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Anterior resection for rectal carcinoma-risk factors for anastomotic leaks and strictures

World Journal of Gastroenterology 2011年第11期17卷 1475-1479页

作者： Ashok kumar Ram Daga Paari Vijayaragavan Anand Prakash Rajneesh kumar singh Anu Behari Vinay k kapoor Rajan Saxena Department of Surgical Gastroenterology sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow 226014India

AIM:To determine the incidence and factors responsible for anastomotic leaks and stricture following anterior resection(AR)and its subsequent ***:Retrospective analysis of data from 108 patients with rectal carcinoma who underwent AR or low anterior resection(LAR)to identify the various preoperative,operative,and post operative factors that might have influence on anastomotic leaks and ***:There were 68 males and 40 females with an average of 47 years(range 21-75 years).The median distance of the tumor from the anal verge was 8 cm(range 3-15 cm).Sixty(55.6%)patients underwent handsewn anastomosis and 48(44.4%)were *** median operating time was 3.5 h(range2.0-7.5 h).Sixteen(14.6%)patients had an anastomotic *** these,11 patients required reexploration and five were managed *** anastomotic leak rate was similar in patients with and without diverting stoma(8/60,13.4%with stoma and 8/48;16.7%without stoma).In 15(13.9%)patients,resection margins were positive for ***(17.6%)patients developed anastomotic strictures at a median duration of 8 mo(range 3-20 mo).Among these,15 patients were successfully managed with per-anal *** multivariate analysis,advance age(>60 years)was the only risk factor for anastomotic leak(P=0.004).On the other hand,anastomotic leak(P=0.00),mucin positive tumor(P =0.021),and lower rectal growth(P=0.011)were found as risk factors for the development of an anastomotic ***:Advance age is a risk factor for an anastomotic *** anastomotic leak,a mucin-secreting tumor,and lower rectal growth predispose patients to develop anastomotic strictures.

关键词： Rectal carcinoma Anterior resection Anastomotic leak Stricture

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聚酰胺地毯废料在聚合物复合材料开发中的应用:压缩行为研究

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国际纺织导报 2022年第11期50卷 15-16页

作者： B.Jaiswal S.Mishra R.k.Verma 吴风帆(译) 孟粉叶(校) Madan Mohan Malaviya理工大学印度不详

重点介绍了由聚酰胺(PA)地毯废料制成的聚合物复合材料的压缩行为。该复合材料是使用改进的真空辅助树脂传递模塑(VARTM)方法开发的。所制备的PA地毯废料复合材料样品的测试结果表明,该样品可承受约2 900 N的压缩载荷,证实了其在结构应... 详细信息

重点介绍了由聚酰胺(PA)地毯废料制成的聚合物复合材料的压缩行为。该复合材料是使用改进的真空辅助树脂传递模塑(VARTM)方法开发的。所制备的PA地毯废料复合材料样品的测试结果表明,该样品可承受约2 900 N的压缩载荷,证实了其在结构应用中的可行性和应用潜力。这项工作旨在最大限度地降低由传统的地毯废物处理法,如填埋、焚烧、分解等造成的环境危害。

关键词：聚酰胺地毯废料聚合物复合材料压缩行为

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Syntax score: The fallacies and remedies—A perspective

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World Journal of Cardiovascular Diseases 2013年第7期3卷 448-453页

作者： Pravin k. Goel Roopali khanna Aditya Batra Sanjeev k. Syal Department of Cardiology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India

The syntax score devised as a tool to grade complexity of coronary artery disease with a view to its suitability for PCI or otherwise on deeper introspection is fraught with some inherent limitations and fallacies largely as a result of the variability in coronary anatomy and the fixed nomenclature of the devised scoring system. We, in this special report, bring out the limitations and fallacies in the same and possible remedies presented as a viewpoint which may be useful to the interventional community at large.

