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Inverse modelling of aquifer parameters in basaltic rock with the help of pumping test method using MODFLOW software

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Geoscience Frontiers 2017年第6期8卷 1385-1395页

作者： Kanak Moharir Chaitanya Pande sanjay patil Sant Gadge Baba Amravati University AmravatiIndia Maharashtra Remote Sensing Application Center PuneIndia

The origin and movement of groundwater are the fundamental questions that address both the temporal and spatial aspects of ground water run and water supply related issues in hydrological *** groundwater flows through an aquifer,its composition and temperature may variation dependent on the aquifer condition through which it ***,hydrologic investigations can also provide useful information about the subsurface geology of a *** because such studies investigate processes that follow under the Earth's shallow,obtaining the information necessary to answer these questions is not continuously ***,which discharge groundwater table directly,afford to study subsurface hydrogeological *** present study of estimation of aquifer factors such as transmissivity(T)and storativity(S)are vital for the evaluation of groundwater *** are several methods to estimate the accurate aquifer parameters(*** analysis,pumping test,etc.).In initial days,these parameters are projected either by means of in-situ test or execution test on aquifer well samples carried in the *** simultaneous information on the hydraulic behavior of the well(borehole)that provides on this method,the reservoir and the reservoir boundaries,are important for efficient aquifer and well data management and *** most common in-situ test is pumping test performed on wells,which involves the measurement of the fall and increase of groundwater level with respect to *** alteration in groundwater level(drawdown/recovery)is caused due to pumping of water from the ***(1935)was first to propose method to evaluate aquifer parameters from the pumping test on a bore well in a confined *** is essential to know the transmissivity(T=Kb,where b is the aquifer thickness;pumping flow rate,Q=TW(dh/dl)flow through an aquifer)and storativity(confined aquifer:S=bS_s,unconfined:S=S_y),for the characterization of the aquifer parameters in an unkn

关键词： Pumping test Hantush method GPS MODFLOW Inverse modelling Hydraulic parameters

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Dual-tree complex wavelet transform and super-resolution based video inpainting application to object removal and error concealment

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 314-319页

作者： Gajanan Tudavekar sanjay R.patil Santosh S.Saraf Department of Electronics&Communication Engineering Angadi Institute of Technology and ManagementBelagaviKarnatakaIndia Visvesvaraya Technological University BelagaviKarnatakaIndia Department of Electronics&Telecommunication Engineering Marathwada Institute of TechnologyAurangabadMaharashtraIndia Department of Electronics&Communication Engineering KLS Gogte Institute of TechnologyBelagaviKarnatakaIndia

Video inpainting is a technique that fills in the missing regions or gaps in a video by using its known *** existing video inpainting algorithms are computationally expensive and introduce seam in the target region that arises due to variation in brightness or contrast of the *** overcome these drawbacks,the authors propose a novel two-stage *** the first step,sub-bands of wavelets of a low-resolution image are obtained using the dualtree complex wavelet *** algorithm and auto-regression technique are then applied to these subbands to inpaint the missing *** fuzzy logic-based histogram equalisation is used to further enhance the image by preserving the image brightness and improve the local *** the second step,the image is enhanced using super-resolution *** process of down-sampling,inpainting and subsequently enhancing the video using the super-resolution technique reduces the video inpainting *** framework is tested on video sequences by comparing and analysing the structural similarity index matrix,peak-signal-to-noise ratio,visual information fidelity in pixel domain and execution time with the state-of-the-art *** experimental analysis gives visually pleasing results for object removal and error concealment.

关键词： resolution video image

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Chlorogenic acid may be a potent inhibitor of dimeric SARS-CoV-2 main protease 3CLpro: an in silico study

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Traditional Medicine Research 2021年第2期6卷 135-148页

作者： Rajkumar sanjay patil Nayeem A.Khatib Vishal Shivalingappa patil Shailendra sanjay Suryawanshi Department of Pharmacology and Toxicology KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchJNMC CampusNehru NagarBelagavi 590010KarnatakaIndia Department of Pharmaceutical Chemistry KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchJNMC CampusNehru NagarBelagavi 590010KarnatakaIndia

