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Splenic infarction associated with sorafenib use in a hepatocellular carcinoma patient

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World Journal of Gastroenterology 2011年第2期17卷 267-270页

作者： sang Ock Kim sang young han Yang Hyun Baek Sung Wook Lee Ji Sun han Byung Geun Kim Jin han Cho Kyung Jin Nam Department of Gastroenterology and Hepatology Dong-A University HospitalDongdaesin-dong Seo-gu Busan 602-103 South Korea Dong-A University Collegeof Medicine 3-ga Dongdaesing-dong Seo-gu Busan 602-103South Korea Department of Radiology Dong-AUniversity Hospital Dongdaesin-dong Seo-gu Busan 602-103South Korea

Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial ***,there are no prior reports of splenic infarction as an adverse effect of ***,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of *** splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.

关键词： Hepatocellular carcinoma Sorafenib Tyrosine kinase inhibitor Adverse effects Splenic infarction

Rapidly aggravated skeletal muscle metastases from an intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2015年第6期21卷 1989-1993页

作者： Jiyoung Lee Sung Wook Lee sang young han Yang Hyun Baek Su young Kim Hyo In Rhyou Department of internal medicine Dong-A University College of Medicine

We present a rare case of intrahepatic cholangiocarcinoma(ICC)with multiple skeletal muscle *** patient was a 55-year-old Asian woman presenting with abdominal pain;abdominal and pelvic computed tomography and magnetic resonance cholangiopancreatography revealed an unresectable ICC with hepatic metastasis and metastastatic lymphadenopathy in the porto-caval *** 3 mo of treatment with palliativeradiotherapy and chemotherapy,magnetic resonance imaging of the thoracolumbar spine detected right psoas muscle and paraspinous muscle *** performed an ultrasound-guided percutaneous fineneedle biopsy that confirmed a similar pattern of poorly differentiated *** patient treated with palliative chemotherapy and achieved 10 mo of *** we report the first case quickly spread to multiple sites of muscle even though the three-month treatment,compare to the other cases reported muscle metastases at diagnosis.

关键词： Intrahepatic cholangiocarcinoma Skeletal muscle me

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第26期18卷 3426-3434页

作者： Yang Hyun Baek Kyoung Tae Kim Sung Wook Lee Jin Sook Jeong Byeong Ho Park Kyung Jin Nam Jin han Cho young Hoon Kim young Hoon Roh Hyung Sik Lee young Min Choi sang young han Department of Internal Medicine Dong-A University College of MedicineBusan 602-103South Korea Department of Pathology Dong-A University College of MedicineBusan 602-103South Korea Department of Radiology Dong-A University College of MedicineBusan 602-103South Korea Department of Surgery Dong-A University College of MedicineBusan 602-103South Korea Department of Radiation Oncology Dong-A University College of MedicineBusan 602-103South Korea

AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the ***:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May *** the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 ***:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial *** tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of *** addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor *** most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of ***:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis.

关键词： Hepatic arterial infusion chemotherapy Floxuridine Advanced hepatocellular carcinoma Child-Pugh classification Portal vein tumor thrombus

Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction

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World Journal of Gastroenterology 2006年第1期12卷 146-149页

作者： Ki-Jae Park Hong-Jo Choi Sung-Heun Kim sang-young han Sook-Hee Hong Jin-han Cho Hyung-Ho Kim Department of Surgery Dong-A University College of MedicinePusanSouth Korea Department of Internal Medicine Dong-A University College of Medicine.PusanSouth Korea Department of Pathology Dong-A University College of MedicinePusanSouth Korea Department of Radiology Dong-A University College of MedicinePusanSouth Korea Department of Surgery Seoul National University Bundang HospitalBundangKyunggi-DoSouth Korea

We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge. Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution. An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum. Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge. CT scan showed the typical finding of intussusception. We performed laparoscopic anterior resection and anastomosis after the sponge-on-the-stickassisted manual reduction. The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.

关键词： Sigmoidorectal intussusception Adenomatouspolyp Laparoscopic resection

Retreatment with peginterferon and ribavirin in chronic hepatitis C

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World Journal of Gastroenterology 2015年第6期21卷 1994-1999页

作者： Yong Min Jo Sung Wook Lee sang young han Yang Hyun Baek Soo young Kim Woo Jae Kim Ji Hye Ahn Ji young Lee Department of Internal Medicine Dong-A University School of Medicine

The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis *** addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and ***,there are several challenges associated with the application of noveldrugs,such as new and more frequent adverse events,new drug interactions,and excessively high treatment *** additional concern is viral *** considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patients who are in need of *** retrospective study revealed that the sustained virologic response was not significantly reduced following peginterferon and ribavirin retreatment compared with the new *** suggest that patients who experience relapse shortly after completing treatment with peginterferon and ribavirin have a reasonable chance of achieving a sustained virologic response when retreated with these drugs alone.

