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Predicting Lumbar Spondylolisthesis: A Hybrid Deep Learning Approach

Intelligent Automation & Soft Computing 2023年第8期37卷 2133-2151页

作者： Deepika Saravagi Shweta Agrawal Manisha Saravagi sanjiv k.jain Bhisham Sharma Abolfazl Mehbodniya Subrata Chowdhury Julian L.Webber Department of Computer Application SAGE UniversityIndore452012Madhya PradeshIndia IAC SAGE UniversityIndore452012Madhya PradeshIndia Shivang College of Physiotherapy Ratlam4570021Madhya PradeshIndia Medi-Caps University Rau IndoreMadhya Pradesh453331India Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Department of Electronics and Communication Engineering Kuwait College of Science and Technology(KCST)DohaKuwait Department of Computer Science and Engineering Sreenivasa Institute of Technology and Management StudiesChittoorAndra PradeshIndia

Spondylolisthesis is a chronic disease,and a timely diagnosis of it may help in avoiding *** identification in x-ray radiographs is very *** the feature extraction tool in VGG16 has improved the classification *** the fully connected layers of VGG16 are not efficient at capturing the positional structure of an object in *** network(CapsNet)works with capsules(neuron clusters)rather than a single neuron to grasp the properties of the provided image to match the *** this study,an integrated model that is a combination of VGG16 and CapsNet(S-VCNet)is *** the model,VGG16 is used as a feature *** feature extraction,the output is fed to CapsNet for disease identification.A private dataset is used that contains 466 X-ray radiographs,including 186 images displaying a spine with spondylolisthesis and 280 images depicting a normal *** suggested model is the first step towards developing a web-based radiological diagnosis tool that can be utilized in outpatient clinics where there are not enough qualified medical *** results demonstrate that the developed model outperformed the other models that are used for lumbar spondylolisthesis diagnosis with 98%*** the performance check,the model has been successfully deployed on the Gradio web app platform to produce the outcome in less than 20 s.

关键词： Gradio lumbar spondylolisthesis transfer learning VGG16 machine learning deep learning

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Pharmacological potential of Manilkara zapota(L.)***(Sapodilla):a narrative review

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Journal of Traditional Chinese Medicine 2024年第2期44卷 403-407页

作者： Priyanka Sharma Aakash Deep Harish kumar Nitin Bansal sanjiv kumar Arun Davinder kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001India

Herbal medicine is safe and effective in treating various *** herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health *** plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological *** genus Manilkara contains 135 plants around the *** overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)***(***),also known as *** has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.

关键词： herbal medicine Manilkara zapota phytoconstituents pharmacological activity review

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Ethnopharmacological,phytochemical and clinical studies on Fenugreek(Trigonella foenum-graecum L.)

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Food Bioscience 2022年第2期46卷 24-54页

作者： Neetu Singh Surender Singh Yadav sanjiv kumar Balasubramaniam Narashiman Department of Botany Maharshi Dayanand UniversityRohtakHaryana124001India Department of Pharmaceutical Sciences Ch.Bansi Lal UniversityBhiwaniHaryanaIndia Department of Pharmaceutical Sciences M.D.UniversityRohtakHaryana124001India

Trigonella foenum-graecum(fenugreek)belonging to the family Fabaceae,is widely used for both culinary as well as clinical purposes since *** medicines across globe particularly use this plant for boosting immunity and combating digestive and reproductive *** plant is rich reservoir of different phytoconstituents attributed to their diverse pharmacological ***,the present article is planned on its ethnomedicinal uses,botanical description,phytochemistry,pharmacology,toxicology,clinical efficacy,mechanism of action and nanoparticle *** all pharmacological studies,the dose,major bioactive,type of extract and possible outcomes is also discussed,to establish its specific role against a particular *** was hypothesized that the nanoparticle synthesis will lead to the enhanced *** showed that ethnomedicinal data well supports the different pharmacological aspects of Trigonella formulations in different ***(phytoestrogen)renders most of therapeutic potential of *** reported therapeutics can also be accounted as the synergistic pharmacology of different *** synthesis significantly improves its pharmacological *** studies well validated its antidiabetic and reproductive health improving *** no serious toxic effects were observed with the use of this plant but further well-designed placebo trials are still needed to demonstrate its full therapeutic potential.

关键词： Trigonella Fenugreek Traditional uses Pharmacology Clinical study Toxicology

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Biomechanics of human optic chiasmal compression: ex vivo experiment and finite element modelling

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Medicine in Novel Technology and Devices 2022年第1期13卷 110-117页

作者： Xiaofei Wang Andrew J.Neely Neeranjali S.jain Swaranjali V.jain sanjiv jain Murat Tahtali Gawn G.McIlwaine Christian J.Lueck Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Centre for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Engineering and Information Technology University of New South WalesCanberraAustralian Capital TerritoryAustralia Department of Neurology The Canberra HospitalCanberraAustralian Capital TerritoryAustralia Faculty of Medicine University of New South WalesKensingtonSydneyNew South WalesAustralia Department of Anatomical Pathology The Canberra HospitalCanberraAustralian Capital TerritoryAustralia Queen׳s University Belfast BelfastNorthern IrelandUK Belfast Health and Social Care Trust BelfastNorthern IrelandUK Australian National University Medical School CanberraAustralian Capital TerritoryAustralia Ophthalmic Engineering&Visual Science Laboratory School of Biological Science and Medical EngineeringBeihang UniversityRoom 424Building 537 Xueyuan RoadBeijing10083China

The mechanism of bitemporal hemianopia arising as a result of chiasmal compression is *** this study,we combined an ex vivo experiment and finite element modelling(FEM)to investigate its potential mechanism.A cadaveric human optic chiasm was scanned using micro-CT before and after deformation by inflation of Foley catheter,to simulate tumour growth from *** geometry of the same chiasm was reconstructed and simulated using finite element *** deformations were extracted from the simulation and compared with those observed during micro-CT *** addition,nerve fibre models examining variation in local fibre distribution patterns of the chiasm were incorporated to investigate the strain(deformation)distributions of the chiasm at an axonal *** FEM model matched the micro-CT scans well both qualitatively and *** of the chiasm induced high strains in the paracentral portions of the chiasm where the crossing optic nerve fibres are *** an axonal level,the magnitude of strains affecting crossed fibres were greater than those affecting uncrossed *** high strains in the paracentral portions of the chiasm,combined with the differences in strain between crossed and uncrossed nerve fibres,are consistent with a biomechanical explanation for the pattern of visual field loss seen in chiasmal compression.

关键词： Bitemporal hemianopia Pituitary tumour Chiasm Finite element modelling Optic nerve fibre

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When the Blood Pressure Misleads You:A Diagnostic Conundrum in an Unusual Case of Coarctation

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Congenital Heart Disease 2021年第6期16卷 675-680页

作者： Eva kapravelou Hugo Issa Gordon Culham Martin Hosking sanjiv k.Gandhi Shubhayan Sanatani Department of Pediatrics Division of CardiologyUniversity of British ColumbiaVancouverCanada Division of Pediatric Cardiothoracic Surgery University of British ColumbiaVancouverCanada Department of Pediatric Radiology British Columbia Children’s HospitalVancouverCanada

A 4-month-old previously healthy baby was found to be in congestive heart failure with LV dysfunction and a right aortic arch with severe coarctation,undetectable by blood pressure measurements.A cardiac CT and central blood pressure led to the diagnosis of a unique anatomic variant of aortic *** diagnosed the patient underwent surgery with an uncomplicated recovery.

关键词： Aorta coarctation right arch congenital heart disease

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Data-driven Bayesian inference of turbulence model closure coefficients incorporating epistemic uncertainty

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Acta Mechanica Sinica 2021年第12期37卷 1812-1838页

作者： Daigo Maruyama Philipp Bekemeyer Stefan Gortz Simon Coggon sanjiv Sharma German Aerospace Center(DLR) Institute of Aerodynamics and Flow Technology Lilienthalplatz 738108 BraunschweigGermany Airbus Operations Limited Pegasus House Aerospace AveFiltonBristol BS347PA

We introduce a framework for statistical inference of the closure coefficients using machine learning *** objective of this framework is to quantify the epistemic uncertainty associated with the closure model by using experimental data via Bayesian *** framework is tailored towards cases for which a limited amount of experimental data is *** consists of two ***,by treating all latent variables(non-observed variables)in the model as stochastic variables,all sources of uncertainty of the probabilistic closure model are quantified by a fully Bayesian *** probabilistic model is defined to consist of the closure coefficients as parameters and other parameters incorporating ***,the uncertainty associated with the closure coefficients is extracted from the overall uncertainty by considering the noise being *** overall uncertainty is rigorously evaluated by using Markov-Chain Monte Carlo sampling assisted by surrogate *** apply the framework to the Spalart-Allmars one-equation turbulence *** test cases are considered,including an industrially relevant full aircraft model at transonic flow conditions,the Airbus ***,we demonstrate that epistemic uncertainties in the closure coefficients result into uncertainties in flow quantities of interest which are prominent around,and downstream,of the shock occurring over the XRF1 *** data-driven approach could help to enhance the predictive capabilities of CFD in terms of reliable turbulence modeling at extremes of the flight envelope if measured data is available,which is important in the context of robust design and towards virtual aircraft *** plentiful amount of information about the uncertainties could also assist when it comes to estimating the influence of the measured data on the inferred model ***,the developed framework is flexible and can be applied to different test cases and to various turbulence model

关键词： Turbulence modeling Uncertainty quantification Parameter calibration Bayesian statistics Surrogate-assisted methods Spalart-Allmaras one-equation turbulence model Large-scale industrial aircraft use-case

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Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review

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World Journal of Gastroenterology 2017年第37期23卷 6788-6801页

作者： M Masudur Rahman sanjiv Mahadeva Uday C Ghoshal Department of Gastroenterology Dhaka Medical College and Hospital Division of Gastroenterology Department of MedicineUniversity of Malaya Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences

Irritable bowel syndrome(IBS) is a chronic gastrointestinal disorder, common in clinic and in the community. It has a significant impact on both society and patients' quality of life. The epidemiology, clinical presentation, and management of IBS may vary in different geographical regions due to differences in diet, gastrointestinal infection, socio-cultural and psychosocial factors, religious and illness beliefs, symptom perception and reporting. Although previous reviews and consensus reports on IBS in Asia have been published, Asia is quite diverse socio-demographically. In this context, India, Bangladesh and Malaysia share some similarities, including:(1) large proportion of the population living in rural areas;(2) rapid development and associated lifestyle changes in urban areas; and(3) dietary, cultural and religious practices. The present review explores the clinical and epidemiological data on IBS from these three major nations in South and South-East Asia. In-depth review of the literature revealed important differences between IBS in the East, as revealed by studies from these three countries, and the West; these include a predominantly rural profile, differences in bowel habit and symptom profile, raising concern with regards to diagnostic criteria and subtyping of IBS, higher dietary fiber consumption, frequent lactose malabsorption, parasitosis, and possible overlap between post-infectious IBS and tropical sprue. Moreover, the current perception on difference in prevalence of the disorder in these countries, as compared to the West, might be related to variation in survey methods.

