检索结果-南通市图书馆

Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

Transversal vibrations of double-plate systems

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2006年第5期22卷 487-501页

作者： Katica(stevanovic) Hedrih Faculty of Mechanical Engineering University of Nis Vojvode Tankosica3/2218000 Nis Serbia and Montenegro

This paper presents an analytical and numerical analysis of free and forced transversal vibrations of an elastically connected double-plate system. Analytical solutions of a system of coupled partial differential equations, which describe corresponding dynamical free and forced processes, are obtained using Bernoulli＇s particular integral and Lagrange＇s method of variation constants. It is shown that one-mode vibrations correspond to two-frequency regime for free vibrations induced by initial conditions and to three-frequency regime for forced vibrations induced by one-frequency external excitation and corresponding initial conditions. The analytical solutions show that the elastic connec- tion between plates leads to the appearance of twofrequency regime of time function, which corresponds to one eigenamplitude function of one mode, and also that the time functions of different vibration modes are uncoupled, for each shape of vibrations. It has been proven that for both elastically connected plates, for every pair of m and n, two possibilities for appearance of the resonance dynamical states, as well as for appearance of the dynamical absorption, are present. Using the MathCad program, the corresponding visualizations of the characteristic forms of the plate middle surfaces through time are presented.

关键词： Double plate system Elastic connection Vibration Multi-frequency Visualization

A non-isothermal Couette slip gas flow

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2013年第9期56卷 1782-1797页

作者： MILICEV Snezana S. stevanovic Nevena D. University of Belgrade Faculty of Mechanical Engineering

A steady plane subsonic compressible non-isothermal Couette gas flow is analyzed for moderately high and low Reynolds *** flow channel is formed by two plates in relative *** cases are considered:(a) isothermal walls where the temperatures of the plates are equal and constant and(b) with constant but different plate *** Knudsen number is Kn 0.1,which corresponds to the slip and continuum *** flow is defined by continuity,Navier-Stokes and energy continuum equations,along with the velocity slip and the temperature jump first order boundary *** analytical solution for velocity and temperature is obtained by developing a perturbation *** first approximation corresponds to the continuum flow conditions,while the others represent the contribution of the rarefaction *** addition,a numerical solution of the problems is given to confirm the accuracy of the analytical *** exact analytical solution,for constant viscosity and conductivity is found for the isothermal walls case as *** is shown that it is entirely a substitution to the exact numerical solution for the isothermal walls case.

关键词： Couette gas flow non-isothermal slip flow analytical solution perturbation scheme

TG-interacting Factor(TGIF) Downregulates SOX3 Gene Expression in the NT2/D1 Cell Line

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2012年第1期39卷 19-27页

作者： Marija Mojsin Jelena Popovic Natasa Kovacevic Grujicic Milena stevanovic Laboratory for Human Molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeVojvode Stepe 444aPO Box 2311010 BelgradeSerbia

SOX3 is a member of the Sox gene family implicated in brain formation and cognitive function. It is considered to be one of the earliest neural markers in vertebrates, playing a role in specifying neuronal fate. Recently, we have established the first link between TALE （three- amino-acid loop extension） proteins, PBX1 （pre-B-cell leukemia homeobox 1） and MEIS1 （myeloid ecotropic viral integration site 1 homologue）, and the expression of the human SOX3 gene. Here we present the evidence that TGIF （TG-interacting factor） is an additional TALE superfamily member involved in the regulation of human SOX3 gene expression in NT2/D1 cells by direct interaction with the consensus binding site that is conserved in primate orthologue promoters. Functional analysis demonstrated that mutation of the TGIF binding site resulted in the activation of SOX3 promoter. TGIF overexpression downregulates SOX3 promoter activity and decreases endogenous SOX3 protein expression in both uninduced and retinoic acid （RA）-induced NT2/D1 ceils. Up to now, this is the first transcription factor identified as a negative regulator of SOX3 gene expression. The obtained results further underscore the significance of TALE proteins as important transcriptional regulators of SOX3 gene expression.

