsanulokThailand School of Architecture Victoria University of WellingtonNew Zealand

This article discusses a survey of contemporary practices of sustainable school *** reveals a trend that relies on technological fixes and outlines barriers to this,primarily related to lack of awareness of benefits,and a limited perception centring on the process of pre-design,design and construction but ignoring the use *** overcome the barriers,this article argues that a paradigm shift is required,embracing the creation of sustainable systems through a holistic approach to education,so that design operates and interacts with other *** suggestions provided could also be used to improve sustainable architectural practices in general。

关键词： sustainable school design sustainable architecture paradigm shift

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Optimized ANN for LiFePO_(4) battery charge estimation using principal components based feature generation

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Green Energy and Intelligent Transportation 2024年第4期3卷 59-71页

作者： Chaitali Mehta Amit V.sant Paawan Sharma Department of Computer Science and Engineering School of TechnologyPandit Deendayal Energy UniversityRaysanGandhinagar 382007India Department of Electrical Engineering School of Energy TechnologyPandit Deendayal Energy UniversityRaysanGandhinagar 382007India Department of Information and Communication Technology School of TechnologyPandit Deendayal Energy UniversityRaysanGandhinagar 382007India

Electric vehicles(EVs)have gained prominence in the present energy transition *** adoption of EVs necessitates an accurate State of Charge estimation(SoC)*** predictive SoC estimations with smart charging strategies not only optimizes charging efficiency and grid reliability but also extends battery lifespan while continuously enhancing the accuracy of SoC predictions,marking a crucial milestone in sustainable electric vehicle *** this research study,machine learning methods,particularly Artificial Neural Networks(ANN),are employed for SoC estimation of LiFePO4 batteries,resulting in efficient and accurate estimation *** investigation first focuses on developing a custom-designed battery pack with 12V,4 Ah capacity with a facility for real-time data collection through a dedicated hardware *** voltage,current and open-circuit voltage of the battery are monitored with computerized battery *** battery temperature is sensed with a DHT22 temperature sensor interfaced with Raspberry *** components are derived for the collected battery data set and analyzed for feature *** principal components were generated as input parameters for the developed *** Stopping for the ANN was also implemented to achieve faster convergence of the *** considering eleven combinations for ten different optimizers loss function is *** analysis of hyperparameter tuning and optimizer selection revealed that the Adafactor optimizer with specific settings produced the best results with an RMSE value of 0.4083 and an R2 Score of *** proposed algorithm was also implemented for two different types of datasets,a UDDS drive cycle and a standard cell-level *** results obtained were in line with the results obtained with the ANN model developed based on the data collected from the developed experimental setup.

关键词： Battery Feature engineering Principal component analysis Artificial neural networks Optimizers

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EV charging station with cascaded low-pass filtering scheme-based control of unified power quality conditioner

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Clean Energy 2022年第5期6卷 738-761页

作者： Arpitkumar J.Patel Amit V.sant Department of Electrical Engineering School of TechnologyPandit Deendayal Energy UniversityGandhinagarGujaratIndia

This paper proposes a cascaded low-pass filter(CLPF)scheme for the control of a unified power quality conditioner(UPQC)installed for enhancing the power quality of an electric vehicle(EV)charging *** the incorporation of UPQC,the EV charging station draws sinusoidal currents at unity power factor and the supply voltage is maintained at the nominal value at the charger *** the CLPF scheme,theα-βcomponents of the load current are individually processed through a cascade connection of two LPFs to determine the corresponding fundamental orthogonal *** on thus determined components,the instantaneous and peak value and phase angle of the fundamental positive sequence component(FPSC)of the load current are ***,the corresponding quantities related to the load and supply voltages are also computed with the CLPF *** the computations related to the load current and supply voltage,the unit voltage templates(UVTs),power factor and fundamental active component(FAC)of the load current are *** the control of shunt compensation,reference currents are generated based on the FAC of the load current and ***,the control of series compensation is employed with the help of UVTs and peak amplitude of the FPSC of the load *** performance of CLPF scheme-based extraction is compared with that of the earlier reported schemes through simulation and experimental *** performance comparison reveals a faster dynamic and more accurate steady-state response with the proposed *** performance analysis of the proposed CLPF scheme-based control of a UPQC deployed at the EV charging station for different operating conditions demonstrates station operation with requisite reactive power compensation and mitigation of voltage sag/swell,and prevention of propagation of harmonic and unbalanced currents into the *** results in increased reliability of charger operation,energy savings and increased efficiency o

关键词： battery chargers custom power devices electric vehicles power quality enhancement unified power quality conditioner

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Integrated transmission and generation planning model in a leregulated environment

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Frontiers in Energy 2013年第2期7卷 182-190页

作者： Enrique B. CEDENO sant ARORA Industrial and Systems Engineering Division Mechanical EngineeringDepartment University of Minnesota Minneapolis MN 55455 USA

After the deregulation of the Power Sector in the U.S., planning for generation and transmission capacities is decentralized. There is, however, still need for the long term integrated planning of generation and transmission capacities at the macro level, since these two sectors must operate in a coordinated manner. This paper presents a model for integrating generation and transmission expansion planning to identify an indicative expansion plan for the total sector at the macro level. The argument for an integrated model is supported using evidence from integrated planning efforts in real life systems. The application of the proposed model is illustrated using an example that requires expansion of generation and transmission capacities over three regions in a deregulated power system. The example considers that addition of generating capacity should come from renewable sources. The test results show the potential cost saving from integrated planning.

关键词： integrated planning indicative plans powergeneration transmission deregulation

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Optimization of micropatterned poly(lactic-coglycolic acid) films for enhancing dorsal root ganglion cell orientation and extension

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Neural Regeneration Research 2018年第1期13卷 105-111页

作者： Ching-Wen Li Brett Davis Jill Shea Himanshu sant Bruce Kent Gale Jayant Agarwal Department of Mechanical Engineering National Chung Hsing University Department of Surgery School of Medicine University of Utah Department of Mechanical Engineering University of Utah

Nerve conduits have been a viable alternative to the ‘gold standard’ autograft for treating small peripheral nerve gap injuries. However, they often produce inadequate functional recovery outcomes and are ineffective in large gap injuries. Ridge/groove surface micropatterning has been shown to promote neural cell orientation and guide growth. However, optimization of the ratio of ridge/groove parameters to promote orientation and extension for dorsal root ganglion （DRG） cells on poly（lactic-co-glycolic acid）（PLGA） films has not been previously conducted. Photolithography and micro-molding were used to define various combinations of ridge/groove dimensions on PLGA films. The DRG cells obtained from chicken embryos were cultured on micropatterned PLGA films for cell orientation and migration *** of the films occurred during the test period, however, this did not cause deformation or distortion of the micropatterns. Results from the DRG cell orientation test suggest that when the ridge/groove ratio equals 1 （ridge/groove width parameters are equal, i.e., 10 μm/10 μm （even））, the degree of alignment depends on the size of the ridges and grooves, when the ratio is smaller than 1 （groove controlled） the alignment increases as the ridge size decreases, and when the ratio is larger than 1 （ridge controlled）, the alignment is reduced as the width of the grooves decreases. The migration rate and neurite extension of DRG neurons were greatest on 10 μm/10 μm and 30 μm/30 μm micropatterned PLGA films. Based on the data, the 10 μm/10 μm and 30 μm/30 μm micropatterned PLGA films are the optimized ridge/groove surface patterns for the construction of nerve repair devices.

关键词： nerve regeneration nerve repair neural cell migration neural cell alignment micropattern dorsal root ganglion topological cues neural regeneration

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