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Preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after curative intent surgical resection

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 450-455页

作者： nam Hee Kim Hong Joo Kim Division of Gastroenterology Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

Background: Postoperative early recurrence(ER) in patients with pancreatic ductal adenocarcinoma(PDAC) is frequently encountered after curative intent surgery. Nonetheless, clinical significance and risk factors of ER after surgery for PDAC have not been extensively investigated. The aim of this study was to determine preoperative risk predictors for ER in patients with PDAC after upfront surgery. Methods: Eighty-one consecutive patients with PDAC who underwent curative intent surgical resection at Kangbuk Samsung Hospital between January 2004 and May 2015 were enrolled. ER was defined as tumor relapse within 6 months after surgery. Results: ER occurred in 26 patients(32.1%), whereas 49 patients(60.5%) had late recurrence( ≥ 6 months after surgery), and 6 patients had no recurrence(7.4%). Univariate analysis showed that C-reactive protein(CRP) > 3.0 mg/dL, modified Glasgow prognostic score(mGPS) = 2, decrease of total lymphocyte count by > 50% of baseline value in the preoperative period, prognostic nutritional index(PNI) 3.0 mg/dL, decrease of total lymphocyte count by > 50% of baseline value, and preoperative SUVmax were significant and independent contributors of ER in patients with resectable PDAC who underwent curative intent surgery. Conclusions: Postoperative ER for resectable PDAC was frequent with poor prognosis after curative intent upfront surgery. It is reasonable to suggest that there is a subgroup of resectable PDAC patients at highrisk of ER and neoadjuvant therapy should be considered in these patients in a clinical trial setting.

关键词： Early recurrence Pancreatic ductal adenocarcinoma Preoperative risk factors C-reactive protein Maximum standardized uptake value

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Lesion localization of global aphasia without hemiparesis by overlapping of the brain magnetic resonance images

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Neural Regeneration Research 2014年第23期9卷 2081-2086页

作者： Woo Jin Kim nam-Jong Paik Department of Rehabilitation Medicine Seoul National University Bundang Hospital Department of Physical Medicine and Rehabilitation Haeundae Paik Hospital Inje University of Medicine Department of Rehabilitation Medicine Seoul National University College of Medicine

Global aphasia without hemiparesis is a striking stroke syndrome involving language impairment without the typically manifested contralateral hemiparesis, which is usually seen in patients with global aphasia following large left perisylvian lesions. The objective of this study is to elucidate the specific areas for lesion localization of global aphasia without hemiparesis by retrospectively studying the brain magnetic resonance images of six patients with global aphasia without hemiparesis to define global aphasia without hemiparesis-related stroke lesions before overlapping the images to visualize the most overlapped area. Talairach coordinates for the most overlapped areas were converted to corresponding anatomical regions. Lesions where the images of more than three patients overlapped were considered significant. The overlapped global aphasia without hemiparesis related stroke lesions of six patients revealed that the significantly involved anatomi- cal lesions were as follows： frontal lobe, sub-gyral, sub-lobar, extra-nuclear, corpus callosum, and inferior frontal gyrus, while caudate, claustrum, middle frontal gyrus, limbic lobe, temporal lobe, superior temporal gyrus, uncus, anterior cingulate, parahippocampal, amygdala, and subcallosal gyrus were seen less significantly involved. This study is the first to demonstrate the heterogeneous anatomical involvement in global aphasia without hemiparesis by overlapping of the brain magnetic resonance images.

关键词： nerve regeneration global aphasia without hemiparesis global aphasia stroke hemiparesis brain magnetic resonance imaging neural regeneration

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Clinical outcomes of self-expandable metal stents in palliation of malignant anastomotic strictures caused by recurrent gastric cancer

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World Journal of Gastroenterology 2009年第28期15卷 3523-3527页

作者： Yu Kyung Cho sang Woo Kim Kwan Woo nam Jae Hyuck Chang Jae Myung Park Jeong-Jo Jeong In Seok Lee Myung-Gyu Choi In-Sik Chung Department of Internal Medicine The Catholic University of Korea

