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Can palliative radiotherapy influence prostate-specific antigen response in patients with castrate-resistant prostate cancer treated with systemic therapy(chemotherapy or abiraterone)?——a report of three cases

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Cancer Biology & Medicine 2015年第1期12卷 60-63页

作者： Mohan Hingorani sanjay dixit Pattu Pugazhenthi Simon Hawkyard Andrew Robertson Richard Khafagy Department of Clinical Oncology Castle Hill HospitalHull and East YorkshireNHS TrustCottinghamEast Riding of YorkshireHU16 5JQUK Department of Urology Scarborough District General Hospital

Palliative radiotherapy(pRT) is primarily employed for palliation of bone pain in patients with castrate-resistant prostate cancer(CRPC). However, evidence that p RT influences prostate-specific antigen response in patients with CRPC on systemic therapy is lacking. We describe three cases of CRPC progressing after treatment with docetaxel(n=2) and abiraterone(n=1), who responded unusually after p RT for bone pain with the development of a significant biochemical response and restoration of response to systemic therapy. The possibility of p RT influencing metastatic disease in CRPC has not been previously reported, and raises the possibility of radiation-induced modulation of anti-tumor immune response mechanisms that may play a role in the restoration of response to systemic treatment.

关键词：全身治疗特异性抗原前列腺癌报告处理患者抗性去势比特

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Sequential maximum androgen blockade(MAB) in minimally symptomatic prostate cancer progressing after initial MAB: two case reports

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Cancer Biology & Medicine 2014年第4期11卷 277-280页

作者： Mohan Hingorani sanjay dixit Fahim Bashir Mohammad Butt Simon Hawkyard Richard Khafagy Andrew Robertson Department of Clinical Oncology Castle Hill Hospital Department of Urology Scarborough General Hospital

The management of castrate-resistant prostate cancer progressing after maximum androgen blockade(MAB) has evolved in the last decade with the development of several novel therapeutic options. However, the initial therapeutic strategy in these patients usually involves withdrawal of anti-androgen that can be associated with biochemical response in approximately 20% of patients. Notably, we have observed evidence of sustained biochemical response in two patients following secondand third-line MAB using rechallenge schedule of previously administered anti-androgen after latent interval. The possibility of response following sequential MAB using the same anti-androgen agent has not yet been reported.

关键词：抗雄激素前列腺癌 MAB 案例症状治疗方案生化反应时间表

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Mechanisms and clinical significance of early recurrences of atrial arrhythmias after catheter ablation for atrial fibrillation

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World Journal of Cardiology 2016年第11期8卷 638-646页

作者： Jackson J Liang sanjay dixit Pasquale Santangeli Division of Cardiology Electrophysiology SectionHospital of the University of Pennsylvania

Early recurrence of atrial arrhythmias(ERAA) after ablation is common and strongly predicts late recurrences and ablation failure. However, since arrhythmia may eventually resolve in up to half of patients with ERAA, guidelines do not recommend immediate reintervention for ERAA episodes occurring during a 3-mo postablation blanking period. Certain clinical demographic, electrophysiologic, procedural, and ERAA-related characteristics may predict a higher likelihood of longterm ablation failure. In this review, we aim to discuss potential mechanisms of ERAA, and to summarize the clinical significance, prognostic implications, and treatment options for ERAA.

关键词： Atrial 纤维性颤动复发导管脱离肺的静脉隔离

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An Experimental Study of Microstructure through SEM and AFM by Interaction from High Power Femtosecond Laser Wave with BaTiO₃

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Journal of Modern Physics 2016年第10期7卷 1068-1081页

作者： Shivani Saxena sanjay dixit sanjay Srivastava Department of Physics Government Motilal Vigyan Mahavidyalaya College Barkatullah University Bhopal India Department of Material Science & Metallurgical Engineering Maulana Azad National Institute of Technology Bhopal India

This paper deals with the interaction of femtosecond laser with strain dependent high dielectric material. For this investigation, ferroelectric material like BaTiO3 has been chosen because of centrosymmetric structure. Due to irradiation of laser light, the micro-structure of BaTiO3 is found to change along the direction of heat propagation. SEM and AFM tools have been used to detect the morphology and roughness of the femotosecond laser treated BaTiO3. The change of morphology and surface behavior depends upon the laser fluence and intensity of laser light. The maximum change in morphology has been observed at a higher laser fluence.

关键词： BaTiO3 Femtosecond Laser Laser Fluence Ablated Areas

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Effect of Hot Carrier on Amplitude Modulation and Demodulation of Gaussian High Power Helicon Wave in Homogeneous Longitudinally Magnetized Strain Dependent Dielectric Material

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Open Journal of Acoustics 2015年第4期5卷 139-152页

作者： Shivani Saxena sanjay dixit sanjay Srivastava Department of Physics Govt. M.V. M College Barkatullah University Bhopal India Department of Material Science & Metallurgical Engineering Maulana Azad National Institute of Technology Bhopal India

In the present communication, the hydrodynamic model is used to investigate the amplitude modulation as well as demodulation of an electromagnetic wave of high power helicon pump wave into another helicon wave in strain dependent dielectric material incorporating carrier heating (CH) effects. The consideration of CH in modulation and demodulation is prime importance for the adding of new dimension in analysis of amplification of acoustic helicon wave. By using the dispersion relation, threshold pump electric filed and growth rate of unstable mode from the modulation and demodulation of the high power helicon wave well above from the threshold value will be discussed in the present analysis. The numerical analysis is applied to a strain dependent dielectric material, BaTiO3 at room temperature and irradiated with high power helicon wave of frequency 1.78 × 1014 Hz. This material is very sensitive to the pump intensities, therefore during studies, Gaussian shape of the helicon pump wave is considered during the propagation in stain dependent dielectric material and opto-acoustic wave in the form of Gaussian profile (ω0,κ0) is induced longitudinally along the crystallographic plane of BaTiO3. Its variation is caused by the available magnetic field (ωc), interaction length (z) and pulsed duration of interaction (τ). From the analysis of numerical results, the incorporation of CH effect can effectively modify the magnitude of modulation or demodulation of the amplitude of high power helicon laser wave through diffusion process. Not only the amplitude modulation and demodulation of the wave, the diffusion of the CH effectively modifies the growth rate of unstable mode of frequency in BaTiO3. The propagation of the threshold electric field shows the sinusoidal or complete Gaussian profile, whereas this profile is found to be completely lost in growth of unstable mode. It has also been seen that the growth rate is observed to be of the order of 108 - 1010 s-1 but from diffusion of carrier heating, and that its order is e

关键词： Amplitude/Frequency Modulation High Power Laser Wave Hot Carrier Effect Plasma Effect in Strain Dependent Dielectric Material

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