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Journal of Forensic Science and Medicine 2023年第3期9卷 228-235页

作者： M.Sai Geethika N.Purnachandra Rao Naik A.Ravi Kiran Y.Samatha B.Naveen Kumar P.Shruthi Sethu Manjusha Saranu K.Pavani sanjana marpuri Department of Oral Medicine and Radiology Sibar Institute of Dental SciencesGunturAndhra PradeshIndia

Background:To evaluate morphologic,radiographic,and stereomicroscopic changes of teeth when subjected to specific high temperatures in both direct heat and gradual heat and to compare the changes among two heat groups and also among different types of *** and Methods:An in vitro study was conducted on 90 healthy extracted human teeth,in which the teeth were divided into two *** 1(45)was subjected to direct heat and Group 2(45)was subjected to gradual *** 1 and Group 2 were further subdivided into three subgroups(A)anteriors,(B)premolars,and(C)molars each consisting of 15 *** were subjected to temperatures of 200°C,400°C,600°C,800°C,and 1000°C in a muffle electric *** color changes were noted using the Revised Munsell soil color chart and the radiographic and stereomicroscopic changes were *** results obtained were subjected to statistical ***:Teeth in direct heat showed more destructive changes at lower temperatures,i.e.,400°C and 600°C when compared to gradual heat where changes are observed at 600°C and 800°*** different types of teeth,anteriors and premolars showed more changes when compared to *** and Conclusion:It can be concluded that dental evidence may provide clues to solve the mystery in fire investigations as dental structures are the last to be destroyed under extreme conditions,whether temperature,acid,or putrefaction.

关键词： Color changes in teeth forensic odontology high temperatures incinerated teeth radiographs stereomicroscope

Coronary artery disease and heart failure:Late-breaking trials presented at American Heart Association scientific session 2023

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World Journal of Cardiology 2024年第7期16卷 389-396页

作者： Avilash Mondal Sashwath Srikanth sanjana Aggarwal Naga R Alle Olufemi Odugbemi Ikechukwu Ogbu Rupak Desai Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19152United States Department of Internal Medicine East Carolina University GreenvilleGreenvilleNC 27834United States Department of Internal Medicine Hamdard Institute of Medical Sciences and ResearchNew Delhi 110062India Department of Medicine Narayana Medical CollegeNelloreAndhra Pradesh 524003India Department of Internal Medicine Lincoln Medical CenterBronxNY 10451United States Department of Internal Medicine Mountainview Hospital Sunrise GMELas VegasNV 89108United States Independent Researcher AtlantaGA 30079United States

The late-breaking science presented at the 2023 scientific session of the American Heart Association paves the way for future pragmatic trials and provides meaningful information to guide management strategies in coronary artery disease and heart failure(HF).The dapagliflozin in patient with acute myocardial infarction(DAPA-MI)trial showed that dapagliflozin use among patients with acute MI without a history of diabetes mellitus or chronic HF has better cardiometabolic outcomes compared with placebo,with no difference in cardiovascular *** MINT trial showed that in patients with acute MI and anemia(Hgb<10 g/dL),a liberal transfusion goal(Hgb≥10 g/dL)was not superior to a restrictive strategy(Hgb 7-8 g/dL)with respect to 30-day all-cause death and recurrent *** ORBITA-2 trial showed that among patients with stable angina and coronary stenoses causing ischemia on little or no antianginal therapy,percutaneous coronary intervention results in greater improvements in anginal frequency and exercise times compared with a sham *** ARIES-HM3 trial showed that in patients with advanced HF who received a HeartMate 3 levitated left ventricular assist device and were anticoagulated with a vitamin K antagonist,placebo was noninferior to daily aspirin with respect to the composite endpoint of bleeding and thrombotic events at 1 *** TEAMMATE trial showed that everolimus with low-dose tacrolimus is safe in children and young adults when given≥6 months after cardiac *** patients being treated for HF with reduced ejection fraction(HFrEF)with specific out-of-pocket(OOP)costs for multiple medication options at the time of the clinical encounter may reduce‘contingency planning’and increase the extent to which patients are taking the medications decided *** primary outcome,which was cost-informed decisionmaking,defined as the clinician or patient mentioning costs of HFrEF medication,occurred in 49%of encounters with the checklist only

关键词： Heart failure Coronary artery disease Clinical trials Myocardial infarction Cardiovascular outcome Percutaneous coronary intervention Blood transfusion Cardiac transplant

Development of a protocol for videoconferencing-based exposure and response prevention treatment of obsessive-compulsive disorder during the COVID-19 pandemic

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World Journal of Psychiatry 2023年第2期13卷 60-74页

作者： sanjana Kathiravan Subho Chakrabarti Department of Psychiatry Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India

BACKGROUND The existing literature indicates that psychotherapeutic treatment,especially exposure and response prevention(ERP)is efficacious in treating obsessivecompulsive disorder(OCD).The coronavirus disease 2019 pandemic adversely impacted many patients with OCD and disrupted their usual ***,the pandemic forced a global switch to telemental health(TMH)services to maintain the standards and continuity of ***,clinicians are increasingly using TMH-based psychotherapeutic treatments to treat ***,several challenges have made it difficult for them to implement these treatments in the changed circumstances imposed by the *** To describe the formulation,implementation,feasibility,and usefulness of videoconferencing-based ERP(VC-ERP)treatment for OCD during the coronavirus disease 2019 *** This prospective,observational study was conducted in the psychiatric unit of a multi-specialty hospital in north India over 12 mo(July 2020-June 2021).All patients with OCD were assessed using the home-based TMH services of the *** VC-ERP protocol for OCD was the outcome of weekly Zoom meetings with a group of clinicians involved in administering the *** a systematic evaluation of the available treatment options,an initial protocol for delivering VC-ERP was *** for clinicians and educational materials for patients and their families were *** protocol was implemented among patients with OCD attending the TMH services,and their progress was *** weekly meetings were used to upgrade the protocol to meet the needs of all *** and efficacy outcomes were *** All patients were diagnosed with OCD as a primary or a comorbid condition according to the International Classification of Diseases,10th version *** of 115 patients who attended the services during the study period,37 were excluded from the final *** the remaining 78 patie

关键词： Videoconferencing Exposure and response prevention Obsessive-compulsive disorder Telemedicine COVID-19

Aesthetics of urban commercial streets from the perspective of cognitive memory and user behavior in urban environments

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Frontiers of Architectural Research 2022年第5期11卷 949-962页

作者： sanjana Balasubramanian Chandramathy Irulappan Jinu Louishidha Kitchley Department of Architecture Thiagarajar College of EngineeringMaduraiIndia

Streets are one of the major elements that make-up the urban environment. Urban commercial and mixed-use street types occur as public spaces in every town and city all around the world. With the paucity of such spaces, streets have taken up to solve the problem. Hence, this study assesses the key physical, visual, and aesthetical characteristics and examines the influence of aesthetical attributes over the activity pattern, user behavioral responses, and the color palette observed. Moreover, this research has been carried out in Coimbatore, Tamilnadu, India. Four significant commercial streets were identified and featured in the main study. The research method comprehends a structured questionnaire and multiple interviews to amass data, photo elicitation, and video corroboration to identify the key visual characteristics to study and scrutinize the aesthetical responses to various attributes that make good-looking urban commercial and mixed-use street types. The results of the study indicate that the diversity and perceived pleasantness of the environment, which includes elements such as facades, colors, aspect ratios, maintenance, and vegetation, has a very close association with walking preferences. The outcome of the study would also help architects, urban designers and planners, and policy makers to create positive spaces to foster urban commercial street types as place-making and aesthetically pleasing streets.

关键词： User behavior Urban commercial streets Mixed-use Aesthetical characteristics Place making Facade characteristics

A step towards zero leprosy: Active case finding through community-based approach

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Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 332-334页

作者： Senthilkumar Ramasamy sanjana Agrawal Hafseera Paradan State Health Resource Centre RaipurChhattisgarhIndia School of Public Health All India Institute of Medical SciencesRaipurChhattisgarhIndia

Leprosy with multidrug therapy and treatment in the early stages can prevent disability,but it still represents a significant health problem,mainly in vulnerable populations[1].However,if left untreated,leprosy can cause progressive and permanent damage to the skin,nerves,limbs,and *** the constant efforts of the National Leprosy Elimination Programme in India,the implementation of multidrug therapy has lowered the prevalence rate to 0.66/10000 in 2016[1].