Background:Since the emergence of coronavirus disease 2019 to date,there is no available approved drug or definitive treatment for coronavirus disease 2019 viral infection,and the identification of novel hits against therapeutic targets has become a global *** purpurea is a traditional herb utilized to treat cough,fever,sore throat,respiratory tract infection,and so on as an immune *** this study,in silico molecular docking approach was used to screen phytocompounds from *** against severe acute respiratory syndrome coronavirus 2 main protease 3C-like protease(3CLpro)and severe acute respiratory syndrome coronavirus main peptidase(96%sequence similarity)to blunt the viral gene expression and viral ***:Initially,we screened phytocompounds for their druggability and ADMET ***,x-ray crystallographic structures of main proteases 3CLpro and main peptidase having Protein Data Bank ID 6LU7 and 2GTB were used as protein targets for the identification of potential drug *** performed docking using AutoDock Vina by PyRx 0.8 *** Discovery Studio Visualizer v2019 was used to analyze ligand-protein *** probable protein targets of the selected compound were predicted by BindingDB(P≥0.7).STRING and Kyoto Encyclopedia of Genes and Genomes pathways are utilized to identify the molecular pathways modulated by the predicted targets(FDR≤0.05),and the network interaction between compounds and protein pathways was constructed by Cytoscape ***:Among all the compounds,chlorogenic acid showed druggable characteristics and scored the lowest binding energy with main protease and main peptidase via interacting with active site 1 domain amino acid ***,chlorogenic acid interacted with Phe140 main protease 3CLpro,which is potentially involved in the *** analysis identified chlorogenic acid to modulate insulin resistance,necroptosis,interleukin-17,tumor nec

关键词： Molecular docking Echinacea purpurea Chlorogenic acid COVID-19 Main protease 3CLpro Network pharmacology

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Fabrication of Nanocrystalline TiO<sub>2</sub>Thin Film Ammonia Vapor Sensor

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Journal of Sensor Technology 2011年第1期1卷 9-16页

作者： Shailesh Pawar Manik Chougule sanjay patil Bharat Raut Dhanaji Dalvi Pramod patil Shashwati Sen Pradeep Joshi Vikas patil 不详

Nanocrystalline titanium oxide thin films have been deposited by spin coating technique and then have been analyzed to test their application in NH3 gas-sensing technology. In particular, spectrophotometric and con-ductivity measurements have been performed in order to determine the optical and electrical properties of titanium oxide thin films. The structure and the morphology of such material have been investigated by X ray diffraction, Scanning microscopy, high resolution electron microscopy and selected area electron diffrac-tion. The X-ray diffraction measurements confirmed that the films grown by this technique have good crys-talline tetragonal mixed anatase and rutile phase structure The HRTEM image of TiO2 thin film showed grains of about 50-60 nm in size with aggregation of 10-15 nm crystallites. Selected area electron diffraction pattern shows that the TiO2 films exhibited tetragonal structure. The surface morphology (SEM) of the TiO2 film showed that the nanoparticles are fine The optical band gap of TiO2 film is 3.26 eV. Gas sensing proper-ties showed that TiO2 films were sensitive as well as fast in responding to NH3. A high sensitivity for ammo-nia indicates that the TiO2 films are selective for this gas.

关键词： Sol Gel Method Structural Properties Optical Properties NH3 Sensor

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Nanocrystalline CuO Thin Films for H<sub>2</sub>S Monitoring: Microstructural and Optoelectronic Characterization

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Journal of Sensor Technology 2011年第2期1卷 36-46页

作者： Vikas patil Datta Jundale Shailesh Pawar Manik Chougule Prsad Godse sanjay patil Bharat Raut Shashwati Sen 不详

Nanocrystalline copper oxide (CuO) thin films were deposited onto glass substrates by a spin coating technique using an aqueous solution of copper acetate. These films were characterized for their structural, mor-phological, optoelectronic properties by means of X-ray diffraction (XRD) scanning electron microscopy (SEM), UVspectroscopy and four probe method. The CuO films are oriented along (1 1 1) plane with the monoclinic crystal structure. These films were utilized in H2S sensors. The dependence of the H2S response on the operating temperature, H2S concentration of CuO film (annealed at 700。C) was investigated. The CuO film showed selectivity for H2S. The maximum H2S response of 25.2 % for the CuO film at gas concentra-tion of 100 ppm at operating temperature 200oC was achieved.

