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Altered gut microbiota patterns in COVID-19:Markers for inflammation and disease severity

World Journal of Gastroenterology 2022年第25期28卷 2802-2822页

作者： Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Kuldeep Dhama sang-soo Lee School of Life Science and Biotechnology Adamas UniversityKolkata 700126India Institute for Skeletal Aging&Orthopaedic Surgery Hallym UniversityChuncheon-si 24252South Korea Department of Zoology Fakir Mohan UniversityBalasore 756020India Division of Pathology Indian Council of Agricultural Research(ICAR)-Indian Veterinary Research Institute(IVRI)Bareilly 243122Uttar PradeshIndia Institute for Skeletal Aging&Orthopedic Surgery Hallym UniversityChuncheon-si 24252South Korea

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection leads to a severe respiratory illness and alters the gut microbiota,which dynamically interacts with the human immune *** alterations include decreased levels of beneficial bacteria and augmentation of opportunistic ***,we describe critical factors affecting the microbiota in coronavirus disease 2019(COVID-19)*** include,such as gut microbiota imbalance and gastrointestinal symptoms,the pattern of altered gut microbiota composition in COVID-19 patients,and crosstalk between the microbiome and the gut-lung axis/gut-brain-lung ***,we have illustrated the hypoxia state in COVID-19 associated gut microbiota *** role of ACE2 in the digestive system,and control of its expression using the gut microbiota is discussed,highlighting the interactions between the lungs,the gut,and the brain during COVID-19 ***,we address the gut microbiota in elderly or co-morbid patients as well as gut microbiota dysbiosis of in severe *** clinical trials to understand the role of probiotics in COVID-19 patients are listed in this *** inflammation is one of the major driving forces for COVID-19 symptoms and gut microbiome disruption and is associated with disease ***,understanding the role of the gut microbiota in immune modulation during SARS-CoV-2 infection may help improve therapeutic strategies for COVID-19 treatment.

关键词： COVID-19 Inflammation Gut microbiota Therapeutic

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Patient-reported ejaculatory function and satisfaction in men with lower urinary tract symptoms/benign prostatic hyperplasia

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Asian Journal of Andrology 2018年第1期20卷 69-74页

作者： Min Chul Cho Jung Kwon Kim sang Hoon Song Sung Yong Cho sang Wook Lee soo Woong Kim Jae-Seung Paick Department of Urology Seoul National University Boramae Medical Center Seou107061 Korea Department of Urology Seoul National University College of Medicine Seoul 03080 Korea Department of Urology Asan Medical Center Seou105505 Korea Department of Urology Kangwon National University College of Medicine Chuncheon 24289 Korea

This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms （LUTS）/benign prostatic hyperplasia （BPH） and to identify associations between specific categories of ejaculatory dysfunctions （EjDs） and LUTS. A total of 1574 treatment-naive men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time. Patients who had sexual intercourse over the past 4 weeks were classified as sexually active group. A total of 783 patients were categorized as sexually active group. Decreased ejaculatory volume and force were reported by 53.4% and 55.7% of 783 sexually active men, respectively, There was a strong correlation between ejaculatory volume and force. Ejaculatory pain/discomfort, premature ejaculation （PE）, and delayed ejaculation （DE） were reported in 41,0%, 16.3%, and 41.4% of the patients, respectively. Over 40.0% of men without decreased ejaculation volume/force were satisfied with ejaculatory function, whereas approximately 6.0% of men with decreased volume/force were satisfied with ejaculatory function. About 30.0% of men with decreased volume/force had orgasmic dysfunction, while approximately 10.0% of men without decreased volume/force did. Decreased ejaculatory volume or force was associated with LUTS severity after adjusting for other influential factors including testosterone level, erectile function, and prostate size on ultrasonography, but PE or DE or ejaculatory pain/discomfort was not. In conclusion, a considerable portion of men with LUTS/BPH appear to have a variety of EjDs. Ejaculatory volume/force and satisfaction/orgasm do not always appear to be concordant. Ejaculatory volume or force is independently associated with LUTS severity, whereas PE or DE or ejaculatory pain/discomfort is not.

