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Journal of Environmental Sciences 2020年第6期32卷 11-17页

作者： Jung joon lee Jihyeon Park Bo-Hyun Kim Sunjong lee Department of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419South Korea Korea Institute of Industrial Technology 89 Yangdaegiro-gilIpjang-myeonCheonan-si 31056South Korea

Regeneration of pure water is an important issue not only for the healthy life but also for the fine control of precise processes in various *** important issue in ultrahigh purified water is to reduce the amount of total organic carbon(TOC).Herein,we introduce a new approach to reduce the TOC using the surface silanized nanoparticles,in which the magnetic nanoparticles(mNPs)are silanized and then complexed with ion exchange resin(IER)*** Fe3O4 mNPs are surface modified by using high concentrated vinyltrimethoxysilane(VTMS)and then adhered on the surface of IER *** surface modified mNPs have a thick-shell of polysiloxane layer varying from 5 to 22 nm depending on the amount of VTMS used,which leads the significant increase of specific surface *** IER beads embedding VTMS-silanized mNPs achieves about 7μg/L of the TOC level in ultrapure water system,which is two orders less than 228μg/L of the feeding water and one order less than 96μg/L from the system using pristine IER *** result is mainly attributed to the polysiloxane layer forming broccoli-like surface structure and some part by the vinyl group of VTMS exposed to the amines in the water.

关键词： Total organic carbon Ultrapure water Magnetic nanoparticle Ion-exchange resin Hybrid structure

Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4^(+)T cells

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Cellular & Molecular Immunology 2023年第5期20卷 525-539页

作者： Jiung Jeong In Kang Yumin Kim Keun Bon Ku Jang Hyun Park Hyun-Jin Kim Chae Won Kim Jeongwoo La Hi Eun Jung Hyeon Cheol Kim Young joon Choi Jaeho Kim joon Kim Heung Kyu lee Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Internal Medicine Seoul National University HospitalSeoul 03080Republic of Korea Department of Biological Sciences KAISTDaejeon 34141Republic of Korea Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea.

CD4^(+)T cells play major roles in the adaptive immune system,which requires antigen recognition,costimulation,and cytokines for its elaborate *** studies have provided new insight into the importance of the supramolecular activation cluster(SMAC),which comprises concentric circles and is involved in the amplification of CD4^(+)T cell ***,the underlying mechanism of SMAC formation remains poorly ***,we performed single-cell RNA sequencing of CD4^(+)T cells left unstimulated and stimulated with anti-CD3 and anti-CD28 antibodies to identify novel proteins involved in their *** found that intraflagellar transport 20(IFT20),previously known as cilia-forming protein,was upregulated in antibody-stimulated CD4^(+)T cells compared to unstimulated CD4^(+)T *** also found that IFT20 interacted with tumor susceptibility gene 101(TSG101),a protein that endocytoses ubiquitinated T-cell *** interaction between IFT20 and TSG101 promoted SMAC formation,which led to amplification of AKT-mTOR ***,IFT20-deficient CD4^(+)T cells showed SMAC malformation,resulting in reduced CD4^(+)T cell proliferation,aerobic glycolysis,and cellular ***,mice with T-cell-specific IFT20 deficiency exhibited reduced allergen-induced airway ***,our data suggest that the IFT20-TSG101 axis regulates AKT-mTOR signaling via SMAC formation.

关键词： CD4^(+)T cell Intraflagellar transport 20 Tumor susceptibility gene 101 AKT-mTOR signaling Asthma Supramolecular activation cluster

Arabidopsis TOR signaling is essential forsugar-regulated callus formation

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Journal of Integrative Plant Biology 2017年第10期59卷 742-746页

作者： Kyounghee lee Pil joon Seo Department of Biological Sciences Sungkyunkwan University Suwon 16419 Korea

Dedifferentiation is a remarkable process that produces pluripotent stem cells from differentiated somatic cells to ensure developmental *** have evolved the ability of cellular dedifferentiation,and signaling cascades related to auxin and cytokinin-dependent callus formation have been extensively ***,the molecular mechanism underlying sugar-dependent callus format:ion remains ***,we show that sugar-dependent callus formation is mainly regulated by the TOR-E;Fa module in ***-activated TOR kinase phosphorylates and stabilizes E;Fa proteins to transcriptionally activate S-phase genes during callus *** parallel,E;Fa is transcriptionally regulated by the ARF-LBD transcription ***:i-layered regulation of E;Fa by sugar and auxin is likely to shape balanced cellular dedifferentiation capability in Arabidopsis.

