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Dynamics modeling and motion control for high-speed underwater vehicles using H-infinity synthesis with anti-windup compensator

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Journal of Ocean Engineering and Science 2022年第1期7卷 84-91页

作者： Phuc Duc Hong Bui Sam-sang You Hwan-Seong Kim sang-do lee Department of Mechanical Engineering The University of TulsaTulsaOK 74104United States Division of Mechanical Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Division of Logistics Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Division of Navigation and Information System Mokpo National Maritime UniversityMokpoJeollanam-do 58628Republic of Korea

The control synthesis of a high-speed supercavitating vehicle(HSSV)faces many difficulties such as the stability,control,and maneuvering with dynamical uncertainties due to parameter perturbations,exter-nal disturbances,unmodeled dynamics,measurement noises,and actuator *** by the HSSV dynamical analysis,this paper proposes the H∞(i.e."H-infinity")robust control synthesis to gen-erate a robust low-order controller,which is intended for real implementations to ensure active control ***,the presented control scheme includes a feedback component and an anti-windup *** anti-windup synthesis is to provide system stability under actuator ***-tensive simulations show that the designed controller provides good performances with high robustness for vertical plane manoeuver while effectively eliminating planning forces,exogenous disturbances and noises as well as overcoming cavitator saturations.

关键词： Vehicle dynamics Planing force Vertical maneuver H-infinity control Anti-windup Actuator saturation

TonEBP expression is essential in the IL-1β–induced migration and invasion of human A549 lung cancer cells

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Oncology Research 2024年第1期32卷 151-161页

作者： HEE JU SONG TAEHEE KIM HAN NA CHOI SOO JIN KIM sang do lee Department of Physiology School of MedicineChungnam National UniversityDaejeon35015Korea

Lung cancer has the highest mortality rate among all cancers,in part because it readily *** tumor microenvironment,comprising blood vessels,fibroblasts,immune cells,and macrophages[including tumor-associated macrophages(TAMs)],is closely related to cancer cell growth,migration,and *** secrete several cytokines,including interleukin(IL)-1β,which participate in cancer migration and invasion.p21-activated kinase 1(PAK1),an important signaling molecule,induces cell migration and invasion in several ***responsive enhancer-binding protein(TonEBP)is also known to participate in cancer cell growth,migration,and ***,the mechanisms by which it increases lung cancer migration remain ***,in this study,we aimed to elucidate the mechanisms by which IL-1βand TonEBP affect lung cancer cell migration and *** found that A549 cocultured-MΦ-secreted IL-1βinduced A549 cell migration and invasion via the PAK1 *** deficiency reduced A549 cell migration and invasion and increased responsiveness to IL-1β–induced migration and ***1 phosphorylation,which was promoted by IL-1β,was reduced when TonEBP was *** results suggest that TonEBP plays an important role in IL-1βinduction and invasiveness of A549 cells via the PAK1 *** findings could be valuable in identifying potential targets for lung cancer treatment.

关键词： Lung cancer TonEBP Tumor microenvironment Tumor-associated macrophage IL-1β

Etanercept-synthesizing adipose-derived stem cell secretome:A promising therapeutic option for inflammatory bowel disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 882-892页

作者： Say-June Kim Ok-Hee Kim Ha-Eun Hong Ji Hyeon Ju do sang lee Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract,with tumor necrosis factor(TNF)-αplaying a key role in its ***,a decoy receptor for TNF,is used to treat inflammatory *** secretome derived from adipose-derived stem cells(ASCs)has anti-inflammatory effects,making it a promising therapeutic option for *** To investigate the anti-inflammatory effects of the secretome obtained from ASCs synthesizing etanercept on colon cells and in a dextran sulfate sodium(DSS)-induced IBD mouse *** ASCs were transfected with etanercept-encoding mini-circle plasmids to create etanercept-producing *** secretory material from these cells was then tested for anti-inflammatory effects both in vitro and in a DSS-induced IBD mouse *** This study revealed promising results indicating that the group treated with the secretome derived from etanercept-synthesizing ASCs[Etanercept-Secretome(Et-Sec)group]had significantly lower expression levels of inflammatory mediators,such as interleukin-6,Monocyte Chemoattractant Protein-1,and TNF-α,when compared to the control secretome(Ct-Sec).Moreover,the Et-Sec group exhibited a marked therapeutic effect in terms of preserving the architecture of intestinal tissue compared to the *** These results suggest that the secretome derived from ASCs that synthesize etanercept has potential as a therapeutic agent for the treatment of IBD,potentially enhancing treatment efficacy by merging the anti-inflam-matory qualities of the ASC secretome with etanercept's targeted approach to better address the multifaceted pathophysiology of IBD.

关键词： Adipose-derived stem cells Etanercept Inflammatory bowel disease Secretome Tumor necrosis factor-α

Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes

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Acta Pharmacologica Sinica 2007年第4期28卷 503-510页

作者： Cuk-seong KIM Nam lee Sook-jin SON Kyu-seung lee Hyo-shin KIM Yong-geun KWAK Soo-wan CHAE sang-do lee Byeong-hwa JEON Jin-bong PARK Department of Physiology College of MedicineChungnam National UniversityDaejeon 301131Korea Department of Pharmacology Chonbuk National UniversityMedical SchoolChonju 561-180Korea

