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An update on Ayurvedic herb Convolvulus pluricaulis Choisy

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Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 245-252页

作者： Parul Agarwa Bhawna Sharma Anireen Fatima sanjay kumar jain Institute of Pharmacy Bundelkhand UniversityJhansi 284121U.P.India

Convolvulus pluricaulis Choisy(***)is a perennial herb that seems like morning *** parts of the herb are known to possess therapeutic *** plant is used locally in Indian and Chinese medicine to cure various *** is used in Ayurvedic formulation for chronic cough,sleeplessness,epilepsy,hallucinations,anxiety *** on the comprehensive review of plant profile,pharmacognosy,phylochemistry,pharmacological and toxicological data on the ***,there will be more opportunities for the future research and development on the herb *** on the *** was collected via electronic search(using Pub Med,SciFinder,Google Scholar and Web of Science)and library search for articles published in peer-reviewed ***,information also was obtained from some local books on *** paper covers the literature,primarily pharmacological,from 1985 to the end of *** *** is an important indigenous medicine,which has a long medicinal application for liver disease,epileptic disease,microbial disease,cytotoxic and viral diseases,central nervous system(CNS)disease in Ayurvedic medicine,traditional Chinese medicine and other indigenous medical *** isolated metabolites and crude extract have exhibited a wide of in vitro and in vivo pharmacological effect,including CNS depression,anxiolytic,tranquillizing,antidepressant,antistress,neurodegenerative,antiamnesic,antioxidant,hypolipidemic,immunomodulatory,analgesic,antifungal,antibacterial,antidiabetic,antiulcer,anticatatonic,and cardiovascular activity.A chemical study of this plant was then initiated,which led to the isolation of carbohydrats,proteins,alkaloids,fatty acids,steroids,***,and glycosides as active chemicals that bring about its biological effects.A scries of pharmacognostical studies of this plant show that it is a herb,its stem and leaves are hairy,more over it has two types of stomata,anisocytic and

关键词： Convolvulus pluricaulis Choisy Pharmacognosy Microscopy Macroscopy Phytochemistry Pharmacology

Herbal antioxidant in clinical practice:A review

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Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 78-84页

作者： Shashi Alok sanjay kumar jain Amita Verma Mayank kumar Alok Mahor Monika Sabharwal Institute Of Pharmacy Bundelkhand University Department of Pharmaceutical Sciences Faculty of Health SciencesSam Higginbottom Institute of AgricultureTechnology and Sciences-DeemedUniversity Society of Pharmaceutical Sciences and Research

Antioxidant-the word itself is *** the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called"free-radical"reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging *** must acknowledge that such"radicals"have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and *** strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and *** paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall *** is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell *** evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally

关键词： Antioxidant Carotenoid Free-radical Herb

Morphology,pharmacological activity,pharmaceutical preparation,doses and side effect of Coccinia indica(Wight&Arn.):An overview

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Journal of Coastal Life Medicine 2013年第4期 330-336页

作者： Mayank kumar Shashi Alok sanjay kumar jain Amita Verma Alok Mahor Monika Sabharwal Institute of Pharmacy Bundelkhand UniversityJhansi(U.P.)India Department of Pharmacy Sam Higginbottom Institute of AgricultureTechnology and SciencesAllahabad(U.P.)India Society of Pharmaceutical Sciences and Research Panchkula(Haryana)India

Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive *** indica belongs to the family *** is a rapidly growing,perennial climber or trailing *** different parts of this plant namely the roots,leaves and fruits are used in folklore medicine for several purposes like jaundice,diabetes,wound healing,ulcers,stomach ache,skin disease,fever,asthma,*** leaf and its constituents have been reported to possess hypoglycaemic,hypolipidemic and antioxidant *** review provides adequate information to develop suitable therapeutics out of these plant parts.

关键词： Coccinia indica(Ivy Gourd) Antidiabetic activity Antibacterial activity

Optimization of Osmotic Drying Parameters for Button Mushroom (<i>Agaricus bisporus</i>)

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Applied Mathematics 2012年第10期3卷 1298-1305页

作者： Birendra kumar Mehta sanjay kumar jain Gyanendra Prakash Sharma Vishvambhar Dayal Mudgal Radha Charan Verma Anila Doshi Hemant kumar jain Department of Processing and Food Engineering College of Technology and Engineering Maharana Pratap University of Agriculture and Technology Udaipur India

Response surface methodology was used to investigate the effect of brine concentration (10% - 20%) solution temperature (35℃ - 55℃), and duration of osmosis (30 - 60 min) with respect to water loss (WL) and salt gain (SG). The solu- tion to sample ratio of 5/1 (w/w) was used. The Box-Behnken design of three variables and three levels including seventeen experiments formed by five central points were used for optimizing input parameters. Linear, quadratic and interaction effects of three variables were analyzed with respect to water loss and solid gain. For each response, second order polynomial models were developed using multiple regression analysis. Analysis of variance (ANOVA) was per- formed to check the adequacy and accuracy of the fitted models. The response surfaces and contour maps showing the interaction of process variables were constructed. The optimum operating conditions were: solution temperature 44.89℃, brine concentration of 16.53 per cent and duration of osmosis of 47.59 min. At this optimum point, water loss and salt gain were predicted to be 44.55 per cent and 2.98 percent respectively.