关键词： TOR Figure CIM LBD

High speed continuous turning of hardened steel with newly developed low content PCBN

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金刚石与磨料磨具工程 2008年第S1期28卷 80-82页

作者： lee sang-Yong Park Byong-joon Oh Jeang Ook ILJIN Diamond Co. Ltd.Eumsung-KunChucheongbuk-Do369-824KOREA

In this study,newly developed low content PCBN was used to evaluate the cutting performance in high speed turning of hardened *** new PCBN and commercially available PCBN tipped inserts under the same cutting condition,cutting performance with variable cutting speed,feed rate and depth of cuts on tools were measured by observation of flank and crater *** microstructures were analyzed through SEM microscope,measurement of surface roughness on workpiece was also performed. According to cutting performance results,it is shown that new PCBN shows much longer tool life in high speed continuous turning than our conventional PCBN tools,with improved wear and chipping *** result on the machinability of new PCBN for hardened steel will provide effective guidelines to manufacturing engineers,also provide useful economic machining solution for high speed continuous turning for hardened steel.

关键词： High speed continuous turning of hardened steel with newly developed low content PCBN high

Primary duodenal dedifferentiated liposarcoma:A case report and literature review

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World Journal of Clinical Cases 2022年第6期10卷 2007-2014页

作者： Nah Ihm Kim Ji Shin lee Chan Choi Jong Hee Nam Yoo Duk Choi Hee joon Kim Sung Sun Kim Department of Pathology Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Dedifferentiated liposarcoma(DDLPS)is an extremely rare neoplasm that exhibits various *** tumor is characterized by immunoreactivity to MDM2 and CDK4 and can be confirmed by detecting MDM2 amplification via fluorescence in situ hybridization(FISH).Herein,we report an unusual case of DDLPS arising from the *** SUMMARY A 64-year-old man presented with repeated abdominal pain and weight *** studies revealed a mass of the duodenum involving the *** patient was treated with pylorus-preserving ***,the tumor showed a high-grade *** demonstrated that the tumor cells were positive for MDM2 and CDK4 ***2 amplification was detected via FISH,leading to the final diagnosis of *** surgery,the patient was treated in the intensive care unit due to peritonitis,and died 60 d after *** To the best of the authors’knowledge,this is the first case of primary duodenal DDLPS in Korea and the third case in the English-language *** must be taken not to misdiagnose DDLPS as another high-grade *** should be in the differential diagnosis list.

关键词： Liposarcoma Primary Small bowel Duodenum Immunohistochemistry Case report

Serial blood concentration of polyethoxylated tallow amine and clinical presentations in acute herbicide poisoning

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World Journal of Emergency Medicine 2022年第4期13卷 305-308页

作者： Jungsoo Park Sun Cheun Kim Youngjoon Jeon Yong Chul Cho Changshin Kang Yeonho You Hong joon Ahn Seung Ryu Jihan lee Wonjoon Jeong Department of Emergency Medicine Chungnam National University HospitalDaejeon 35015South Korea Department of Emergency Medicine College of MedicineChungnam National UniversityDaejeon 35015South Korea Forensic Toxicology Division National Forensic ServiceDaejeon 34054South Korea Department of Emergency Medicine Chungbuk National University HospitalCheongju 28644South Korea

Most commercially available herbicides contain surfactants as co-formulants to increase adhesion and absorption by plant *** amines,one of the most used surfactants,are non-ionic and derived from animal *** represent a class of surfactants with similar structural features,including polyethoxylated tallow amine(POEA).POEA is widely used in glyphosate,glufosinate-containing *** 2015,the European Food Safety Society(EFSA)concluded that POEA was more toxic than glyphosate when tested in glyphosate-based formulations.[1]They also attributed the poisoning following ingestion by humans to the presence of POEA.

关键词： attributed formulation ethoxy

Anti-C4d chimeric antigen receptor regulatory T cells suppressed allograft rejection in ABO-incompatible heart transplantation

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Genes & Diseases 2022年第1期9卷 1-4页

作者： Sun-Kyung lee Jerome Han Honglin Piao Nara Shin joon Young Jang Ji-Jing Yan Hyori Kim Junho Chung Jaeseok Yang Biomedical Research Institute Seoul National University HospitalSeoul 03080Republic of Korea Department of Medicine Graduate SchoolSeoul National University College of MedicineSeoul 03080Republic of Korea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Biomedical Science Seoul National University College of MedicineSeoul 03080Republic of Korea Cancer Research Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Nephrology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Convergence Medicine Research Center Asan Medical CenterSeoul 05505Republic of Korea

ABO blood group-incompatible(ABOi)transplantation has been developed to overcome the serious problem of donor organ ***,antibody-mediated rejection(ABMR)remains as the main limitation to successful ABOi *** of desensitization treatment improved the outcomes of ABOi transplantation by suppressing ABMR;however,this strong,nonspecific immunosuppression also increases infectious ***,chimeric antigen receptor regulatory T cells(CAR Tregs)were developed to improve the antigen specificity,viability,and suppressive activity of Tregs.C4d deposition is a marker of ABMR and is also found in most ABOi allograft *** on these findings,we developed anti-C4d CAR Tregs to suppress ABMR in ABOi allografts.

