检索结果-南通市图书馆

维普期刊数据库

Comparative Literature in Korea

在线全文

学校读者我要写书评

暂无评论

Comparative Literature:East & West 2001年第1期 185-188页

作者： sang tae kim Ewha Womans Univ.

I would like to offer my perspectives on the development of comparative literature in Korea,a process which can be divided into three *** is distinguished as a particular historical moment by the writing system used in Korea at the time,and by the set of cultural influences which informed and shaped *** first stage comprises the period before Western influence,the second the mid-nineteenth through mid- twentieth centuries,and the third the late twentieth and early twenty-first centuries. At the beginning of the first period,Korean writers adopted Chinese characters for writing,a process which can be traced as far back

关键词：

Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2022年第6期10卷 1167-1175页

作者： Yeon Ji Chae Hwon Heo Chul-Woong Woo sang-tae kim Jae-Im Kwon Monica Young Choi Yu Sub Sung Kyung Won kim Jeong Kon kim Yoonseok Choi Dong-Cheol Woo Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Convergence Medicine Research Center Asan Institute for Life SciencesAsan Medical CenterSeoulRepublic of Korea Clinical Research Center Asan Medical CenterSeoulRepublic of Korea Department of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Medical Research Institute Gangneung Asan HospitalGangneung-siGangwon-doRepublic of Korea

Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal *** study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in *** analysis was conducted to assess compare the monitoring of liver function by MRI and ***-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-SY)groups,silymarin was administered three times weekly from week *** images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-SY ***:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control *** the TAA-SY group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA ***,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin *** correlations between either AUCtmax or T_(2)*values and the serological biomarkers were ***:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development.

关键词： Liver fibrosis Magnetic resonance imaging Silymarin T1-weight-ed dynamic contrast-enhanced T_(2)*

Profile Design and Numerical Calculation of Instantaneous Flow Rate of a Gerotor Pump

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Applied Mathematics and Physics 2015年第1期3卷 92-97页

作者： Hao Liu Jae-Cheon Lee Alex Yoon sang-tae kim Department of Mechanical and Automotive Engineering Keimyung University Daegu South Korea Automotive Motor Biz. Division LG Innotek Incheon South Korea

Gerotor pump is a special kind of internal rotary pump, which contains a trochoid profile (commonly called as cycloid). Generation of trochoid is normally realized by external rolling method, namely a circle rotating on a fixed circle without slipping. This paper proposes derivative process of the trochoid profile by means of internal rolling method, which is that internal surface of a circle contacts with a fixed circle and rotates around it without slipping. Moreover the instantaneous flow rate can be obtained by numerically calculating the change ratio of area between the inner and outer rotors in the outlet region of the gerotor pump, which avoids to complicatedly derivative process.

关键词： Gerotor Oil Pump Trochoid Internal Rolling Method Instantaneous Flow Rate

Synergistic Effect of Watermelon Powder and Lactococcus lactis subsp lactis Supplemented Diet Partially Ameliorates Aβ42-Dependent Lifespan Shorten and Flight Impairment in Transgenic Drosophila

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2016年第6期7卷 991-1000页

作者： Dong Gyun Ko Young Bum Eun Jong Uk Na sang-tae kim Korean Minjok Leadership Academy Hoengseong-gun Republic of Korea Biomedical Research Institute Department of Neuropsychiatry Bundang Hospital of Seoul National University College of Medicine Seongnam Republic of Korea

Oxidative stress has been strongly related with Alzheimer disease pathogenesis. We determined the effects of watermelon powder (WMP) and Lactococcus lactis subsp lactis (LAL) supplementation on the generated Aβ42-induced phenotypes in a Drosophila melanogaster model of AD. Enhanced Aβ42 expression in D. melanogaster neurons can diminish lifespan and flight ability. We have observed longevity methods to assay the effects of WMP and LAL on D. melanogaster survival. Furthermore, flies expressing Aβ42 in their body fed WMP and LAL had up to 90 days, or 35% longer median lifespan than those fed a control diet. In addition, synergistic effect of WMP and LAL improved Aβ42-induced flight impairments in the Drosophila wing tissues. Our microscope experiments revealed that individuals fed synergistic effect of WMP and LAL had ameliorated Aβ42 expression as well as increment of flight ability than Aβ42-induced flies. We propose that WMP is typically rich in L-citrulline and LAL, rich in naturally occurring probiotics and antioxidants, and that it promotes the survival of neurons in brain and wing muscle tissues with increased levels of Aβ42 via a protective cell survival mechanism.

