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Chinese Chemical Letters 2007年第7期18卷 817-819页

作者： Xiao Zhong Fu Sai Hong Jiang Jian Xin Yu She Yang RU yun Ji School of Pharmacy Guiyang Medical College Guiyang 550004 China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institute for Biological SciencesChinese Academy of Science Shanghai 201203 China Shanghai Fudan-Yueda Bio-Tech Co. Ltd. Shanghai 201203 China

A series of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 μmol/L and 2530 μmol/L, respectively.

关键词： Acyclic nucleoside phosphonates L-Amino acid Prodrug Anti-HBV activity

Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study

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World Journal of Gastroenterology 2017年第7期23卷 1268-1277页

作者： Rui-Qi Yang Hua Mao Li-yun Huang Pei-Zhu Su Min Lu Department of Digestive Diseases Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280Guangdong ProvinceChina

AIM To evaluate the effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality. METHODS Forty-eight patients diagnosed with gastric ulcer between June 2014 and February 2016 were randomly allocated to the combination therapy group or monotherapy group. The former received hydrotalcite combined with esomeprazole, and the latter received esomeprazole alone, for 8 wk. Twenty-four healthy volunteers were recruited and acted as the healthy control group. Endoscopic ulcer healing was observed using white light endoscopy and narrow band imaging magnifying endoscopy. The composition of collagen fibers, amount of collagen deposition, expression of factor. and TGF-beta 1, and hydroxyproline content were analyzed by Masson staining, immunohistochemistry, immunofluorescent imaging and ELISA. RESULTS Following treatment, changes in the gastric microvascular network were statistically different between the combination therapy group and the monotherapy group (P < 0.05). There were significant differences (P < 0.05) in collagen deposition, expression level of Factor. and TGF-beta 1, and hydroxyproline content in the two treatment groups compared with the healthy control group. These parameters in the combination therapy group were significantly higher than in the monotherapy group (P < 0.05). The ratio of collagen. to collagen. was statistically different among the three groups, and was significantly higher in the combination therapy group than in the monotherapy group (P < 0.05). CONCLUSION Hydrotalcite combined with esomeprazole is superior to esomeprazole alone in improving gastric ulcer healing quality in terms of improving microvascular morphology, degree of structure maturity and function of regenerated mucosa.

关键词： Hydrotalcite Esomeprazole Gastric ulcer Quality of ulcer healing

Value of Adjuvant Radiotherapy for Thymoma with Myasthenia Gravis after Extended Thymectomy

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Chinese Medical Journal 2018年第8期131卷 927-932页

作者： Chang-Feng Lu Lei YU yun Jing yun-Feng Zhang Ji Ke Department of Neurology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Thoracic Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background：The co-existence of myasthenia gravis （MG） and thymoma makes the surgical treatment more complicated and adjuvant radiation more controversial. The aim of this study was to investigate adjuvant radiotherapy for thymoma with MG after extended ***：A total of 181 patients with both MG and thymoma were recruited between 2003 and 2014 at Tongren Hospital, China. Among all the patients, 157 patients received radiation therapy after surgery （Group A）; whereas the other 24 patients did not receive radiation therapy （Group B）. According to the time that patients started mediastinal radiation therapy, we subdivided the 157 patients in Group A into subgroups （1-month subgroup, n = 98; 2-month subgroup, n = 7; and 3-month subgroup, n = 52）. We then compared the effect of the mediastinal radiation therapy across these different groups using the survival rate, the rate of postoperative myasthenic crisis, and the complete stable remission （CSR） rate as the primary ***：There was a significant difference in the occurrence of postoperative myasthenic crisis between 1-month subgroup and Group B （χ2 = 4.631, P = 0.031）. The rates of reaching CSR were 32.6% in 1-month subgroup, 25% in 3-month subgroup, and 22.7% in Group B, respectively. The overall survival rates of 1-month subgroup, 3-month subgroup, and Group B were 88.8%, 83.3%, and 77.3%, respectively. Analysis on the Kaplan-Meier survival curves demonstrated that within 8 years after surgery, there was no significant difference in aspects of overall survival and disease-free survival between 1-month subgroup and Group B, and between 3-month subgroup and Group B; over 8 years after surgery, the disease-free survival rates in 1-month subgroup, 3-month subgroup and Group B were 79.4%, 70.6%, and 55.3%, ***：Adjuvant radiation within 1 month after extended thymectomy may be helpful in controlling postoperative MG, such as decreasing the possibility of postoperative myasthenic