关键词： C4d ABO allograft

Intraoperative sudden arrhythmias in cervical spine surgery adjacent to the stellate ganglion:A case report

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世界临床病例杂志 2023年第24期11卷 5789-5796页

作者： Jong-Hun Seo Su-Yeon Cho Ji-Hwan Park Jin-Young Seo Hyun-Young lee Dong-joon Kim Department of Neurosurgery Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine College of MedicineChosun UniversityGwangju 61453South Korea

BACKGROUND Atrial arrhythmias such as paroxysmal supraventricular tachycardia(PSVT)and atrial flutter(AF)are common in the perioperative *** commonly resolve ***,occasionally,they may continually progress to fatal arrhythmias or cause ***,prompt and appropriate management is *** SUMMARY A 46-year-old female patient diagnosed with cervical C6-7 radiculopathy characterized by decreased sensation in the right third,fourth and fifth fingers underwent C6-7 anterior cervical disc fusion *** showed PSVT and ventricular tachycardia during C6-7 disc ***,the patient remained *** treatment with esmolol and lidocaine for ventricular tachycardia was *** massage and Valsalva maneuver were attempted but PSVT did not *** surgery was paused,and the patient’s fraction of inspired oxygen was set to 100%.Adenosine was administered for pharmacological management of *** arrhythmia temporarily ***,it then transformed into *** was administered,which briefly decreased blood pressure,which immediately *** resumed while the patient was in normal sinus *** was discharged safely on postoperative day 6 without complications or ***,she is living a healthy life without arrhythmia *** Ganglia associated with cardiac arrhythmias in the surgical site should be identified during cervical spine surgery.

关键词： Supraventricular tachycardia Atrial flutter Stellate ganglion Adenosine Diltiazem Case Report

S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis

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Bone Research 2019年第4期7卷 424-436页

作者： Haemin Kim Bongjun Kim sang Il Kim Hyung joon Kim Brian YRyu Junho Chung Zang Hee lee Hong-Hee Kim Department of Cell and Developmental Biology BK21 Program and DRISeoul National UniversitySeoulKorea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Cancer Biology Seoul National University College of MedicineSeoulKorea Department of Oral Physiology BK21 PLUS Projectand Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanKorea Interdisciplinary Program in Bioinformatics Seoul National University College of Natural SciencesSeoulKorea Department of Biomedical Sciences Seoul National University Graduate SchoolSeoulKorea

Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer *** between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and ***-derived factors play fundamental roles in this form of *** identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer *** subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor *** S100A4 stimulated osteoclastogenesis in vitro and bone loss in *** medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate ***,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown *** addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in *** together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.

关键词： S100A4 breast metastatic

New Insights into Sinus Venosus Defects from Cross-Sectional Imaging

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Congenital Heart Disease 2022年第1期17卷 5-23页

作者： Shi-joon Yoo sanga lee Regina de la Mora Ankavipar Saprungruang Christoph Haller lee N.Benson Vladimiro Vida Alvise Guariento Christopher Z.Lam Department of Diagnostic Imaging Hospital for Sick ChildrenUniversity of TorontoTorontoCanada Division of Cardiology Department of PaediatricsLabatt Family Heart CentreHospital for Sick ChildrenUniversity of TorontoTorontoCanada Department of Diagnostic Imaging Sejong Heart CenterBucheonKorea Department of Radiology Instituto Nacional de CardiologíaMexico CityMexico Division of Cardiac Surgery Department of SurgeryLabatt Family Heart CentreHospital for Sick ChildrenUniversity of TorontoTorontoCanada Pediatric and Congenital Cardiac Surgery Unit University of Padua Medical SchoolPaduaItaly

Sinus venosus defects include two varieties,superior and inferior sinus venosus *** superior sinus venosus defect is characterized by abnormal communication between two closely related venoatrial structures:1)the normally positioned superior vena cava-right atrium complex and 2)the right pulmonary vein-left atrium complex that is displaced leftward,forward and *** sinus venosus defects primarily involve the inferior vena cava-right atrial junction while the right pulmonary vein-left atrial junction can also be *** of the rarity and wide variation of the defects,the morphological characterization of sinus venosus defects is inconsistent among investigators and often *** imaging technologies with high spatial and temporal resolutions have allowed accurate and detailed assessment of the pathological anatomy in larger numbers of *** this pictorial essay,we revisit the established and controversial features of the sinus venous defects using twodimensional(2D)and three-dimensional(3D)images obtained by magnetic resonance(MR)or computed tomography(CT)with brief discussion on imaging and treatment strategies.

关键词： Sinus venosus defect superior sinus venosus defect inferior sinus venosus defect anomalous pulmonary venous connection overriding superior vena cava overriding inferior vena cava