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Small cell carcinoma of the liver and biliary tract without jaundice

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World Journal of Gastroenterology 2013年第44期19卷 8146-8150页

作者： Jae-Min Jo Yoo-Kyung Cho Chang-Lim Hyun Kyoung-Hee han Ji-Young Rhee Jung-Mi Kwon Woo-Kun Kim sang-hoon han Department of Internal Medicine Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing Province South Korea Department of Pathology Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing ProvinceSouth Korea Jeju National University School of Medicine Jeju-si 890-716 Jeju Self-Governing Province South Korea

An 80-year-old woman presenting with chest pain was found to have a large,lobulated soft tissue mass in the liver and nearby tissues on abdominal computed tomography(CT).The tumor had invaded the common hepatic artery and main portal *** developed 4 wk later,at which point,a pancreas and biliary CT scan revealed a large mass in the right lobe of the liver and a hilar duct obstruction,which was found to be a small cell *** its rarity,liver and bile duct small cell carcinoma should be considered in the differential diagnosis of atypical chest pain without jaundice.

关键词： Extrapulmonary small cell carcinoma Jaundice Liver mass Bile duct mass Neuroendocrine tumor

Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer

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World Journal of Gastroenterology 2015年第34期21卷 9887-9899页

作者： Jung Ho Kim You-Jin Hwang sang hoon han Young Eun Lee Saerom Kim Yoon Jae Kim Jae Hee Cho Kwang An Kwon Ju Hyun Kim Se-Hee Kim Department of Internal Medicine Gachon University Gil Medical Center Division of Biological Science Gachon University of Medicine and Science Department of Internal Medicine Jeju National University School of Medicine Gachon Medical Research Institute Gachon University Gil Medical Center

AIM:To elucidate the effects of dexamethasone on hypoxia-induced epithelial-to-mesenchymal transition(EMT) in colon ***:Human colon cancer HCT116 and HT29 cells were exposed to normoxic(21%) and hypoxic(1%) conditions. First,the effect of dexamethasone on cell viability was examined by MTT cell proliferation assay. In order to measure the expression levels of EMT markers(Snail,Slug,Twist,E-cadherin,and integrin αVβ6) and hypoxia-related genes [Hypoxia-inducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF)] by dexamethasone,quantitative real-time polymerase chain reaction and western blot analysis were performed. Furthermore,the morphological changes of colon cancer cells and the expression pattern of E-cadherin by dexamethasone were detected through immunocytochemistry. Finally,the effects of dexamethasone on the invasiveness and migration of colon cancer cells were elucidated using matrigel invasion,migration,and wound healing migration ***:Under hypoxia,dexamethasone treatment inhibited HIF-1α protein level and its downstream gene,VEGF m RNA level in the colon cancer cell lines,HCT116 and HT29. In addition,the presence of dexamethasone down-regulated the m RNA levels of hypoxia-induced Snail,Slug,and Twist,all transcriptional factors of EMT,as well as hypoxia-induced integrin αVβ6 protein level,a well-known EMT marker for colon cancer cells. Furthermore,reduced E-cadherin in hypoxic condition was found to be recoverable by treating with dexamethasone in both colon cancer cell lines. Similarly,under hypoxic conditions,dexamethasone restored the growth pattern and morphological phenotype reminiscent of colon cancer cells grown under normoxic conditions; dexamethasone blocked the migration and invasion of both colorectal cancer cell lines in ***:Our study suggested that dexamethasone has inhibitory effects on cell migration and invasion by suppressing EMT of colon cancer cell lines in hypoxic condition.

关键词： Dexamethasone Colon cancer Hypoxia Hypoxia-inducib

Preliminary Level 1 PSA Results for Sodium-Cooled Fast Reactor KALIMER-600 Conceptual Design

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Journal of Energy and Power Engineering 2011年第12期5卷 1113-1125页

作者： Tae Woon Kim sang hoon han Hae Yong Jeong Joon Eon Yang Korea Atomic Energy Research Institute 1045 Daedeok-daero Yuseong-gu Daejeon 305-353 Korea

Core damage accident scenarios are identified for the metal-fueled, sodium-cooled fast reactor （SFR）, KALIMER-600, which is under development at KAERI. A level 1 probabilistic safety assessment （PSA） model is developed using the identified accident scenarios and the system fault tree models for the safety systems which are needed to mitigate the accidents. Using the preliminary level 1 PSA models, core damage frequency is estimated for the metal fueled KALIMER-600 conceptual design. Sensitivity studies for various design alternatives of safety systems are performed to find out optimal configurations in point of view of risk minimization.

关键词： PRA PSA SFR metallic fuel accident scenarios core damage frequency safety system configuration.

Repair of heat-induced skin aging by herbal extracts and thermal protection factor(TPF)

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Repair of heat-induced skin aging by herbal extracts and the...