关键词： Myasthenia Gravis Prognosis Radiotherapy Thymectomy Thymoma

Some improvements of the marching cubes algorithm for the rendering of an orebody

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Journal of China University of Mining and Technology 2008年第2期18卷 194-198页

作者： LI Chun-min LI Zhong-xue WANG yun-hai HAO Xiu-qiang Institute of Mine Safety China Academy of Safety Science and Technology Beijing 100029 China School of Civil and Environment Engineering University of Science and Technology Beijing Beijing 100083 China

Orebody-rendering techniques are developed using the marching cubes (MC) algorithm. The shape of an orebody is viv- idly displayed in real time and can be used to guide mining design as well. The MC algorithm has been improved in two aspects. By analyzing the principles of the MC algorithm, as well as the features of the specific application, improvements were developed to: eliminate ambiguities by using a unified isosurface constructing method in the voxels, and improve the operating efficiency of the MC algorithm by incorporating an octree structure. The analytical results of the examples demonstrate the effectiveness of our proposal.

关键词： underground mines marching cubes algorithm 3D visualization octree

Adaptive Control of MIMO Mechanical Systems with Unknown Actuator Nonlinearities Based on the Nussbaum Gain Approach

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IEEE/CAA Journal of Automatica Sinica 2016年第1期3卷 26-34页

作者： Ci Chen Zhi Liu yun Zhang C.L.Philip Chen Shengli Xie School of Automation Guangdong University of Technology IEEE Faculty of Science and Technology University of Macao Guangdong Key Laboratory of IoT Information Processing

This paper investigates MIMO mechanical systems with unknown actuator nonlinearities. A novel Nussbaum analysis tool for MIMO systems is established such that unknown time-varying control coefficients are tackled. In contrast to existing literatures on continuous-time systems, the newly-developed Nussbaum tool focuses on extending the traditional Nussbaum result from one dimensional case to the multiple one. Specifically, not only the multiple unknown input coefficients are extended to the time-varying, but also the limitation of the prior knowledge of coefficients' upper and lower bounds is removed. Furthermore, an adaptive robust controller associated with the proposed tool is presented. The asymptotic tracking of MIMO mechanical systems is guaranteed with the help of the Lyapunov Theorem. Finally, a simulation example is provided to examine the validity of the proposed scheme. © 2014 Chinese Association of Automation.

关键词： Actuators Adaptive control systems Control nonlinearities Mechanical actuators Mechanics MIMO systems Time varying control systems

Synergistic Interfacial and Doping Engineering of Heterostructured NiCo(OH)_(x)-Co_(y)W as an Efficient Alkaline Hydrogen Evolution Electrocatalyst

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Nano-Micro Letters 2021年第8期13卷 94-106页

作者： Ruopeng Li Hao Xu Peixia Yang Dan Wang yun Li Lihui Xiao Xiangyu Lu Bo Wang Jinqiu Zhang Maozhong An MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China

