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Journal of Traditional Chinese Medicine 2018年第5期38卷 769-772页

作者： JiEun Lee Seung-Yeon Cho Seong-Uk Park Woo-sang Jung sang-kwan moon Jung-Mi Park Chang-Nam Ko Ki-Ho Cho Seungwon Kwon Department of Cardiology and Neurology College of Korean Medicine Kyung Hee University

OBJECTIVE: To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang(DSWST) has any transient effect on erythrocyte deformability in normal ***: A total of 25 subjects [mean age(27.8± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte ***: The elongation index increased significantly after 2 h(P = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant differenceobserved. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration,DSWST improved erythrocyte deformability significantly compared to water(P < 0.001).CONCLUSION: DSWST has a transient effect on erythrocyte deformability in normal subjects.

关键词： Erythrocyte deformability Peptide elongation factors Raynaud disease Coldness of hands and feet Cross-over studies Danggui Sini plus Wuzhuyu Shengjiang Tang

Neuroprotective Effect of Chunghyuldan(Qing Xue Dan)on Hypoxia-Reoxygenation Induced Damage of Neuroblastoma 2a Cell Lines

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Chinese Journal of Integrative Medicine 2013年第12期19卷 940-944页

作者： Chang-Nam Ko In-Seo Park Seong-Uk Park Woo-sang Jung sang-kwan moon Jung-Mi Park Chulhun Kang Ki-Ho Cho Department of Cardiology and Neurology Diseases College of Korean MedicineKyung Hee University Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University

Objectives： Chunghyuldan （CHD）, a combinatorial drug that has anti-hyperlipidemic and anti inflammatory activities, has been shown to reduce infarct volume in a focal ischemia-reperfusion rat model. To explore the molecular basis of CHD＇s neuroprotective effect, we examined whether CHD shows a cell-protective activity and has a regulatory effect on Bax and/or B-cell leukemia/lymphoma 2 （Bcl-2） expression in mouse neuroblastoma 2a （N2a） cells subjected to hypoxia-reoxygenation （H/R）. Methods： In order to evaluate the effects of CHD on the cytotoxicity induced from hypoxia or H/R condition, lactate dehydrogenase （LDH） assay was performed. To explore whether the suppression of neural damage when pre-treated with CHD is associated with its anti-apoptotic effect, the CHD effect on the expression of Bcl-2 and Bax was analyzed by Western blotting analysis. Results： Cytotoxicity of N2a cell line was slightly increased in 42 h hypoxia condition and dramatically increased under the H/R condition. CHD treatment markedly decreased the cytotoxicity in both conditions （P〈0.01, P〈0.05）. H/R markedly increased the expression of the pro-apoptotic protein, Bax, but slightly increased the expression of the anti-apoptotic protein, Bcl-2, compared with the normoxia or hypoxia group. CHD significantly decreased Bax expression （P〈0.01） and slightly decreased Bcl-2 expression （P〉0.05）, resulted in a reduction of Bax/Bcl-2 ratio in N2a cells subjected to H/R. Conclusion： CHD has neuroprotective effect in N2a cells subjected to H/R, which might be derived at least in part from its ability to decrease the expression of the pro-apoptotic protein, Bax.

关键词： apoptosis stroke Chunghyuldan herbal

Therapeutic Effects of Traditional Herbal Medicine on Cerebral Ischemia:A Perspective of Vascular Protection

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Chinese Journal of Integrative Medicine 2013年第11期19卷 804-814页

作者： Youngmin Bu Kyungjin Lee Hyuk-sang Jung sang-kwan moon Department of Herbal Pharmacology College of Korean MedicineKyung Hee University Department of Anatomy College of Korean Medicine Institute of Korean MedicineKyung Hee University Department of Cardiovascular and Neurologic Disease College of Korean MedicineKyung Hee University

Although many agents for acute ischemic stroke treatment have been developed from extensive preclinical studies, most have failed in clinical trials. As a result, researchers are seeking other methods or agents based on previous studies. Among the various prospective approaches, vascular protection might be the key for development of therapeutic agents for stroke and for improvements in the efficacy and safety of conventional therapies. Traditional medicines in Asian countries are based on clinical experiences and literature accumulated over thousands of years. To date, many studies have used traditional herbal medicines to prove or develop new agents based on stroke treatments mentioned in traditional medicinal theory or other clinical data. In the current review, we describe the vascular factors related to ischemic brain damage and the herbal medicines that impact these factors, including Salviae Miltiorrhizae Radix, Notoginseng Radix, and Curcumae Rhizoma, based on scientific reports and traditional medical theory. Further, we point out the problems associated with herbal medicines in stroke research and propose better methodologies to address these problems.