关键词： nerves finding damage

The relationship between age,acceptable noise level,and listening effort in middle-aged and older-aged individuals

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中华耳科学杂志:英文版 2023年第4期18卷 220-229页

作者： Hemanth Narayan Shetty Suma Raju sanjana Singh S Department of Audiology JSS Institute of Speech and HearingMysuruKarnatakaIndia Department of Speech-Language Pathology JSS Institute of Speech and HearingMysuruKarnatakaIndia

Objective:The purpose of the study was to evaluate listening effort in adults who experience varied annoyance towards *** and methods:Fifty native Kannada-speaking adults aged 41e68 years *** evaluated the participant's acceptable noise level while listening to ***,a sentence-final wordidentification and recall test at 0 dB SNR(less favorable condition)and 4 dB SNR(relatively favorable condition)was used to assess listening *** repeat and recall scores were obtained for each ***:The regression model revealed that the listening effort increased by 0.6%at 0 dB SNR and by 0.5%at 4 dB SNR with every one-year advancement in *** effort increased by 0.9%at 0 dB SNR and by 0.7%at 4 dB SNR with every one dB change in the value of Acceptable Noise Level(ANL).At 0 dB SNR and 4 dB SNR,a moderate and mild negative correlation was noted respectively between listening effort and annoyance towards noise when the factor age was ***:Listening effort increases with age,and its effect is more in less favorable than in relatively favorable ***,if the annoyance towards noise was controlled,the impact of age on listening effort was *** effort correlated with the level of annoyance once the age effect was ***,the listening effort was predicted from the ANL to a moderate degree.

关键词： Listening effort Acceptable noise level Cognitive reservoir Repeat and recall task

Antioxidant phenolic compounds from seeds of Hordeum vulgare *** diabetic nephropathy in streptozotocin-induced diabetic rats

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 353-361页

作者： Renuka Mahajan Satyendra Prasad sanjana Gaikwad Prakash Itankar Nagpur College of Pharmacy Dr.Babasaheb Ambedkar Technological UniversityNagpur 441110India Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur UniversityNagpur 440033India

Objective:To examine the effects of hydroalcoholic extract and fractions of Hordeum vulgare Linn.(***,Da Mai)on streptozotocin(STZ)-induced diabetic nephropathy in Sprague-Dawley rat ***:The study involved preliminary phytochemical screening of extract and fractions,estimation of secondary metabolites,chromatographic studies using high performance liquid chromatography(HPLC),antioxidant potential using 1,1-diphenyl-2-picrylhydrazyl(DPPH),nitric oxide radical scavenging and reducing power methods along with the determination of potential against diabetic nephropathy in STZ-induced rat ***:The phytochemical evaluation of the hydroalcoholic extract of *** and fractions revealed the presence of various phytoconstituents such as alkaloids,saponins,tannins,flavonoids,and *** chromatographic analysis indicated the peak complementing marker compound epicatechin and significant antioxidant activity in the extract and aqueous ***-induced rats showed abnormal levels of serum albumin,creatinine,total cholesterol,blood urea nitrogen(BUN),and triglycerides,and urine albumin and creatinine,which returned to normal after 8 weeks of treatment with hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of ***:Hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of *** have significant antioxidant potential and positive effects on diabetic *** fractionation and optimization increase the concentration of polyphenols in aqueous extract,causing a decrease in the dose required for effects against diabetic nephropathy.

关键词： Fractionation HPLC DPPH Nitric oxide radical scavenging Serum albumin Creatinine Blood urea nitrogen

Formulation of Ayurvedic Medicines and Extracts of Medicinal Plants as an Alternative Therapeutic Treatment Option for Nephrolithiasis

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 278-283页

作者： Shikha Sachdeva Jaspreet Kaur sanjana Mehta Renu Saharan Parminder Nain Department of Pharmacy M.M College of PharmacyMaharishi Markandeshwar(Deemed to be University)AmbalaHaryanaIndia Chitkara College of Pharmacy Chandigarh-Patiala National HighwayRajpura140401Patiala(Punjab)India CT Institute of Pharmaceutical Sciences CT Group of InstitutionsShahpurJalandharIndia

The incidence of nephrolithiasis,commonly known as kidney stone,is increasing worldwide with significant health and economic *** 2 million people every year in India are affected by kidney *** affects all ages,genders,and races,but between the ages of 20 and 49 years,it affects most frequently in men than *** types of stones include calcium stones,cysteine stones,struvite or magnesium ammonium phosphate stones,uric acid stones,and drug-induced *** review article provides information about general pathophysiology,epidemiology,clinical presentation,and pharmacological treatment,which includes ayurvedic and herbal medicines for *** understanding of the pathophysiological link between nephrolithiasis and systemic disorders is necessary for the development of new therapeutic options.