Aim:To characterize the effects of papaverine on HERG channels expressed inXenopus oocytes as well as cardiac action potential in rabbit ventricular ***:Conventional microelectrodes were used to record action potential inrabbit ventricular *** currents were recorded by 2-electrode voltageclamp technique in Xenopus oocytes injected with HERG ***:Papa-verine increased the cardiac action potential duration in rabbit ventricular *** blocked heterologously-expressed HERG currents in a concentration-depen-dent manner (IC5071.03±4.75 μmol/L,NH 0.80,n=6),whereas another phosphodi-esterase inhibitor,theophylline （500 μmol/L）,did *** blockade of papaverineon HERG currents was not *** slope conductance measuredas a slope of the fully activated HERG current-voltage curves decreased from78.03±4.25 μS of the control to 56.84±5.33,36.06±6.53,and 27.09±5.50 μS （n=4） by30,100,and 300 μmol/L of papaverine,*** （100 μmol/L）caused a 9 mV hyperpolarizing shift in the voltage-dependence of steady-stateinactivation,but there were no changes in the voltage-dependence of HERG cur-rent *** blocked HERG channels in the closed,open,andinactivated ***:These results showed that papaverine blockedHERG channels in a voltage-and state-independent manner,which may mostlikely be the major mechanism of papaverine-induced cardiac arrhythmia reportedin humans.

关键词： papaverine HERG cardiac action potential

Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferationinducing ligand

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World Journal of Stem Cells 2024年第11期16卷 956-973页

作者： Hyung-Jin Kim do sang lee Jung Hyun Park Ha-Eun Hong Ho Joong Choi Ok-Hee Kim Say-June Kim Department of Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Translational Research Team Surginex Co.Ltd.Seoul 06591South Korea

BACKGROUND Recent advancements in nanomedicine have highlighted the potential of exosome(Ex)-based therapies,utilizing naturally derived nanoparticles,as a novel approach to targeted cancer *** To explore the targetability and anticancer effectiveness of small interfering peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 RNA(siPIN1)-loaded soluble a proliferation-inducing ligand(sAPRIL)-targeted Exs(designated as tEx[p])in the treatment of colon cancer *** tEx was generated by harvesting conditioned media from adipose-derived stem cells that had undergone transformation using pDisplay vectors encoding sAPRIL-binding peptide ***,tEx[p]were created by incorporating PIN1 siRNA into the tEx using the Exofect *** therapeutic efficacy of these Exs was evaluated using both in vitro and in vivo models of colon *** The tEx[p]group exhibited superior anticancer effects in comparison to other groups,including tEx,Ex[p],and Ex,demonstrated by the smallest tumor size,the slowest tumor growth rate,and the lightest weight of the excised tumors observed in the tEx[p]group(P<0.05).Moreover,analyses of the excised tumor tissues,using western blot analysis and immunohistochemical staining,revealed that tEx[p]treatment resulted in the highest increase in Ecadherin expression and the most significant reduction in the mesenchymal markers Vimentin and Snail(P<0.05),suggesting a more effective inhibition of epithelial-mesenchymal transition tEx[p],likely due to the enhanced delivery of *** The use of bioengineered Exs targeting sAPRIL and containing siPIN1 demonstrated superior efficacy in inhibiting tumor growth and epithelial-mesenchymal transition,highlighting their potential as a therapeutic strategy for colon cancer.

关键词： Colon cancer Drug delivery system Exosome Soluble a proliferation-inducing ligand Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Targeted therapy

Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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Journal of Traditional Chinese Medicine 2023年第4期43卷 686-694页

作者： dong-Wook Kang Jae-Gyun Choi Hee Ju Song Jaehyuk Kim Miae lee Taehee Kim Suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo Jin Sun lee Jin Bong Park sang do lee Hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

维普期刊数据库

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： do-Hun lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

维普期刊数据库

Cloning of heat shock protein genes from the brown planthopper, Nilaparvata lugens, and the small brown planthopper, Laodelphax striatellus, and their expression in relation to thermal stress

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Insect Science 2008年第5期15卷 415-422页

作者： dong Hun Kim sang-Chul lee do-Yeon Kwak Kyeong-Yeoll lee School of Applied Biosciences College of Agricultura and Life Sciences Kyungpook National University Daegu Yeongnam Agricultural Research Institute Milyang Republic of Korea

Three heat shock protein （HSP） genes （hsp70, hsc70, hsp90） were partially cloned from the brown planthopper Nilaparvata lugens and the small brown planthopper Laodelphax striatellus （Homoptera： Delphacidae）, which are serious pests of the rice plant. Sequence comparisons at the deduced amino acid level showed that the three HSPs of planthoppers were most homologous to corresponding HSPs of dipteran and lepidopteran species. Identities of both heat shock cognate 70 and HSP90 were higher than HSP70 in both species. Identity of the HSP70 between the two planthopper species was only 81%, a value much lower than seen among fly and moth groups. Effects of heat and cold shocks were demonstrated on expression of the three hsp genes in the two planthopper species. Heat shock （40 ℃） upregulated the hsp90 level but did not change the hsc70 level in either the nymph and adult stages of either species. On the other hand, the hsp70 level was only upregulated in L. striatellus. This heat shock response was prompt and lasted only for 1 h after treatment. In contrast, cold shock at 4℃ did not change the expression levels of any hsp in either species.

关键词： cold shock gene expression heat shock heat shock protein genes planthoppers thermal stress

Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression

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World Journal of Gastroenterology 2014年第11期20卷 3011-3017页

作者： sang Hwa lee Sung-Im do Hyun-Soo Kim Department of Pathology Aerospace Medicine Research CenterAerospace Medical CenterRepublic of Korea Air ForceChungcheongbuk-do 363-849South Korea Department of Pathology Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea

AIM: To investigate the effect of hypoxia or hyperoxia on the progression of hepatic fibrosis and to examine the role of transforming growth factor-β (TGF-β) in the livers of rats exposed to hypoxic or hyperoxic con... 详细信息

关键词： Hepatic fibrosis, Cirrhosis, Hypoxia, Hyperoxia, Transforming growth factor-β