The Effect of Surfactant on the Shear-induced Structure and Rheological Properties of SAA/Oil/Fatty Alcohol/Water Quaternary System

第九届中国化妆品学术研讨会

作者： Hyeon Chung Kim Kuan Chi Hsu Sung Il Park Eui Dong Son Myeong hoon Yeom Dae Jin Min sang hoon han Hak Hee Kang Quen Quen He Jeong Cheol Ha Su Sun An Jae Ho Yeon Amorepacific Corporation R&D Center

Long term exposure of skin to high temperature induces activation of transient receptor potential cation channel subfamily V member 1(TRPV-1), as well as increase of matrix metalloprotease 9(MMP-9), which breaks down extracellular matrix in skin. Thus, along with photo-aging, heat also accelerates skin-aging as a long term effect. Here, heat-absorbing substances with heat energy-blocking effects were screened, and the blockage rate was calculated as "Thermal Protection Factor(TPF)". Herbal plant extracts such as Prunus Mume fruit extract and Chamaecyparis Obtusa polysaccharide were able to reduce skin damage by reducing TRPV-1 activation, heat-induced MMP-9 expression and other heat-induced inflammatory responses such as monocyte chemoattractant protein-1(MCP-1) expression. Also, a cream containing heat-absorbing and modulating actives showed statistically significant skin elasticity and redness-controlling effects in a clinical study.

关键词： Heat,skin aging TPF Prunus Mume Chamaecyparis Obtusa TRPV-1

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The Effect of Surfactant on the Shear-induced Structure and ...

Real-world outcomes of ibrutinib therapy in Korean patients with relapsed or refractory mantle cell lymphoma:amulticenter,retrospective analysis

第八届中国化妆品学术研讨会

作者： Sung-Ho Moon Chang Seok Ki Woori Bae Pi Bongsoo Heeseon An Chang Man Park Soonae An Byung-guen Chae sang-hoon han Hak-Hee Kang Jae Ho Yeon Cosmetics & Personal Care Research Institute Amore-Pacific R&D CenterKorea Amore-Pacific Shanghai R&D Center China

The effect of surfactant on the rheological properties of quaternary systems consisting of surfactant, oil,fatty alcohol and water is studied to improve the stability of O/W *** basic ternary systems show the formation of lamella liquid crystals called∝gel(alpha).On the other hand,the quaternary systems behave lamella liquid crystals including M and D *** is the study of the diverse rheological responses was done by a polarizing microscope,rheometer,differential scanning calorimetry,small angle X-ray scattering(SAXS) and *** the different kinds of surfactant is added,quaternary systems show the diverse rheological *** surfactants are used as emulsifier which is nonionic surfactant,anionic surfactant,cationic surfactant and surfactant mixtures.

关键词： Lamella liquid crystals quaternary systems Rheological Properties

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Cancer Communications 2021年第3期41卷 275-278页

作者： Jun Ho Yi Seok Jin Kim Dok Hyun Yoon Cheolwon Suh Myung Hee Chang Deok Hwan Yang Jae-Cheol Jo Shin Young Hyun Hyeon-Seok Eom Jeong-Ok Lee Ji Hyun Kwon sang hoon han Seung-Shin Lee Jae-Yong Kwak Se Hyung Kim Dae Sik Kim Ji Hyun Lee Sung Yong Oh Hun Mo Ryoo Hyo Jung Kim Won Seog Kim Division of Hematology-Oncology Department of MedicineChung-Ang UniversityDongjak-guSeoul 06973Korea Division of Hematology and Oncology Department of MedicineSamsung Medical Center Sungkyunkwan University School of MedicineGangnam-guSeoul 06351Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea National Health Insurance Corporation Ilsan Hospital Ilsandong-guGoyang 10444Korea Department of Hemato-Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolHwasunGwangju 58128Korea Department of Hematology and Oncology Ulsan University HospitalUniversity of Ulsan College of MedicineDong-guUlsan 44033Korea Department of Internal Medicine Yonsei University Wonju College of MedicineGangwon-DoWonju 26426Korea Department of Internal Medicine National Cancer CenterGoyang-si Gyeonggi-doGoyang 10408Korea Department of Internal Medicine Seoul National University Bundang HospitalBundang-guSeongnam 13620Korea Department of Internal Medicine ChungBuk National University HospitalChungbukCheongju 28644Korea Department of Internal Medicine Jeju National University HospitalJeju National University School of MedicineJeju 63241Korea Department of Hematology-Oncology Wonkwang University HospitalIksan-daeroIksan 54538Korea Department of Internal Medicine Jeonbuk National University Medical SchoolJeollabuk-doJeonju 54907Korea Division of Hematology-Oncology Department of Internal MedicineSoonchunhyang University College of MedicineBucheon HospitalWonmi-guBucheon 14584Korea Division of Hematology-Oncology Department of Internal MedicineKorea University Guro HospitalGuro-guSeoul 08308Korea Division of Hematology-Oncology Department of Internal MedicineDong-A University College of MedicineSeo-guBusan 49201Korea Department of Internal Medicine Division of Hematology-Oncology Catholic University of DaeguDaegu 42472Korea Division of Hematology-Oncology Department of Internal MedicineHallym U

Dear Editor,Despite the introduction of novel front-line therapies including rituximab plus high-dose cytarabine followed by consolidative autologous stem cell transplantation(ASCT)and salvage therapy with bendamustine,lenalidomide or bortezomib,mantle cell lymphoma(MCL)is still considered incurable and most patients experience relapse or refractory(RR)disease.

