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Clinical significance and risk factors of postembolization fever in patients with hepatocellular carcinoma

World Journal of Gastroenterology 2013年第2期19卷 284-289页

作者： Chung Hwan Jun Ho Seok Ki hoon Ki Lee Kang Jin Park Seon Young Park Sung Bum Cho Chang Hwan Park Young Eun Joo Hyun Soo Kim Sung Kyu choi Jong Sun Rew Division of Gastroenterology Department of Internal MedicineChonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate tumor response and survival in patients with postembolization fever(PEF) and to determine the risk factors for ***:Four hundred forty-three hepatocellular carcinoma(HCC) patients who underwent the first session of transcatheter arterial chemoembolization(TACE) between January 2005 and December 2009 were analyzed *** was defined as a body temperature greater than 38.0 ℃ that developed within 3 d of TACE without evidence of *** tumor progression-free interval was defined as the interval from the first TACE to the second TACE based on mRECIST *** staging was based on the American Joint Committee on Cancer tumor,node,metastases(TNM) classification of malignant *** patients were admitted before their 1 st TACE treatment,and blood samples were obtained from all patients before and after *** variables and host-related variables were compared between two groups:patients with PEF vs patients without ***,variables related to 20-mo mortality and tumor progression-free survival were ***:The study population comprised 370(85.4%) men and 73(14.6%) women with a mean age of 62.29 ± 10.35 years.A total of 1836 TACE sessions were conducted in 443 patients,and each patient received between 1 and 27(mean:4.14 ± 3.57) TACE *** mean follow-up duration was 22.23 ± 19.6 mo(range:0-81 mo).PEF developed in 117 patients(26.41%) at the time of the first TACE *** was not associated with 20-mo survival(P = 0.524) or computed tomography(CT) response(P = 0.413) in a univariate analysis.A univariate analysis further indicated that diffuse-type HCC(P = 0.021),large tumor size(≥ 5 cm)(P = 0.046),lipiodol dose(≥ 7 mL,P = 0.001),poor blood glucose control(P = 0.034),alanine aminotransferase(ALT) value after TACE(P = 0.004) and C-reactive protein(CRP) value after TACE(P = 0.036) served as possible risk factors correlated with *** ALT value after TACE(P = 0.02

关键词： Chemoembolization Therapeutic Fever Carcinoma Hepatocellular Prognosis Progression-free survival

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共面转换液晶显示器中获得对比度高于1:600的新技术

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现代显示 2004年第5期 31-33页

作者： Jae Hyun Kim Joun Ho Lee Ji Chul Lim Chang hoon Lee Moo Hyoung Song Ju Yeon Yoon Hee Dong choi Jeom Jae Kim Chang Ho Oh sang Deog Yeo 李路海 LG菲利普液晶显示电视开发部乐凯胶片厂

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树... 详细信息

薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树脂、电极锥角和摩擦条件等都进行了研究。优化的背光板组合,光滑的电极锥角和摩擦方法的控制是提高对比度的主要控制因素。应用新开发的滤色片树脂,对获得高对比度最为有效。

关键词：高对比度共面转换液晶显示器薄膜晶体管背光 TFT-LCD 滤色片光板偏振片紧凑

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柔性有源OLED显示器制造几点技术方面的考虑

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现代显示 2009年第2期 21-24,49页

作者： Juhn S.Yoo Nackbong choi Yong-Chul Kim In-Hwan Kim Seung-Chan Byun sang-hoon Jung Jong-Moo Kim Soo-Young Yoon Chang-Dong Kim In-Byeong Kang In-Jae Chung 代永平 LG显示公司南开大学

AMOLED在柔性显示领域前途似锦。LG显示展示了一款全彩4in柔性AMOLED样机,衬底为80μm厚的不锈钢薄片,曲率达到5cm弯曲半径。本文就此项柔性显示技术所面临的挑战进行了探讨,包括柔性衬底衬底的传送、如何获得特性稳定可靠的TFT以使OLE... 详细信息

AMOLED在柔性显示领域前途似锦。LG显示展示了一款全彩4in柔性AMOLED样机,衬底为80μm厚的不锈钢薄片,曲率达到5cm弯曲半径。本文就此项柔性显示技术所面临的挑战进行了探讨,包括柔性衬底衬底的传送、如何获得特性稳定可靠的TFT以使OLED的亮度和一致性适用于此项技术的商业化推广。

关键词：有源有机发光二极管柔性显示器电泳显示器

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Rare case of pancreatic cancer with leptomeningeal carcinomatosis

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World Journal of Gastroenterology 2015年第3期21卷 1020-1023页