关键词：传染病学功能的胃肠的混乱急躁的肠症候群亚洲症状便秘腹泻

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Tumor Molecular Imaging with Nanoparticles

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Engineering 2016年第1期2卷 132-140页

作者： Zhen Cheng Xuefeng Ya Xilin Sun BaozhongShen sanjiv Sam Gambhir a Molecular Imaging Program at Stanford Department of Radiology Stanford University Stanford CA 94305 USA Molecular Imaging Research Center of Harbin Medical University Harbin 150001 China TOF-PET/CT/MR Center the Fourth Hospital of Harbin Medical University Harbin 150001 China ora Umverslty Stanford CA 94305 USA

Molecular imaging(MI)can provide not only structural images using traditional imaging techniques but also functional and molecular information using many newly emerging imaging *** the past decade,the utilization of nanotechnology in MI has exhibited many significant advantages and provided new opportunities for the imaging of living *** is expected that multimodality nanoparticles(NPs)can lead to precise assessment of tumor biology and the tumor *** review addresses topics related to engineered NPs and summarizes the recent applications of these nanoconstructs in cancer optical imaging,ultrasound,photoacoustic imaging,magnetic resonance imaging(MRI),and radionuclide *** challenges involved in the translation of NPs to the clinic are discussed.

关键词：肿瘤生物学分子成像纳米颗粒放射性核素显像成像技术纳米粒子磁共振成像心肌梗死

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Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2022年第15期28卷 1563-1573页

作者： Thaninee Prasoppokakorn Wah-kheong Chan Vincent Wai-Sun Wong Panyavee Pitisuttithum sanjiv Mahadeva Nik Raihan Nik Mustapha Grace Lai-Hung Wong Howard Ho-Wai Leung Pimsiri Sripongpun Sombat Treeprasertsuk Department of Medicine Division of GastroenterologyFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Medicine Division of GastroenterologyDivision of Gastroenterology and Hepatology UnitFaculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Medicine Division of General Internal MedicineFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Pathology Hospital Sultanah BahiyahAlor SetarKedah 05460Malaysia Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong KongChina Department of Internal Medicine Prince of Songkla UniversityHat Yai 90110Thailand Department of Medicine Division of Gastroenterology and HepatologyStanford University School of MedicinePalo AltoCA 94305United States

BACkGROUND Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease(NAFLD)*** fibrosis-8(FIB-8)score,recently developed by incorporating four additional variables into the fibrosis-4(FIB-4)score,showed better performance in predicting significant fibrosis in *** To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score(NFS)for predicting significant *** We collected the data of biopsy-proven NAFLD patients from three Asian centers in three *** the patients with available variables for the FIB-4 score(age,platelet count,and aspartate and alanine aminotransferase levels)and FIB-8 score(the FIB-4 variables plus 4 additional parameters:The body mass index(BMI),albumin to globulin ratio,gamma-glutamyl transferase level,and presence of diabetes mellitus)were *** fibrosis stage was scored using nonalcoholic steatohepatitis CRN criteria,and significant fibrosis was defined as at least fibrosis stage *** A total of 511 patients with biopsy-proven NAFLD and complete data were included for *** these 511 patients,271(53.0%)were female,with a median age of 51(interquartile range:41,58)*** median BMI was 29(26.3,32.6)kg/m2,and 268(52.4%)had *** the 511 NAFLD patients,157(30.7%)had significant fibrosis(≥F2).The areas under the receiver operating characteristic curves of the FIB-8 and FIB-4 scores and NFS for predicting significant fibrosis were 0.774,0.743,and 0.680,*** FIB-8 score demonstrated significantly better performance for predicting significant fibrosis than the NFS(P=0.001)and was also clinically superior to FIB-4,although statistical significance was not reached(P=0.073).The low cutoff point of the FIB-8 score for predicting significant fibrosis of 0.88 showed 92.36%sensitivity,and the high cutoff point of the FIB-8 score for predicting significant fibrosis of 1.

关键词： Nonalcoholic fatty liver disease Fibrosis-8 score Fibrosis-4 score Nonalcoholic fatty liver disease fibrosis score

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Coal Mines Workers and Motivation

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Psychology Research 2017年第3期7卷 186-204页

作者： sanjiv k. Nimbalkar SRM College of Social Work Gondwana University Gadchiroli Padoli India

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