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Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury

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Neural Regeneration Research 2021年第12期16卷 2349-2352页

作者： Asit kumar Santosh kumar Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA

Traumatic brain injury is a sudden trauma or blow on the head,and severe traumatic brain injury is a major cause of death and disability *** acute and chronic consequences following traumatic brain injury can lead to progressive secondary neurodegenerative changes and cognitive *** date,there is no effective pharmaceutical products for the treatment to reduce secondary damage after brain *** discovery of extracellular vesicles has attracted considerable scientific attention due to their role in cell-to-cell *** vesicles have shown their potential to carry not only biological molecules but also as a drug delivery *** a carrier of molecular information,extracellular vesicles have been involved in physiological functions as well as in the modulation of immune ***,we aim to provide new insights into the contrasting role of extracellular vesicles in the propagation of inflammatory responses after brain *** a carrier of pro-inflammatory molecules,their role as functional mediators in the pathophysiology of brain injury is discussed,addressing the inhibition of the extracellular vesicle pathway as an anti-inflammatory or neuroprotective approach to improve the outcome of both acute and chronic inflammation following brain ***,we summarize therapeutic strategies to diminish the risk the neurodegeneration post brain injury and propose that neutral sphingomyelinase inhibitors could be used as potentially useful therapeutic agents for the treatment of brain injury associated neuroinflammation.

关键词： brain injury ceramide extracellular vesicles microglia neuroinflammation neuroprotection neutral sphingomyelinase

A Local Contrast Fusion Based 3D Otsu Algorithm for Multilevel Image Segmentation

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 200-213页

作者： Ashish kumar Bhandari Arunangshu Ghosh Immadisetty Vinod kumar Department of Electronics and Communication Engineering National Institute of Technology Patna

To overcome the shortcomings of 1 D and 2 D Otsu’s thresholding techniques, the 3 D Otsu method has been *** all Otsu’s methods, 3 D Otsu technique provides the best threshold values for the multi-level thresholding processes. In this paper, to improve the quality of segmented images, a simple and effective multilevel thresholding method is introduced. The proposed approach focuses on preserving edge detail by computing the 3 D Otsu along the fusion phenomena. The advantages of the presented scheme include higher quality outcomes, better preservation of tiny details and boundaries and reduced execution time with rising threshold levels. The fusion approach depends upon the differences between pixel intensity values within a small local space of an image;it aims to improve localized information after the thresholding process. The fusion of images based on local contrast can improve image segmentation performance by minimizing the loss of local contrast, loss of details and gray-level distributions. Results show that the proposed method yields more promising segmentation results when compared to conventional1 D Otsu, 2 D Otsu and 3 D Otsu methods, as evident from the objective and subjective evaluations.

关键词： 1D Otsu 2D Otsu 3D Otsu image fusion local contrast multi-level image segmentation

A Novel Variant of Moth Flame Optimizer for Higher Dimensional Optimization Problems

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Journal of Bionic Engineering 2023年第5期20卷 2389-2415页

作者： Saroj kumar Sahoo Sushmita Sharma Apu kumar Saha Department of Mathematics National Institute of Technology AgartalaJiraniaTripura799046India

Moth Flame Optimization(MFO)is a nature-inspired optimization algorithm,based on the principle of navigation technique of moth toward *** to less parameter and easy implementation,MFO is used in various field to solve optimization ***,for the complex higher dimensional problems,MFO is unable to make a good trade-off between global and local *** overcome these drawbacks of MFO,in this work,an enhanced MFO,namely WF-MFO,is introduced to solve higher dimensional optimization *** a more optimal balance between global and local search,the original MFO’s exploration ability is improved by an exploration operator,namely,Weibull flight *** addition,the local optimal solutions have been avoided and the convergence speed has been increased using a Fibonacci search process-based technique that improves the quality of the solutions ***-nine benchmark functions of varying complexity with 1000 and 2000 dimensions have been utilized to verify the projected *** popular algorithms and MFO versions have been compared to the achieved *** addition,the robustness of the proposed WF-MFO method has been evaluated using the Friedman rank test,the Wilcoxon rank test,and convergence *** to other methods,the proposed WF-MFO algorithm provides higher quality solutions and converges more quickly,as shown by the ***,the proposed WF-MFO has been used to the solution of two engineering design issues,with striking *** improved performance of the proposed WF-MFO algorithm for addressing larger dimensional optimization problems is guaranteed by analyses of numerical data,statistical tests,and convergence performance.