关键词： NT2/D1 cells TGIF Retinoic acid SOX3

First-principles calculation of intrinsic defect chemistry and self-doping in PbTe

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2017年第1期3卷 106-114页

作者： Anuj Goyal Prashun Gorai Eric S.Toberer Vladan stevanovic Colorado School of Mines GoldenCO 80401USA National Renewable Energy Laboratory GoldenCO 80401USA

Semiconductor dopability is inherently limited by intrinsic defect *** many thermoelectric materials,narrow band gaps due to strong spin-orbit interactions make accurate atomic level predictions of intrinsic defect chemistry and self-doping computationally *** we use different levels of theory to model point defects in PbTe,and compare and contrast the results against each other and a large body of experimental *** find that to accurately reproduce the intrinsic defect chemistry and known self-doping behavior of PbTe,it is essential to(a)go beyond the semi-local GGA approximation to density functional theory,(b)include spin-orbit coupling,and(c)utilize many-body GW theory to describe the positions of individual band *** hybrid HSE functional with spin-orbit coupling included,in combination with the band edge shifts from G0W0 is the only approach that accurately captures both the intrinsic conductivity type of PbTe as function of synthesis conditions as well as the measured charge carrier concentrations,without the need for experimental *** results reaffirm the critical role of the position of individual band edges in defect calculations,and demonstrate that dopability can be accurately predicted in such challenging narrow band gap materials.

关键词： defect intrinsic doping

Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第11期17卷 2325-2334页

作者： Milena stevanovic Danijela Stanisavljevic Ninkovic Marija Mojsin Danijela Drakulic Marija Schwirtlich Laboratory for Human Molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeBelgradeSerbia University of Belgrade Faculty of BiologyBelgradeSerbia Serbian Academy of Sciences and Arts BelgradeSerbia

Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain *** SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial *** represent a class of small non-coding RNAs that play important roles in the regulation of gene *** with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for *** emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult *** SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and *** strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of *** in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological *** focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies.

关键词： dysregulation of miRNA expression glioblastoma gliogenesis glioma stem cells ischemic stroke neural stem cells neural tissue regeneration neurodegenerative diseases neurodevelopment neurogenesis SOX/miRNA interplay traumatic brain injury

Comparison of light absorption and oxidative potential of biodiesel/diesel and chemicals/diesel blends soot particles

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第1期32卷 184-193页

作者： Yu Kuang Yi Guo Jiaqi Chai Jing Shang Jiali Zhu Svetlana stevanovic Zoran Ristovski State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineeringand Center for Environment and HealthPeking UniversityBeijing 100871China International Laboratoryfor Air Quality&Health(ILAQH) School of ChemistryPhysics and Mechanical EngineeringQueensland University of TechnologyBrisbaneQLD 4001Australia School of Engineering Faculty of Science Engineering&Built EnvironmentDe akin UniversityGeelong Waum Ponds CampusLocked Bag 20000GeelongVIC 3220Australia

Soot particles,mainly coming from fuel combustion,affect climate forcing through absorbing light and also result in adverse human health *** biodiesel or additives blending with diesel was considered environmentally friendly,the understanding on absorbing and oxidative capacity of soot emitted from them are still *** watersoluble organic carbon(WSOC)content,surface chemical structure,light absorption and oxidative potential(OPDTT)of soot from biodiesel/diesel and chemicals/diesel blends were investigated utilizing total organic carbon analyzer,X-ray photoelectron spectrometer,ultraviolet–visible spectrophotometry and dithiothreitol(DTT)*** differences and correlations between soot properties were statistically ***/diesel blends soot owned significantly higher WSOC content,ratio of mass absorbing efficiency(MAE)in250 and 365 nm(E2/E3),OPDTT,and higher surface carbonyl *** biodiesel/diesel blends soot contained evidently higher aromatic carbon–oxygen single bond(ArC–O)content,and higher *** individual comparison of biodiesel/diesel blends showed20%coconut biodiesel blend owned the lowest WSOC,E2/E3 and OPDTT,while highest ArC–O and MAE365,representing strongest absorbing *** analysis showed OPDTTwas significantly positively correlated with ***,the evident negative correlation between MAE365 and OPDTT was *** results showed coconut biodiesel/diesel blends soot induced lower levels of oxidative potential,whereas absorption of light was higher,which have far reaching consequences on climate ***,it is important to evaluate the balance point between light-absorbing properties and oxidative potential,under the wide use of biodiesel.