作者： In Kyung Yoo Hong Sik Lee Chang Duk Kim hoon Jai Chun Yoon Tae Jeen Bora Keum Eun Sun Kim Hyuk Soon choi Jae Min Lee Seung Han Kim Seung Joo Nam Jong Jin Hyun Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan Hospital 123Gyeonggi-do 425-707South Korea

Leptomeningeal carcinomatosis occurs very rarely in patients with pancreatic *** is characterized by multifocal seeding of the leptomeninges by malignant cells that originate from a solid *** the best of our knowledge,brain metastasis from pancreatic cancer is extremely *** carcinomatosis is estimated to occur in 3% to 8% of cases of solid *** clinical manifestation usually involves neurological symptoms,including dizziness,headache,vomiting,nausea,and hemiparesis,symptoms similar to those of meningitis or brain *** methods for leptomeningeal carcinomatosis include brain magnetic resonance imaging and cerebrospinal fluid ***,we describe a case of leptomeningeal carcinomatosis in which the primary tumor was later determined to be pancreatic *** magnetic resonance imaging findings showed mild enhancement of the leptomeninges,and cerebrospinal fluid cytology was negative at ***,after repeated spinal taps,atypical cells were observed on cerebrospinal fluid analysis and levels of tumor markers such as carbohydrate antigen 19-9 in cerebrospinal fluid were *** computed tomography,performed to determine the presence of extracerebral tumors,revealed pancreatic *** cancer was confirmed histopathologically on examination of an endoscopic ultrasound-guided fine needle aspiration specimen.

关键词： Pancreatic cancer Radiation therapy Tumor marker L

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Robotic versus laparoscopic liver resection for huge (≥10 cm) liver tumors: an international multicenter propensity-score matched cohort study of 799 cases

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 205-215,I0005页

作者： Tan-To Cheung Rong Liu Federica Cipriani Xiaoying Wang Mikhail Efanov David Fuks Gi-Hong choi Nicholas L.Syn Charing C.N.Chong Fabrizio Di Benedetto Ricardo Robles-Campos Vincenzo Mazzaferro Fernando Rotellar Santiago Lopez-Ben James O.Park Alejandro Mejia Iswanto Sucandy Adrian K.H.Chiow Marco V.Marino Mikel Gastaca Jae hoon Lee TPeter Kingham Mathieu D’Hondt Sung hoon choi Robert P.Sutcliffe Ho-Seong Han Chung-Ngai Tang Johann Pratschke Roberto I.Troisi Go Wakabayashi Daniel Cherqui Felice Giuliante Davit L.Aghayan Bjorn Edwin Olivier Scatton Atsushi Sugioka Tran Cong Duy Long Constantino Fondevila Mohammad Abu Hilal Andrea Ruzzenente Alessandro Ferrero Paulo Herman Kuo-Hsin Chen Luca Aldrighetti Brian K.P.Goh International robotic and laparoscopic liver resection study group investigators Department of Surgery Queen Mary HospitalThe University of Hong KongHong Kong SARChina Faculty of Hepatopancreatobiliary Surgery The First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijingChina Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscowRussia Department of Digestive Oncologic and Metabolic SurgeryInstitute Mutualiste MontsourisUniversite Paris DescartesParisFrance Division of Hepatopancreatobiliary Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoulKorea Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital and Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong Kong SARChina HPB Surgery and Liver Transplant Unit University of Modena and Reggio EmiliaModenaItaly Department of General Visceral and Transplantation SurgeryClinic and University Hospital Virgen de la ArrixacaIMIB-ARRIXACAMurciaSpain HPB Surgery Hepatology and Liver TransplantationFondazione IRCCS Istituto Nazionale Tumori di MilanoMilanItaly HPB and Liver Transplant Unit Department of General SurgeryClinica Universidad de NavarraUniversidad de NavarraPamplonaSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Hepatobiliary and Pancreatic Surgery Unit Department of SurgeryDr.Josep Trueta HospitalIdIBGiGironaSpain Hepatobiliary Surgical Oncology Department of SurgeryUniversity of Washington Medical CenterSeattleWAUSA The Liver Institute Methodist Dallas Medical CenterDallasTXUSA AdventHealth Tampa Digestive Health InstituteTampaFLUSA Hepatopancreatobiliary Unit Department of SurgeryChangi General

Background:The use of laparoscopic(LLR)and robotic liver resections(RLR)has been safely performed in many institutions for liver tumours.A large scale international multicenter study would provide stronger evidence and insight into application of these techniques for huge liver tumours≥10 ***:This was a retrospective review of 971 patients who underwent LLR and RLR for huge(≥10 cm)tumors at 42 international centers between ***:One hundred RLR and 699 LLR which met study criteria were *** comparison between the 2 approaches for patients with huge tumors were performed using 1:3 propensity-score matching(PSM)(73 vs.219).Before PSM,LLR was associated with significantly increased frequency of previous abdominal surgery,malignant pathology,liver cirrhosis and increased median *** PSM,RLR and LLR was associated with no significant difference in key perioperative outcomes including media operation time(242 vs.290 min,P=0.286),transfusion rate rate(19.2%vs.16.9%,P=0.652),median blood loss(200 vs.300 mL,P=0.694),open conversion rate(8.2%vs.11.0%,P=0.519),morbidity(28.8%vs.21.9%,P=0.221),major morbidity(4.1%vs.9.6%,P=0.152),mortality and postoperative length of stay(6 vs.6 days,P=0.435).Conclusions:RLR and LLR can be performed safely for selected patients with huge liver tumours with excellent *** was no significant difference in perioperative outcomes after RLR or LLR.

关键词： Laparoscopic liver resection(LLR) robotic liver resection(RLR) hepatocellular carcinoma colorectal liver metastases huge

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机器人甲状腺切除术在韩国将成为一种新的规范术式？

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中国微创外科杂志 2012年第7期12卷 590-593页

作者： M.Rahman Selamat June Young choi Do hoon Koo Kyu Eun Lee Yeo-Kyu Youn 潘笑露嵇武 Department of Surgery Seoul National University College of Medicine Cancer Research Institute Seoul National University College of Medicine Department of Surgery Seoul National University Boramae Medical Center 南京军区南京总医院解放军普通外科研究所南京210002

近年来,日新月异的医学技术新发明为外科技术带来了巨大发展。当今,甲状腺手术技术的趋势在韩国也正逐渐发生着改变。因为机器人手术较腔镜手术具有更好的术后美容效果及在人体工程学上的巨大优势,机器人在甲状腺手术中的应用日益增加... 详细信息

近年来,日新月异的医学技术新发明为外科技术带来了巨大发展。当今,甲状腺手术技术的趋势在韩国也正逐渐发生着改变。因为机器人手术较腔镜手术具有更好的术后美容效果及在人体工程学上的巨大优势,机器人在甲状腺手术中的应用日益增加。此外,机器人甲状腺手术可能成为治疗甲状腺疾病的新规范术式,尤其是在青少年患者的甲状腺恶性肿瘤中。常规机器人及机器人辅助甲状腺手术有多种方法。本文对经双侧腋窝和乳晕入路法(bilateral axillo-breast approach,BABA)在首尔国立大学医学院的运用进行介绍,并讨论其优势。

关键词：机器人甲状腺切除术 BABA法机器人甲状腺手术肿瘤整形甲状腺术甲状腺微创手术韩国

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Expression and the Functional Roles of Sox9 in Human Epidermal Keratinocytes

Expression and the Functional Roles of Sox9 in Human Epiderm...

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中华医学会第十八次全国皮肤性病学术年会

作者： Kyung-Cheol Sohn Dae-Kyoung choi Young Min Park Jin-Hwa Kim Kyung-Chae Kye Sooyeon Kim Myung Im Young Lee Young-Joon Seo Seo Chang Deok Kim Jeung-hoon Lee Department of Dermatology and Research Institute for Medical Sciences School of MedicineChungnam National University

Although Sox9 is an important regulator in maintenance of stemness for hair cells,its role in normal human epidermal keratinocytes(NHKCs)has not yet been well *** staining showed that Sox9 is predominantly expressed in the basal layer of normal human skin epidermis and is highly expressed in some cutaneous tumors and *** mRNA and protein levels for Sox9 can also be

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International expert consensus on laparoscopic pancreaticoduodenectomy

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 464-483页

作者： Renyi Qin Michael L.Kendrick Christopher L.Wolfgang Barish H.Edil Chinnusamy Palanivelu Rowan WParks Yinmo Yang Jin He Taiping Zhang Yiping Mou Xianjun Yu Bing Peng Palanisamy Senthilnathan Ho-Seong Han Jae hoon Lee Michiaki Unno Steven WMOlde Damink Virinder Kumar Bansal Pierce Chow Tan To Cheung Nim choi Yu-Wen Tien Chengfeng Wang Manson Fok Xiujun Cai Shengquan Zou Shuyou Peng Yupei Zhao Department of Biliary-Pancreatic Surgery Affiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Mayo Clinic RochesterMNUSA Division of Surgical Oncology Department of SurgeryThe John Hopkins University School of MedicineBaltimoreMDUSA Department of Surgery University of OklahomaOklahoma CityOKUSA Department of Surgical Gastroenterology and Hepatopancreatobiliary Surgery GEM Hospital and Research CentreCoimbatoreTamil NaduIndia Clinical Surgery Royal Infirmary of Edinburgh and University of EdinburghEdinburghUK Department of General Surgery Peking University First HospitalBeijingChina Department of Surgery Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Gastroenterology and Pancreatic Surgery Zhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhouChina Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghaiChina Department of Pancreatic Surgery West China HospitalSichuan UniversityChengduChina Department of Surgery Seoul National University College of MedicineSeoul National University Bundang HospitalSeoulKorea Division of Hepatopancreatobiliary Surgery Department of SurgeryAsan Medical CenterSeoulKorea Department of Surgery Tohoku University Graduate School of MedicineSendaiJapan Department of Surgery NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical CentreMaastrichtThe Netherlands Department of Surgical Disciplines All India Institute of Medical SciencesNew DelhiIndia Department of Hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingaporeSingapore Department of Surgery The University of Hong KongQueen Mary HospitalHong KongChina Department of General Surgery Hospital Conde S.JanuárioMacaoChina Department of Surgery National Ta