To achieve high efficiency of water electrolysis to produce hydrogen(H_(2)),developing non-noble metal-based catalysts with consid-erable performance have been considered as a crucial strategy,which is correlated with both the interphase properties and multi-metal synergistic ***,as a proof of concept,a delicate NiCo(OH)_(x)-CoyW catalyst with a bush-like heterostructure was realized via gas-template-assisted electrodeposition,followed by an electrochemical etching-growth process,which ensured a high active area and fast gas release kinetics for a superior hydrogen evolution reaction,with an overpotential of 21 and 139 mV at 10 and 500 mA cm^(−2),*** and electrochemical analyses demonstrated that the synergistic effect of the NiCo(OH)_(x)-Co_(y)W heteroge-neous interface resulted in favorable electron redistribution and faster electron transfer *** amorphous NiCo(OH)_(x) strengthened the water dissociation step,and metal phase of CoW provided sufficient sites for moderate H immediate adsorption/H_(2) *** addition,NiCo(OH)_(x)-CoyW exhibited desirable urea oxidation reaction activity for matching H_(2) generation with a low voltage of 1.51 V at 50 mA cm^(−2).More importantly,the synthesis and testing of the NiCo(OH)_(x)-CoyW catalyst in this study were all solar-powered,sug-gesting a promising environmentally friendly process for practical applications.

关键词： Interfacial and doping engineering Heterostructured electrocatalyst Solar-driven Hydrogen evolution Urea-assisted water splitting

Synthesis and Photocatalytic Activity of Ti-pillared Bentonite

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Acta Geologica Sinica(English Edition) 2006年第2期80卷 273-277页

作者： TANG Jianwen WU Pingxiao ZHENG Shaoyan LIU yun WANG Feifei XIE Xianfa College of Environmental Science and Engineering South China University of Technology Guangzhou Guangdong 510640

Ti-pillared bentonite has been successfully prepared using a modified method that can induce the transformation of TiO2 pillar from amorphous to anatase phase at a low temperature （150℃）. The value of d0.01 =1.94 nm obtained by Ti-pillared bentonite is larger than that of corresponding raw clay （1.56 nm）. Due to large numbers of Ti-pillars formed, the Ti-pillared bentonite shows an excellent ability in adsorbing Rhodamine B （RB）. The photocatalytic activity and kinetic equation are investigated by decomposing RB solution under the UV irradiation. It is found that the Ti- pillared bentonite shows super photocatalytic activity for the degradation of RB solution compared with the untreated bentonite and pure TiO2, and the kinetic equation of the degradation of RB solution is a 1.5-oder equation.

关键词： Ti-pillared bentonite photocatalyst kinetic equation adsorption clay

Preliminary Studies on CPG/Hinf Ⅰ RFLP Groups of Citrus tristeza virus Infected Sweet Oranges in China

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Agricultural Sciences in China 2006年第1期5卷 39-44页

作者： XU Xiao-feng ZHOU Chang-yong SONG Zhen YANG Fang-yun Citrus Research Institute Chinese Academy of Agricultural Sciences Chongqing 400712 P.R.China College of Plant Protection Southwest University Chongqing 400716 P.R.China

Citrus tristeza virus （CTV） causes economically important losses to the citrus industry worldwide. Mild strain cross protection （MSCP） against tristeza has hardly been practised due to mixed infection of different CTV-strains and little background of its molecular biology in China. For better cognition on CTV, 192 sweet orange samples collected from eight provinces （Chongqing, Sichuan, Fujian, Hunan, Guangxi, yunnan, Guangdong and Jiangxi） were tested by direct tissue blot immuno-assay （DTBIA）, and 158 of them were tested positively, which therefore were subjected to coat protein gene （CPG）/Hinf Ⅰ restriction fragment length polymorphism （RFLP） analysis. Sample bulks were compared between Chongqing and Fujian by some statistical data, including ratios of single infection and mixed infection to local samples, proportions of CTV isolates with single RFLP groups, and rates of each RFLP group. The simplified analysis of samples from the other six provinces were then conducted. This study suggests that CTV isolates with CPG/Hinf Ⅰ RFLP groups Ⅲ and Ⅰ are the main epidemic ones in China, and mixed infection of CTV in fields are popular. Based on observation of severity of stem-pitting symptom in field trees, CTV isolates with CPG/Hinf Ⅰ RFLP groups Ⅲ and Ⅰ caused severe stem-pittings in sweet oranges in China.

