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World Journal of Gastroenterology 2014年第14期20卷 3938-3949页

作者： Choong Nam Shim sang kil lee Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine

Although endoscopic submucosal dissection (ESD) is now accepted for treatment of early gastric cancers (EGC) with negligible risk of lymph node (LN) metastasis, ESD for intramucosal undifferentiated type EGC without ulceration and with diameter ≤ 2 cm is regarded as an investigational treatment according to the Japanese gastric cancer treatment guidelines. This consideration was largely based on the analysis of surgically resected EGCs that contained undifferentiated type EGCs; however, results from several institutes showed some discrepancies in sample size and incidence of LN metastasis. Recently, some reports about the safety and efficacy of ESD for undifferentiated type EGC meeting the expanded criteria have been published. Nonetheless, only limited data are available regarding long-term outcomes of ESD for EGC with undifferentiated histology so far. At the same time, endoscopists cannot ignore the patients’ desire to guarantee quality of life after the relatively non-invasive endoscopic treatment when compared to conventional surgery. To satisfy the needs of patients and provide solid evidence to support ESD for undifferentiated EGC, we need more delicate tools to predict undetected LN metastasis and more data that can reveal predictive factors for LN metastasis.

关键词： Early gastric cancer Endoscopic submucosal dissection Undifferentiated histology Indications

Melatonin combined with exercise cannot alleviate cerebral injury in a rat model of focal cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2012年第13期7卷 993-999页

作者： Seunghoon lee Jinhee Shin Minkyung lee Yunkyung Hong sang-kil lee Youngjeon lee Tserentogtokh Lkhagvasuren Dong-Wook Kim Young-Ae Yang Kyu-Tae Chang Yonggeun Hong Department of Rehabilitation Science in Interdisciplinary Ph.D.Program Inje UniversityGimhae 621-749Republic of Korea Cardiovascular & Metabolic Disease Center College of Biomedical Science & EngineeringGimhae 621-749Republic of Korea Department of Smart Foods & Drugs School of Food & Life SciencesInje UniversityGimhae 621-749Republic of Korea Department of Pharmaceutical Engineering College of EngineeringInje UniversityGimhae 621-749Republic of Korea National Primate Research Center Korea Research Institute of BiotechnologyOchang 363-883Republic of Korea

Previous studies have demonstrated that melatonin combined with exercise can alleviate secondary damage after spinal cord injury in rats. Therefore, it is hypothesized that melatonin combined with exercise can also alleviate ischemic brain damage. In this study, adult rats were subjected to right middle cerebral artery occlusion after receiving 10 mg/kg melatonin or vehicle subcutaneously twice daily for 14 days. Forced exercise using an animal treadmill was performed at 20 m/min for 30 minutes per day for 6 days prior to middle cerebral artery occlusion. After middle cerebral artery occlusion, each rat received melatonin combined with exercise, melatonin or exercise alone equally for 7 days until sacrifice. Interestingly, rats receiving melatonin combined with exercise exhibited more severe neurological deficits than those receiving melatonin or exercise alone. Hypoxia-inducible factor la mRNA in the brain tissue was upregulated in rats receiving melatonin combined with exercise. Similarly, microtubule associated protein-2 mRNA expression was significantly upregulated in rats receiving melatonin alone. Chondroitin sulfate proteoglycan 4 （NG2） mRNA expression was significantly decreased in rats receiving melatonin combined with exercise as well as in rats receiving exercise alone. Furthermore, neural cell loss in the primary motor cortex was significantly reduced in rats receiving melatonin or exercise alone, but the change was not observed in rats receiving melatonin combined with exercise. These findings suggest that excessive intervention with melatonin, exercise or their combination may lead to negative effects on ischemia/reperfusion-induced brain damage.

关键词： wfocal cerebral ischemiaJreperfusion melatonin exercise neurological function brain tissue loss microtubule associated protein-2 chondroitin sulfate proteoglycan 4 NG2 hypoxia-inducible factor1 alpha neural regeneration

Extracolonic findings of computed tomographic colonography in Koreans

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World Journal of Gastroenterology 2009年第12期15卷 1487-1492页

作者： Sung Keun Park Dong Il Park Sun-Young lee sang kil lee Young-Ho Kim Soon Jin lee Jeong-Sik Byeon Kyu Chan Huh Ki-Nam Shim Department of Medicine Sungkyunkwan University School of MedicineKangbuk Samsung Hospital 108Pyung-dongJongro-guSeoul 110-746South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 110-746South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 110-746South Korea Departments of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul110-746South Korea Departments of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul110-746South Korea Department of Internal Medicine Ulsan University College of MedicineAsan Medical CenterSeoul110-746South Korea Department of Internal Medicine Konyang University School of MedicineDaejon 302-718South Korea Department of Internal Medicine Ewha Womans University School of MedicineSeoul 110-746South Korea

AIM:To determine the frequency and characteristics of extracolonic lesions detected using computed tomographic(CT)***:The significance of extracolonic lesions was classified as high,intermediate,or *** records were reviewed to establish whether further investigations were carried out pertaining to the extracolonic lesions that were detected by CT ***:A total of 920 cases from 7 university hospitals were included,and 692 extracolonic findings were found in 532(57.8%)*** 692 extracolonic findings,60 lesions(8.7%)were highly significant,250(36.1%)were of intermediate significance,and 382(55.2%)were of low *** colonography revealed fewer extracolonic findings in subjects who were without symptoms(P<0.001),younger(P<0.001),or who underwent CT colonography with no contrast enhancement(P=0.005).CT colonography with contrast enhancement showed higher cost-effectiveness in detecting highly significant extracolonic lesions in older subjects and in subjects with ***:Most of the extracolonic findings detected using CT colonography were of less significant *** role of CT colonography would be optimized if this procedure was performed with contrast enhancement in symptomatic older subjects.

关键词： Computed tomographic colonography Extracolonic lesion Cost Contrast enhancement Clinical availability

Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection

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World Journal of Gastroenterology 2014年第26期20卷 8631-8637页

作者： Ji Young Yoon Choong Nam Shim Sook Hee Chung Wan Park Hyunsoo Chung Hyuk lee Sung Kwan Shin sang kil lee Yong Chan lee Jun Chul Park Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine

AIM: To determine whether there is a correlation between the location of the lesion and endoscopic submucosal dissection (ESD) outcome.

关键词： Endoscopic submucosal dissection Gastric neoplasm Location Complication Outcomes

Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up

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World Journal of Gastroenterology 2004年第2期10卷 223-226页

作者： sang kil lee Yong Chan lee Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang Division of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea Department of Internal Medicine NHIC Ilsan HospitalIlsanSouth Korea Department of Radiation Oncology Yonsei University College of MedicineSeoulSouth Korea Department of Pathology Yonsei University College of MedicineSeoulSouth Korea

AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities. METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed. RESULTS:Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori (Hpylori) regimen *** duration to reach complete remission was 12 months (85 percentile,2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases. CONCLUSION:Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloriinfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication.

关键词： Adult Aged Endoscopy, Digestive System Follow-Up Studies Gastric Mucosa Helicobacter Infections Helicobacter pylori Humans Lymphoma, Mucosa-Associated Lymphoid Tissue Middle Aged Pyloric Antrum Remission Induction Retrospective Studies Stomach Ulcer

Establishment of a chicken intestinal organoid culture system to assess deoxynivalenol‑induced damage of the intestinal barrier function

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1119-1130页

作者： Tae Hong Kang sang In lee Department of Animal Science and Biotechnology Kyungpook National UniversitySangjuGyeong‑Sangbuk‑Do 37224Republic of Korea Research Institute for Innovative Animal Science Kyungpook National University37224SangjuGyeong‑Sangbuk‑DoRepublic of Korea

Background Deoxynivalenol(DON)is a mycotoxin that has received recognition worldwide because of its ability to cause growth delay,nutrient malabsorption,weight loss,emesis,and a reduction of feed intake in *** DON-contaminated feedstuff is absorbed in the gastrointestinal tract,we used chicken organoids to assess the DON-induced dysfunction of the small *** We established a culture system using chicken organoids and characterized the organoids at passages 1 and *** confirmed the mRNA expression levels of various cell markers in the organoids,such as KI67,leucine-rich repeat containing G protein-coupled receptor 5(Lgr5),mucin 2(MUC2),chromogranin A(CHGA),cytokeratin 19(CK19),lysozyme(LYZ),and microtubule-associated doublecortin-like kinase 1(DCLK1),and compared the results to those of the small *** results showed that the organoids displayed functional similarities in permeability compared to the small *** damaged the tight junctions of the organoids,which resulted in increased *** Our organoid culture displayed topological,genetic,and functional similarities with the small intes-tine *** on these similarities,we confirmed that DON causes small intestine *** organoids offer a practical model for the research of harmful substances.

关键词： Barrier function Deoxynivalenol Organoids

YOLO-Based Damage Detection with StyleGAN3 Data Augmentation for Parcel Information-Recognition System

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Computers, Materials & Continua 2024年第7期80卷 195-215页

作者： Seolhee Kim sang-Duck lee Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Logistics System Research Division Korea Railroad Research InstituteUiwang16105Republic of Korea

Damage to parcels reduces customer satisfactionwith delivery services and increases return-logistics *** can be prevented by detecting and addressing the damage before the parcels reach the ***,various studies have been conducted on deep learning techniques related to the detection of parcel *** study proposes a deep learning-based damage detectionmethod for various types of *** is intended to be part of a parcel information-recognition systemthat identifies the volume and shipping information of parcels,and determines whether they are damaged;this method is intended for use in the actual parcel-transportation *** this purpose,1)the study acquired image data in an environment simulating the actual parcel-transportation process,and 2)the training dataset was expanded based on StyleGAN3 with adaptive discriminator ***,3)a preliminary distinction was made between the appearance of parcels and their damage status to enhance the performance of the parcel damage detection model and analyze the causes of parcel ***,using the dataset constructed based on the proposed method,a damage type detection model was trained,and its mean average precision was *** model can improve customer satisfaction and reduce return costs for parcel delivery companies.

关键词： Parcel delivery service damage detection damage classification data augmentation generative adversarial network

Weighted Forwarding in Graph Convolution Networks for Recommendation Information Systems

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Computers, Materials & Continua 2024年第2期78卷 1897-1914页

作者： sang-min lee Namgi Kim Department of Computer Science Kyonggi UniversitySuwonKorea

Recommendation Information Systems(RIS)are pivotal in helping users in swiftly locating desired content from the vast amount of information available on the *** Convolution Network(GCN)algorithms have been employed to implement the RIS ***,the GCN algorithm faces limitations in terms of performance enhancement owing to the due to the embedding value-vanishing problem that occurs during the learning *** address this issue,we propose a Weighted Forwarding method using the GCN(WF-GCN)*** proposed method involves multiplying the embedding results with different weights for each hop layer during graph *** applying the WF-GCN algorithm,which adjusts weights for each hop layer before forwarding to the next,nodes with many neighbors achieve higher embedding *** approach facilitates the learning of more hop layers within the GCN *** efficacy of the WF-GCN was demonstrated through its application to various *** the MovieLens dataset,the implementation of WF-GCN in LightGCN resulted in significant performance improvements,with recall and NDCG increasing by up to+163.64%and+132.04%,***,in the *** dataset,LightGCN using WF-GCN enhanced with WF-GCN showed substantial improvements,with the recall and NDCG metrics rising by up to+174.40%and+169.95%,***,the application of WF-GCN to Self-supervised Graph Learning(SGL)and Simple Graph Contrastive Learning(SimGCL)also demonstrated notable enhancements in both recall and NDCG across these datasets.