关键词： dysfunction ejaculation lower urinary tract symptoms (LUTS) satisfaction

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PPARγLBD and its ligand specificity reveal a selection of potential partial agonist:Molecular dynamics based T2D drug discovery initiative

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BIOCELL 2021年第4期45卷 953-961页

作者： BIDYUT MALLICK ASHISH RANJAN SHARMA MANOJIT BHATTACHARYA sang-soo LEE CHIRANJIB CHAKRABORTY Department of Applied Science Galgotias College of Engineering and TechnologyKnowledge Park-IIGreater Noida201306India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Korea Department of Zoology Fakir Mohan UniversityVyasa ViharBalasore756020India Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityKolkata700126India

PPARγis a peroxisome proliferator-activated receptor(PPAR)family protein and is a target for type 2 diabetes(T2D).In this paper,we have performed a molecular docking analysis between ligand molecules(CID9816265,CID11608015,CID20251380,CID20251343,CID20556263,CID624491,CID42609928,and CID86287562)and PPARγto determine the ligand *** also helps to understand the ligand-binding domain(LBD)activity of PPARγduring the binding of the ***,a molecular dynamics simulation study was performed to determine the ligand biding stability in the PPARγ*** ligand specificity informed us about the potentiality of selecting a partial *** study also shows the binding conformation of Ceramicine B having hydrogen bonding affinity with a tricyclic polar head and stabilized theβ-sheet *** the other hand,the tricyclic polar head of nimbolide also formed hydrogen bonding(Ser342),but it shows a lesser degree of stabilization in theβ-sheet *** shows the binding conformation of partial agonist(PPARγ)in the Pocket-II of PPARγLBD,which has a significant role in stabilizing theβ-sheet *** might help to regulate ERK/Cdk5 mediated phosphorylation of *** study helps us understand the valid pose of a set of ligands confirmation and target protein conformation using docking and molecular dynamics *** in silico study will also help to initiate a drug discovery process of T2D.

关键词： PPARγ Partial agonist Molecular simulation T2D Drug discovery

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Characterization and sensor application of cellulose electro-active paper (EAPap)

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Chinese Science Bulletin 2009年第15期54卷 2703-2707页

作者： LEE sang-Woo KIM Joo-Hyung KIM Jaehwan KIM Heung soo Creative Research Center for EAPap Actuator Mechanical Engineering Department Inha University School of Mechanical and Automotive Engineering Catholic University of Daegu

As a novel piezoelectric material, the mechanical and piezoelectric properties of cellulose electro-active paper (EAPap) were studied. Young's modulus of piezoelectric EAPap was dependant on the material orientation as compared with other EAP materials. The highest Young's modulus was obtained at 0° direction, while the highest direct piezoelectric charge constant was achieved at 45°. By measuring the induced output voltage from the thin piezoelectric cellulose film under the applied impact force, we demonstrate that piezoelectric EAPap film has a potential for sensor applications.

关键词：传感器应用纤维素膜压电材料表征杨氏模量压电性能电子机械输出电压

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Detection and pathogenesis of a novel swine H3N2 influenza virus containing three genes from the 2009 pandemic H1N1 influenza viruses in Korea in 2015

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Virologica Sinica 2016年第6期31卷 513-516页

作者： Tran Bac Le In Hong Lee Byung Jun Kim Hyun soo Kim sang Heui Seo Laboratory of Public Health College of Veterinary Medicine Chungnam National University Daejeon 34134 Republic of Korea.

Dear Editor,Influenza A viruses cause pandemics at an interval of approximately 10-40 years,and pigs are regarded as a＂mixing vessel＂because they are easily infected with avian and human influenza viruses（Ito et al.,1998）.According to previous studies,H3N2,H1N2,and H1N1 subtypes o（swine influenza viruses have been detected in Korean pigs （Pascua et al., 2013; Kim et al., 2014; Song et al., 2007）. Moreover, a novel H3N2 influenza virus containing the matrix （34） gene from a 2009 pandemic influenza virus was detected in Korean pigs in 2013 （Pascua et al., 2013）, an H1N2 influenza virus con- taining the internal genes from a 2009 pandemic influ- enza virus was found in Korean pigs in 2014 （Kim et al., 2014）, and an H1N1 influenza virus containing all genes from the classical swine influenza viruses was isolated from Korean pigs in 2007 （Song et al., 2007）.