AIM： To examine the technical feasibility and clinical outcomes of the endoscopic insertion of a selfexpandable metal stent （SEMS） for the palliation of a malignant anastomotic stricture caused by recurrent gastric cancer. METHODS： The medical records of patients, who had obstructive symptoms caused by a malignant anastomotic stricture after gastric surgery and underwent endoscopic insertion of a SEMS from January 2001 to December 2007 at Kangnam St Mary＇s Hospital, were reviewed retrospectively. RESULTS： Twenty patients （15 male, mean age 63 years） were included. The operations were a total gastrectomy with esophagojejunostomy （n = 12）, subtotal gastrectomy with Billroth-Ⅰ reconstruction （n = 2） and subtotal gastrectomy with Billroth- Ⅱ reconstruction （n = 8）. The technical and clinical success rates were 100% and 70%, respectively. A small bowel or colon stricture was the reason for a lack of improvement in symptoms in 4 patients. Two of these patients showed improvement in symptoms after another stent was placed. Stent reobstruction caused by tumor ingrowth or overgrowth occurred in 3 patients （15%） within 1 mo after stenting. Stent migration occurred with a covered stent in 3 patients who underwent a subtotal gastrectomy with Billroth-Ⅱ reconstruction. Two cases of partial stent migration were easily treated with a second stent or stent repositioning. The median stent patency was 56 d （range, 5-439 d）. The median survival was 83 d （range, 12-439 d）. CONCLUSION： Endoscopic insertion of a SEMS provides safe and effective palliation of a recurrent anastomotic stricture caused by gastric cancer, A meticulous evaluation of the presence of other strictures before inserting the stent is essential for symptom improvement.

关键词： Stents Surgical anastomosis Stricture Endoscopic gastrointestinal surgery Stomach neoplasms

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Mode of Operation for Modification, Insertion, and Deletion of Encrypted Data

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Computers, Materials & Continua 2022年第10期73卷 151-164页

作者： Taek-Young Youn nam-Su Jho Dankook University YonginGyeonggi16890Korea Electronics and Telecommunications Research Institute Daejeon34129Korea

Due to the development of 5G communication,many aspects of information technology(IT)services are *** the development of communication technologies such as 5G,it has become possible to provide IT services that were difficult to provide in the *** of the services made possible through this change is cloud-based *** order to support secure collaboration over cloud,encryption technology to securely manage dynamic data is ***,since the existing encryption technology is not suitable for encryption of dynamic data,a new technology that can provide encryption for dynamic data is required for secure cloudbased *** this paper,we propose a new encryption technology to support secure collaboration for dynamic data in the ***,we propose an encryption operation mode which can support data updates such as modification,addition,and deletion of encrypted data in an encrypted *** support the dynamic update of encrypted data,we invent a new mode of operation technique named linked-block cipher(LBC).Basic idea of our work is to use an updatable random value so-called link to link two encrypted *** to the use of updatable random link values,we can modify,insert,and delete an encrypted data without decrypt it.

关键词： Data encryption cloud-based collaboration dynamic data update

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Are prostatic calculi independent predictive factors of lower urinary tract symptoms？

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Asian Journal of Andrology 2010年第2期12卷 221-226页

作者： Sung-Woo Park Jong-Kil nam sang-Don Lee Moon-Kee Chung Medical Research Institute and Department of Urology Pusan National University Yangsan Hospital Yangsan 626-770Korea

We determined the correlation between prostatic calculi and lower urinary tract symptoms （LUTS）,as well as the predisposing factors of prostatic calculi. Of the 1 527 patients who presented at our clinic for LUTS,802underwent complete evaluations,including transrectal ultrasonography,voided bladder-3 specimen and international prostatic symptoms score （IPSS）. A total of 335 patients with prostatic calculi and 467 patients without prostatic calculi were divided into calculi and no calculi groups,respectively. Predictive factors of severe LUTS and prostatic calculi were determined using uni/multivariate analysis. The overall IPSS score was 15.7±9.2 and 14.1±9.1 in the calculi and no calculi group,respectively （P = 0.013）. The maximum flow rate was 12.1±6.9 and 14.2±8.2 mL s^（-1） in the calculi and no calculi group,respectively （P = 0.003）. On univariate analysis for predicting factors of severe LUTS,differences on age （P = 0.042）,prostatic calculi （P = 0.048） and prostatitis （P = 0.018） were statistically significant. However,on multivariate analysis,no factor was significant. On multivariate analysis for predisposing factors of prostatic calculi,differences on age （P〈0.001） and prostate volume （P = 0.001） were significant. To our knowledge,patients who have prostatic calculi complain of more severe LUTS. However,prostatic calculi are not an independent predictive factor of severe LUTS. Therefore,men with prostatic calculi have more severe LUTS not only because of prostatic calculi but also because of age and other factors. In addition,old age and large prostate volume are independent predisposing factors for prostatic calculi.

