检索结果-南通市图书馆

clustering-based label estimation for network anomaly detection

在线全文

学校读者我要写书评

暂无评论

Digital communications and Networks 2021年第1期7卷 37-44页

作者： Sunhee Baek Donghwoon Kwon sang c.suh Hyunjoo Kim Ikkyun Kim Jinoh Kim computer Science Department Texas A&M UniversityCommerceTX75429USA ETRI 218 Gajeong-roYuseong guDaejeon34129Republic of Korea

A substantial body of work has been done to identify network anomalies using supervised and unsupervised learning techniques with their unique strengths and *** this work,we propose a new approach that takes advantage of both worlds of unsupervised and supervised *** main objective of the proposed approach is to enable supervised anomaly detection without the provision of the associated labels by *** this end,we estimate the labels of each connection in the training phase using ***“estimated”labels are then utilized to establish a supervised learning model for the subsequent classification of connections in the testing *** set up a new property that defines anomalies in the context of network anomaly detection to improve the quality of estimated *** our extensive experiments with a public dataset(NSL-KDD),we will prove that the proposed method can achieve performance comparable to one with the “original”labels provided in the *** also introduce two heuristic functions that minimize the impact of the randomness of clustering to improve the overall quality of the estimated labels.

关键词： Label estimation Network anomaly detection clustering randomness

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： chanchal Sharma Sehwan Kim Hyemi Eo sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Quantitative analysis of mechanical properties associated with aging treatment and microstructure in Mg-Al-Zn alloys through machine learning

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第12期107卷 52-63页

作者： Joung Sik suh Byeong-chan suh sang Eun Lee Jun Ho Bae Byoung Gi Moon Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The present study proposes a methodology for predicting the mechanical properties of AZ61 and AZ91alloys associated with microstructure,texture and aging parameters and estimating predictor *** this,we investigate quantitative correlations between microstructure,texture and mechanical properties of aged AZ61 and AZ91 rods through machine *** regression analysis focuses on the precipitation behavior of Mg17Al12as the main second phase of Mg-Al-Zn alloys with respect to aging *** simplify data generation,only SEM images were used to quantify the features of discontinuous and continuous *** overcome the lack of data and make the most of the measured data,we devised a method to extend the existing dataset by a factor of 9 using the mean and standard deviation of the measured *** neural networks predicted tensile and compressive yield strengths and resultant yield asymmetry with a high accuracy of over 98%using 11 predictors for a total of *** tree learning quantitatively assessed the importance of predictors in determining the mechanical properties of aged AZ61 and AZ91 rods.

关键词： Magnesium alloy Aging treatment Microstructure Mechanical properties Machine learning

Status and prospects for symmetric organic redox flow batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Prognostic value of changes in serum carcinoembryonic antigen levels for preoperative chemoradiotherapy response in locally advanced rectal cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第44期26卷 7022-7035页

作者： chinock cheong Jun sang Shin Kwang Wook suh Department of Surgery Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BAcKGROUND Preoperative chemoradiotherapy(cRT)is a standard treatment modality for locally advanced rectal ***,cRT alone cannot improve overall *** 20%of patients with cRT-resistant tumors show disease ***,predictive factors for treatment response are needed to identify patients who will benefit from *** theorized that the prognosis may vary if patients are classified according to pre-to post-cRT changes in carcinoembryonic antigen(cEA)*** To identify patients with locally advanced rectal cancer for preoperative chemoradiotherapy based on carcinoembryonic antigen *** We retrospectively included locally advanced rectal cancer patients who underwent preoperative cRT and curative resection between 2011 and *** were assigned to groups A,B,and c based on pre-and post-cRT serum cEA levels:Both>5;pre>5 and post≤5;and both≤5 ng/mL,*** compared the response to cRT based on changes in serum cEA *** operating characteristic curve analysis was performed to determine optimal cutoff for neutrophil–lymphocyte ratio and platelet–lymphocyte *** logistic regression analysis was used to evaluate the prognostic factors for pathologic complete response(pcR)/good *** The cohort comprised 145 patients;of them,27,43,and 65 belonged to groups A,B,and c,respectively,according to changes in serum cEA levels before and after ***-(PcRT(PcEA levels and the ratio of downstaging(P=0.013)were higher in Groups B and c than in Group *** ratio of pathologic tumor regression grade 0/1 significantly differed among the groups(P=0.003).Group c had the highest number of patients showing pcR(PcR showed pre-and post-cRT cEA levelscRT cEA levels were important risk factors for pcR(OR=18.71;95%cI:4.62–129.51,PcI:1.92–14.83,P=0.002),***-cRT