关键词： CuO Thin Films Structural Properties Optoelectronic Properties H2S Sensor

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Study of boundary layer characteristics during the landfalling of a Nisarga cyclone

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Tropical Cyclone Research and Review 2024年第2期13卷 55-71页

作者： Rani P.Pawar Prajna Priyadarshini T.Dharmaraj Dada P.Nade Mahendra N.patil Omkar M.patil N.Jeni Victor Sambhaji M.Pawar D.G.Kanase Sunil D.Pawar Indian Institute of Tropical Meteorology Ministry of Earth SciencesPuneIndia Department of Physics Bharati Vidyapeeth’s Dr.Patangrao Kadam Mahavidyalaya(Shivaji University Kolhapur)SangliIndia KSK Geomagnetic Research Laboratory IIGPrayagrajAllahabadIndia Department of Physics Sanjay Ghodawat University KolhapurIndia

One of the most important parameters in meteorology is the mean wind proﬁle in the tropical cyclone boundary *** vertical proﬁle of wind speed and wind direction were measured during the period of the Nisarga cyclone from May 31st,2020,to June 5th,2020,using the newly installed Phased Array Doppler Sodar system at the Center for Space and Atmospheric Science(CSAS),sanjay Ghodawat University,Kolhapur(16.74◦N,74.37◦E;near India's western coast).Our analysis revealed that the maximum mean wind speed was 17 m/s on June 3,2020,at 10:00 *** also shows the change in wind direction from southwest to southeast on June 2 and 3,*** high-resolution reanalysis data in the domain,0–25◦N,65–110◦E,during the period from May 31st to June 5th,2020,revealed the variation of the atmospheric pressure of the Nisarga cyclone from 1000 to 1008 hPa,sea surface temperature(SST)between 30◦C and 31◦C,outgoing longwave radiation(OLR)between 100 and 240 Wm-2,wind speed between 3 and 15 m/s,and low values of vertical wind shear(VWS)were observed to the north of Nisarga *** observations may provide more insights for the study of boundary layer turbulence during cyclonic activities.

关键词： Doppler Sodar Tropical cyclone Atmospheric boundary layer Vertical turbulence intensity

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Potential of herbal constituents as new natural leads against helminthiasis: A neglected tropical disease

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Asian Pacific Journal of Tropical Medicine 2019年第7期12卷 291-299页

作者： Kiran D.patil Shashikant B.Bagade sanjay R.Sharma Ketan V.Hatware NMIMS School of Pharmacy and Technology Management

The WHO reports that billions of people and animals in tropical and subtropical regions are affected by helminthiasis as neglected tropical disease. It is predominant in underdeveloped areas;nevertheless, the increase in the number of travelers and migrants has made this infection more common. The current mass drug treatment produces severe side effects and many strains of helminths are resistant to them. None of the chemotherapeutic drugs meets the ideal requirements of anthelmintics, such as broad spectrum of activity, single dose cure, free from side effect and cost-effectiveness. Today, many researchers are screening the traditional herbal system in search of the anthelmintic herbal constituents which overcome all the problems of synthetic drugs. Several researchers proclaim anthelmintic activity of herbal medicines by using different experimental models. The present review demonstrates natural product drug discovery, outlining potential of herbal constituents from natural sources as natural leads against helminthiasis.

关键词： Neglected tropical diseases Herbal constituents Helminthiasis Herbal anthelmintics

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Dual inhibition of COVID-19 spike glycoprotein and main protease 3CLpro by Withanone from Withania somnifera

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Chinese Herbal Medicines 2021年第3期13卷 359-369页

作者： Vishal Shivalingappa patil Vrushabh B.Hupparage Ajay P.Malgi sanjay H.Deshpande Sathgowda A.patil Shamanand P.Mallapur Department of Pharmacology and Toxicology KLE College of PharmacyKLE Academy of Higher Education and Research(KAHER)Belagavi 590010India Regional Centre for Biotechnology NCR-Biotech Science ClusterFaridabad 121001India

Objective:To identify the safe and effective natural inhibitors of spike glycoprotein and main protease 3CLpro using potential natural antiviral compounds which are studied under various animal models and viral cell ***:First,compounds were retrieved from the Pub Chem database and predicted for their druggability using the Mol Soft web server,and compounds having drug-like property were predicted for major adverse drug reactions like cardiotoxicity,hepatotoxicity,arrhythmia,myocardial infarction,and nephrotoxicity using *** of nontoxic antiviral compounds with spike glycoprotein and main protease 3CLpro was performed using Auto Dock vina by PyRx 0.8 *** stability of compoundprotein interactions was checked by molecular dynamic(MD)simulation using Schrodinger Desmond ***:Based on the druggable and nontoxic profile,nine compounds were *** them,Withanone from Withania somnifera showed the highest binding affinity and best fit at active sites 1 of spike glycoprotein(glycosylation site)and main protease 3CLpro via interacting with active site amino acid residues before and after MD simulation at 50 ***,which may reduce the glycosylation of SARS-CoV-2 via interacting with Asn343 and inhibit viral ***:The current study reports Withanone as a non-toxic antiviral against SARS-CoV-2 and serve as a potential lead hit for further experimental validation.

