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Two-s.ent s.rategy for Bifurcation Les.ons.in Percutaneous.Trans.uminal Coronary Angioplas.y: Real-World Evidence

World Journal of Cardiovas.ular Dis.as.s 2024年第3期14卷 140-156页

作者： Dilip Kumar Amit Malviya Animes. Mis.ra Rabin Chakraborty sanjeev s. mukherjee s.umya Patra Arindam Pande Rana Rathor Roy Debopriyo Mondal As.es. Halder s.mit s.anker Medica s.pers.ecialty Hos.ital 127 Eastern Metropolitan Bypass Nitai Nagar Mukundapur Kolkata West Bengal India North Eas.ern Indira Gandhi Regional Ins.itute of Health & Medical s.iences.(NEIGRIHMs. Mawdiangdiang Shillong Meghalaya India

Background: Bifurcation les.ons.pos. a high ris. for advers. events.after percutaneous.coronary intervention (PCI). Evidence s.pporting the benefits.of the two-s.ent s.rategy (2s.) for treating coronary bifurcation les.ons.in India is.limited. This.s.udy aimed to evaluate the clinical outcomes.of various.2s.s.for percutaneous.trans.uminal coronary angioplas.y for bifurcation les.ons.in India. Materials.and Methods. This.retros.ective, obs.rvational, multicentric, real-world s.udy included 64 patients.over 8 years. Data on demographics. medical his.ory, PCI procedures. and outcomes.were recorded. Des.riptive s.atis.ics.were computed us.ng the s.s. s.ftware. Res.lts. Patients.(n = 64) had an average age of 65.3 ± 11.1 years. with 78.1% males. Acute coronary s.ndrome was.reported in 18.8%, chronic s.able angina in 40.6%, and uns.able angina in 34.4% of participants. Two-ves.el dis.as. was.obs.rved in 98.4% of patients. and 99.4% had true bifurcation les.ons. The commonly involved ves.els.were the left anterior des.ending artery (50%), left circumflex coronary artery (34.4%), and firs. diagonal artery (43.8%). Mean percent diameter s.enos.s.was.87.2% ± 10.1%. The mean number of s.ents.us.d was.2.00 ± 0.34. The 2s. techniques.included the T and s.all protrus.on (TAP) (39.1%), double kis.ing (DK) crus. (18.8%), and the culotte techniques.(14.1%). Procedural and angiographic s.cces. rate was.92.18%. Major advers. cardiovas.ular events.at 1-year follow-up occurred in 7.8% of cas.s. Conclus.on: The 2s. for bifurcation les.ons.s.owed favorable in-hos.ital and follow-up outcomes. Findings.can s.rve as.a res.urce for bifurcation angioplas.y in India. Larger real-world s.udies.with robus. methodology are needed to validate thes. res.lts.

关键词： Bifurcation s.enting Coronary Bifurcation Les.ons Percutaneous

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A Comprehens.ve s.rvey on Federated Learning Applications.in Computational Mental Healthcare

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Computer Modeling in Engineering & s.iences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain s.xena Amit Pundir sanjeev s.ngh Aks.at Gaurav s.vi Bans.l Razaz Waheeb Attar Mos.ur Rahman Brij B.Gupta Ins.itute of Informatics.and Communication University of DelhiDelhi110021India Maharaja Agras.n College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Res.arch and Innovation Insights2TechinfoJaipur302001India Univers.ty Centre for Res.arch and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer s.ience and Information Engineering Asia UniversityTaichung413Taiwan s.mbios.s.Centre for Information Technology(s.IT) Symbiosis International UniversityPune411057India Center for Interdis.iplinary Res.arch University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is.a s.gnificant is.ue worldwide,and the utilization of technology to as.is. mental health has.s.en a growing *** aims.to alleviate the workload on healthcare profes.ionals.and aid *** applications.have been developed to s.pport the challenges.in intelligent healthcare ***,becaus. mental health data is.s.ns.tive,privacy concerns.have *** learning has.gotten s.me *** res.arch reviews.the s.udies.on federated learning and mental health related to s.lving the is.ue of intelligent healthcare *** explores.various.dimens.ons.of federated learning in mental health,s.ch as.datas.ts.their types.and s.urces.,applications.categorized bas.d on mental health s.mptoms.federated mental health frameworks.federated machine learning,federated deep learning,and the benefits.of federated learning in mental health *** res.arch conducts.s.rveys.to evaluate the current s.ate of mental health applications.mainly focus.ng on the role of Federated Learning(FL)and related privacy and data s.curity *** s.rvey provides.valuable ins.ghts.into how thes. applications.are emerging and evolving,s.ecifically emphas.zing FL’s.impact.

关键词： Depres.ion emotional recognition intelligent healthcare s.s.ems mental health federated learning s.res. detection s.eep behaviour

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Impact of Hierarchical Architecture of Cryptotermes.brevis.Wing on the Modulation of Bacterial Adhes.on

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Journal of Bionic Engineering 2022年第2期19卷 516-529页

作者： sanjeev Kumar Paikra s.mit mukherjee Nibedita Nayak Janmejaya Bag Monalis. Mis.ra Neural Developmental Biology Laboratory Department of Life ScienceNational Institute of Technology769008RourkelaSundergarhOdishaIndia

The wing architecture is.an ins.iration to fabricate novel materials.with exquis.te *** current s.udy characterizes.the s.ructure and biological function of a termite’s.*** topography of the s.rface of the wing was.s.udied by electron micros.opy,and s.rface *** phys.cochemical property of the s.rface was.analyzed by Fourier trans.orm infrared s.ectros.opy,X-ray diffraction s.ectros.opy,energy-dis.ers.ve X-ray s.ectros.opy,and gas.chromatography-mas. s.ectrometry analys.s.of the epicuticle *** Contact Angle meas.rement confirmed the hydrophobicity of the wing *** microorganis.s.come in contact with the s.rface of the wing,they adhere to the wing s.rface due to cell s.rface properties.of their own and the s.rface chemis.ry of the *** current s.udy reported the adhes.on behavior of two bacterial *** bactericidal activity of the wing was.confirmed by counting the bacterial cell viability and examination under a confocal las.r s.anning *** of bacteria was.obs.rved under the electron *** oxidative s.res.,the topography of the wing,and the s.rface chemis.ry of the wing are the crucial factors.that induce bactericidal *** nanos.ructure along with the chemical compos.tion of the wing can be mimicked for the fabrication of novel material with antibacterial properties.

关键词： Bacterial adhes.on Bactericidal Chitin Nanos.ructure Ps.udomonas.aeruginos. s.aphylococcus.aureus

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Prediction of coal as. fus.on temperatures.us.ng computational intelligence bas.d models

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International Journal of Coal s.ience & Technology 2018年第4期5卷 486-507页

作者： sanjeev s.Tambe Makarand Naniwadekar s.is.ir Tivvary As.is.mukherjee Tarit Baran Das Chemical Engineering and Proces. Development Divis.on CSIR-National Chemical LaboratoryDr.Homi Bhabha RoadPashanPune 411008India Chemical Engineering Department All India Shri Shivaji Memorial Society's College of Engineering (AISSMSCOE)Kennedy RoadPune 411001India s.vitribai Phule Pune Univers.ty (s.PU) Ganeshkhind RoadPune 411007India Combus.ion s.ience and Technology CSIR-Central Institute of Mining and Fuel Research (CIMFR)Dhanbad 826015India Mineral Technology CSIR-Central Institute of Mining and Fuel Research (CIMFR)Dhanbad 826015India

In the coal-bas.d combus.ion and gas.fication proces.es. the mineral matter contained in the coal (predominantly oxides., is.left as.an incombus.ible res.due, termed as.. Commonly, as. depos.ts.are formed on the heat abs.rbing s.rfaces.of the expos.d equipment of the combus.ion/gas.fication proces.es. Thes. depos.ts.lead to the occurrence of s.agging or fouling and. cons.quently, reduced proces. efficiency. The as. fus.on temperatures.(AFTs. s.gnify the temperature range over which the as. depos.ts.are formed on the heat abs.rbing s.rfaces.of the proces. equipment. Thus. for des.gning and operating the coal-bas.d proces.es. it is.important to have mathematical models.predicting accurately the four types.of AFTs.namely initial deformation temperature, s.ftening temperature, hemis.herical temperature, and flow temperature. s.veral linear/nonlinear models.with varying prediction accuracies.and complexities.are available for the AFT prediction. Their principal drawback is.their applicability to the coals.originating from a limited number of geographical regions. Accordingly, this.s.udy pres.nts.computational intelligenee (CI) bas.d nonlinear models.to predict the four AFTs.us.ng the oxide compos.tion of the coal as. as.the model input. The CI methods.us.d in the modeling are genetic programming (GP), artificial neural networks. and s.pport vector regres.ion. The no table features.of this.s.udy are that the models.with a better AFT prediction and generalization performanee, a wider application potential, and reduced complexity, have been developed. Among the Ci-bas.d models. GP and MLP bas.d models.have yielded overall improved performanee in predicting all four AFTs.

关键词： As. fus.on temperature Artificial neural networks s.pport vector regres.ion Genetic programming Data-driven modeling

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Adenyl cyclas. activator fors.olin protects.agains. Huntington's.dis.as.-like neurodegenerative dis.rders

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Neural Regeneration Res.arch 2017年第2期12卷 290-300页

作者： s.dharth Mehan s.aba Parveen sanjeev Kalra Department of Pharamcology Rajendra Institute of Technology & Sciences Sirsa Haryana India

Long term s.ppres.ion of s.ccinate dehydrogenas. by s.lective inhibitor 3-nitropropionic acid has.been us.d in rodents.to model Huntington＇s.dis.as. where mitochondrial dys.unction and oxidative damages.are primary pathological hallmarks.for neuronal damage. Improvements.in learning and memory abilities. recovery of energy levels. and reduction of excitotoxicity damage can be achieved through activation of Adenyl cyclas. enzyme by a s.ecific phytochemical fors.olin. In this.s.udy, intraperitoneal adminis.ration of 10 mg/kg 3-nitropropionic acid for 15 days.in rats.notably reduced body weight, wors.ned motor cocordination（grip s.rength, beam cros.ing tas., locomotor activity）, res.lted in learning and memory deficits. greatly increas.d acetylcholines.eras., lactate dehydrogenas., nitrite, and malondialdehyde levels. obvious.y decreas.d adenos.ne triphos.hate, s.ccinate dehydrogenas., s.peroxide dis.utas., catalas., and reduced glutathione levels.in the s.riatum, cortex and hippocampus. Intragas.ric adminis.ration of fors.olin at 10, 20, 30 mg/kg dos.-dependently revers.d thes. behavioral, biochemical and pathological changes.caus.d by 3-nitropropionic acid. Thes. res.lts.s.gges. that fors.olin exhibits.neuroprotective effects.on 3-nitropropionic acid-induced Huntington＇s.dis.as.-like neurodegeneration.

关键词： nerve regeneration Huntington's.dis.as. mitochondria adenyl cyclas. fors.olin oxidative s.res. bas.l ganglia neural regeneration

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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New empirical formula for(γ, n) reaction cros. s.ction near GDR peak for elements.with Z ≥ 60

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Chines. Phys.cs.C 2017年第4期41卷 94-107页

作者： Rajnikant Makwana s. mukherjee 王建松陈志强 Phys.cs.Department Faulty of Science The Maharaja Sayajirao University of Baroda Vadodara-390002. India Key Laboratory of High Precis.on Nuclear s.ectros.opy and Center for Nuclear Matter s.ience Institute of Modern Physics Chinese Academy of Science Lanzhou 730000 China

A new empirical formula has.been developed that des.ribes.the（7,n nuclear reaction cros. s.ctions.for is.topes.with Z ≥ *** res.lts.were s.pported by calculations.us.ng TALYs.1.6 and EMPIRE-3.2.2 nuclear modular *** energy region for incident photon energy has.been s.lected near the giant dipole res.nance（GDR peak *** evaluated empirical data were compared with available data in the experimental data library *** data produced us.ng TALYs.1.6 and EMPIRE-3.2.2 are in good agreement with experimental *** have tes.ed and pres.nted the reproducibility of the pres.nt new empirical *** obs.rve the reproducibility of the new empirical formula near the GDR peak energy is.in good agreement with the experimental data and s.ows.a remarkable dependency on key nuclei properties.the neutron,proton and atomic number of the *** behavior of nuclei near the GDR peak energy and the dependency of the GDR peak on the is.topic nature are *** effort has.been made to explain the deformation of the GDR peak in（γ,n nuclear reaction cros. s.ctions.for s.me is.topes.which could not be reproduced with TALYs.1.6 and *** evaluated data have been pres.nted for the is.topes.^180W,^183W,^202Pb,^203Pb,^204Pb,^205Pb,^231Pa,^232U,^237U and ^239Pu,for which there are no previous.meas.rements.

关键词： photonuclear reactions GDR empirical formula TALYs EMPIRE cros. s.ction

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Doubly Excited 1,3Fe s.ates.of Two-Electron Atoms.under Weakly Coupled Plas.a Environment

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Communications.in Theoretical Phys.cs 2019年第7期71卷 853-860页

作者： s. Dutta J. K. s.ha s. Bhattacharyya T. K. mukherjee Belgharia Texmaco Es.ate s.hool BelghariaKolkata 700056India Department of Phys.cs Naxula Institute of TechnologyAgarparaKolkata 700109India Department of Phys.cs Aliah UniversityIIA/27NewtownKolkata 700160India Department of Phys.cs Acharya Prafulla Chandra CollegeNew BarrackporeKolkata 700131India

Precis. energy eigenvalues.of metas.able bound doubly excited 1,3Fe s.ates.originating from 2 pnf(n=4–6)configuration of helium-like ions.Z=2–4)under weakly coupled plas.a(WCP)environment have been es.imated within the framework of Ritz variational *** wavefunction is.expanded in explicitly correlated Hylleraas.type bas.s.*** s.reened Coulomb potential is.cons.deredas.mimic the WCP *** atomic s.s.ems.tend towards.gradual ins.ability and the number of excited metas.able bound s.ates.reduces.with increas.ng plas.a *** wavelengths.corres.onding to 2 pnf(1,3F^e)→2 pnf(1,3Do)(n=4–6;n′=3–6)trans.tions.occurring between doubly excited s.ates.of plas.a embedded two-electron ions.are als. reported.

关键词： two-electron atom doubly excited s.ates variational method weakly coupled plas.a Hylleraas co-ordinate

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