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International Journal of Biomathematics 2018年第8期11卷 363-392页

作者： Ranjit Kumar Upadhyay Sarita kumari sangeeta kumari Department of Applied Mathematics Indian Institute of Technology (ISM) Dhanbad 826004 Jharkhand India

Salton Sea (a destination resort) is to be saved from being converted into a skeletonfilled wasteland. The critical amount of water flowing into the sea to maintain its level and salinity has been diverted since January 2018. This will lead to shrinking volumes and increasing salinities. Ecological consequences and public health impacts of altered conditions will be phenomenal. We design and analyze a minimal eco-epidemiological model to figure out future journey of this sea;a way station for fish-eating migratory birds. The mathematical model has been assembled in terms of prey-predator interaction. The salient feature of the proposed model is its seasonally varying contact rate which represents rate of conversion of susceptible fishes into infectives. We have analytically investigated the global stability, disease persistence and periodic solutions of the proposed model system. Susceptible prey-induced periodic solution is globally asymptotically stable when R01 *** stability and Hopf bifurcation (HB) analysis help us extract parameter values to explore the dynamical behavior of the model system. Two-dimensional parameter scans and bifurcation diagrams reveal that the model displays propensity towards chaotic dynamics, which is associated with extinction-sized population densities. In the presence of stochastic external forces, this implies extinction of most of the fish species. This, in turn, suggests that resident birds will have to migrate to other destinations. The fish-eating migratory birds will be forced to switch over to invertebrates. Ecological consequences and public health impacts of this transition would be severe. Conservation groups are solicited to draw attention of the government to avert this impounding danger. It is important to plan for an ecosystem-wide transition such that impacts on birds and on human inhabitants living adjacent to the shrinking and salinizing sea are minimized

关键词： Eco-epidemiological model seasonally varying contact rate diseases in fish species avian predator chaotic dynamics fish-eating migratory birds invertebrates

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Androgen receptor co-regulation in prostate cancer

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Asian Journal of Urology 2020年第3期7卷 219-232页

作者： Dhirodatta Senapati sangeeta kumari Hannelore V.Heemers Department of Cancer Biology Cleveland ClinicClevelandOHUSA Department of Urology Cleveland ClinicClevelandOHUSA Department of Hematology/Medical Oncology Cleveland ClinicClevelandOHUSA

Prostate cancer(PCa)progression relies on androgen receptor(AR)*** AR’s ligand-activation is the frontline treatment for metastatic *** deprivation therapy(ADT)that inhibits AR ligand-binding initially induces remission but eventually fails,mainly because of adaptive PCa responses that restore AR *** vast majority of castration-resistant PCa(CRPC)continues to rely on AR *** therapeutic strategies are being explored that involve targeting other critical AR domains such as those that mediate its constitutively active transactivation function,its DNA binding ability,or its interaction with co-operating transcriptional *** molecular and clinical variability has been found in AR’s interaction with its ligands,DNA binding motifs,and its associated coregulators and transcription ***,we review evidence that each of these levels of AR regulation can individually and differentially impact transcription by *** addition,we examine emerging insights suggesting that each can also impact the other,and that all three may collaborate to induce gene-specific AR target gene expression,likely via AR allosteric *** the purpose of this review,we refer to the modulating influence of these differential and/or interdependent contributions of ligands,cognate DNA-binding motifs and critical regulatory protein interactions on AR’s transcriptional output,which may influence the efficiency of the novel PCa therapeutic approaches under consideration,as co-regulation of AR activity.

关键词： Androgen Coregulator Gene transcription Hormonal therapy Allostery

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一类具有非线性发生率的无线传感网络蠕虫传播模型的延迟动力学行为（英文）

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浙江大学学报（理学版） 2019年第2期46卷 168-186,199页

作者：张子振储煜桂 kumari sangeeta UPADHYAY Ranjit Kumar 安徽财经大学管理科学与工程学院印度理工学院(印度矿业学院)应用数学系

研究了一类具有不同发生率的无线传感网络蠕虫传播模型的延迟动力学行为。由于在监测节点隔离不稳定节点需要消耗一定的时间,在模型中考虑了处理时滞。通过分析相应特征方程根的分布情况,得到了平衡点存在性、模型局部稳定性和Hopf分岔... 详细信息

