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MRI在评估临床低风险前列腺癌中的性能特点:前瞻性研究

American Journal of Plant Sciences（美国植物学期刊） 2011年第6期

作者： Priti Tiwari Himanshu Rai Dalip Kumar Upreti Suman Trivedi Preeti shukla

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国际医学放射学杂志 2013年第1期 64-65页

作者： H.A.Vargas O.Akin A.shukla-Dave J.Zhang K.L.Zakian J.Zheng 柴超 Department of Radiology Memorial Sloan-Kettering Cancer Center1275 York AveRoom C-278New YorkNY 10065

目的对于临床诊断低风险前列腺癌的病人,前瞻性评价T2WI和MRS在检测不同病理体积和Gleason评分的前列腺癌中的诊断效能。材料与方法本前瞻性研究获得单位伦理委员会批准,符合HIPAA原则。对183例临床患低风险前列腺癌病人[T1-T2a期,活检G... 详细信息

目的对于临床诊断低风险前列腺癌的病人,前瞻性评价T2WI和MRS在检测不同病理体积和Gleason评分的前列腺癌中的诊断效能。材料与方法本前瞻性研究获得单位伦理委员会批准,符合HIPAA原则。对183例临床患低风险前列腺癌病人[T1-T2a期,活检Gleason评分≤6,前列腺特异性抗原(PSA)<10ng/mL]在前列腺切除前行MR检查,所有病人均签署了知情同意书。2名放射学医师分别在T2WI上对前列腺六分区中肿瘤存在的可能性进行评分,按照1～5分的标准(1分,绝对没有肿瘤;5分,确定存在肿瘤)。2名波谱学专家共同记录病灶的位置,评价其在MRS中的代谢特点是否与肿瘤相一致。参考标准为整体组织的病理学分析。评价前列腺六分区内0.5cm3或更大体积病灶的诊断效能(T2WI)和检测敏感性(T2WI联合MRS)。结果 2位阅片者在T2WI上发现六分区内病灶的ROC曲线下面积分别为0.77和0.82。当病灶体积≥0.5cm3而<1cm3时,对于Gleason评分≤6的病灶的敏感度(阅片者1,0.44;阅片者2,0.61)较Gleason评分≥7者的敏感度(阅片者1,0.73,P=0.02;阅读者2,0.84,P=0.05)明显降低。对于体积≥1cm3的病灶,病灶的Gleason评分对敏感度并无显著的影响(Gleason评分≤6,阅片者1,0.83,阅片者2,1.0;Gleason评分≥7,分别为0.82,0.92;P≥0.07)。MRS的敏感性较低,与病灶体积或Gleason评分无明显联系。结论对于临床低风险前列腺癌的病人,在T2WI上发现体积<1cm3的病灶明显受Gleason评分的影响;对于体积≥1cm3的病灶检测明显优于小病灶,并且不受病灶Gleason评分的影响。在这类病人中,单独应用MRS的作用有限。

关键词：前列腺癌病人病灶体积 MRI 前瞻性研究

蒺藜水提取物对雄性成年大鼠尿草酸盐过多的治疗效应

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国际中医中药杂志 1994年第2期16卷 39-39页

作者： sangeeta-D 李宗友

研究了蒺藜(Tribulus terrestris)水提取物对雄性成年大鼠尿草酸盐和甘醇酸钠分泌的治疗效应。具体步骤如下:对雄性Wistar大鼠注射羟基脯氨,诱发大鼠尿草酸盐过多,尔后通过经口投与甘醇酸钠,维持尿草酸盐过多。在给蒺藜提取物之前,测定... 详细信息

研究了蒺藜(Tribulus terrestris)水提取物对雄性成年大鼠尿草酸盐和甘醇酸钠分泌的治疗效应。具体步骤如下:对雄性Wistar大鼠注射羟基脯氨,诱发大鼠尿草酸盐过多,尔后通过经口投与甘醇酸钠,维持尿草酸盐过多。在给蒺藜提取物之前,测定24h尿草酸盐分泌是1.97±0.314mg/mg肌酸酐,给药1周后,尿草酸盐分泌降至