关键词： Soot particle Biodiesel Light absorption Mass absorbing efficiency Oxidative potential Dithiothreitol(DTT)

Characterization particulate matter from several Chinese cooking dishes and implications in health effects

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第10期30卷 98-106页

作者： Lina Wang Xinran Zheng Svetlana stevanovic Xin Wu Zhiyuan Xiang Mingzhou Yu Jing Liu State Environmental Protection Key Laboratory of Risk Assessment and Control on Chemical Process School of Resources and Environmental Engineering East China University of Science and TechnologyShanghai 200237 China International Laboratory of Air Quality and Health Queensland University of Science and TechnologyShanghai 200237 China The security environmental protection bureau of Ningbo daxie development zone Ningbo 315812 China Department of physics China Jiliang UniversityHangzhou 310018 China School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 250001 China

Cooking fume produced by oil and food at a high temperature releases large amount of fine particulate matter（PM） which have a potential hazard to human health. This chamber study investigated particle emission characteristics originated from using four types of oil（soybean oil, olive oil, peanut oil and lard） and different kinds of food materials（meat and vegetable）. The corresponding emission factors（EFs） of number, mass, surface area and volume for particles were discussed. Temporal variation of size-fractionated particle concentration showed that olive oil produced the highest number PM concentration for the entire cooking process. Multiple path particle dosimetry（MPPD） model was performed to predict deposition in the human respiratory tract. Results showed that the pulmonary airway deposition fraction was the largest. It was also found that particles produced from olive oil led to the highest deposition. We strongly recommend minimizing the moisture content of ingredients before cooking and giving priority to the use of peanut oil instead of olive oil to reduce human exposure to PM.

关键词： Chinese cooking Ultrafine particle Black carbon Emission factor Lung deposition

SOX transcription factors and glioma stem cells:Choosing between stemness and differentiation

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2021年第10期13卷 1417-1445页

作者： Milena stevanovic Natasa Kovacevic-Grujicic Marija Mojsin Milena Milivojevic Danijela Drakulic Laboratory for Human Molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeBelgrade 11042Serbia Chair Biochemistry and Molecular Biology Faculty of BiologyUniversity of BelgradeBelgrade 11158Serbia Department of Chemical and Biological Sciences Serbian Academy of Sciences and ArtsBelgrade 11000Serbia

Glioblastoma(GBM)is the most common,most aggressive and deadliest brain ***,remarkable progress has been made towards understanding the cellular and molecular biology of *** tumor initiation,progression and relapse as well as resistance to treatments are associated with glioma stem cells(GSCs).GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types,generating a range of distinct cell types within the tumor,leading to cellular *** tumors may contain different subsets of GSCs,and some of them may adopt a quiescent state that protects them against chemotherapy and *** enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties,making them more malignant,able to rapidly *** impact of SOX transcription factors(TFs)on brain tumors has been extensively studied in the last *** all SOX genes are expressed in GBM,and their expression levels are associated with patient prognosis and *** SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC *** fine-tuning of SOX gene expression levels controls the balance between cell stemness and ***,innovative therapies targeting SOX TFs are emerging as promising tools for combatting *** GBM has been a demanding and challenging goal for *** current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient *** approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM.

关键词： Glioblastoma SOX transcription factors Glioma stem cells Stemness Differentiation