Importance:While laparoscopic pancreaticoduodenectomy(LPD)is being adopted with increasing enthusiasm worldwide,it is still challenging for both technical and anatomical ***,there is no consensus on the technical standards for ***:The aim of this consensus statement is to guide the continued safe progression and adoption of *** Review:An international panel of experts was selected based on their clinical and scientific expertise in laparoscopic and open *** were produced upon reviewing the literature and assessed by the members of the expert *** literature search and its critical appraisal were limited to articles published in English during the period from 1994 to *** Web of Science,Medline,and Cochrane Library and Clinical Trials databases were searched,The search strategy included,but was not limited to,the terms'laparoscopic','pancreaticoduodenectomy,'pancreatoduodenectomy','Whipple's operation',and'minimally invasive surgery'.Reference lists from the included articles were manually checked for any additional studies,which were included when *** method was used to establish expert consensus and the AGREE II-GRS Instrument was applied to assess the methodological quality and externally validate the final *** statements were further discussed during a one-day face-to-face meeting at the 1st Summit on Minimally Invasive Pancreatico-Biliary Surgery in Wuhan,***:Twenty-eight international experts from 8 countries constructed the expert *** statements were produced by the members of the expert *** least 80%of responders agreed with the majority(80%)of *** than three randomized controlled trials published to date,most evidences were based on level 3 or 4 studies according to the AGREE II-GRS *** and Relevance:The Wuhan international expert consensus meeting on LPD has produced a set of clinical practice statement

关键词： Consensus pancreaticoduodenectomy laparoscopy Delphi technique

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Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction

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World Journal of Gastroenterology 2015年第30期21卷 9134-9141页

作者： Seung Han Kim hoon Jai Chun In Kyung Yoo Jae Min Lee Seung Joo Nam Hyuk Soon choi Eun Sun Kim Bora Keum Yeon Seok Seo Yoon Tae Jeen Hong Sik Lee Soon Ho Um Chang Duck Kim Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of Medicine

AIM:To investigate the predictive factors of selfexpandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS:A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS:Self-expandable metallic stent placement was technically successful in all patients(100%),and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model,carcinoembryonic antigen(CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio(a HR)= 2.92,95%CI:1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency(P = 0.009; a HR = 0.27,95%CI:0.10-0.72).CONCLUSION:CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.

关键词： Malignant gastroduodenal obstruction Stent Patency Predictive factor Carcinoembryonicantigen

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International experts consensus guidelines on robotic liver resection in 2023

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世界胃肠病学杂志:英文版 2023年第32期29卷 4815-4830页

作者： Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100000China Hepatobiliary Pancreatic Robotic&Laparoscopic SurgeryPoliambulanza Foundation HospitalBrescia 25100Italy Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalSaitama 362-0075Japan Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeoul 03080South Korea GEM Hospital&Research Centre GEM Hospital&Research CentreCoimbatore 641045India Division of General and Transplant Surgery University of PisaPisa 56126Italy Department of General Visceral and Thoracic SurgeryUniversity Hospital Hamburg-EppendorfHamburg 20251Germany Department of Surgery Yeungnam University HospitalDaegu 42415South Korea Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Division of Hepato-Biliary-Pancreatic Surgery Department of SurgerySeverance HospitalYonsei UniversityCollege of MedicineSeoul 03722South Korea Department of Surgery/Division of Robotic and HBP Surgery Montpellier University Hospital-School of MedicineMontpellier 34090France Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscow 111123Russia Department of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of General VisceralVascular and Transplant SurgeryUniversity Hospital MagdeburgMagdeburg 39120Germany Department of Surgery City of Hope Medical CenterDuarteCA 91010United States Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100000China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Ho

The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still *** on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical *** guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation *** to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were *** them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM *** international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future.

关键词： Robotic liver resection Laparoscopic liver resection Guidelines Expert consensus

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