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Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors?

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World Journal of Gastroenterology 2017年第11期23卷 2037-2043页

作者： su Bum park Dong Jun Kim Hyung Wook Kim Cheol Woong Choi Dae Hwan Kang su Jin Kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanGyeongsangnam-do 626-770South Korea

AIM To evaluate the importance of endoscopic ultrasonography(EUS) for small(≤ 10 mm) rectal neuroendocrine tumor(NET) *** Patients in whom rectal NETs were diagnosed by endoscopic resection(ER) at the Pusan National University Yangsan Hospital between 2008 and 2014 were included in this study. A total of 120 small rectal NETs in 118 patients were included in this study. Histologic features and clinical outcomes were analyzed, and the findings of endoscopy, EUS and histology were compared. REsuLTS The size measured by endoscopy was not significantly different from that measured by EUS and histology(r = 0.914 and r = 0.727 respectively). Accuracy for the depth of invasion was 92.5% with EUS. No patients showed invasion of the muscularis propria or metastasis to the regional lymph nodes. All rectal NETswere classified as grade 1 and demonstrated an L-cell phenotype. Mean follow-up duration was 407.54 ± 374.16 d. No patients had local or distant metastasis during the follow-up periods. CONCLUSION EUS is not essential for ER in the patient with small rectal NETs because of the prominent morphology and benign behavior.

关键词： Neuroendocrine tumor Small Rectal Endoscopic ultrasonography Histology Endoscopy

Assessment of disease activity by fecal immunochemical test in ulcerative colitis

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World Journal of Gastroenterology 2016年第48期22卷 10617-10624页

作者： Dae Gon Ryu Hyung Wook Kim su Bum park Dae Hwan Kang Cheol Woong Choi su Jin Kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or *** All of 21 patients with MES 0 had negative FIT( 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not

关键词： Ulcerative colitis Fecal immunochemical test Mayo endoscopic subscore Biomarker Disease activity

Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

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World Journal of Gastroenterology 2017年第9期23卷 1627-1636页

作者： Hyeong Seok Nam Dae Hwan Kang Hyung Wook Kim Cheol Woong Choi su Bum park su Jin Kim Dae Gon Ryu Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan-siGyeongsangnam-do 50612South Korea

To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of self-expandable metal stent (SEMS).METHODSThis was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography (ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis (PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were *** the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients, pancreatic cancer in 79, and non-pancreatic or non-biliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients (3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy (cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP *** ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.

关键词： Endoscopic sphincterotomy Endoscopic retrograde cholangio pancreatography Complications Pancreatitis Bleeding Cholestasis Self-expandable metal stent

Growth and Magnetic Properties of Sol-Gel Derived Co-Doped ZnO Thin Film

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Journal of Rare Earths 2006年第z1期24卷 59-63页

作者： Young sung Kim Ki Chul Kim Won Pil Tae Dae Ho Yoon Tae Seok park su Jeong suh Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Cambridge-ETRI Joint R&D Centre Electronics and Telecommunications Research Institute Daejeon 305-350 Korea Ulsan Industry Promotion Techno Park Ulsan 683-804 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea

Zn1-xCoxO films were grown on glass by sol-gel spin coating process. A homogeneous and stable Zn1-xCoxO sol was prepared by dissolving zinc acetate dihydrate, cobalt acetate tetrahydrate and aluminium chloride hexahydrate as solutes in solution of isopropanol and monoethanolamine. The films were postheated and vacuum annealed, and investigated for c-axis preferred orientation and electromagnetic properties. Zn1-xCoxO films with different Co concentrations were oriented well along the c-axis, especially the Zn1-xCoxO film with 10% Co(atom fraction) was highly c-axis oriented. The transmittance spectra show that Zn1-xCoxO films occur d-d transition and sp-d exchange interaction between Co2+ ions. The electrical resistivity of the films at 10% Co had the lowest value because the crystallite size became largest and the crystallinity of the c-axis was improved. X-ray photoelectron spectroscopy and alternating gradient magnetometer analyses indicated that no Co metal cluster was formed, and the ferromagnetism at room temperature appeared. The characteristics of the electrical resistivity and room temperature ferromagnetism of sol-gel derived Zn1-xCoxO films suggest a potential application of dilute magnetic semiconductor devices.

关键词： sol-gel Zn1-xCoxO thin film dilute magnetic semiconductor (DMS)

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某项目调蓄池工程设计要点

河南水利与南水北调 2024年第4期53卷 40-41页

作者：苏林海深圳市南山区水务局广东深圳518502

某项目调蓄池工程是河道综合治理过程采用调蓄池截流调蓄,项目工程主要是采取高标准的初(小)雨截流调蓄措施,减少雨季面源污染入河入湾,提高河流水质保障率。文章根据调蓄池位置,结合调蓄池旱季及雨季运行工况调,详细分析了调蓄池1#、4#... 详细信息

某项目调蓄池工程是河道综合治理过程采用调蓄池截流调蓄,项目工程主要是采取高标准的初(小)雨截流调蓄措施,减少雨季面源污染入河入湾,提高河流水质保障率。文章根据调蓄池位置,结合调蓄池旱季及雨季运行工况调,详细分析了调蓄池1#、4#、5#工艺设计方案。调蓄池工程的实施提升了河道水环境,为河流生态长廊景观公园的建设创造良好水环境条件。

关键词：调蓄池设计方案水环境

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考虑频率耦合特性的D-PMSG复数域阻抗建模及其特征分析

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电力系统自动化 2024年第10期48卷 118-128页

作者：苏晨博刘崇茹王瑾媛郝琪董浩云华北电力大学电气与电子工程学院北京市102206

阻抗分析法因其简单有效被广泛用于含电力电子变换器的互联系统稳定性研究。然而,采用传统方法对频域序阻抗建模时,需通过非线性变换(park变换及其反变换)进行坐标系转换,这会导致不同周期分量的卷积运算及相应的频移,其过程较为烦琐。... 详细信息

阻抗分析法因其简单有效被广泛用于含电力电子变换器的互联系统稳定性研究。然而,采用传统方法对频域序阻抗建模时,需通过非线性变换(park变换及其反变换)进行坐标系转换,这会导致不同周期分量的卷积运算及相应的频移,其过程较为烦琐。针对上述问题,基于复向量时域微分算子,提出了永磁直驱同步发电机(D-PMSG)等效阻抗建模方法。该方法在时域周期系统稳定运行轨迹的邻域内直接进行小信号线性化,并采用指数旋转因子灵活反映系统受扰后的时变特性,结合时域微分算子等效表征互联系统控制环节的动态特性,避免了频域阻抗建模时坐标系的反复变换,大幅降低了解析建模的复杂度。此外,所提方法能够更加清晰地阐释互联系统受到扰动时D-PMSG并网逆变器产生频率耦合现象的物理意义;同时,能够说明基频电压初始相位对耦合分量相频特性的影响。最后,利用仿真验证了所提算法的有效性。

关键词：复向量阻抗建模永磁直驱同步发电机(D-PMSG) 频率耦合系统稳定性分析

Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation

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International Journal of Oral Science 2022年第2期14卷 164-173页

作者： So Mi Jeon Je sun Lim su Hwan park Hyung Joon Kim Hyung-Ryong Kim Jong-Ho Lee Department of Health Sciences The Graduate School of Dong-A UniversityBusanRepublic of Korea Department of Oral Physiology Periodontal Diseases Signaling Network Research CenterDental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanRepublic of Korea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuRepublic of Korea Department of Biomedical Sciences Dong-A UniversityBusanRepublic of Korea

The programmed cell death ligand 1(PD-L1)and its receptor programmed cell death 1(PD-1)deliver inhibitory signals to regulate immunological tolerance during immune-mediated ***,the role of PD-1 signaling and its blockade effect on human dental pulp stem cells(h DPSCs)differentiation into the osteo-/odontogenic lineage remain *** show here that PD-L1 expression,but not PD-1,is downregulated during osteo-/odontogenic differentiation of h ***,PD-L1/PD-1 signaling has been shown to negatively regulate the osteo-/odontogenic differentiation of h ***,depletion of either PD-L1 or PD-1 expression increased ERK and AKT phosphorylation levels through the upregulation of Ras enzyme activity,which plays a pivotal role during h DPSCs osteo-/odontogenic *** with nivolumab(a human anti-PD-1 monoclonal antibody),which targets PD-1 to prevent PD-L1 binding,successfully enhanced osteo-/odontogenic differentiation of h DPSCs through enhanced Ras activity-mediated phosphorylation of ERK and *** findings underscore that downregulation of PD-L1 expression accompanies during osteo-/odontogenic differentiation,and h DPSCs-intrinsic PD-1 signaling inhibits osteo-/odontogenic *** findings provide a significant basis that PD-1 blockade could be effective immunotherapeutic strategies in h DPSCs-mediated dental pulp regeneration.

关键词： death finding monoclonal

Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods：Association with particle constituents

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Journal of Environmental Sciences 2016年第9期28卷 201-210页

作者： Bin Wang Ning Li Furong Deng Nicholas Buglak George park Shu su Aiguo Ren Guofeng Shen Shu Tao Xinbiao Guo Institute of Reproductive & Child Health/Ministry of Health Key Laboratory of Reproductive Health School of Public Health Peking University Beijing 100192 China Department of Pathobiology & Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing 48824 USA Department of Occupational & Environmental Health Sciences School of Public Health Peking University Beijing 100191 China Laboratory for Earth surface Processes College of Urban & Environmental Sciences Peking University Beijing 100871 China Jiangsu Provincial Academy of Environmental Science Nanjing 210036 China

Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter（PM） *** presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM 〈 2.5 μm（PM2.5）pollution in China have led to serious concerns regarding the health effects of PM2.5during Asian *** investigated how changes in PM2.5composition,as the weather transitioned towards a sandstorm,affected human airway epithelial *** PM2.5samples covering two sandstorm events and their respective background and transition periods were collected in Baotou,an industrial city near the Gobi Desert in *** samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B,which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several *** PM samples potently increased the release of interleukin-6（IL-6） and interleukin-8（IL-8）.Endotoxin in all samples contributed significantly to the IL-6 response,with only a minor effect on *** was positively correlated with both IL-6 and IL-8 release,while Si was only associated with the increase of *** study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM.

关键词： Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings

Toothpick impaction with sigmoid colon pseudodiverticulum formation successfully treated with colonoscopy

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World Journal of Gastroenterology 2008年第6期14卷 948-950页

作者： Youn Son Chung Yong Woo Chung sun You Moon su Mi Yoon Min-Jeong Kim Kyoung Oh Kim Cheol Hee park Taeho Hahn Kyo-sang Yoo sang Hoon park Jong Hyeok Kim Choong Kee park Department of Gastroenterology Hallym University College of Medicine Anyang Korea Department of Radiology Hallym University College of Medicine Anyang Korea

Foreign bodies in the colon are encountered with increasing frequency, but only sporadic reports concerning their management have appeared in the literature. While most ingested foreign bodies usually pass through the gastrointestinal tract uneventfully, sharp foreign bodies such as toothpicks infrequently cause intestinal perforation and may even result in death. We report our experience with a patient with a sigmoid colon pseudodiverticulum formation, a complication of accidental ingestion of a toothpick that was diagnosed and successfully managed colonoscopically.

关键词： Toothpick Colon Colonoscopy Pseudodiverticulum