关键词： gene Detection and pathogenesis of a novel swine H3N2 influenza virus containing three genes from the 2009 pandemic H1N1 influenza viruses in Korea in 2015

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The 2019 novel coronavirus disease(COVID-19) pandemic: A zoonotic prospective

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Asian Pacific Journal of Tropical Medicine 2020年第6期13卷 242-246页

作者： Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Garima Sharma sang-soo Lee Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityBarasat-Barrackpore RdKolkataWest Bengal 700126India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Gangwon-doRepublic of Korea Neuropsychopharmacology and Toxicology Program College of PharmacyKangwon National UniversityRepublic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),a novel coronavirus(CoV),has recently emerged as a significant pathogen for humans and the cause for the recent outbreak of the 2019 novel coronavirus disease(COVID-19)throughout the *** developing any preventive measure,an understanding of the zoonotic pattern for this virus is a *** should have a clear knowledge of its reservoir host,its distribution pattern and spreading *** about zoonotic reservoirs and its transmission among them can help to understand the COVID-19 *** this article,we discuss about the bats as the zoonotic reservoir of several CoV strains,co-existence of bats and CoV/viruses,the sequence similarity of SARS-CoV-2 with bat SARS-like CoV,the probable source of the origin of SARS-CoV-2 strain and COVID-19 outbreak,intermediate host of CoVs and SARS-CoV-2,human to human transmission and the possibility to maintain the zoonotic *** knowledge about the zoonotic reservoir of SARS-CoV-2 and its transmission ability may help develop the preventive measures and control for the future outbreak of CoV.

关键词： SARS-CoV-2 COVID-19 Coronavirus Zoonotic reservoir

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QKD system with fast active optical path length compensation

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 1-7页

作者： Byung Kwon Park Min soo Lee Min Ki Woo Yong-Su Kim sang-Wook Han Sung Moon Center for Quantum Information Korea Institute of Science and Technology Department of Nano-materials Science and Engineering Korea University of Science and Technology

We develop a quantum key distribution (QKD) system with fast active optical path length compensation. A rapid and reliable active optical path length compensation scheme is proposed and applied to a plug-and-play QKD system. The system monitors changes in key rates and controls it is own operation automatically. The system achieves its optimal performance within three seconds of operation, which includes a sifted key rate of 5.5 kbps and a quantum bit error rate of less than 2% after an abrupt temperature variation along the 25 km quantum channel. The system also operates well over a 24 h period while completing more than 60 active optical path length compensations.

关键词： quantum key distribution optical path length compensation plug and play field programmable gate array

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^(27)Al MAS-NMR study of inorganic polymer formation at ambient temperature

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 182-187页

作者： sang-Wook AHN Hee-soo LEE Wan-Hee YANG Jung-Woo LEE Young-Keun jeonG National Core Research Center for Hybrid Materials Solution Pusan National University School of Material Science and Engineering Pusan National University INTChem Co. Ltd.

Inorganic polymers are a novel class of materials formed by the polymerization of silicon, aluminium and oxygen species to form an amorphous three-dimensional framework structure. The basis of this process is the alkaline solutions to induce a certain amount of Si and AI atoms to dissolve from a feedstock such as aluminosilicate. A study of 27A1 MAS-NMR was carried out in an attempt to understand the reaction mechanism of the inorganic polymerization at ambient temperature. Scanning electron microscopy （SEM） and X-ray diflYactometry （XRD） were also employed to establish the composition and microstructure of the inorganic polymerization. Specimens were prepared with different A1/Si mole ratios from the starting materials. The higher the AI content, the more sufficient the AI atoms that can combine with SiO4, and the longer the reaction time, the more the bonded Si--O--A1--O polymer structure, and then the higher the A1 content, the fewer the octahedral A1 with a uniform Si--O--A1--O structure in four directions, because four AI atoms are combined with SiO4, resulting in a uniform Si--O--AI--O structure in four directions. The results show that they have an amorphous microstructure.