关键词： Citrus tristeza virus (CTV) CPG/Hinf Ⅰ RFLP groups stem-pitting sweet orange

Compound Sophorae Decoction:treating ulcerative colitis by affecting multiple metabolic pathways

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Chinese Journal of Natural Medicines 2021年第4期19卷 267-283页

作者： HONG Zong-Chao CAI Quan WU He-Zhen YANG Yan-Fang FAN Heng DUAN Xue-yun Hubei University of Chinese Medicine Wuhan 430065China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061China Hubei Province Academy of Traditional Chinese Medicine Wuhan 430074China Department of Integrated Traditional Chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Huangshi No.5 Hospital Huangshi 435005China

Ulcerative colitis(UC)is a chronic refractory non-specific intestinal inflammatory disease that is difficult to be *** discovery of new ulcerative colitis-related metabolite biomarkers may help further understand UC and facilitate early *** may also provide a basis for explaining the mechanism of drug action in the treatment of *** Sophorae Decoction(CSD)is an empirical formula used in the clinical treatment of *** it is known to be efficacious,its mechanism of action in the treatment of UC is *** purpose of this study was to investigate the changes in endogenous substances in UC rats and the effects of CSD on metabolic pathways using the metabonomics *** studies in rats with UC and normal rats were performed using LC-MS/*** with UC induced using TNBS enema were used as the study *** profiling and pathway analysis of biomarkers was performed using statistical and pathway enrichment analyses.36 screened potential biomarkers were found to be significantly different between the UC and the normal groups;it was also found that CSD could modulate the levels of these potential *** was found to be efficacious in UC by regulating multiple metabolic pathways.

关键词： Compound Sophorae Decoction Ulcerative colitis LC-MS/MS Biomarker Metabolomics

Distribution of O^(+)and O_(2)^(+) fluxes and their escape rates in the near-Mars magnetotail:A survey of MAVEN observations

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Earth and Planetary Physics 2022年第6期6卷 536-545页

作者： HengLe Du Xing Cao BinBin Ni Song Fu Xin Ma XiaoTong yun MinYi Long Qiong Luo Department of Space Physics School of Electronic InformationWuhan UniversityWuhan 430072China Chinese Academy of Sciences Center for Excellence in Comparative PlanetologyHefei 230026China

Tailward ion outflows in the Martian-induced magnetotail are known to be one of the major channels for Martian atmospheric *** the basis of nearly 6.5 years of observations from the Mars Atmosphere and Volatile EvolutioN(MAVEN)mission,we investigate the statistical distribution of tailward and Marsward fluxes of heavy ions(i.e.,O^(+),and O_(2)^(+))in the near-Mars magnetotail and explore their characteristic responses to the corotating interaction region(CIR),solar wind dynamic pressure,and local magnetic field *** results show that the tailward fluxes of oxygen ions and molecular oxygen ions in the magnetotail are significantly greater than their Marsward fluxes and that the tailward flux of molecular oxygen ions is generally larger than that of oxygen ***,the tailward ion flux distribution exhibits dependence on the CIR,solar wind dynamic pressure,and local magnetic field strength in a manner stronger than the Marsward ion flux *** to the distribution of tailward ion fluxes,we calculate the corresponding escape rates of heavy ions and show that when the CIR occurs,the total escape rates of oxygen ions and molecular oxygen ions increase by a factor of~2 and~1.2,*** also find that the escape rates of heavy ions increase with the enhancement of solar wind dynamic pressure,whereas the overall effect of the local magnetic field is relatively *** study has important implications for improved understanding of the underlying mechanisms responsible for the Martian atmospheric escape and the evolution of the Martian atmospheric climate.

关键词： Martian-induced magnetotail atmospheric heavy ion outflow corotating interaction region escape rate