关键词： patients relapse lymphoma

Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hy brid nanocomposite system

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4249-4261页

作者： sang hoon Lee Jae Geun Song Hyo-Kyung han College of Pharmacy Dongguk University-SeoulGoyang 10326South Korea

This study aimed to develop a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for site-selective oral delivery of therapeutic antibodies. A folic acid-grafted aminoclay(FA-AC) was prepared via an in situ sol-gel method. Then, a drug-loaded nanocomplex was prepared via the electrostatic interaction of FA-AC with infliximab(IFX), a model antibody, and coated with Eudragit? S100(EFA-AC-IFX). FA-AC exhibited favorable profiles as a drug carrier including low cytotoxicity, good target selectivity, and capability to form a nanocomplex with negatively charged macromolecules. A pH-responsive FA-AC-based nanocomplex containing IFX(EFA-AC-IFX) was also obtained in a narrow size distribution with high entrapment efficiency(>87%). The conformational stability of IFX entrapped in EFA-AC-IFX was well maintained in the presence of proteolytic enzymes. EFA-ACIFX exhibited pH-dependent drug release, minimizing premature drug release in gastric conditions and the upper intestine. Accordingly, oral administration of EFA-AC-IFX to colitis-induced mice was effective in alleviating the progression of ulcerative colitis, while oral IFX solution had no efficacy. These results suggest that a pH-responsive FA-AC-based nanocomposite system can be a new platform for the site-selective oral delivery of therapeutic antibodies.

关键词： Infliximab Aminoclay Colonic delivery:TNF-x Infammation Folate rceptor Anibody Nanocomposite

Transient elastography in chronic hepatitis B: An Asian perspective

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World Journal of Gastroenterology 2010年第41期16卷 5173-5180页

作者： Seung Up Kim Kwang-Hyub han sang hoon Ahn Department of Internal Medicine Institute of Gastroenterology Yonsei University College of Medicine Seoul 120-752 South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752 South Korea Brain Korea 21 Project for Medical Science Seoul 120-752 South Kore

Transient elastography (TE) is a new non-invasive tool for assessing liver stiffness, which is correlated with the histologic stage of liver fibrosis. Many studies have reported a good accuracy of TE in predicting signif icant fibrosis and an optimal accuracy in predicting cirrhosis. Furthermore, the potential role of TE in screening the general population has also been proven. TE thus helps physicians to decide treatment strategies, predict prog-nosis, and monitor disease progression in patients with chronic liver disease and to screen the general popula-tion to identify high risk patients with potential liver disease. However, most data on the clinical roles of TE have been gathered in European patients with chronic hepatitis C (CHC), because TE was first developed in France. Accordingly, much data on the usefulness of TE in patients with CHC has accumulated. Recently, however, vigorous efforts have been made to apply TEto patients with chronic hepatitis B (CHB), and TE has also proved to have acceptable accuracy in diagnosing liver fibrosis and cirrhosis in these patients. Thus, we focused on TE in the Asian population with CHB in comparison with the European population with CHC and found that the diagnostic performance and cutoff values were different between the 2 populations possibly as a result of several different confounders between Asian and European populations (the etiology of chronic liver disease, histologic features, major fluctuation in alanine aminotransferase levels, and the prevalence of high body mass index and metabolic syndrome). Therefore, further studies tailored to the Asian population with CHB should be performed before the widespread application of TE in Asian populations with CHB.

关键词： Asia Chronic hepatitis B Fibroscan Hepatitis B virus Liver stiffness measurement Transient elas-tography

Exergetical Analysis of Organic Flash Cycle with Two-Phase Expander for Recovery of Finite Thermal Reservoirs

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Journal of Thermal Science 2014年第6期23卷 572-579页

作者： Chul Ho han Kyoung hoon Kim Department of Intelligent Mechanical Engineering Kumoh National Institute of TechnologyDaehakro 61GumiGyeongbuk 730-701Korea Department of Mechanical Engineering Kumoh National Institute of TechnologyDaehakro 61GumiGyeongbuk 730-701Korea

In this work exergetical performance analysis is carried out based on the second law of thermodynamics for organic flash cycle(OFC) using a two-phase expander instead of throttle expansion in order to recover efficiently finite thermal *** exergy destructions(anergies) at various components of the system are theoretically investigated as well as the exergy *** show that the anergy of heat exchanger or two-phase expander decreases while the anergy of throttle valve increases with increasing flash temperature,and the exergy efficiency has an optimum value with respect to the flash *** the optimal conditions with respect to the flash temperature,exergy efficiency increases with the heating temperature and the component having the largest exergy destruction varies with the flash temperature or heating temperature.

关键词： organic flash cycle(OFC) low grade heat source exergy anecgy