关键词： Drosophila melanogaster Lactococcus lactis Watermelon Lifespan Ommatidia Aβ42

Dual PINK Mutant and A<i>β</i>42-Dependent Lifespan Shorten and Flight Impairment in Transgenic Drosophila Partially Alleviates by a <i>Lactococcus lactis</i>Supplemented Diet

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2015年第7期5卷 266-273页

作者： Dong Gyun Ko Young Bum Eun Jong Uk Na sang-tae kim Korean Minjok Leadership Academy Hoengseong-Gun Republic of Korea Department of Neuropsychiatry Bundang Hospital of Seoul National University College of Medicine Biomedical Research Institute Seongnam City Republic of Korea

Oxidative stress has been strongly related with Parkinson disease (PD) and Alzheimer disease pathogenesis. We determined the effects of Lactococcus lactis (LAL) supplementation on the generated loss-of-function mutants of PINK1 B9, an AR-JP-linked gene and Aβ42 induced phenotypes in a Drosophila melanogaster model of PD/AD. Enhanced mutant PINK1 B9 and Aβ42 expression in D. melanogaster dopaminergic (DA) neurons can curtail lifespan, flight muscle accompanied by locomotive defects and we have observed longevity methods to assay the effects of LAL on D. melanogaster survival. Furthermore, flies expressing mutant PINK1 B9 and Aβ42 in their brain fed LAL had up to the two weeks, or 25%, greater median lifespan than those fed a standard sucrose diet. In addition, LAL improved mutant PINK1 B9 and Aβ42-induced flight impairments in the Drosophila wing. Our microscopy analyses revealed that individuals fed LAL had improved atypical ommatidia as well as an increased thirteen percentage of flight ability than those fed a control diet. We propose that LAL, rich in naturally occurring probiotics and antioxidants, promotes the survival of neurons in brain and wing muscle tissues with increased levels of mutant PINK1 B9 and Aβ42 via a protective cell survival mechanism.

关键词： Drosophila melanogaster Lactococcus lactis PINK1 Lifespan Ommatidia Aβ42

A New Index for Evaluating Protection Vulnerability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A New Index for Evaluating Protection Vulnerability

Profile Design and Numerical Calculation of Instantaneous Flow Rate of a Gerotor Pump

2011 International Conference on Advanced Power System Automation and Protection(APAP 2011)

作者： Sung-Jun Park Seung-Jae Lee Myeon-Song Choi tae-Wan kim sang-tae kim Jin-Hwan kim Myongji University Korea

A cascading trip of distance relay due to overload caused by another line tripping has been observed in some black-outs. Preventing such an unwanted trip of a distance relay could contribute to blackout prevention. In this paper, a new index （PVI） for evaluating vulnerability from distance protection viewpoint is proposed which indicates the risk level of a distance relay that can lead to multiple line outages due to overload. Case studies on a real system show effectiveness of the proposed index. The proposed index can be utilized to make a decision on execution of preventive actions before a blackout develops.

关键词： Distance protection distance relaying power blackout power system stability

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Profile Design and Numerical Calculation of Instantaneous Fl...

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

The 2nd Computational Mathematics and Applications Conference

作者： Hao Liu Jae-Cheon Lee Alex Yoon sang-tae kim Department of Mechanical and Automotive Engineering Keimyung University Automotive Motor Biz. Division LG Innotek Incheon South Korea

Gerotor pump is a special kind of internal rotary pump, which contains a trochoid profile(commonly called as cycloid). Generation of trochoid is normally realized by external rolling method, namely a

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

维普期刊数据库

Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo Park Jong-Seong Bae taehyun Park Il tae kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery