检索结果-南通市图书馆

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

引用

National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian k.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar kam Alfred Wei-Chieh kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang krishnakumar Madhavan Tony kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce kah-Hoe Chow Genome Institute of singapore Agency for Science Technology and Research key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： NADH oxidase H2O2 production oxidative phosphorylation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

胸腺嘧啶合酶的表达水平可良好预测结肠直肠癌患者对5-氟尿嘧啶的化学敏感度

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 56-56页

作者： Inoue T Hibi k Nakayama G 杨雪娟 Gastroenterological Surgery Nag oya Univ. Grad. Sch. of Medicine65 Tsurumai-cho Showa-ku Nagoya 466-8560 Japan

Background. It is important to seek the appropriate chemo- therapy drugs to effectively eliminate colorectal cancers. To avoid unnecessar y medication and uncomfortable side effects,it is important to estimate the chem osensitivity of cancers to 5-fluorouracil (5-FU) before chemotherapy. Methods. We examined thymidylate synthase (TS) and dih- ydropyrimidine dehydrogenase (DPD) gene expressions in 23 colorectal cancers,u sing quantitative reverse transcription-polymerase chain reaction (RT-PCR).We then evaluated the relationship between (TS) and (DPD) gene expression levels an d the sensitivity of colorectal cancers to 5-FU, as determined by histoculture drug response assay (HDRA). Results. A significant increase in the TS expr- ession score was observed in 5-FU-sensitive colorectal cancers (0.57 ±0.19) compared to 5-FU-resistant o- nes (1.16±0.98; P = 0.029), whereas no significant differences in DPD express ion scores were observed in 5-FU-sensitive colorectal cancers (0.86 ±1.19) co mpar- ed to 5-FU-resistant ones (0.56 ±1.05; P = 0.603). Conclusions. TS mRNA may be useful as a predictor of the 5-FU chemosensitivity of colorectal cancers.

关键词：结肠直肠癌尿嘧啶合酶胸腺嘧啶基因表达药敏测试化疗药物药疗组织培养 RNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

多区域互联电力系统输送服务边际电价的实现和分析

引用

电力系统自动化 2000年第17期24卷 4-7,19页

作者：余志伟高大伟谢志棠钟志勇汪震香港理工大学

在电力工业中 ,按参与转运的电力公司和其他电力公司 (电力交易方 )在地域上的关系可以划分为不同的转运类型 :区域内部 ,母线到母线 ;区域间 ,区域到区域 ;区域间 ,区域到母线 ;区域间 ,母线到区域 ;区域间 ,母线到母线。在一个多区域... 详细信息

在电力工业中 ,按参与转运的电力公司和其他电力公司 (电力交易方 )在地域上的关系可以划分为不同的转运类型 :区域内部 ,母线到母线 ;区域间 ,区域到区域 ;区域间 ,区域到母线 ;区域间 ,母线到区域 ;区域间 ,母线到母线。在一个多区域互联电力系统中 ,一个区域的有功 /无功的边际转运成本是系统中电力交易买卖双方的功率变换变化一个单位时引起的该区域内运行成本的变化。每一个转运区域的边际转运成本是用多区域最优潮流模型基于最优发电调度计算得到的。应用每个区域的发电成本对母线功率需求变化和功率交换水平变化的信息 ,可以计算不同类型的电力交易的边际转运成本。文中通过一个有 1 6条母线和 4个互联区域的系统来分析和运用所提方法 ,并讨论了负荷水平和交换功率水平变化对边际转运价格的影响。

关键词：输电服务边际成本电力系统电价电力工业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一项雷尼替丁和硫糖铝预防自发性脑内出血患者胃出血的随机安慰剂对照试验

引用

世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 20-20页

作者： Misra U.k. kalita J. Pandey S. 袁海峰 Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences PGIMS LKO Raebareily Road Lucknow 226014 India

Aim: Due of paucity of studies on stress ulcer prophylaxis in intracerebral hemorrhage (ICH), we have evaluated the usefulness of ranitidine and sucralfate in preventing gastric hemorrhage (GH) in patients with ICH. Subjects and methods: In a hospital-based randomized placebo-controlled study, patients with CT-proven ICH within 7 days of ictus were randomized into ranitidine 50 mg i.v. eight hourly, sucralfate 1 g six hourly and placebo groups. Patients were conservatively managed. Primary endpoint was occurrence of GH within 15 days of ictus and secondary endpoint 1-month mortality. Results: The mean age of the patients was 57.2 (range 25-90) years and 40 were females. There were 45 patients in ranitidine, 49 in sucralfate and 47 in placebo group. Demographic, clinical and radiological features were not significantly different in 3 groups. GH occurred in 11 (23.4%) patients in placebo, 5 (11.1%) in ranitidine and 7 (14.3%) in sucralfate group, which was not significant. Only one female had GH. There were 13 (27.7%) deaths in placebo, 5 (11.1%) in ranitidine and 12 (24.5%) in sucralfate group. Pneumonia occurred in placebo group in 5 (10.6%), ranitidine in 2 (4.4%) and sucralfate in 5 (10.2%) patients, which was not significantly different. Co nclusion: Ranitidine and sucralfate do not seem to significantly prevent GH or r educe 1-month mortality.

关键词：自发性脑内出血硫糖铝胃出血安慰剂对照雷尼应激性溃疡次要终点无显著性差异影像学人口统

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

抗菌药物实验治疗模型——II.小白鼠实验感染金黄色葡萄球菌的探讨

引用

微生物学报 1964年第1期 94-101页

作者：刘文富阎桂华邝启荫唐冀雪中国医学科学院药物研究所药理学系

耐药葡萄球菌感染的治疗是目前传染病化学治疗中的一个重大问题。研究葡萄球菌在体内形成耐药性的理论问题,和寻找新药的工作都需要有适用的葡萄球菌动物感染模型供实验治疗之用。为此,我们进行了小白鼠实验感染金黄色葡萄球菌的探讨。... 详细信息

耐药葡萄球菌感染的治疗是目前传染病化学治疗中的一个重大问题。研究葡萄球菌在体内形成耐药性的理论问题,和寻找新药的工作都需要有适用的葡萄球菌动物感染模型供实验治疗之用。为此,我们进行了小白鼠实验感染金黄色葡萄球菌的探讨。材料和方法

关键词：小白鼠胃粘液菌悬液 II 金黄色葡萄球菌治疗模型抗菌药物

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：