关键词：水提取物甘醇酸钠成年大鼠蒺藜平肝熄风药尿草酸盐治疗效应

伴炎性肌纤维母细胞肿瘤样特征的去分化脂肪肉瘤

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临床与实验病理学杂志 2010年第5期26卷 608-608页

作者： Lucas D R shukla A Thomas D G 李岩(摘译 ) 张仁亚(审校) 不详济宁医学院附属医院病理科济宁272029

去分化脂肪肉瘤的去分化成分有着广泛的组织学变异，这些变异包括肿瘤的异源性分化。已经证实去分化脂肪肉瘤有肌纤维母细胞的分化，但是尚未见去分化脂肪肉瘤酷似炎性肌纤维母细胞肿瘤的报道。作者研究了6例具有炎性肌纤维母细胞肿瘤... 详细信息

去分化脂肪肉瘤的去分化成分有着广泛的组织学变异，这些变异包括肿瘤的异源性分化。已经证实去分化脂肪肉瘤有肌纤维母细胞的分化，但是尚未见去分化脂肪肉瘤酷似炎性肌纤维母细胞肿瘤的报道。作者研究了6例具有炎性肌纤维母细胞肿瘤特征的去分化脂肪肉瘤的临床病理、免疫组织化学以及分子学所见。

关键词：炎性肌纤维母细胞肿瘤去分化脂肪肉瘤瘤样免疫组织化学临床病理肿瘤特征组织学异源性

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T2WI与扩散加权MRI联合测量前列腺肿瘤体积与病理肿瘤体积的对照研究

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国际医学放射学杂志 2009年第5期32卷 497-498页

作者： Y.Mazaheri H.Hricak S.W.Fine O.Akin A.shukla-Dave N.M.Ishill 秦乃姗 Department of Medical Physics Memorial Sloan-Kettering Cancer Center

目的回顾性测定扩散加权（DW）MR1分辨前列腺外周带（PZ）肿瘤的准确性，并以手术病理检查为参考标准评价T2WI和T2W联合DWMRI测量肿瘤体积的准确性。材料和方法本研究经机构审核委员会批准免除知情同意通知．研究符合健康医疗保险要求。

关键词：扩散加权MRI MRI测量肿瘤体积 T2WI 病理检查前列腺医疗保险委员会

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Cell Stem Cell：利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展

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现代生物医学进展 2016年第32期16卷 I0001-I0002页

作者： Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu Biomedical Informatics Training Program Stanford University School of Medicine Stanford CA 94305 USA

在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞（iPS细胞）制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此，这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤... 详细信息

在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞（iPS细胞）制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此，这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为＂Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro＂.

关键词：多能干细胞 Cell 心肌细胞 Stem 制造利用心血管美国斯坦福大学

Evaluation and Comparison of DTPA Extractanting Methods for Available Cationic Micronutrients in Non-acidic Soils of Andhra Pradesh,India

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Journal of Agricultural Science and Technology(A) 2019年第5期9卷 269-277页

作者： Shankaraiah Mekala Chandidni Patnaik Mantri Soniya Purma Surendra Babu Pasupuleti Aravind Kumar shukla AICRP on Micronutrients Professor Jayashankar Telangana State Agricultural UniversityARIRajendranagarHyderabad500030India Micronutrients Indian Institute of Soil ScienceBhopal462038India

The research work was carried out to compare and evaluate the extractability of cationic micronutrients(Zn,Cu,Fe and Mn)using widely employed diethylene triamine pentaacetic acid(DTPA)-triethanolamine(TEA)-CaCl2 method with that of multinutrient extractant(ammonium bicarbonate(AB)-DTPA)in Inceptisols,Alfisols and Entisols in the erstwhile united Andhra *** percent variation of extraction of Zn was higher in soils with DTPA-TEA-CaCl2 over AB-DTPA method in all the soil orders(types)in the range of 35.3% to 46.2%.AB-DTPA extracted high amounts of Cu to an extent of 10%-21% in Entisols and Alfisls,*** Inceptisols both extracatants extracted equal amounts of ***-DTPA extracted high amounts of Fe 13% and 18% in Alfisols and Entisols compared to that of DTPA-TEA-CaCl2 method and DTPA-TEA-CaCl2 method was good extract for Fe in Inceptisols and even for Mn in *** amounts of micronutrient contents extracted were found to be highly and significantly correlated with soil properties like electrical conductivity(EC)and organic carbon(OC).The individual micronutrient contents of Zn,Cu and Fe extracted by DTPA-TEA-CaCl2 methods were found to be highly correlated with that of AB-DTPA ***,such correlation was not observed for Mn extraction when all soils were grouped.

关键词： Cationic micronutrients multinutrient extractant correlation and regression equation

Record of Additional Middle Eocene Vertebrate Remains from the Mikir Hills, NE India:Implications on Paleoenvironment and Paleobiogeography

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Bio-Fortification of Oats Fodder through Zinc Enrichment to Reduce Animal Malnutrition

International Journal of Geosciences（地球科学国际期刊） 2022年第8期

作者： shantajhara biswal kapesa lokho annie needham ansuya bhandari uma kant shukla kezhakielie whiso kuldeep prakash

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Journal of Agricultural Science and Technology(A) 2020年第2期10卷 98-108页

作者： Salwinder Singh Dhaliwal Amandeep Singh Sandhu Arvind Kumar shukla Vivek Sharma Balwinder Kumar Ravinder Singh Department of Soil Science Punjab Agricultural UniversityLudhiana 141004India Indian Institute of Soil Science Bhopal 462038India Krishi Vigyan Kendra GADVASUTarn TaranPunjab 143412India

The availability of poor quality fodders for livestock feeding is a major hurdle for the dairy industry in South Asia. Thelow content of Zn in fodders, leads to its malnutrition in animals. In fodders, Zn facilitates protein synthesis, gene expressions,energy production and involves in various metabolic activities of plants, animals and humans. To achieve these objectives,multi-location field trials were conducted on enrichment of oats fodder with Zn through bio-fortification. The experiment consists ofeight different treatment combinations for enrichment of oats fodder with Zn including control, soil and soil plus foliar application ofZn at different stages of plant growth. The results of the study reported that soil application of Zn at the rate of 25 kg/ha and soil +foliar application of Zn at 0.5% at 60 days after sowing (DAS) (jointing stage), 90 DAS (booting stage) and both 60 DAS and 90DAS showed improvement in plant growth parameters. The results further reported that foliar application of Zn at the rate of 0.5% at60 DAS, 90 DAS, both 60 DAS and 90 DAS reported significant increase in biomass yield and fodder quality. Integrated applicationof Zn at 25 kg/ha in soil along with foliar Zn at the rate of 0.5% at 60 DAS and 90 DAS showed maximum Zn enrichment, greenfodder yield, dry fodder yield, plant height, and Zn accumulation in oats fodder as compared to other treatments of Zn *** treatments of Zn application through integrated mode also reported significant improvement in fodder quality with maximumcrude protein (CP) and crude protein yield (CPY) while neutral detergent fiber (NDF), acid detergent fiber (ADF), ash content andorganic matter showed a non-significant effect. Thus, the results of experimental study concluded that soil and foliar application ofZn at 25 kg/ha and 0.5% Zn, respectively, at 60 DAS and 90 DAS enhanced the growth, yield and quality of oats fodder which willcertainly improve livestock production through bio-fortification

关键词： Zn oats fodder growth parameters fodder yield Zn enrichment fodder bio-fortification

An epidemiological study on delay in treatment initiation of cancer patients

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