关键词： micturition prostate prostatic diseases

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Spectrum of final pathological diagnosis of gastric adenoma after endoscopic resection

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World Journal of Gastroenterology 2011年第47期17卷 5177-5183页

作者： Kwan Woo nam Kyu sang Song Heon Young Lee Byung Seok Lee Jae Kyu Seong Seok Hyun Kim Hee Seok Moon Eaum Seok Lee Hyun Yong Jeong Gastroenterology Center Sun Hospital Pathologic Department Chung-Nam National University Hospital Gastroenterology Unit of Internal Medicine Department Chung-Nam National University Hospital

AIM: To investigate how many discrepancies occur in patients before and after endoscopic treatment of referred adenoma and the reason for these results. METHODS: We retrospectively reviewed data from 554 cases of 534 patients who were referred from primary care centres for adenoma treatment and treated for endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) at Chungnam National University Hospital, from July 2006 to June 2009. Reendoscopy was examined in 142 cases and biopsywas performed in 108 cases prior to treatment. Three endoscopists (1, 2 and 3) performed all EMRs or ESDs and three pathologists (1, 2 and 3) diagnosed most of the cases. Transfer notes, medical records and endoscopic pictures of these cases were retrospectively reviewed and analyzed. RESULTS: Adenocarcinoma was 72 (13.0%) cases in total 554 cases after endoscopic treatment of referred adenoma. When the grade of dysplasia was high (55.0%), biopsy number was more than three (22.7%), size was no smaller than 2.0 cm (23.2%), morphologic type was depressed (35.8%) or yamada type Ⅳ (100%), and color was red (30.9%) or mixed-or-undetermined (25.0%), it had much more malignancy rate than the others (P < 0.05). All 18 cases diagnosed as adenocarcinoma in the re-endoscopic forceps biopsy were performed by endoscopist 1. There were different malignancy rates according to the pathologist (P = 0.027). CONCLUSION: High grade dysplasia is the most important factor for predicting malignancy as a final pathologic diagnosis before treating the referred gastric adenoma. This discrepancy can occur mainly through inappropriately selecting a biopsy site where cancer cells do not exist, but it also depends on the pathologist to some extent.

关键词： Discrepancy Adenoma High grade dyspla-sia Endoscopic mucosal resection Endoscopic submu-cosal dissection

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Void defect detection in ball grid array X-ray images using a new blob filter

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第11期13卷 840-849页

作者： Shao-hu PENG Hyun Do nam Department of Electronics and Electrical Engineering Dankook University

Ball grid arrays (BGAs) have been used in the production of electronic devices/assemblies because of their advantages of small size, high I/O port density, etc. However, BGA voids can degrade the performance of the board and cause failure. In this paper, a novel blob filter is proposed to automatically detect BGA voids presented in X-ray images. The proposed blob filter uses the local image gradient magnitude and thus is not influenced by image brightness, void position, or component interference. Different sized average box filters are employed to analyze the image in multi-scale, and as a result, the proposed blob filter is robust to void size. Experimental results show that the proposed method obtains void detection accuracy of up to 93.47% while maintaining a low false ratio. It outperforms another recent algorithm based on edge detection by 40.69% with respect to the average detection accuracy, and by 16.91% with respect to the average false ratio.