关键词： Chronic hepatitis C Direct-acting antiviral agents

Nonconvulsive status epilepticus disguising as hepatic encephalopathy

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World Journal of Gastroenterology 2015年第16期21卷 5105-5109页

作者： Yong Min Jo Sung Wook Lee sang young han Yang Hyun Baek Ji Hye Ahn Won Jong Choi Ji young Lee sang Ho Kim Byeol A Yoon Department of Internal Medicine Dong-A University School of Medicine Department of Neurology Dong-A University School of Medicine

Nonconvulsive status epilepticus has become an important issue in modern neurology and *** is based on difficulty in definitively elucidating thecondition and its various clinical phenomena and on our inadequate insight into the intrinsic pathophysiological *** nonconvulsive status epilepticus being a situation that requires immediate treatment,this disorder may not be appreciated as the cause of mental status *** the pathophysiology of nonconvulsive status epilepticus remains unknown,this disorder is thought to lead to neuronal damage,so its identification and treatment are *** status epilepticus should be considered in the differential diagnosis of patients with liver cirrhosis presenting an altered mental *** report a case of a 52-year-old male with liver cirrhosis presenting an altered mental *** was initially diagnosed with hepatic encephalopathy but ultimately diagnosed with nonconvulsive status epilepticus by electroencephalogram.

关键词： Liver cirrhosis Hepatic encephalopathy Nonconvulsive status epilepticus Electroencephalogram

Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy

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World Journal of Gastroenterology 2013年第38期19卷 6494-6499页

作者： In-Chul Park Yang-Hyun Baek sang-young han Sung-Wook Lee Won-Tae Chung Sung-Won Lee sang-Hyeon Kang Duk-Song Cho Division of Gastroenterology and Hepatology Department of Internal MedicineCollege of MedicineDong-A University

Warfarin is a widely used *** differences in drug response,a narrow therapeutic range and the risk of bleeding render warfarin difficult to use *** 18-year-old woman with antiphospholipid syndrome received long-term warfarin therapy for a recurrent deep vein *** years later,she developed right flank *** diagnosed intrahepatic and subgaleal hemorrhages secondary to anticoagulation *** stopping oral anticoagulation,a follow-up computed tomography showed improvement in the *** restarting warfarin because of a recurrent thrombosis,the intrahepatic hemorrhage *** decided to start clopidogrel and hydroxychloroquine instead of *** patient has not developed further recurrent thrombotic or bleeding *** hemorrhage is a very rare complication of warfarin,and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control.

关键词： Warfarin Liver Subgaleal Hemorrhage Antiphospholipid syndrome

Fabrication and Mechanical Properties of Sm2O3 Doped CeO2 Reinforced Ti3AlC2 Nano Composite

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Journal of Rare Earths 2004年第Z2期22卷 85-88页

作者： Jae Ho han sang Whan Park young Do Kim Division of Materials Science & Engineering Hanyang UniversitySeoul133-791Korea Korea Institute of Science and TechnologyMulti-Functional Ceramics Research CenterSeoul136-791Korea Division of Materials Science & EngineeringHanyang UniversitySeoul133-791Korea

The fabrication process of Sm2O3 doped CeO2 reinforced Ti3AlC2 nano composites including the nano particle dispersion process by a hetero-coagulation process was developed using in-situ synthesis and densification process of Ti3AlC2. The effects of Sm2O2 doped CeO2 nano particles on mechanical properties of Ti3AlC2 were investigated. It was found that the presence of 20SDC nano particles in Ti3AlC2 was very effective to improve the mechanical properties of Ti3AlC2 without spoiling the unique characteristics of Ti3AlC2temary carbide.

关键词： nano ceramic composite Ti3AlC2 CeO2 fabrication rare earths

Cardiff acne disability index： cross-cultural translation in Korean and its relationship with clinical acne severity, pathological patterns, and general quality of life

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Journal of Traditional Chinese Medicine 2017年第5期37卷 702-709页

作者： Kyeong-han Kim sang-Chul Lee young-Bae Park young-Jae Park Department of Human Informatics of Korean Medicine Interdisciplinary Programs Kyung Hee University Seoul02447 Korea Department of Business Administration Korea Christian University Seoul07661 Korea Department of Biofunctional Medicine and Diagnostics College of Korean MedicineKyung Hee University Seoul02447 Korea Department of Diagnosis and Biofunctional Medicine Kyung Hee University Hospital at Gangdong Seoul 05278 Korea

OBJECTIVE: To culturally translate the cardiff acne disability index(CADI) into Korean, and to examine its relationship with clinical acne severity,pathological patterns, and general quality of life(Qo L).METHODS: The CADI was culturally and lin-guistically translated into Korean via translation,back-translation, and face validity test process. Two hundred and fifty-four Korean adolescents were asked to complete the Korean version of the CADI(K-CADI), the Phlegm Pattern, the Cold-Heat Pattern, and the Korean version of the General Health Questionnaires. A clinician estimated acne severity for the adolescents, using the Korean Acne Grading System. Finally, reliability and validity of the K-CADI was examined, and the relationships between acne severity, Phlegm, Cold, and Heat patterns, and Qo L level were examined via pathway ***: The K-CADI had satisfactory internal consistency(α = 0.827). The examination of construct validity indicated that the K-CADI had one factor(explaining 59.6% of the total variance). Pathway analysis showed satisfactory model fit(normal fit index = 0.960 and comparative fit index = 0.983),and acne-related Qo L was determinant to Phlegm,Heat, and Cold patterns(0.13-0.27 of β), and Phlegm and Heat patterns lowered one's Qo L level(0.17-0.34 of β).CONCLUSION: The K-CADI is a valid and reliable instrument. Phlegm and Heat patterns should be managed when treating acne since they have a moderating effect on general Qo L aggravation.

关键词： Acne vulgaris Quality of life Medicine East Asian Traditional Psychology adolescent Causality Cardiff acne disability index