关键词： Button Mushroom Osmotic Dehydration Optimization Response Surface Methodology Water Loss Salt Gain

Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb sanjay Nag Roushan Patel Prashant Sharma Vamsi Krishna Uppalapati Umesh kumar Singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACKGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

Liquefaction proneness of stratified sand-silt layers based on cyclic triaxial tests

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1826-1845页

作者： Arpit jain Satyendra Mittal sanjay kumar Shukla Department of Civil Engineering Indian Institute of TechnologyRoorkeeUttarakhandIndia School of Engineering Edith Cowan UniversityJoondalupPerthAustralia Department of Civil Engineering Indian Institute of Technology MadrasChennaiIndia Department of Civil Engineering BIT SindriIndia

Most studies on liquefaction have addressed homogeneous soil strata using sand or sand with fine content without considering soil *** this study,cyclic triaxial tests were conducted on the stratified sand specimens embedded with the silt layers to investigate the liquefaction failures and void-redistribution at confining stress of 100 kPa under stress-controlled *** loosening of underlying sand mass and hindrance to pore-water flow caused localized bulging at the sand-silt *** is observed that at a silt thickness of 0.2H(H is the height of the specimen),nearly 187 load cycles were required to attain liquefaction,which was the highest among all the silt thicknesses with a single silt ***,0.2H is assumed as the optimum silt thickness(t_(opt)).The silt was placed at the top,middle and bottom of the specimen to understand the effect of silt layer *** to the increase in depth of the silt layer from the top position(capped soil state)to the bottom,the cycles to reach liquefaction(N_(cyc,L))increased 2.18 ***,when the number of silt layers increased from single to triple,there was an increase of about 880%in N_(cyc,L).The micro-characterization analysis of the soil specimens indicated silty materials transported in upper sections of the specimen due to the dissipated pore *** main parameters,including thickness(t),location(z),cyclic stress ratio(CSR),number of silt layers(n)and modified relative density(D_(r,m)),performed significantly in governing the lique-faction *** this,a multilinear regression model is developed based on critical parameters for prediction of N_(cyc,L).Furthermore,the developed constitutive model has been validated using the data from the present study and earlier findings.

关键词： Cyclic triaxial tests Soil stratification Soil liquefaction Regression model

Novel targeting approaches and signaling pathways of colorectal cancer: An insight

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World Journal of Gastroenterology 2018年第39期24卷 4428-4435页

作者： Ankita Tiwari Shivani Saraf Amit Verma Pritish kumar Panda sanjay K jain Pharmaceutics Research Projects Laboratory Department of Pharmaceutical SciencesDr. Hari Singh Gour Central University

Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC.

关键词： Colorectal cancer Immunotherapy Gene therapy Signaling Targeted therapy

A multiplicative Gauss-Newton minimization algorithm:Theory and application to exponential functions

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Applied Mathematics(A Journal of Chinese Universities) 2021年第3期36卷 370-389页

作者： Anmol Gupta sanjay kumar Department of Electronics and Communication Engineering Thapar Institute of Engineering and TechnologyPatiala 147004India

Multiplicative calculus(MUC)measures the rate of change of function in terms of ratios,which makes the exponential functions significantly linear in the framework of ***,a generally non-linear optimization problem containing exponential functions becomes a linear problem in *** this as motivation,this paper lays mathematical foundation of well-known classical Gauss-Newton minimization(CGNM)algorithm in the framework of *** paper formulates the mathematical derivation of proposed method named as multiplicative Gauss-Newton minimization(MGNM)method along with its convergence *** proposed method is generalized for n number of variables,and all its theoretical concepts are authenticated by simulation *** case studies have been conducted incorporating multiplicatively-linear and non-linear exponential *** simulation results,it has been observed that proposed MGNM method converges for 12972 points,out of 19600 points considered while optimizing multiplicatively-linear exponential function,whereas CGNM and multiplicative Newton minimization methods converge for only 2111 and 9922 points,***,for a given set of initial value,the proposed MGNM converges only after 2 iterations as compared to 5 iterations taken by other methods.A similar pattern is observed for multiplicatively-non-linear exponential ***,it can be said that proposed method converges faster and for large range of initial values as compared to conventional methods.

关键词： multiplicative calculus multiplicative least square method multiplicative Newton minimization multiplicative Gauss-Newton minimization non-linear exponential functions

Handling higher order time series forecasting approach in intuitionistic fuzzy environment

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Journal of Control and Decision 2020年第4期7卷 327-344页

作者： Abhishekh sanjay kumar Department of Mathematics Institute of ScienceBanaras Hindu UniversityVaranasi 221005India

This study presents a new method of forecasting based on a higher order intuitionistic fuzzy time series(FTS)by transforming FTS data into intuitionistic FTS data via defining their appropriate membership and non-membership *** fuzzification of time series data is intuitionistic fuzzification which is based on the maximum score degree of intuitionistic fuzzy ***,the intuitionistic fuzzy logical relationship groups are defined and introduced into a defuzzification process for a higher order intuitionistic FTS that enhances in the forecasted *** order to assess the performance of the proposed method,the method has been implemented on the historical data of rice *** comparison result shows that the proposed method can achieve a better forecasting accuracy rate in terms of RMSE and MAPE than the existing methods such as Song and Chissom[(1993).Forecasting enrolments with fuzzy time series-Part *** Sets and System,54,1-9],Chen[(1996).Forecasting enrolments based on fuzzy time *** Sets and System,81,311-319],Singh[(2007a).A simple method of forecasting based on fuzzy time *** Mathematics and Computation,186,330-339]and Abhishekh,Gautam,and Singh[(2017).A refined weighted method for forecasting based on type 2 fuzzy time *** Journal of ModellingandSimulation,38,180-188;(2018).A score function based method of forecasting using intuitionistic fuzzy time *** Mathematics and Natural Computation,14(1),91-111].

关键词： Fuzzy time series intuitionistic fuzzy number membership grades accuracy function higher order IFLR