关键词： antiviral COVID-19 docking dynamics main protease 3CLpro SARS-CoV-2 spike glycoprotein Withanone Withania somnifera(Linn.)Dunal

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Comparison of skeletal, dental and soft tissue changes in young adults with Class II malocclusion, treated either by camouflage, fixed functional appliance or orthognathic surgery—A prospective study on Indian subjects

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Open Journal of Stomatology 2012年第4期2卷 373-382页

作者： Anjana Shetty Anand patil sanjay Ganeshkar Department of Orthodontics and Dentofacial Orthopaedics AECS Maaruthi Dental College Banglore India Department of Orthodontics and Dentofacial Orthopaedics SDM College of Dental Sciences Dharwad India

Introduction: Borderline Class II malocclusion due to deficient mandible can be treated either by orthodontic camouflage, fixed functional appliances or by orthodontics followed by surgical mandibular advancement. Methodology: A prospective study was designed on young adults with Class II malocclusion on account of a deficient mandible. A total of 45 subjects were divided into three groups of 15 individuals each. The patients were treated either by camouflage, fixed functional appliances or by orthognathic surgery. Pre and post treatment cephalograms were used to assess the skeletal, dental and soft tissue changes. Pre and post treatment profile photographs were assessed on a Visual Analogue Scale (VAS) by orthodontists, oral surgeons and laypersons. Results: Each group achieved a reduction in facial convexity, but the results obtained from the surgical group were more pronounced than the camouflage and the fixed functional group. Conclusion: The reduction in convexity in the camouflage group was by retracting the upper anteriors, which increases the nasolabial angle. In the fixed functional appliance a combination of skeletal and dentoalveolar changes can be observed. However the most appropriate reduction in profile convexity can be obtained by combined orthodontic and surgical treatment of malocclusion.

关键词： Class II Malocclulsion Camouflage Fixed Function Appliance Orthognathic Surgery

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Aloin attenuates chronic constriction injury-induced neuropathic pain in rats by inhibiting inflammatory cytokines and oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 205-213页

作者： Aarti S.Kale Avinash R.Wadkar Umesh B.Mahajan Lalit A.Birari Sateesh Belemkar Sameer N.Goyal Shreesh Ojha sanjay J.Surana Chandragouda R.patil Kalpesh R.patil Department of Pharmacology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia School of Pharmacy&Technology Management SVKM's NMIMSMPTPShirpur-425405Dist-DhuleMaharashtraIndia Shri Vile Parle Kelavani Mandal's Institute of Pharmacy Dhule-424001MaharashtraIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityP.O.Box 17666Al AinAbu DhabiUAE Department of Pharmacognosy R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia

Objective:To investigate the effect of aloin against chronic constriction injury(CCI)-induced neuropathic pain in ***:Rats were randomly divided into 7 groups:GroupⅠ(normal control),GroupⅡ(sham-operated),GroupⅢ(CCI control)and GroupⅣ,Ⅴ,Ⅵ,andⅦ,which underwent CCI surgery and then were administered with aloin(5 mg/kg,p.o.;25 mg/kg,p.o.;125 mg/kg,p.o.)and gabapentin(50 mg/kg,p.o.),respectively for 14 *** neuropathy was induced by silk ligatures(4-0)loosely placed around the sciatic *** thresholds against mechanical stimuli(Von-Frey filaments)and thermal stimuli(12℃and 40℃)were measured at midplantar paw region ipsilateral to the compressed nerve on day-3,7,11,and *** concentration of cytokines including tumor necrosis factor-α(TNF-α),interleukin-6,and interleukin-1βwas estimated at *** day 14,motor nerve conduction velocity was determined under urethane anesthesia(1.25 g/kg).Oxidative stress parameters(malondiadehyde,glutathione,catalase,and superoxide dismutase)were estimated in sciatic nerve homogenates at day *** nerve samples were processed for histological ***:Aloin significantly reduced CCI-induced mechanical and thermal *** also improved motor nerve conduction velocity and decreased oxidative stress in nerve *** addition,it decreased pro-inflammatory cytokine levels and restored the histoarchitecture of compressed sciatic ***:Aloin mitigates CCI-induced neuropathic pain in rats by inhibiting oxidative stress and pro-inflammatory cytokines in the afflicted sciatic nerve.

关键词： Aloin Chronic constriction injury Antioxidant Neuropathic pain

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