关键词： Ball grid array (BGA) X-ray Defect detection Blob detection Void detection

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Extracolonic findings of computed tomographic colonography in Koreans

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World Journal of Gastroenterology 2009年第12期15卷 1487-1492页

作者： Sung Keun Park Dong Il Park Sun-Young Lee sang Kil Lee Young-Ho Kim Soon Jin Lee Jeong-Sik Byeon Kyu Chan Huh Ki-nam Shim Department of Medicine Sungkyunkwan University School of MedicineKangbuk Samsung Hospital 108Pyung-dongJongro-guSeoul 110-746South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 110-746South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 110-746South Korea Departments of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul110-746South Korea Departments of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul110-746South Korea Department of Internal Medicine Ulsan University College of MedicineAsan Medical CenterSeoul110-746South Korea Department of Internal Medicine Konyang University School of MedicineDaejon 302-718South Korea Department of Internal Medicine Ewha Womans University School of MedicineSeoul 110-746South Korea

AIM:To determine the frequency and characteristics of extracolonic lesions detected using computed tomographic(CT)***:The significance of extracolonic lesions was classified as high,intermediate,or *** records were reviewed to establish whether further investigations were carried out pertaining to the extracolonic lesions that were detected by CT ***:A total of 920 cases from 7 university hospitals were included,and 692 extracolonic findings were found in 532(57.8%)*** 692 extracolonic findings,60 lesions(8.7%)were highly significant,250(36.1%)were of intermediate significance,and 382(55.2%)were of low *** colonography revealed fewer extracolonic findings in subjects who were without symptoms(P<0.001),younger(P<0.001),or who underwent CT colonography with no contrast enhancement(P=0.005).CT colonography with contrast enhancement showed higher cost-effectiveness in detecting highly significant extracolonic lesions in older subjects and in subjects with ***:Most of the extracolonic findings detected using CT colonography were of less significant *** role of CT colonography would be optimized if this procedure was performed with contrast enhancement in symptomatic older subjects.

关键词： Computed tomographic colonography Extracolonic lesion Cost Contrast enhancement Clinical availability

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Development of Fault Management Dispatcher Training Simulator for TDAS in Korea

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Engineering（科研） 2013年第1期5卷 7-12页

作者： In-Yong Seo sang-Ok Kim Bok-nam Ha Smart Energy Lab KEPCO Research Institute 65 Munjiro Yuseong Daejeon Korea

A fault management dispatcher training simulator for large-scale Distribution Automation System (TDAS) is developed to train operators in distribution control center. This simulator is composed of independent simulation server and operator consoles and can be used for network analysis, network operation, fault management and evaluation. TDAS DB is duplicated online to the simulation server keeping the data security. The system can model distribution network penetrated with distributed generations (DG) using the real data from the TDAS DB. Network fault scenarios are automatically generated by calculating fault current and generating fault indicators. Also, manual entry of cry wolf alarm is available. Moreover, operation solution for scenario of fault isolation and service restoration is generated automatically so that trainee can check their operation result. Operator actions during training session are saved and can be played back as well as displayed on one-line diagram pictures.

关键词： Distribution Automation System Fault Management Dispatcher Training Simulator Distributed Generation

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Development of a Peristaltic Micropump for Bio-Medical Applications Based on Mini LIPCA

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Journal of Bionic Engineering 2008年第2期5卷 135-141页

作者： Thanh Tung Nguyen My Pham nam Seo Goo Department of Aerospace Engineering Konkuk University Department of Advanced Technology Fusion Konkuk University

This paper presents the design, fabrication, and experimental characterization of a peristaltic micropump. The micropump is composed of two layers fabricated from Polydimethylsiloxane （PDMS） material. The first layer has a rectangular channel and two valve seals. Three rectangular mini lightweight piezo-composite actuators are integrated in the second layer, and used as actuation parts. Two layers are bonded, and covered by two Polymethyl Methacrylate （PMMA） plates, which help increase the stiffness of the micropump. A maximum flow rate of 900μ*** 1 and a maximum backpressure of 1.8 kPa are recorded when water is used as pump liquid. We measured the power consumption of the micropump. The micropump is found to be a promising candidate for bio-medical application due to its bio-compatibility, portability, bidirectionality, and simple effective design.

关键词： peristaltic micropump LIPCA PDMS bio-medical applications

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