关键词： inorganic polymer amorphous tetrahedral

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Estimation of Non-CO_2 GHGs Emissions by Analyzing Burn Severity in the Samcheok Fire,South Korea

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Journal of Mountain Science 2012年第6期9卷 731-741页

作者： WON Myoung soo KOO Kyo sang LEE Myung Bo LEE Woo Kyun KANG Kyu-Young Division of Forest Disaster Management Korea Forest Research Institute130712 SeoulRepublic of Korea Faculty of Environmental Science and Ecological Engineering Korea University-Seoul136701 SeoulRepublic of Korea Department of Biological and Environmental Science Dongguk University-Seoul100715 SeoulRepublic of Korea

This study was performed to estimate the emission of non-CO 2 greenhouse gases(GHGs) from biomass burning at a large fire *** extended methodology adopted the IPCC Guidelines(2003) equation for use on data from the Samcheok forest fire gathered using 30 m resolution Landsat TM satellite imagery,digital forest type maps,and growing stock information per hectare by forest type in *** burn ratio(NBR) technique was employed to analyze the area and severity of the Samcheok forest fire that occurred in *** differences between NBR from pre-and post-fire datasets are examined to determine the extent and degree of change detected from *** results of burn severity analysis by dNBR of the Samcheok forest fire area revealed that a total of 16,200 ha of forest were *** proportion of the area characterized by a 'Low' burn severity(dNBR below 152) was 35%,with 'Moderate'(dNBR 153-190) and 'High'(dNBR 191-255) areas were at 33% and 32%,*** combustion efficiency for burn severity was calculated as 0.43 for crown fire where burn severity was 'High',as 0.40 for 'Moderate' severity,and 0.15 for 'Low' severity surface *** emission factors for estimating non-CO 2 GHGs were separately applied to CO 130,CH 4 9,NO x 0.7 and N 2 O ***-CO 2 GHGs emissions from biomass burning in the Samcheok forest fire area were estimated to be CO 44.100,CH 4 3.053,NO x 0.238 and N 2 O 0.038 Gg.

关键词： Biomass burning Non-CO 2 GHGs Normalized burn ratio Combustion efficiency Emission factor Landsat TM

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A study on hydrogen uptake and release of a eutectic mixture of biphenyl and diphenyl ether

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Journal of Energy Chemistry 2020年第3期29卷 11-16页

作者： Munjeong Jang Byeong soo Shin Young Suk Jo jeong Won Kang sang Kyu Kwak Chang Won Yoon Hyangsoo jeong Center for Hydrogen Fuel Cell Research Korea Institute of Science and Technology(KIST)5 Hwarang-ro 14-gilSeongbuk-guSeoul 02792Republic of Korea Divison of Energy and Environment Technology KIST SchoolKorea University of Science and Technology5 Hwarang-ro 14-gilSeongbuk-guSeoul 02792Republic of Korea Department of Chemical and Biological Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology50UNIST-gilUlsan 44919Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoul 02447Republic of Korea

Hydrogen storage in Liquid Organic Hydrogen Carrier(LOHC)systems is appealing for the safe storage and distribution of excess renewable energy via existing gasoline infrastructures to *** present the eutectic mixture of biphenyl and diphenyl ether of its first use as a LOHC *** material is hydrogenated with 99%selectivity without the cleavage of C–O bond,with commercial heterogeneous catalysts,which is confirmed by nuclear magnetic spectroscopy and gas chromatography-mass *** concentration,dehydrogenation enthalpy,and thermo-neutral temperature are calculated using a density functional *** results indicate that O-atom-containing material exhibits more favorable dehydrogenation thermodynamics than that of the hydrocarbon *** H2-rich material contains6.8 wt%of gravimetric hydrogen storage capacity.A preliminary study of catalytic dehydrogenation on a continuous reactor is presented to demonstrate a reversibility of this material.

关键词： Hydrogen storage Liquid organic hydrogen carrier Diphenyl ether Dehydrogenation Thermodynamics

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