关键词： Deep learning graph neural network graph convolution network graph convolution network model learning method recommender information systems

Experience of Mental Health Professionals Collaborating with Peer Supporters in a Community Mental Health Service Team

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International Journal of Mental Health Promotion 2024年第4期26卷 251-260页

作者： Sowon lee Boyoung Kim Chung kil Park College of Nursing Chonnam National UniversityGwangju61469South Korea College of Oriental Medicine Wonkwang UniversityIksan54538South Korea

This study explored how mental health professionals collaborate with peer supporters with mental disabilities in a community mental health *** January 19 to February 23,2021,three 60 min interviews were conducted with six mental health professionals working at a Korean community *** results were qualitatively analyzed and divided into four themes and eight *** four themes were the perceptions of and challenges in working with peer supporters with mental disabilities,conflict and confusion about working with peer supporters,forming partnerships with peer supporters,and policy support for peer supporters’job *** reported vague anxiety about working with a peer supporter and difficulties with the trial-and-error process of adjusting to the role as *** time,however,they realized that they needed to make an effort to develop meaningful relationships with peer supporters and mental health ***,through this study,we realized that there was a need to improve the system,such as building infrastructure for job stability for peer support workers and capacity building tailored to the mental *** peer supporters play various roles while working with mental health professionals,this study showed the possibility of mutual growth through communication and *** findings will help prepare systems necessary for collaboration between the two teams amidst the increasing institutionalization of peer support for mental disorders.

关键词： Peer supporters mental health mental health professionals collaborating

Comparison of the efficacy and safety of sedation between dexmedetomidine-remifentanil and propofol-remifentanil during endoscopic submucosal dissection

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World Journal of Gastroenterology 2015年第12期21卷 3671-3678页

作者： Namo Kim Young-Chul Yoo sang kil lee Hyunzu Kim Hyang Mi Ju Kyeong Tae Min Department of Anesthesiology and Pain Medicine Severance Hospital Yonsei University College of Medicine Department of Internal Medicine Yonsei University College of Medicine Department of Anesthesiology and Pain Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine

AIM: To compare the efficacy and safety of sedation protocols for endoscopic submucosal dissection(ESD) between dexmedetomidine-remifentanil and ***: Fifty-nine patients scheduled for ESD were randomly allocated into a dexmedetomidineremifentanil(DR) group or a propofol-remifentanil(PR) group. To control patient anxiety, dexmedetomidine or propofol was infused to maintain a score of 4-5 on the Modified Observer's Assessment of Alertness/Sedation scale. Remifentanil was infused continuously at a rate of 6 μg/kg per hour in both groups. The ease of advancing the scope into the throat, gastric motility grading, and satisfaction of the endoscopist and patient were assessed. Hemodynamic variables and hypoxemic events were compared to evaluate patient ***: Demographic data were comparable between the groups. The hemodynamic variables and pulse oximetry values were stable during the procedure in both groups despite a lower heart rate in the DR group. No oxygen desaturation events occurred in either group. Although advancing the scope into the throat was easier in the PR group("very easy" 24.1% vs 56.7%, P = 0.010), gastric motility was moresuppressed in the DR group("no + mild" 96.6% vs 73.3%, P = 0.013). The endoscopists felt that the procedure was more favorable in the DR group("very good + good" 100% vs 86.7%, P = 0.042), whereas patient satisfaction scores were comparable between the groups. En bloc resection was performed 100% of the time in both groups, and the complete resection rate was 94.4% in the DR group and 100% in the PR group(P = 0.477). CONCLUSION: The efficacy and safety of dexmedetomidine and remifentanil were comparable to propofol and remifentanil during ESD. However, the endoscopists favored dexmedetomidine perhaps due to lower gastric motility.

关键词： Dexmedetomidine Efficacy Peristalsis Safety Endosc