关键词： Syntax Score PCI

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

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Frontiers of Medicine 2021年第2期15卷 275-291页

作者： Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John kField sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus Akiemeney Shan Zienolddiny kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State key Laboratory of Reproductive Medicine Center for Global HealthNanjing Medical UniversityNanjing 211166China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China Jiangsu key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China China International Cooperation Center for Environment and Human Health School of Public HealthNanjing Medical UniversityNanjing 211166China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892-9304USA Department of Integrative Oncology British Columbia Cancer AgencyVancouverBC V5Z 1L3Canada Faculty of Medicine University of Oviedo and CIBERESPOviedo 33006Spain Program in Epidemiology Public Health Sciences DivisionFred Hutchinson Cancer Research CenterSeattleWA 98109-1024USA Public Health Sciences Division Swedish Cancer InstituteSeattleWA 98026USA Department of Clinical Biochemistry Copenhagen University HospitalCopenhagen DK-1017Denmark National Cancer Institute BethesdaMD 20892-9304USA Genetic Epidemiology Group International Agency for Research on CancerLyon 69372France Cancer Center Cluster Salzburg at PLUS Department of Molecular BiologyUniversity of SalzburgHeidelberg 5020Austria Institute of Medical Informatics Biometry and EpidemiologyChair of EpidemiologyLudwig Maximilians UniversityMunichBavaria 80539Germany Department of Genetic Epidemiology University Medical Center GoettingenGoettingen 37075Germany Technion Faculty of Medicine Carmel Medical CenterHaifa 3448516Israel Markey Cancer Center University of KentuckyLexingtonKY 40506-0054USA Department of Molecular and Clinical Cancer Medicine Roy Castle Lung Cancer Research ProgrammeThe University of Liverpool Institute of Translational MedicineLiverpool L697Z

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely *** integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility *** identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive *** factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was *** annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency *** results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments.

关键词： lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity

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mpaired flow-mediated vasodilatation in Asian Indians with erectile dysfunction

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Asian Journal of Andrology 2013年第5期15卷 652-657页

作者： Tanuj Bhatia Aditya kapoor Jatinder kumar Archana Sinha Priyadarshi Ranjan Sudeep kumar Naveen Garg Satyendra-Tewari Aneesh Srivastava Rakesh kapoor Pravin k Goel Departments of Cardiology Sanjay Gandhi PGIMS Lucknow 226014 India Urology and Renal Transplantation Sanjay Gandhi PGIMS Lucknow 226014 India

Endothelial dysfunction is the postulated link between coronary artery disease （CAD） and erectile dysfunction （ED）. Brachial artery flow-mediated vasodilatation （FMD） is a non-invasive surrogate marker for endothelial function assessment. Despite Asian Indians representing a considerable global CAD burden, data on FMD and ED in these patients are lacking. Of the 225 patients undergoing coronary angiography, 72% had ED （assessed using the International Index of Erectile Function （IIEF-5） questionnaire）; ED was moderate to severe in 61% of the patients. ED patients had a higher incidence of severe and diffuse angiographic CAD, a greater number of coronary vessels involved and a lower mean brachial artery FMD （6.40%±4.60% vs. 9.10%±4.87%, P〈0.001） compared to non-ED patients. A progressive reduction in FMD was noted with increasing severity of ED. Impaired FMD （ ≤ 5.5%） was twice as common in ED patients （52% vs. 24% without ED）. Patients with impaired FMD had higher ED prevalence （85% vs. 62%） and lower mean I IEF-5 scores compared to those with normal FMD. Impaired FMD was a significant ED predictor independent of other risk factors （odds ratio, 2.33; 95% confidence interval： 0.59-9.23; P=0.03）. An inverse correlation between FMD and ED severity was observed （r=-0.22; P=0.004）. ED is common among Asian Indians with angiographically documented CAD. Patients with ED have impaired FMD independent of other risk factors, suggesting that endothelial dysfunction is the underlying pathophysiology. Urologists and cardiologists need to be aware of the association between ED, CAD and endothelial dysfunction.

关键词： Asian Indians brachial artery flow mediated vasodilatation erectile dysfunction (ED)

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钾改性铁-钼碳化物CO加氢合成低碳混合醇的研究

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天然气化工—C1化学与化工 2010年第2期35卷 6-9页

作者：王宁房克功林明桂姜东李德宝孙予罕中国科学院山西煤炭化学研究所煤转化国家重点实验室山西太原030001 中国科学院研究生院北京100039

使用程序升温反应法制备了一系列k改性的铁-钼碳化物催化剂,用XRD、SEM及XPS进行了表征,并对其CO加氢合成低碳混合醇性能进行了考察。结果表明,k改性的铁-钼碳化物催化剂,其产物中具有较高的低碳混合醇的选择性。k助剂与碳化物主体之间... 详细信息

使用程序升温反应法制备了一系列k改性的铁-钼碳化物催化剂,用XRD、SEM及XPS进行了表征,并对其CO加氢合成低碳混合醇性能进行了考察。结果表明,k改性的铁-钼碳化物催化剂,其产物中具有较高的低碳混合醇的选择性。k助剂与碳化物主体之间的电子作用导致其CO加氢产物选择性发生显著变化,这可能与该催化剂表面"k-Fe-Mo-C"新相的生成有关。XPS表征显示,在该催化剂中存在的Mo4+对应于醇的生成,而Mo2+则对应于烃类的生成。另外,对该催化剂CO加氢的温度效应也进行了考察。

关键词： k改性 β-碳化钼碳化铁 CO加氢低碳醇合成

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南京地区2004-2007年血培养病原菌分布和耐药性变迁

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中华检验医学杂志 2009年第8期32卷 889-894页

作者：顾兵潘世扬魏雪菲夏文颖文怡梅亚宁童明庆南京医科大学第一附属医院医学检验科 210029

目的了解南京医科大学第一附属医院2004-2007年血培养阳性标本的病原菌分布和耐药性变迁。方法采用BacT／Alert3D血培养仪；细菌及真菌鉴定采用API系统；细菌药物敏感性测定采用纸片扩散法（k-B法），真菌药物敏感性测定采用Rosco纸片法... 详细信息

目的了解南京医科大学第一附属医院2004-2007年血培养阳性标本的病原菌分布和耐药性变迁。方法采用BacT／Alert3D血培养仪；细菌及真菌鉴定采用API系统；细菌药物敏感性测定采用纸片扩散法（k-B法），真菌药物敏感性测定采用Rosco纸片法；Whonet5．3软件进行统计分析。结果2004-2007年南京医科大学第一附属医院血培养共分离出病原菌1313株，阳性率分别为13．1％（292／2226）、13．2％（327／2471）、13．3％（342／2563）和10．6％（352／3366）。血培养阳性菌多见于血液科、ICU、传染科、普通外科及老年医学科。检出率较高的革兰阳性菌主要为凝固酶阴性葡萄球菌（CNS）和金黄色葡萄球菌，其中耐甲氧西林株分别占32．9％（171／520）和39．2％（51／310）。葡萄球菌和肠球菌中均未发现对万古霉素和替考拉宁的耐药株。检出率较高的革兰阴性菌主要为大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌和不动杆菌。铜绿假单胞菌和不动杆菌对多种抗菌药物耐药率较高，肠杆菌科细菌对碳青霉烯类抗菌药高度敏感。结论血培养检出病原菌种类复杂，对多种抗菌药物耐药，应引起重视。

关键词：革兰氏阳性菌革兰氏阴性菌真菌微生物敏感性试验抗药性多药

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乙烯类单体的负离子聚合研究——第三丁基乙烯基酮的聚合

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高分子通讯 1965年第1期 48-55页

作者：冯新德邱南飞蒋德彰北京大学化学系山西大学北京大学化学系教师 1961-1962在北京大学进修

本文报导了第三丁基乙烯基酮在不同溶剂中应用各种负离子引发剂的聚合研究。以正丁基锂为引发剂,吡啶或四氢呋喃为溶剂时,都是均相聚合,得到无定形聚合物,它们的软化温度为40—180°之间,如果以苯、甲苯、二甲苯或正庚烷为溶剂,则都是... 详细信息

本文报导了第三丁基乙烯基酮在不同溶剂中应用各种负离子引发剂的聚合研究。以正丁基锂为引发剂,吡啶或四氢呋喃为溶剂时,都是均相聚合,得到无定形聚合物,它们的软化温度为40—180°之间,如果以苯、甲苯、二甲苯或正庚烷为溶剂,则都是非均相聚合,得到结晶性聚合物,有着高达260—280°之间的熔点。上述结晶性与无定形聚第三丁基乙烯基酮的红外光谱有着显著的不同,结晶性聚合物具有特征的吸收峯,以1100厘米-1与1330厘米1二处最为明显。还研究了不同比例的混合物的红外光谱,当结晶性聚合物含量降至 87％以下时,则 1100厘米-1 ,1290厘米-1及 1330厘米-1三处吸收峯逐渐减弱,当减少至13％时则与无定形聚合物的光谱一致。此外金属锂、钠与钾都能引发聚合第三丁基乙烯基酮,也试用了NaH,LiAlH4,RONa,ROk,RMgX,二苯酮以及二苯酮钠等引发剂进行非均相聚合。