研究了一类具有不同发生率的无线传感网络蠕虫传播模型的延迟动力学行为。由于在监测节点隔离不稳定节点需要消耗一定的时间,在模型中考虑了处理时滞。通过分析相应特征方程根的分布情况,得到了平衡点存在性、模型局部稳定性和Hopf分岔存在的充分性条件。通过构造合适的李雅普诺夫函数,证明了蠕虫病毒平衡点的全局稳定性。数值仿真实验验证了理论分析结果的正确性。仿真结果表明,当处理时滞的值越过关键值时,网络中的蠕虫传播将失去控制,发现无线传感网络的覆盖范围是控制蠕虫传播和保证无线传感网络安全最为重要的因素之一。并通过仿真发现消除模型混沌状态的一些关键参数,其中非线性发生率βSI/I+1是控制蠕虫病毒传播、保证无线传感网络安全的最佳选择。

关键词：处理时滞 Hopf分岔稳定性分析无线传感网络 SIQRS蠕虫传播模型

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Anticancer Activity of Rice Callus Suspension Cultures from Aromatic Varieties and Metabolites Regulated in Treated Cancer Cell Lines

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Rice science 2024年第4期31卷 449-462,I0027-I0030页

作者： Anuradha kumari Wusirika RAMAKRISHNA Department of Biochemistry Central University of PunjabPunjab 151401India

Tissue culture techniques were used to produce large amounts of bioactive compounds with medicinal potential, overcoming space and time constraints for cancer prevention. Rice callus suspension cultures(RCSC) and seed extracts prepared from aromatic rice varieties were used to evaluate the cytotoxic impact on human colon and lung cancer cell lines, as well as a normal control cell line, using Taxol as a positive control. RCSC and seed extracts from two Indian aromatic rice varieties were applied at different concentrations to treat the cancer cell lines and normal lung fibroblasts over varying time intervals. Apoptosis was assessed in 1:5 dilutions of the A549 and HT-29 cell lines treated with RCSC for 72 h, using propidium iodide staining and flow cytometry. RCSC showed a more potent cytotoxic effect than seed extracts with minimal effect on the normal cell line, in contrast to Taxol. Confocal microscopy and flow cytometry further confirmed the apoptotic effect of RCSC. Gas chromatography-mass spectrometry-based metabolic profiling identified metabolites involved in cytotoxicity and highlighted altered pathways. RCSC is proposed as an alternative source for the development of novel anticancer drugs with reduced side effects.

关键词： anticancer cytotoxicity metabolite profiling plant tissue culture rice callus suspension culture secondary metabolite

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Switching effect on a two prey-one predator system with strong Allee effect incorporating prey refuge

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International Journal of Biomathematics 2024年第2期17卷 1-50页

作者： sangeeta Saha Guruprasad Samanta Department of Mathematics Indian Institute of Engineering Science and Technology Shibpur Howrah 711103India

In an environment,the food chains are balanced by the prey-predator *** a predator species is provided with more than one prey population,it avails the option of prey switching between prey species according to their ***,prey switching of predators mainly helps to increase the overall growth rate of a predator *** this work,we have proposed a two prey-one predator system where the predator population adopts switching behavior between two prey species at the time of *** the prey population exhibit a strong Allee effect and the predator population is considered to be a generalist *** proposed system is biologically well-defined as the system variables are positive and do not increase abruptly with *** local stability analysis reveals that all the predator-free equilibria are saddle points whereas the prey-free equilibrium is always *** intrinsic growth rates of prey,the strong Allee parameters,and the prey refuge parameters are chosen to be the controlling parameters *** numerical simulation reveals that in absence of one prey,the other prey refuge parameter can change the system dynamics by forming a stable or unstable limit ***,a situation of bi-stability,tri-stability,or even multi-stability of equilibrium points occurs in this *** in presence of the switching effect,the predator chooses prey according to their abundance,so,increasing refuge in one prey population decreases the count of the second prey *** is also observed that the count of predator population reaches a comparatively higher value even if they get one prey population at its fullest quantity and only a portion of other prey ***,in the scarcity of one prey species,switching to the other prey is beneficial for the growth of the predator population.

关键词： Prey-predator model switching effect strong Allee effect prey refuge

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Medicinal Effects, Phytochemistry,Pharmacology of Euphorbia prostrata and Promising MolecularMechanisms

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Chinese Journal of Integrative Medicine 2024年第2期30卷 181-192页

作者： Nirmala kumari Yadav Rakesh Yadav Department of Pharmacy Banasthali VidyapithBanasthali(304022)RajasthanIndia Department of Pharmaceutical Sciences Indira Gandhi UniversityMeerpurRewari(122502)HaryanaIndia National Forensic Sciences University Tripura CampusAgartala(799001)TripuraIndia

Euphorbiaceae is a large family of dicotyledonous angiosperms with diverse genera including Euphorbia prostrata(***).Current research has provided scientific evidence for traditional uses of *** against diverse pathological conditions such as anti-hemorrhoidal,anti-inflammatory,analgesic,wound healing,antioxidant,antibacterial,leishmanicidal,antitumor activity,and so *** phytochemical screening has revealed the presence of glycosides,phytosterols,flavonoids,polyphenols,tannins,and anthraquinones with chemical structures elucidation of their respective *** uniqueness of such multifactorial compounds present in this species endorses it as the potent therapeutic or prophylactic choice for several fatal *** ethnomedical applications served as a significant citation for pharmacology,the molecular mechanism has not been reviewed *** present paper provides a comprehensive review of research outcomes,pharmacology,toxicology,and molecular signaling of phytochemicals of *** species as a reference for relevant *** study of bioactive compounds in crude extracts and fractions,the demonstration of primary mechanisms of pharmacology,along with the addition of toxicity,and clinical trials,should be conceded in *** review underlines the *** species that can be a promising phytomedicine since we are committed to excavating more intensely into their pharmacological role.

关键词： Euphorbia prostrata Euphorbiaceae phytochemicals ethnomedical applications toxicology molecularmechanism

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MXenes: Versatile 2D materials with tailored surface chemistry and diverse applications

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Journal of Energy Chemistry 2024年第3期90卷 253-293,I0008页

作者： Sunil Kumar Nitu kumari Yongho Seo Department of Nanotechnology and Advanced Materials Engineering and HMC Sejong UniversitySeoul 05006South Korea School of Studies in Chemistry Jiwaji UniversityGwalior 474011India

MXenes,the most recent addition to the 2D material family,have attracted significant attention owing to their distinctive characteristics,including high surface area,conductivity,surface characteristics,mechanical strength,*** review begins by presenting MXenes,providing insights into their structural characteristics,synthesis methods,and surface functional *** review covers a thorough analysis of MXene surface properties,including surface chemistry and termination group *** properties of MXenes are influenced by their synthesis,which can be fluorine-based or ***-based synthesis techniques involve etching with fluorine-based reagents,mainly including HF or LiF/HCl,while fluorine-free methods include electrochemical etching,chemical vapor deposition(CVD),alkaline etching,Lewis acid-based etching,*** techniques result in the emergence of functional groups such as-F,-O,-OH,-Cl,*** the MXenes surface,depending on the synthesis method *** of MXenes,such as electrical conductivity,electronic properties,catalytic activity,magnetic properties,mechanical strength,and chemical and thermal stability,are examined,and the role of functional groups in determining these properties is *** review delves into the diverse applications of MXenes,encompassing supercapacitors,battery materials,hydrogen storage,fuel cells,electromagnetic interference(EMI) shielding,pollutant removal,water purification,flexible electronics,sensors,additive manufacturing,catalysis,biomedical and healthcare fields,***,this article outlines the challenges and opportunities in the current and future development of MXenes research,addressing various aspects such as synthesis scalability,etching challenges,and multifunctionality,and exploring novel *** review concludes with future prospects and conclusions envisioning the impact of MXenes on future technologies and innovation.

关键词： MXenes 2D materials Surface chemistry MXenes structure Synthesis Applications

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A Spectral Convolutional Neural Network Model Based on Adaptive Fick’s Law for Hyperspectral Image Classification

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Computers, Materials & Continua 2024年第4期79卷 19-46页

作者： Tsu-Yang Wu Haonan Li Saru kumari Chien-Ming Chen School of Artificial Intelligence(School of Future Technology) Nanjing University of Information Science&TechnologyNanjing210044China College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao266590China Department of Mathematics Chaudhary Charan Singh UniversityMeerutUttar Pradesh250004India

Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant *** response to this challenge,a Spectral Convolutional Neural Network model based on Adaptive Fick’s Law Algorithm(AFLA-SCNN)is *** Adaptive Fick’s Law Algorithm(AFLA)constitutes a novel metaheuristic algorithm introduced herein,encompassing three new strategies:Adaptive weight factor,Gaussian mutation,and probability update *** adaptive weight factor,the algorithmcan adjust theweights according to the change in the number of iterations to improve the performance of the *** helps the algorithm avoid falling into local optimal solutions and improves the searchability of the *** probability update strategy helps to improve the exploitability and adaptability of the *** the AFLA-SCNN model,AFLA is employed to optimize two hyperparameters in the SCNN model,namely,“numEpochs”and“miniBatchSize”,to attain their optimal ***’s performance is initially validated across 28 functions in 10D,30D,and 50D for CEC2013 and 29 functions in 10D,30D,and 50D for *** results indicate AFLA’s marked performance superiority over nine other prominent optimization ***,the AFLA-SCNN model was compared with the Spectral Convolutional Neural Network model based on Fick’s Law Algorithm(FLA-SCNN),Spectral Convolutional Neural Network model based on Harris Hawks Optimization(HHO-SCNN),Spectral Convolutional Neural Network model based onDifferential Evolution(DE-SCNN),SpectralConvolutionalNeuralNetwork(SCNN)model,and SupportVector Machines(SVM)model using the Indian Pines dataset and PaviaUniversity *** experimental results show that the AFLA-SCNN model outperforms other models in terms of Accuracy,Precision,Recall,and F1-score on Indian Pines and Pavia *** them,the Accuracy of the AFLA-SCNN model on India

关键词： Adaptive Fick’s law algorithm spectral convolutional neural network metaheuristic algorithm intelligent optimization algorithm hyperspectral image classification

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Microalgal bioinoculants for sustainable agriculture and their interactions with soil biotic and abiotic components:A review

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Pedosphere 2024年第2期34卷 297-314页

作者： Shisy JOSE Nirmal RENUKA Sachitra Kumar RATHA Sheena kumari Faizal BUX Institute for Water and Wastewater Technology Durban University of TechnologyP.O.Box 1334Durban 4000South Africa Algal Biotechnology Laboratory Department of BotanyCentral University of PunjabBathinda 151401India Phycology Laboratory Council of Scientific and Industrial Research-National Botanical Research InstituteLucknowUttar Pradesh 226001India

Modern agricultural practices have posed a detrimental impact on the environment due to their intensive use to meet the food demands of an ever-increasing *** this context,microalgal bioinoculants,specifically cyanobacteria and green microalgae,have emerged as sustainable options for agricultural practices to improve soil organic carbon,nutrient availability,microbial quality,and plant *** overview of current and future perspectives on the use of microalgal bioinoculants in agriculture practices is presented in this review,along with a discussion of their interactions with soil biotic and abiotic factors that affect soil fertility,plant health,and crop *** benefits of microalgal bioinoculants include releasing agronomically important metabolites(exopolymers and phytohormones)as well as solubilizing soil ***,they function as biocontrol agents against soil-borne pathogens and facilitate the establishment of rhizosphere communities of agricultural *** far,very few studies have explored the basic mechanisms by which microalgal bioinoculants interact with soil biotic and abiotic *** recent years,advanced molecular techniques have contributed to a better understanding of these interactions.

关键词： biocontrol agent biofertilizer cyanobacteria microalgae microbial community molecular technique plant growth soil fertility

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GeMemiOM: the curated database on genes, putative methylation study targets, and microRNA targets for otitis media

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Journal of Genetics and Genomics 2024年第2期51卷 260-263页

作者： Kondyarpu Abhishek Bineet Kumar Mohanta Pratima kumari Anshuman Dixit Puppala Venkat Ramchander Institute of Life Sciences Nalco SquareChandrasekharpurBhubaneswarIndia Regional Center for Biotechnology FaridabadHaryanaIndia

Otitis media(OM),the most underrated middle ear disease,often onsets during childhood and gets complicated in susceptible *** of the middle ear(ME)leads to its degradation and abnormal physiological *** ME inflammation sometimes results in lethal secondary complications(Penido et al.,2016).OM is a corroboration of multiple facets that leads to disabling hearing loss and associated *** of the facets constituted are genetic,epigenetic,immunogenetic,anatomical.

关键词： inflammation media

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