关键词： Rectal cancer Neoadjuvant chemoradiation therapy carcinoembryonic antigen levels Prognostic factor change in serum carcinoembryonic antigen Response of chemoradiotherapy

Effect of Al addition on corrosion behavior of high-purity Mg in terms of processing history

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2023年第3期11卷 851-868页

作者： sang Kyu Woo Byeong-chan suh Ha Sik Kim chang Dong Yim Helmholtz Zentrum Hereon Max-Planck-Straße 1Geesthacht D-21502Germany Korea Institute of Materials Science 797 Changwondae-roSeongsan-guChangwonGyeongnam 51508Republic of Korea University of Science and Technology 217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

In this study,the effects of Al addition on the corrosion behavior of pure Mg with controlled impurity contents were systematically analyzed according to the processing *** results revealed that the corrosion behavior of high-purity Mg-Al alloys is strongly related to changes in the microstructure,including theβphase and Al-Mn or Al-Fe phases,and the protectiveness of the surface film according to the Al content and processing *** the as-cast alloys,the corrosion rate increased due to the increase ofβphase as the Al content increased,but in the as-extruded alloys,the corrosion rate,which was high due to intermetallic compounds caused by impurities in the low Al alloy,decreased as the Al content increased,and then increased *** is due to the combined effect of the increase of theβphase and decrease of the impurity effect,and the increase of the dissolved Al *** results suggest that it is necessary to analyze the effect of alloying elements on the corrosion behavior of pure Mg with information concerning the impurity content and processing history.

关键词： Mg High purity Mg-Al alloys Processing history Micro-galvanic Surface film

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

current management of hepatocellular carcinoma:An Eastern perspective

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第13期21卷 3826-3842页

作者： Hyung Joon Yim sang Jun suh Soon Ho Um Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalAnsan-si 425-707Gyeonggi-doSouth Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Anam HospitalKorea University College of MedicineSeoul 136-705South Korea

Hepatocellular carcinoma(Hcc) is one of the leading causes of cancer death, especially in Eastern areas. With advancements in diagnosis and treatment modalities for Hcc, the survival and prognosis of Hcc patients are improving. However, treatment patterns are not uniform between areas despite efforts to promote a common protocol. Although many hepatologists in Asian countries may adopt the principles of the Barcelona clinic Liver cancer staging system, they are also independently making an effort to expand the indications of each treatment and to combine therapies for better outcomes. Several expanded criteria for liver transplantation in Hcc have been developed in Asian countries. Living donor liver transplantation is much more commonly performed in these countries than deceased donor liver transplantation, and it may be preceded by other treatments such as the down-staging of tumors. Local ablation therapies are often combined with transarterial chemoembolization( TAcE) and the outcome is comparable to that of surgical resection. The indications of TAcE are expanding, and there are new types of transarterial therapies. Although data on drug-eluting beads, TAcE, and radioembolization in Asian countries are still relatively sparse compared with Western countries, these methods are gradually gaining popularity because of better tolerability and the possibility of improved response rates. Hepatic arterial infusion chemotherapy and radiotherapy are not included in Western guidelines, but are currently being used actively in several Asian countries. For more advanced Hccs, appropriate combinations of TAcE, radiotherapy, and sorafenib can be considered, and emerging data indicate improved outcomes of combination therapies compared with single therapies. To include these paradigm shifts into newer treatment guidelines, more studies may be needed, but they are certainly in progress.

关键词： Hepatocellular carcinoma Eastern Treatment Guideli

Multiple sclerosis is at a checkpoint: advancing the program

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage