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Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression

Neural Regeneration Research 2019年第9期14卷 1530-1535页

作者： Hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon Sung Ho Kim In Sik Shin Miyoung Yang sangwoo bae Joong Sun Kim Division of Basic Radiation Bioscience Korea Institute of Radiological&Medical Sciences(KIRMAS)SeoulRepublic of Korea National Primate Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)CheongjuRepublic of Korea College of Pharmacy Kyungpook National UniversityDaeguRepublic of Korea College of Veterinary Medicine Veterinary Medical Research InstituteChonnam National UniversityGwangjuRepublic of Korea School of Medicine Wonkwang UniversityJeonbukRepublic of Korea Research Center Dongnam Institute of Radiological&Medical Sciences(DIRAMS)BusanRepublic of Korea

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain *** investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial *** impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after *** also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic ***-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** butyrate pretreatment reversed these *** findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval ***16-0002)on December 30,2016.

关键词： sodium butyrate radioprotector ionizing radiation hippocampal damage cAMP response element binding brain-derived neurotrophic factor histone deacetylase inhibitor neurogenesis

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo Park Jong-Seong bae Taehyun Park Il Tae Kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Perovskite

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Boosting efficiency in state estimation of power systems by leveraging attention mechanism

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Energy and AI 2024年第2期16卷 438-449页

作者： Elson Cibaku Fernando Gama sangwoo Park Industrial Engineering New Jersey Institute of TechnologyNewarkNJUnited States Pendulum Systems DenverCOUnited States

Ensuring stability and reliability in power systems requires accurate state estimation, which is challenging due to the growing network size, noisy measurements, and nonlinear power-flow equations. In this paper, we introduce the Graph Attention Estimation Network (GAEN) model to tackle power system state estimation (PSSE) by capitalizing on the inherent graph structure of power grids. This approach facilitates efficient information exchange among interconnected buses, yielding a distributed, computationally efficient architecture that is also resilient to cyber-attacks. We develop a thorough approach by utilizing Graph Convolutional Neural Networks (GCNNs) and attention mechanism in PSSE based on Supervisory Control and Data Acquisition (SCADA) and Phasor Measurement Unit (PMU) measurements, addressing the limitations of previous learning architectures. In accordance with the empirical results obtained from the experiments, the proposed method demonstrates superior performance and scalability compared to existing techniques. Furthermore, the amalgamation of local topological configurations with nodal-level data yields a heightened efficacy in the domain of state estimation. This work marks a significant achievement in the design of advanced learning architectures in PSSE, contributing and fostering the development of more reliable and secure power system operations.

关键词： Power grids State estimation Attention mechanism Graph neural networks Distributed computation Grid cyber-security

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Clinical and genetic analysis of Ser341Pro MYOC variant in a Korean family with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1689-1696页

作者： sangwoo Moon Namhee Kim Jiwoong Lee Department of Ophthalmology Pusan National University College of MedicineBusan 49241Republic of Korea Biomedical Research Institute Pusan National University HospitalBusan 49241Republic of Korea Department of Laboratory Medicine Dong A University College of MedicineBusan 49201Republic of Korea

AIM:To report the first discovery of Ser341Pro myocilin(MYOC)variant in Korea and analyze its clinical characteristics and genetic ***:Ten family members from three generations participated in this study and received the thorough ophthalmologic *** exome sequencing on a proband was performed to confirm the target mutations(MYOC c.1021T>C)in the family members,and the direct sequencing was *** was analyzed according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology(ACMG/AMP)***:A nucleotide change from thymine to cytosine at c.1021T>C was found in eight family *** members diagnosed with primary open angle glaucoma(POAG)were characterized by severe clinical presentations,high intraocular pressure,and poor response to medical treatment(100%of the patient required filtering surgery).On variant analysis by ACMG/AMP guidelines,Ser341Pro is not found in normal *** computational predictive programs support a deleterious effect of Ser341Pro variant(PoIyPhen 2,SIFT,Mutation Taster).Ser341Pro could be involved in moderate(PM)and supporting(PP)criteria(PM1,PM2,PP2,PP3).Combiningthe criteria,Ser341Pro has a combination of 2 moderate(PM1+PM2)and 2 supporting(PP2+PP3)criteria,which is interpreted to"likely pathogenic".CONCLUSION:The Ser341Pro variant is correlated with severe phenotype of *** are similar clinical aspects to previous studies:autosomal dominant inheritance,incomplete penetrance(62.50%and 66.67%),and proportion of patients requiring trabeculectomy(100%in both study).According to ACMG/AMP guidelines and the previous basic researches,the Ser341Pro variant had a"strong evidence of pathogenicity(PS3)"and then it could be interpreted to“pathogenic(PS3,PM1,PM2,PP2,PP3)”.Additionally,Ser341Pro variant can be reported as"c.1021T>C(***341Pro)",likely pathogenic,POAG,autosomal dominant”according to guideline.

关键词： Ser341Pro variant primary open angle glaucoma Korean

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Characterization of particulate matter from diesel passenger cars tested on chassis dynamometers

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Journal of Environmental Sciences 2017年第4期29卷 21-32页

作者： Sungwoon Jung Jaehyun Lim Sangil Kwon sangwoo Jeon Jeongsoo Kim Jongtae Lee Sunmoon Kim Transportation Pollution Research Center National Institute of Environmental Research Incheon Republic of Korea Division of Global Environment Research National Institute of Environmental Research Incheon Republic of Korea Compliance & Defects Investigation Office Korea Automobile Testing & Research Institute Hwasung Republic of Korea

Emission characterization of particle number as well as particle mass from three diesel passenger cars equipped with diesel particulate filter（DPF）, diesel oxidation catalyst（DOC）and exhaust gas recirculation（EGR） under the vehicle driving cycles and regulatory *** particle number emissions（PNEs） decreased gradually during speed-up of vehicle from 17.3 to 97.3 km/hr. As the average vehicle speed increases, the size-segregated peak of particle number concentration shifts to smaller size ranges of particles. The correlation analysis with various particulate components such as particle number concentration（PNC）,ultrafine particle number concentration（UFPNC） and particulate matter（PM） mass was conducted to compare gaseous compounds（CO, CO2, HC and NOx）. The UFPNC and PM were not only emitted highly in Seoul during severe traffic jam conditions, but also have good correlation with hydrocarbons and NOxinfluencing high potential on secondary aerosol generation. The effect of the dilution temperature on total PNC under the New European Driving Cycle（NEDC）, was slightly higher than the dilution ratio. In addition, the nuclei mode（DP： ≤ 13 nm） was confirmed to be more sensitive to the dilution temperature rather than other particle size ranges. Comparison with particle composition between vehicle speed cycles and regulatory cycle showed that sulfate was slightly increased at regulatory cycle, while other components were relatively similar. During cold start test, semivolatile nucleation particles were increased due to effect of cold environment. Research on particle formation dependent on dilution conditions of diesel passenger cars under the NEDC is important to verify impact on vehicular traffic and secondary aerosol formation in Seoul.

关键词： Diesel passenger cars Particle number emissions Correlation analysis Particle number concentration Ultrafine particle number concentration

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Influence of new town development on the urban heat island-The case of the Bundang area

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Journal of Environmental Sciences 2005年第4期17卷 641-645页

作者： SONG Young-bae School of Architecture Landscape Architecture and Civil Engineering Sung Kyun Kwan UniversityKorea

Five new towns have been developed around the Seoul metropolitan area since 1996 However, these new towns generate lots of traffic and related problems in the areas including those new towns and Seoul as a result of increases in population and a lack of ecological-self-sufficiency. Currently, construction of another new town is under deliberation, and what should be a major consider is the notion that the new town be located within a wide, green zone. Many studies have revealed that green space can play an important role in improving urban eco-meteorological capability and air quality. In order to analyze the urban heat island which will be created by the new urban development, and to investigate the local thermal environment and its negative effects caused by a change of land use type and urbanization, Landsat TM images were used for extraction of urban surface temperature according to changes of land use over the last 15 years. These data are analyzed together with digital land use and topographic information. As a study result, it was found the urban heat island of the study area from 1985 to 1999 rapidly developed which showed a difference of mean temperature above +2 0 Before the Bundang new town construction the temperature of the residential area was the same as a forest, but during the new town construction in 1991 analysis revealed the creation of an urban heat island. The temperature of a forest whose size is over 50% of the investigation area was lowest, and thus the presence of a forest is believed to have a direct cooling effect on the urban environment and its surroundings. The mean temperature of the residential and commercial areas in the study was found to be +4 5 higher than the forest, and therefore this part of land use is believed to be the main factor causing the temperature increase of the urban heat island.