关键词： Moth Flame Optimization(MFO)algorithm Bio-inspired algorithm Fibonacci search method Weibull distribution Higher dimensional functions

Strategy and Future Prospects to Develop Room-Temperature-Recoverable NO2 Gas Sensor Based on Two-Dimensional Molybdenum Disulfide

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Nano-Micro Letters 2021年第2期13卷 305-362页

作者： Abhay V.Agrawal Naveen kumar Mukesh kumar Functional and Renewable Energy Materials Laboratory Indian Institute of Technology RoparRupnagarPunjab 140001India

Nitrogen dioxide(NO2),a hazardous gas with acidic nature,is continuously being liberated in the atmosphere due to human *** NO2 sensors based on traditional materials have limitations of high-temperature requirements,slow recovery,and performance degradation under harsh environmental *** limitations of traditional materials are forcing the scientific community to discover future alternative NO2 sensitive *** disulfide(MoS2)has emerged as a potential candidate for developing next-generation NO2 gas ***2 has a large surface area for NO2 molecules adsorption with controllable morphologies,facile integration with other materials and compatibility with internet of things(IoT)*** aim of this review is to provide a detailed overview of the fabrication of MoS2 chemiresistance sensors in terms of devices(resistor and transistor),layer thickness,morphology control,defect tailoring,heterostructure,metal nanoparticle doping,and through light ***,the experimental and theoretical aspects used in designing MoS2-based NO2 sensors are also discussed ***,the review concludes the challenges and future perspectives to further enhance the gas-sensing performance of *** and addressing these issues are expected to yield the development of highly reliable and industry standard chemiresistance NO2 gas sensors for environmental monitoring.

关键词： MoS2 NO2 gas sensors Light illumination Heterojunction

Room-Temperature Gas Sensors Under Photoactivation:From Metal Oxides to 2D Materials

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Nano-Micro Letters 2020年第11期12卷 292-328页

作者： Rahul kumar Xianghong Liu Jun Zhang Mahesh kumar Department of Electrical Engineering Indian Institute of Technology JodhpurJodhpur 342037India College of Physics Center for Marine Observation and CommunicationsQingdao UniversityQingdao 266071People’s Republic of China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071People’s Republic of China

Room-temperature gas sensors have aroused great attention in current gas sensor technology because of deemed demand of cheap,low power consumption and portable sensors for rapidly growing Internet of things *** an important approach,light illumination has been exploited for room-temperature operation with improving gas sensor's attributes including sensitivity,speed and *** review provides an overview of the utilization of photoactivated nanomaterials in gas sensing ***,recent advances in gas sensing of some exciting different nanostructures and hybrids of metal oxide semiconductors under light illumination are ***,excellent gas sensing performance of emerging two-dimensional materialsbased sensors under light illumination is discussed in details with proposed gas sensing *** impressive features from the interaction of photons with sensing materials are elucidated in the context of modulating sensing ***,the review concludes with key and constructive insights into current and future perspectives in the light-activated nanomaterials for optoelectronic gas sensor applications.

关键词： Gas sensor Room temperature Photoactivation Metal oxide 2D materials

Numerical investigation of the effect of transitory strand opening on mixing in a multistrand tundish

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International Journal of Minerals,Metallurgy and Materials 2011年第5期18卷 535-542页

作者： Sabin kumar Mishra Pradeep kumar Jha Satish Chandra Sharma Satish kumar Ajmani Department of Mechanical and Industrial Engineering Indian Institute of Technology RoorkeeRoorkee 247667UttarakhandIndia Steelmaking and Casting Research Group Tata SteelR&DBurma MinesJamshedpur 831007JharkhandIndia

In a multistrand,the outlet near the inlet produces short circuiting *** leads to the formation of dead zones inside the tundish,and consequently,the mean residence time *** the present study,numerical investigation of mixing inside a delta shaped tundish with sloping boundaries was carried out by solving the Navier-Stokes equation and employing the standard turbulence *** decrease the dead zone volume inside the tundish,the effect of closing the outlet near the inlet for a small amount of time and further opening it on the mixing behavior of the tundish was *** outlets near the inlet were closed for varying amount of time,and the transient analysis of fluid flow and the tracer dispersion study were carried out to find the mixing parameters of the tundish,namely,mean residence time and the ratio of mixed to dead volume of the *** optimum closure time of the near outlet has been found,which yields best mixing inside the *** numerical code was validated against the experimental observation by performing the tracer dispersion study inside a multistrand tundish and the reasonably good match between the experimental and numerical results in terms of residence time distribution （RTD） *** results obtained from the present study confirm the strong role of choosing the right time for opening and closing the outlets to get improved characteristics for the fluid flow and mixing behavior of the *** educational version of computational fluid dynamics （CFD） software PHOENICS was used to solve the governing equations and interpret the results in different forms.

关键词： continuous casting billets tundish flow simulation mean residence time dead volume computational fluid dynamics (CFD)

Factorial Correlators and Oscillatory Multiplicity Moments at the CERN SPS Energy for Ring-Like and Jet-Like Events

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Chinese Physics Letters 2011年第1期28卷 62-65页

作者： Prabir kumar Haldar Sanjib kumar Manna Dinhata College Department of Physics Dinhata Coochbehar West Bengal India

We present an analysis of ring-like and jet-like events in terms of factorial correlations and oscillatory multiplicity moments of 32S Ag/Br interactions at 200 A OeV. The investigation reveals that the correlated moments increase with decrease in bin-bin separation D, following the power law, which suggests the presence of an intermittent nature of self-similar dynamical fluctuations pattern for ring-like and jet-like events. The analysis further shows that the strength of the non-statistical fluctuations is larger for jet-like events than those of ring-like events and total events. However, ring-like and jet-like events are not to be consistent with the total events of the c~ model of intermittency. To go beyond the lower order correlation, the oscillatory multiplicity moments are used to study the higher order correlation. The ratios Hq （cumulant over factorial moments, Kq/Fq） are determined for ring-like, jet-like and the total events. The presence of few-particle short range correlation is established. It is extremely interesting to observe that the oscillations of ring-like events are different from the jet-like events and the total events. However, in almost all the cases, the simulated interactions fail to replicate the experimental results.

关键词： Nuclear physics

Adaptive Three-phase Estimation of Sequence Components and Frequency Using H∞ Filter Based on Sparse Model

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Journal of Modern Power Systems and Clean Energy 2020年第5期8卷 981-990页

作者： Umamani Subudhi Harish kumar Sahoo Sanjeev kumar Mishra Department of Electronics and Telecommunication Engineering Indian Institute of Information Technology(IIIT)BhubaneshwarIndia Department of Electronics and Telecommunication Engineering Veer Surendra Sai University of Tecnology(Burla)SambalpurIndia

The estimation of sequence or symmetrical components and frequency in three-phase unbalanced power system is of great importance for protection and *** paper proposes a new H∞filter based on sparse model to track the sequence components and the frequency of three-phase unbalanced power *** inclusion of sparsity improves the error convergence behavior of estimation model and hence short-duration non-stationary PQ events can easily be tracked in the time *** proposed model is developed using l1 norm penalty in the cost function of H∞filter,which is quite suitable for estimation across all the three phases of an unbalanced *** model uses real state space modeling across three phases to estimate amplitude and phase parameters of sequence ***,frequency estimation uses complex state space modeling and Clarke transformation generates a complex measurement signal from the unbalanced three-phase *** state vector used for frequency estimation consists of two state *** proposed sparse model is tested using distorted three-phase signals from IEEE-1159-PQE database and the data generated from experimental laboratory *** analysis of absolute and mean square error is presented to validate the performance of the proposed model.

关键词： Sequence component Clarke transformation H∞filter state space model

A novel hybrid authentication protocol utilizing lattice-based cryptography for IoT devices in fog networks

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Digital Communications and Networks 2024年第4期10卷 989-1000页

作者： kumar Sekhar Roy Subhrajyoti Deb Hemanta kumar Kalita Department of Computer Science and Engineering Manipal Institute of Technology BengaluruManipal Academy of Higher EducationManipal576104KarnatakaIndia Department of Computer Science&Engineering ICFAI UniversityAgartala799210India Department of Computer Science&Engineering Central Institute of TechnologyKokrajhar783370India

The Internet of Things(IoT)has taken the interconnected world by *** to their immense applicability,IoT devices are being scaled at exponential proportions ***,very little focus has been given to securing such *** these devices are constrained in numerous aspects,it leaves network designers and administrators with no choice but to deploy them with minimal or no security at *** have seen distributed denial-ofservice attacks being raised using such devices during the infamous Mirai botnet attack in *** we propose a lightweight authentication protocol to provide proper access to such *** have considered several aspects while designing our authentication protocol,such as scalability,movement,user registration,device registration,*** define the architecture we used a three-layered model consisting of cloud,fog,and edge *** have also proposed several pre-existing cipher suites based on post-quantum cryptography for evaluation and *** also provide a fail-safe mechanism for a situation where an authenticating server might fail,and the deployed IoT devices can self-organize to keep providing services with no human *** find that our protocol works the fastest when using ring learning with *** prove the safety of our authentication protocol using the automated validation of Internet security protocols and applications *** conclusion,we propose a safe,hybrid,and fast authentication protocol for authenticating IoT devices in a fog computing environment.

关键词： Internet of things Authentication Post-quantum cryptography Lattice-based cryptography Cloud computing Fog computing Fail-safe