关键词： traditional medicine vascular protection ischemic stroke Salviae Miltiorrhizae Radix Notoginseng Radix Curcumae Rhizoma

Scutellaria baicalensis in Stroke Management:Nature's Blessing in Traditional Eastern Medicine

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Chinese Journal of Integrative Medicine 2014年第9期20卷 712-720页

作者： Bhakta Prasad Gaire sang-kwan moon Hocheol Kim Department of Herbal Pharmacology College of Korean MedicineKyung Hee UniversitySeoul 130-701Korea Department of Carcliology and Neurology Hospital of Oriental MedicineKyung Hee UniversitySeoulKorea

Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastem medicine, especially in Chinese medicine. The major phytochemicals isolated from S. baicalensis are flavonoids, glycosides and their glucoronides such as baicalin, baicalein, wogonin etc. More than 30 different kinds of flavonoids are isolated from this plant. S. baicalensis and its flavonoids are reported to have several pharmacological activities, which includes anti-allergic, antioxidant, anti apoptic, anti-inflammatory effects and many more. Recently, S. baicalensis and its isolated flavonoids have been studied for their neuroprotective effects, through a variety of in vitro and in vivo models of neurodegenerative diseases, plausibly suggesting that S. baicalensis has salutary effect as a nature＇s blessing for neuroprotection. In this review, we are focousing on the neuroprotective effects of S. baicalensis and its flavonoids in ischemia or stroke-induced neuronal cell death. We aimed at compiling all the information regarding the neuroprotective effect of S. baicalensis in various experimental models of cerebral ischemia or stroke.

关键词： Scutellaria baicalensis flavonoids neuroprotection ischemia stroke

Uhwang Chungsim Won Decreases Blood Oxygen Level-Dependent fMRI Signal Response to A Motor Stimulation Task

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Chinese Journal of Integrative Medicine 2015年第7期21卷 493-499页

作者： Woo-sang Jung Jong-Man Ryu Young-Jee Kim Seong-Uk Park Geon-Ho Jahng Jung-Mi Park sang-kwan moon Chang-Nam Ko Ki-Ho Cho Department of Cardiovascular&Neurologic Diseases(Stroke Center) College of Oriental MedicineKyung Hee University Department of Radiology College of MedicineKyung Hee University

Objectives： TO evaluate the effect of Uhwang Chungsim Won [UC, Niuhuang Qingxin Pill （牛黄清心丸] on the blood oxygen level-dependent （BOLD） functional magnetic resonance imaging （fMRI） signal response to a motor stimulation task using a hand grasping paradigm. Methods： Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC. Results： With the administration of UC, BOLD responses to the right hand motor task showed a decrease in both hemispheres including the right cerebellar culmen, right and left medial frontal gyrus, right parahippocampal gyrus, right and left sublobar insula, right and left posterior cingulate, left precuneus, and right precentral gyrus. Decreased BOLD responses to the left hand motor task were shown in the right lingual gyrus, right cerebellar culmen, left superior temporal gyrus, right and left middle frontal gyrus, and right precentral gyrus after UC administration. Increased BOLD responses to the left hand motor task were shown in the left and right posterior cingulate, while there was no increased response to the right hand motor task after UC administration. Conclusions： UC administration significantly decreased fMRI BOLD signal responses to hand grasping in most of the brain areas including the primary motor cortex, but it is not clear whether these decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to the cerebral vasodilatory effects of UC. Further studies using positron emission tomography or single photon emission computed tomography are needed to fully elucidate these findings.

