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Electromagnetic design and performance of conduction cooled superconducting magnet for spoke resonator cryomodule for Proton Improvement Plan(PIP)-II

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Superconductivity 2024年第3期11卷 14-33页

作者： Kumud Singh Janvin Itteera Mahima Vikas Tiwari Himanshu Bisht sanjay malhotra R.R.Singh Rajesh Jalan sanjay Howa Rajesh Chimurkar Sunil Kumar S.Stoynev M.Turenne M.Yu B.Hanna J.Hayman C.Boffo Electromagnetic Applications&Instrumentation Division Bhabha Atomic Research CentreTrombay 400085India Fermi Accelerator National Laboratory Batavia IL 60510-5011USA

The Proton Improvement Plan(PIP)-II project is part of Fermilab’s upgrade of its proton accelerator complex,to provide a powerful,high-intensity proton beam to the laboratory’s upcoming research *** project includes an 800 MeV superconducting(SC)linear accelerator(linac),with five flavours of cavities and *** medium energy section of the linac contains two types of superconducting Single Spoke Resonator(SSR)RF cavities(SSR1 and SSR2),which are interleaved with strong solenoid focusing lenses.A unified design of the solenoid has been developed,with one solenoid design satisfying both SSR1 and SSR2 *** integral focusing strength requirement of 4.5 T^(2)m with a full width half maximum(FWHM)of 180 mm indicates the peak field strength∼6.8 T in the magnet aperture,necessitating a superconducting design within the limits of NbTi as magnet wire *** are complex combined units that include one focusing solenoid with bucking coils to minimize fringe fields and four corrector coils each,with independent current leads to produce dipole and quadrupole *** simplify the current lead design and reduce complexity,the project opted conduction cooling for these magnets,thus requiring a redesign compared to previous prototype bath cooled *** designs for high energy accelerators adopt bath cooled design of the solenoid focusing lenses for medium energy *** present design explores a unique and technically superior solution for the cryomodule operation by decoupling the magnet and cavity cooling to certain *** in cryomodule operations shall be studied after integration of magnets in the Linac *** we discuss the design requirements,challenges,electromagnetic design,superconducting wire selection and the results from magnetic measurements of the first pre-series units.

关键词： conduction module magnets

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Significance of inferior wall ischemia in non-dominant right coronary artery anatomy

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World Journal of Cardiology 2017年第3期9卷 261-267页

作者： Ali Osama Malik Oliver Abela Subodh Devabhaktuni Arhama Aftab Malik Gayle Allenback Chowdhury H Ahsan sanjay malhotra Jimmy Diep Department of Internal Medicine University of Nevada School of Medicine Department of Cardiovascular Medicine University of Nevada School of Medicine Aga Khan Univesity Medical College Office of Medical Research Universtiy of NevadaSchool of Medicine

AIM To investigate the relationship of inferior wall ischemia on myocardial perfusion imaging in patients with nondominant right coronary artery *** This was a retrospective observational analysis of consecutive patients who presented to the emergency department with primary complaint of chest *** patients who underwent single photon emission computed tomography(SPECT)myocardial perfusion imaging(MPI)were *** who showed a reversible defect on SPECT MPI and had coronary angiography during the same hospitalization was *** with prior history of coronary artery disease(CAD)including history of percutaneous coronary intervention and coronary artery bypass graft surgerys were *** positive and false positive results were identified on the basis of hemodynamically significant CAD on coronary angiography,in the same territory as identified on SPECT *** artery dominance was determined on coronary *** were divided into group 1 and group ***1 included patients with non-dominant right coronary artery(RCA)(left dominant and codominant).Group2 included patients with dominant RCA ***,baseline characteristics and positive predictive value(PPV)were analyzed for the two *** The mean age of the study cohort was 57.6 *** point seven percent of the patients were *** prevalence of self-reported diabetes mellitus,hypertension and dyslipidemia was 36%,71.9%and 53.9%respectively.A comparison of baseline characteristics between the two groups showed that patients with a non-dominant RCA were more likely to be *** inferior wall ischemia on SPECT MPI,patients in study group 2 had a significantly higher PPV,32/42(76.1%),compared to patients in group 1,in which only 3 out of the 29 patients(10.3%)had true positive results(P value<0.001 Z test).The difference remained statistically significant even when only patients with left dominant coronary system(without co-do

关键词： Myocardial perfusion imaging Single photon emission commuted tomography False positive results Coronary artery dominance Inferior wall ischemia

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Novel Nitrobenzazolo[3,2-a]quinolinium Salts Induce Cell Death through a Mechanism Involving DNA Damage, Cell Cycle Changes, and Mitochondrial Permeabilization

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Open Journal of Apoptosis 2013年第2期2卷 13-22页

作者： Christian Vélez Osvaldo Cox Carlos A. Rosado-Berrios Dennise Molina Luz Arroyo Sujey Carro Anton Filikov Vineet Kumar sanjay V. malhotra Marisol Cordero Beatriz Zayas Arkansas State University Jonesboro USA Laboratory of Synthetic Chemistry-SAIC Frederick National Laboratory for Cancer Research Frederick USA Universidad Metropolitana Caracas Venezuela Universidad Metropolitana San Juan Puerto Rico University of Puerto Rico San Juan USA