关键词： urban heat island new town development urban climate landsat TM nand 6 air corridor

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Toward Fast and Efficient Mobility in Aquatic Environment： A Robot with Compliant Swimming Appendages Inspired by a Water Beetle

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Journal of Bionic Engineering 2017年第2期14卷 260-271页

作者： Bokeon Kwak Joonbum bae Department of Mechanical Engineering UNIST Ulsan Korea

Water beetles are proficient drag-powered swimmers, with oar-like legs. Inspired by this mechanism, here we propose a miniature robot, with mobility provided by a pair of legs with swimming appendages. The robot has optimized linkage structure to maximize the stroke angle, which is actuated by a single DC motor with a series of gears and a spring. A simplified swimming appendage model is proposed to calculate the deflection due to the applied drag force, and is compared with simulated data using COMSOL Multiphysies. Also, the swimming appendages are optimized by considering their locations on the legs using two fitness functions, and six different configurations are selected. We investigate the performance of the robot with various types of appendage using a high-speed camera, and motion capture cameras. The robot with the proposed configuration exhibits fast and efficient movement compared with other robots. In addition, the locomotion of the robot is analyzed by considering its dynamics, and compared with that of a water boatman （Corixidae）.

关键词： mobility compliant appendage drag-powered swimming miniature robot water beetle

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Design and Analysis of a Rotational Leg-type Miniature Robot with an Actuated Middle Joint and a Tail （RoMiRAMT-II）

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Journal of Bionic Engineering 2018年第2期15卷 356-367页

作者： Bokeon Kwak Joonbum bae Department of Mechanical Engineering UNIST Ulsan 44919 Korea

In this paper, a rotational leg-type miniature robot with a bioinspired actuated middle joint and a tail is proposed for stable locomotion and improved climbing ability. The robot has four independently actuated rotational legs, giving it advantages of both wheel-type and leg-type locomotion. The design parameters of the rotational legs were determined by 3D simulation within the seven candidates that selected by a newly proposed metric. It also has unique characteristics inspired by biological structures： a middle joint and a tail. An actuated middle joint allows the frontal body to be lifted or lowered, which was inspired by a flexible body joint of animals, to climb higher obstacles. Effectiveness of the middle joint was analytically verified by the geometric analysis of the robot. Additionally, a multi-functional one Degree Of Freedom （1-DOF） tail was added; the tail prevented the body being easily flipped, while allowed the robot to climb higher obstacles. A bristle-inspired micro structure was attached to the tail to enhance straightness of locomotion. Body size of the robot was 158 mm × 80 mm × 85 mm and weighed 581 g including a 7.4 V Li-Polymer battery. The average velocity of the robot was 2.74 m·s ^-1 （17.67 body lengths per second） and the maximum height of an obstacle that the robot could climb was 106 mm （2.5 times of leg length）, which all were verified by experiments.

关键词： locomotion rotational leg actuated middle joint actuated tail bionic miniature robot

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On Uniform Decay for Transmission Problem of Kirchhoff Type Viscoelastic Wave Equation

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1197-1206页

作者： Jeong Ja bae Department of Mathematics Dongeui University

In this paper we consider the large time behavior of solutions to an n-dimensional transmission problem for two Kirchhoff type viscoelastic wave equations, that is, the wave propagation over bodies consisting of two physically different types of materials. One component is a simple elastic part while the other is a viscoelastic component endowed with a long range memory. We show that the dissipation produced by the viscoelastic part is strong enough to produce exponential or polynomial decay of the solution

关键词： existence of solution uniform decay wave equation boundary value problem a priori estimates

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Autonomous SLAM Technique with Stereo Vision

Autonomous SLAM Technique with Stereo Vision

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第二十七届中国控制会议

作者： Gim Suhyeon Lee sangwoo Yang Taekyu Department of Intelligent Robot Engineering Mokwon University

ISBN: (纸本)9787900719706

This paper proposes some algorithms integrating grid and topology map and its performance is faster and more *** proposed scheme uses an occupancy grid map in representing the environment and then formulate topological information in path finding by *** localization process and the dynamic obstacle avoidance can be accomplished by topological information on grid based *** simulator mapping process is shown and the shortest path is decided on grid based *** topological information such as direction,distance is calculated on simulator program then transmitted to robot hardware *** one stereo camera and electronic compass are implemented on our mobile robot and two DC geared motor wheels are individually controlled by PD control *** matching was accomplished by image processing from two parallel positioned cameras and new algorithms such as fast object labeling,measuring depth by image overlapping and local information of optical *** and experimental results show the performance and efficiency of the proposed scheme.

关键词： Mobile robot Coverage pattern SLAM Path finding A*algorithm Stereo vision

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