关键词： Uhwang Chungsim Won Niuhuang Qingxin Pfll pharmacological fMRI cerebral blood flow

Brain Activity Associated with Memory and Cognitive Function During Jaw-Tapping Movement in Healthy Subjects Using Functional Magnetic Resonance Imaging*

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Chinese Journal of Integrative Medicine 2013年第6期19卷 409-417页

作者： Seung-Yeon Cho Ae-Sook Shin Byung-Jo Na Geon-Ho Jahng Seong-Uk Park Woo-sang Jung sang-kwan moon Jung-Mi Park Department of Cardiovascular and Neurological Diseases College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Internal Medicine Kang-Nam Korean HospitalKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongSchool of MedicineKyuna Hee UniversitySeoulKorea

Objective： TO determine whether jaw-tapping movement, a classically described as an indication of personal well-being and mental health, stimulates the memory and the cognitive regions of the brain and is associated with improved brain performance. Methods： Twelve healthy right-handed female subjects completed the study. Each patient performed a jaw-tapping task and an n-back task during functional magnetic resonance imaging （fMRI）. The subjects were trained to carry out the jaw-tapping movement at home twice a day for 4 weeks. The fMRI was repeated when they returned. Results： During the first and second jaw-tapping session, both sides of precentral gyrus and the right middle frontal gyrus （BA 6） were activated. And during the second session of the jaw-tapping task, parts of frontal lobe and temporal lobe related to memory function were more activated. In addition, the total percent task accuracy in n-beck task significantly increased after 4 weeks of jaw- tapping movement. After jaw-tapping training for 4 weeks, brain areas related to memory showed significantly increased blood oxygen level dependent signals. Conclusion： Jaw-tapping movement might be a useful exercise for stimulating the memory and cognitive regions of the brain.

关键词： Jaw-tapping movement functional magnetic resonance imaging memory cognitive function dementia

Berberine inhibits inflammatory activation of rat brain microglia

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Neural Regeneration Research 2010年第18期5卷 1384-1390页

作者： Kyong Nyon Nam Jae-Hong Kim Hoon-Ji Jung Jung-Mi Park sang-kwan moon Young-Suk Kim Sun Yeou Kim Eunjoo H. Lee Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University Department of Cardiovascular & Neurologic Diseases (Stroke Center) Hospital of Oriental MedicineKyung Hee University

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Berberine, the effective ingredient of Coptidis Rhizoma and Cortex Phellodendti, has a wide range of pharmacological functions, including anti-inflammatory, anti-atherosclerotic and anti-cancer effects. The neuroprotective potential of berberine has previously been demonstrated. The present study aimed to examine whether berberine could repress microglial activation and can be considered a potential therapeutic candidate to target neurodegenerative diseases. Primary microglial cells and BV2 microglial cells were cultured and stimulated with bacterial lipopolysaccharide （LPS）. Berberine chloride was treated prior to LPS or simultaneously with LPS stimulation. Results revealed that berberine was effective at inhibiting nitric oxide release from primary microglial cells when cells were exposed to the compound prior to LPS or simultaneously with LPS. It also reduced the LPS-stimulated production of tumor necrosis factor-α, interleukin-1β, prostaglandin E2, and intracellular reactive oxygen species and nuclear factor-kappa activation. Additionally, berberine reduced nitric oxide release from microglia stimulated with interferon-γ and amyloid β. These results suggest that berberine provides neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.

关键词： brain inflammation berberine interleukin-1β microglia nuclear factor-kappa nitric oxide prostaglandin tumor necrosis factor-a

The Anti-hypertensive Effect of Ginseng in Patients with Mild Hypertension

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The Anti-hypertensive Effect of Ginseng in Patients with Mil...

Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation

第三届国际中医药工程学术会议

作者： Woo sang Jung Seong Uk Park sang kwan moon Seong Gyu Ko Chang Ho Han Ki Ho Cho Department of Cardiovascular ＆ Neurologic Diseases（Stroke Center） College of Oriental Medicine Kyung-Hee UniversitySeoulKorea Department of Preventive Medicine College of Oriental Medicine Kyung-Hee UniversitySeoulKorea Department of Korean Internal Medicine College of Korean Medicine Dongguk Hee UniversityKyunggi-doKorea

＜正＞Objectives:Ginseng has been traditionally used to recover vital energy from Qi deficiency in oriental countries, and showed its various biomedical effects in scientific literatures. Recent reports suggested that ginseng could regulate blood pressure （BP）, but much controversy still remain. Therefore, we intended to assess the anti-hypertensive effect of some ginseng species on Koreans and Chinese. Method:This is a randomized, double blinded controlled trial. We conducted this study in Department of Cardiovascular and Neurologic Diseases （Stroke Center）, Hospital of Oriental Medicine, Kyung Hee Medical Center, from June 2004 to October 2004, and In China, 96 subjects were recruited at the Emergency Room of Teaching Hospital of The Traditional Chinese Medicine of Chengdu University, from July 2004 to April 2005. The study subjects were recruited from the mild hypertensive patients who belonged pre-hypertension （120/80 to 139/89 mmHg） and stage I hypertension （140/90 to 159/99 mmHg） in Korea and China. After assigning the subjects into a Korean, a Chinese, a Red, and an American ginseng group by randomization, we prescribed ginseng with the dose of 4.5 g per a day for 4 weeks. To assess the anti-hypertensive effect, we compared the mean of systolic and diastolic BP between before and after ginseng medication by 24 hours Ambulatory Blood Pressure Monitor （24hr ABPM）. We also monitored adverse effect and laboratory findings to secure the subjects’ safety. Results:There were 64 subjects who had been treated with Korean ginseng, 58 treated with Chinese ginseng, 33 treated with Red ginseng, and 64 treated with American ginseng. Korean, Chinese, and American ginseng reduced subjects’ BP. Especially, Korean and Chinese ginseng showed more excellent effects. The secondary analysis on the subjects’ nationality revealed that all of the ginseng species showed more significant anti-hypertensive effect in Chinese than in Koreans. Conclusions:We suggest ginseng, especially Panax

关键词： Panax ginseng Hypertension Panax Quinquefalium

来源： cnki会议评论

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Neural Regeneration Research 2013年第18期8卷 1637-1643页

作者： Kyong Nyon Nam Byung-Cheol Woo sang-kwan moon Seong-Uk Park Joo-young Park Jae-Woong Hwang Hyung-Sup Bae Chang-Nam Ko Eunjoo Hwang Lee Graduate School of East-West Medical Science Kyung Hee University Department of Cardiovascular & Neurologic Diseases (Stroke Center) Hospital of Oriental Medicine Kyung Hee University

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional oriental medicine. Paeonol, found in the root of Paeonia lactiflora Pall, has a wide range of pharmacological functions, including anti-oxidative, anti-inflammatory and neuroprotective activities. The objective of this study was to examine the efficacy of paeonol in the repression of inflammation-induced neurotoxicity and microglial cell activation. Organotypic hippocampal slice cultures and primary microglial cells from rat brain were stimulated with bacterial lipopolysaccharide. Paeonol pretreatment was performed for 30 minutes prior to lipopolysaccharide addition. Cell viability and nitrite （the production of nitric oxide）, tumor necrosis factor-alpha and interleukin-lbeta products were measured after lipopolysaccharide treatment. In organotypic hippocampal slice cultures, paeonol blocked lipopolysaccharide-related hippocampal cell death and inhibited the release of nitrite and interleukin-lbeta. Paeonol was effective in inhibiting nitric oxide release from primary microglial cells. It also reduced the lipopolysaccharide-stimulated release of tumor necrosis factor-alpha and intefleukin-1β from microglial cells. Paeonol possesses neuroprotective activity in a model of inflammation-induced neurotoxicity and reduces the release of neurotoxic and proinflammatory factors in activated microglial cells.

关键词： neural regeneration traditional Chinese medicine brain inflammation interleukin-lbeta microglia neurotoxicity neuroprotection nitric oxide organotypic hippocampal slice culture Paeonia lactifloraPall paeonol tumor necrosis factor-alpha neuroregeneration

Clinical trial to evaluate the efficacy and safety of Tongxinluo in high risk group of cardiovascular diseases

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Clinical trial to evaluate the efficacy and safety of Tongxi...