This study reports the capacity of three nitro substituted benzazolo[3,2-a]quinolinium salts NBQs: NBQ 95 (NSC-763304), NBQ 38 (NSC 763305), and NBQ 97 (NSC-763306) as potential antitumor agents. NBQ’s are unnatural alkaloids possessing a positive charge that could facilitate interaction with cell organelles. The anticancer activities of these compounds were evaluated through the National Cancer Institute (NCI) 60 cell line screening which represents diverse histologies. The screening was performed at 10 μM on all cell lines. Results from the NCI screening indicated cytotoxicity activity on six cell lines. In order to explore a possible mechanism of action, a detailed biological activity study of NBQ 95 and NBQ 38 was performed on A431 human epidermoid carcinoma cells to determine an apoptotic pathway involving, cell cycle changes, DNA fragmentation, mutations, mitochondrial membrane permeabilization and caspases activation. DNA fragmentation, cell cycle effects, mutagenesis, mitochondrial permeabilization and activation of caspases were determined by fluorimetry and differential imaging. Our data showed that A431 growth was inhibited with an average IC50 of 30 mM. In terms of the mechanism, these compounds interacted with DNA causing fragmentation and cell cycle arrest at sub G0/G1 stage. Mutagenesis was higher for NBQ 38 and moderate for NBQ 95 Mitochondrial permeabilization was observed with NBQ 38 and slightly for NBQ 95. Both compounds caused activation of Caspases 3 and 7 suggesting an apoptotic cell death pathway through an intrinsic mechanism. This study reports evidence of the toxicity of these novel compounds with overlapping structural and mechanistic similarities to ellipticine, a known anti-tumor compound.

关键词： Apoptosis A431 Quinolinium Salts Mutagenesis Caspase Activation

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“A Prospective Randomized Case-Control Study To Evaluate Mini Right Thoracotomy versus Conventional Sternotomy For Mitral Valve Repair In Rheumatic Heart Disease.”

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World Journal of Cardiovascular Surgery 2016年第11期6卷 139-152页

作者： Ashok Kumar Chahal Preeti Gehlaut sanjay Johar Ashish Asija Divya Arora Naveen malhotra Kuldeep Singh Lallar Shamsher Singh Lohchab Department of Cardiac Surgery Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India Department of Anaesthesiology Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India Department of Cardiac Surgery Max Hospital Delhi India Department of Cardiology Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences Rohtak India

Purpose: Right mini thoracotomy has been evaluated in many studies for mitral valve repair mainly in degenerative valvular disease but not in rheumatic heart disease. Mitral valve repair is more challenging in rheumatic etiology due to complexity of lesions. This prospective randomized case control study was designed to evaluate repair through mini right thoracotomy and to compare the clinical and echocardiographic outcomes with sternotomy in rheumatic patients. Methods: 25 patients of rheumatic heart disease underwent mitral valve repair through mini right thoracotomy (group I). Various clinical and functional parameters were compared with 25 patients of mitral valve repair through sternotomy (group II). On follow up the results were compared in both groups for clinical and echocardiographic parameters. Results: The various pre-operative demographic parameters were comparable in two groups. Equal rate of mitral valve repair (group I-21/25, 84% and group II-21/25, 84%) was achieved in both groups. The various intra-operative and post-operative clinical parameters were better in group I .There were equivalent functional and valve related outcomes in both groups in term of NYHA class (1.28 ± 0.613 vs 1.08 ± 0.276, P = 0.144), post-operative mitral valve area (2.43 ± 0.891 vs 2.82 ± 0.662, P = 0.090), incidence of more than mild mitral regurgitation (0) and mean pressure gradient across mitral valve (4.98 ± 3.33 vs 4.23 ± 1.5, P = 0.309). Conclusion: Mitral valve repair through mini right thoracotomy approach in rheumatic etiology is feasible and safe with equivalent rate of successful repair as compared to median sternotomy. It is associated with lesser morbidity, cosmetic advantage and lesser resource utilization.

关键词： “Rheumatic Heart Disease Minimally Invasive Mitral Valve Repair Right antero-lateral thoracotomy.” Mitral valve repair

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Extracellular Vesicles and Their Significance in COVID-19

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Advances in Human Physiology Research 2022年第1期4卷 1-4页

作者： sanjay Kumar Soumi Sadhu Himanshu Narayan Singh Navneet Kumar Dubey Nikhil Kumar Prashant Kumar Tiwari Rajan malhotra Himani Sharma Department of Life Science School of Basic Science and ResearchSharda UniversityGreater NoidaUP201310India Division of Nephrology Mayo ClinicRochesterMN55905USA Department of System Biology Columbia University Irving Medical CenterNew YorkNY10032USA Victory Biotechnology Co. Ltd.TaipeiTaiwan114757China ShiNeo Technology Co. Ltd.New Taipei CityTaiwan24262China Department of Medicine All India Institute of Medical Sciences(AIIMS)New Delhi-110029India

Over the last few years,there is huge scientific attention towards the research related to Extracellular Vesicles(EVs),because of their unique property of inter cellular communications and effective biological significance in diagnosis and therapy[1].Extracellular Vesicles are lipid bilayer membrane bound biological entity,which contains different bioactive compounds(cargoes)such as microRNAs(miRNAs),mRNAs,proteins,and *** on their origin and size,EVs have been categorized into three different types(a)Exosomes(40 nm-150 nm)are smallest EVs,which are synthesized by endocytic pathways in the cells and secreted in extracellular space through exocytosis process,(b)Microvesicles are secreted from direct budding off plasma membranes and their size varying from 50 nm to 1000 nm and,(c)Apoptotic bodies are formed during apoptotic cell death process and respectively larger in size>1000 nm[1-3].EVs have been identified using different markers,that includes tetraspanins proteins(CD9,CD63,CD81,and CD83),endosomal sorting complexes required for transport(TSG101,Alix),heat shock proteins(Hsp60,Hsp70,Hsp90),and Rab proteins(RAB27a/b)[1].

关键词： CD63 diagnosis CD81

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