关键词：烯类单体负离子聚合烯基引发剂非均相聚合正丁基锂无定形红外光谱二苯酮聚合管

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On the Nonequilibrium of Radiation-Induced Bystander Effects in Tumor Surface and Its Implications in Radiation Therapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2015年第3期4卷 208-214页

作者： R. Vaitheeswaran k. J. Maria Das Philips Radiation Oncology Systems Philips India Ltd. Bangalore India Research & Development Center Bharathiar University Coimbatore India Department of Radiotherapy Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India

This work aims to theoretically show the development of a nonequilibrium of radiation-induced bystander effect (RIBE) under steep dose gradient regions that typically occur in the field edges of a beam. We applied the kinetics model proposed by (McMahon et al. 2013) for in vivo conditions coupled with a hypothesis called “Layer-limited bystander signaling (LLBS)” to demonstrate 1) an enhancement in TCP (i.e. Enhanced TCP or ETCP) due to bystander signals, 2) the development of nonequilibrium of RIBE under steep dose gradient regions and 3) the reduction in ETCP in the surface of Clinical Target Volume (CTV) due to the non-equilibrium of RIBE. We incorporated the elements of RIBE directly in the existing Poisson LQ model available in Pinnacle3 TPS (Version 9.10.0) to compute the percentage reduction of ETCP in the tumor surface due to nonequilibrium of RIBE. The percentage improvement in TCP obtained in tumor surface by accounting for RIBE is about 46% lower than that obtained in the interior of the tumor. This suggests that relatively more number of cancerous cells might survive in the vicinity of tumor surface. The result obtained from the study is indicative of an additional uncertainty component associated with radiation treatment. Hence, this paper suggests that the radiation treatments employing steep dose gradients could be biophysically different in many ways.

关键词： Bystander Effect TCP RIBE CTV IMRT Dose Gradients

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Microbiome data analysis with applications to pre-clinical studies using QIIME2: Statistical considerations

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Genes & Diseases 2021年第2期8卷 215-223页

作者： Shesh N.Rai Chen Qian Jianmin Pan Jayesh P.Rai Ming Song Juhi Bagaitkar Michael Merchant Matthew Cave Nejat k.Egilmez Craig J.McClain Biostatistics and Bioinformatics Facility James Graham Brown Cancer CenterUniversity of LouisvilleLouisvilleKY40202USA Department of Biostatistics and Bioinformatics University of LouisvilleLouisvilleKY40202USA University of Louisville Alcohol Research Center University of LouisvilleLouisvilleKY40202USA University of Louisville Hepatobiology&Toxicology Center University of LouisvilleLouisvilleKY40202USA Department of Oral Immunology&Infectious Diseases University of LouisvilleLouisvilleKY40202USA Department of Medicine University of LouisvilleLouisvilleKY40202USA Robley Rex Louisville VAMC LouisvilleKY40206USA Department of Microbiology&Immunology University of LouisvilleLouisvilleKY40202USA

Diversity analysis and taxonomic profiles can be generated from marker-gene sequence data with the help of many available computational *** Quantitative Insights into Microbial Ecology Version 2(QIIME2)has been widely used for 16S rRNA data *** many articles have demonstrated the use of QIIME2 with suitable datasets,the application to preclinical data has rarely been talked *** issues involved in the pre-clinical data include the low-quality score and small sample size that should be addressed properly during *** addition,there are few articles that discuss the detailed statistical methods behind those alpha and beta diversity significance tests that researchers are eager to *** the program without knowing the logic behind it is extremely *** this article,we first provide a guideline for analyzing 16S rRNA data using *** we will talk about issues in pre-clinical data,and how they could impact the ***,we provide brief explanations of statistical methods such as group significance tests and sample size calculation.

关键词： 16S rRNA gene Alpha diversity ANOVA Beta diversity Bioinformatics Microbiome data QIIME Sample size calculation

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