关键词： Allopathic management ayurvedic treatment calcium stones nephrolithiasis

Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel

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Nano Research 2022年第5期15卷 4302-4309页

作者： Boyang Sun sanjana Ghosh Xuedan He Wei-Chiao Huang Breandan Quinn Meiling Tian Dushyant Jahagirdar Moustafa T.Mabrouk Joaquin Ortega Yumiao Zhang Shuai Shao Jonathan F.Lovell Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Biomedical Engineering University at BuffaloState University of New YorkBuffaloNY 14260USA Department of Anatomy and Cell Biology McGill UniversityMontrealQuebec H3A0C7Canada School of Chemical Engineering and Technology Tianjin UniversityTianjin 300000China

Photodynamic therapy(PDT)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent ***,we demonstrated that liposomes containing a bilayer-anchored photosensitizer(porphyrin-phospholipid;PoP)can be loaded with drugs in their aqueous core to improve drug delivery and tumor ablation upon target tissue irradiation with *** the present work,we demonstrate that this concept can be extended to drugs loaded within the hydrophobic bilayer of ***(CTX)is a potent second generation taxane anti-cancer drug that was loaded in the bilayer of liposomes also containing 0.1 molar%PoP,generating CTX-loaded PoP liposomes(CTX-PoP-Lip).CTX-PoP-Lip showed unilamellar vesicle morphology,and exhibited integrity in storage and serum,while maintaining drug stability under laser *** vitro cell killing evaluation showed that red-light laser irradiation induced cytotoxicity in cells incubated with CTX-PoP-Lip,compared to control *** vivo pharmacokinetic analysis revealed that following intravenous administration to mice,CTX and PoP exhibited somewhat altered circulation profiles,suggesting that the CTX may have exchanged with serum factors in ***,when a single treatment of CTX-PoP-Lip with laser irradiation was administered to mice bearing human MIA Paca-2 tumors,tumors were effectively ablated whereas the equivalent chemotherapy and PDT monotherapies were *** results demonstrate the versatility of liposome delivery systems for achieving tumor ablation with chemophototherapy.

关键词： photodynamic therapy cabazitaxel liposome chemotherapy porphyrin-phospholipid

Cardiac risk stratification of the liver transplant candidate:A comprehensive review

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World Journal of Transplantation 2022年第7期12卷 142-156页

作者： sanjana Nagraj Spyros Peppas Maria Gabriela Rubianes Guerrero Damianos G Kokkinidis Felipe I Contreras-Yametti Sandhya Murthy Ulrich P Jorde Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineNew York CityNY 10461United States Department of Gastroenterology Athens Naval HospitalAthens 11521Greece Section of Cardiovascular Medicine Yale University School of MedicineYale New Haven HospitalNew HavenCT 06510United States Department of Medicine Wellstar Atlanta Medical CenterAtlantaGA 30312United States Division of Cardiology Montefiore Medical CenterAlbert Einstein College of MedicineNew York CityNY 10467United States

Cardiovascular diseases(CVD)form a principal consideration in patients with end-stage liver disease(ESLD)undergoing evaluation for liver transplant(LT)with prognostic implications in the peri-and post-transplant *** the predominant etiology of ESLD continues to evolve,addressing CVD in these patients has become increasingly ***,as the number of LTs increase by the year,the proportion of older adults on the waiting list with competing comorbidities increase,and the demographics of LT candidates evolve with parallel increases in their CVD risk *** primary goal of cardiac risk assessment is to preemptively reduce the risk of cardiovascular morbidity and mortality that may arise from hemodynamic stress in the peri-and post-transplant *** complex hemodynamics shared by ESLD patients in the pre-transplant period with adverse cardiovascular events occurring in only some of these recipients continue to challenge currently available guidelines and their uniform *** review focusses on cardiac assessment of LT candidates in a stepwise manner with special emphasis on preoperative patient *** hope that this will reinforce the importance of cardiovascular optimization prior to LT,prevent futile LT in those with advanced CVD beyond the stage of optimization,and thereby use the finite resources prudently.

关键词： Cardiovascular risk Liver transplantation End stage liver disease Liver cirrhosis Cardiovascular diseases Cardiovascular diagnostic techniques