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Quality assurance and safety of hippocampal avoidance prophylactic cranial irradiation in the multicenter randomized phase III trial(NCT01780675)

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Journal of the National Cancer Center 2023年第2期3卷 135-140页

作者： Oscar Candiff JoséBelderbos Anne Lisa Wolf Eugène Damen Paul van Haaren Wouter Crijns Sandra Hol Leen Paelinck Zdenko van Kesteren Jaap Jaspers Geert de Kerf Wouter van Elmpt Fred Ubbels sanne schagen Dirk de Ruysscher Michiel de Ruiter Department of Radiation Oncology the Netherlands Cancer InstituteAmsterdamthe Netherlands Department of Radiation Oncology Catharina HospitalEindhoventhe Netherlands Department of Radiation Oncology/Department of Oncology Laboratory of Experimental RadiotherapyKU LeuvenBelguimthe Netherlands Department of Radiation Oncology Institute VerbeetenTilburgthe Netherlands Department of Radiation Oncology Ghent University Hospital and Ghent UniversityGentBelgium Department of Radiation Oncology Amsterdam UMC-Location University of AmsterdamAmsterdamthe Netherlands Department of Radiation Oncology Erasmus Mc Cancer Institute-Erasmus Mc University Medical CenterRotterdamthe Netherlands Department of Radiation Oncology Antwerp University and Antwerp University Hospital/Iridium NetwerkAntwerpBelgium Department of Radiation Oncology University of Groningen-University Medical Center GroningenGroningenthe Netherlands Division of Psychosocial Research and Epidemiology the Netherlands Cancer InstituteAmsterdamthe Netherlands Radiation Oncology(Maastro) School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastrichtthe Netherlands

Objective:NCT01780675,a multicenter randomized phase III trial of prophylactic cranial irradiation(PCI)versus PCI with hippocampal sparing in small cell lung cancer(SCLC)investigated neurocognitive decline and *** part of quality assurance,we evaluated if hippocampal avoidance(HA)-PCI was performed according to the NCT01780675 trial protocol instructions,and performed a safety analysis to study the incidence and location of brain metastases for patients treated with ***:This retrospective analysis evaluated the quality of the irradiation given in the randomized controlled trial(RCT)comparing SCLC patients receiving PCI with or without hippocampal avoidance,using intensity mod-ulated radiotherapy(IMRT)or volumetric modulated arc therapy(VMAT).The dose distribution for each patient receiving HA-PCI was retrieved and analyzed to evaluate if the treatment dose constraints were met.A ques-tionnaire was sent out to all participating sites,and data on radiotherapy technique,pre-treatment dummy runs,phantom measurements and treatment electronic portal imaging device(EPID)dosimetry were collected and *** part of the safety analysis,the follow-up magnetic resonance imaging(MRI)or computerized to-mography(CT)scans on which cranial disease progression was first diagnosed were collected and matched to the radiotherapy planning dose *** matched scans were reviewed to analyze the location of the brain metastases in relation to the prescribed ***:A total of 168 patients were randomized in the NCT01780675 trial in 10 centers in the Netherlands and Belgium from April 2013 until March *** two patients receiving HA-PCI without evidence of brain metastases were *** patients were treated with 25 Gy in 10 *** runs and phantom measurements were performed in all institutions prior to enrolling patients into the *** radiotherapy(RT)plans showed a median mean bilateral hippocampal dose of 8.0 Gy,range 5.4-11.4(c

关键词： Hippocampus-avoidance profylactic cranial irradiation Small cell lung cancer Quality assurance NCT01780675 Neurocognition

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