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Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis

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World Journal of Gastroenterology 2012年第25期18卷 3223-3234页

作者： Gi-sang Bae Min-Sun kim Kyoung-Chel Park Bon Soon Koo Il-Joo Jo Sun Bok Choi Dong-Sung Lee Youn-Chul kim Tae-Hyeon kim sang-Wan Seo Yong Kook Shin Ho-joon Song Sung-Joo Park Department of Herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju Women's UniversityKwangju 506-713South Korea Standardized Material Bank for New Botanical Drugs College of PharmacyWonkwang UniversityIksan 570-749South Korea Department of Internal Medicine College of MedicineWonkwang UniversityIksanJeonbuk 570-749South Korea ChungBuk Technopark Bio Center JecheonChungBuk 390-250South Korea

AIM:To determine if the fraction of Nardostachys jatamansi(NJ) has the potential to ameliorate the severity of acute pancreatitis(AP).METHODS:Mice were administered the biologically active fraction of NJ,i.e.,the 4th fraction(NJ4),intraperitoneally,and then injected with the stable cholecystokinin analogue cerulein hourly for 6 *** hours after the last cerulein injection,the pancreas,lung,and blood were harvested for morphological examination,measurement of cytokine expression,and examination of neutrophil ***:NJ4 administration attenuated the severity of AP and lung injury associated with *** also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heme oxygenase-1(HO-1).Furthermore,NJ4 and its biologically active fraction,NJ4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pancreatic acinar ***:These results suggest that NJ4 may be a candidate fraction offering protection in AP and NJ4 might ameliorate the severity of pancreatitis by inducing HO-1 expression.

关键词：急性胰腺炎生物活性蛙皮素诱导活性部位蜘蛛香胰腺腺泡细胞严重程度

Experimental Investigation of Flexible Hawkmoth-like Wings on the Wing-wake Interaction in Hovering Flight

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Journal of Bionic Engineering 2018年第1期15卷 139-153页

作者： YeongGyun Ryu Jo Won Chang joon Chung Dong-Ha kim Department of Aerospace Engineering Ryerson University Toronto Ontario M5B 2K3 Canada Department of Aeronautical Science and Flight Operation Korea Aerospace University 76 Hanggongdaehak-ro Deogyang-gu Goyang-si Gyeonggi-do 10540 Republic of Korea Aerodynamics Group Korean Air R&D Center Daejeon Metropolitan City 34054 Republic of Korea

To study wing-wake interaction for various wing flexibilities, force measurements and digital particle image velocimetry were carried out on flapping hawkmoth-like wings in a water tank. Wing thickness was employed as a design variable for the wing flexi- bility distributions. Abrupt flap-down and phase delay in flexible wings influenced the behaviors of the Leading-Edge Vortex （LEV） and Trailing-Edge Vortex （TEV）, generated by the previous stroke. While the rigid wing exhibited a detached LEV at the end of the stroke, wing with specific flexibilities obtained attached LEVs. The attached LEVs induced a relatively rapid flow toward the wing surface as a result of encountering the TEV, and the flow caused a higher lift peak. On the other hand, the wings with larger wing deformations generated distinctive changes in LEV and TEV behaviors. The flap-down helped the TEV form closer to the wing surface, and it thus caused a downwash rather than wing-wake interaction. Furthermore, the most flexible wing had a newly-formed pair of LEVs above the wing during the wing reversal, thereby being not able to generate the wing-wake interaction. These results help to understand the different vortex structures generated by flexible wings during the wing reversal and the corresponding effects of wing-wake interaction.

关键词： hovering flight flexible hawkmoth wings wing-wake interaction Digital Particle Image Velocimetry (DPIV)

Weave-pattern-dependent fabric piezoelectric pressure sensors based on polyvinylidene fluoride nanofibers electrospun with 50 nozzles

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npj Flexible Electronics 2022年第1期6卷 699-707页

作者： Da Bin kim Ju Han Sun Min Sung Min Seong kim Bo Kyoung Choi Sung Jun Park Hyae Rim Hong Hong Je Choi Byeong Kon kim Chung Hee Park Jong Hoo Paik joon-Seok Lee Yong Soo Cho Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Textile Engineering and Technology Yeungnam UniversityGyeongsan 38541Republic of Korea Deparment of Textile Merchandising and Fashion DesignSeoul National UniversitySeoul 08826Republic of Korea Samsung Electro-Mechanics Co.Ltd. Suwon 16674Republic of Korea Ceratorq Inc. Seoul 08511Republic of Korea Electronic Materials and Component Center Korea Institute of Ceramic Engineering and TechnologyJinju 52851Republic of Korea

Wearable pressure sensors having versatile device structures have been extensively investigated to achieve high sensitivity under mechanical ***,we introduce piezoelectric pressure sensors based on fabrics woven using polyvinylidene fluoride(PVDF)weft and polyethylene terephthalate(PET)warp yarns with different weave structures:1/1(plain),2/2,and 3/3 weft rib *** dependence of the pressure-sensing performance on the weave pattern is demonstrated with an actual large-scale fabric up to the~2 m *** optimized pressure sensor with a 2/2 weft rib pattern produced a high sensitivity of 83 mV N−1,which was 245%higher than that of the 1/1 *** detection performance of the optimal fabric was extensively evaluated with a variety of ambient input sources,such as pressing,bending,twisting,and crumpling,as well as various human ***,a large allfabric pressure sensor with arrayed touch pixel units demonstrated highly sensitive and stable sensing performance.

关键词： pattern fluoride piezoelectric

Stud welding for fixation of cryogenic insulation of membrane tanks in LNG ship building

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中国有色金属学会会刊：英文版 2009年第B9期19卷 271-275页

作者： Jeong-Soo LEE Young-Soo RYU Nam-In kim Bong-joon kim Yoo-Kyung kim Myung-Hyun kim Hanjin Heavy Industries & Construction Co. Ltd Department of Naval Architecture and Ocean Engineering Pusan National University

The support plates including all of the inner hulls such as E grade steel, weld seams and SUS304L were considered to establish the optimal stud welding condition in LNG ship building. The stainless steel plate was especially applied to the bracket on the liquid dome. The polished and etched surfaces of the welded stud and support plate were examined if the bead was properly formed. With the micrographic examination, the fusion boundary of metal weld zone formed by stud welding was analyzed to optimize the welding parameters. And also the analysis of the unacceptable welding faults such as cold and hot weld were performed. The mechanical tests such as tensile tests and bending tests were carried out to reveal any abnormal variation in the relationship of process parameters and the strength.

关键词：螺柱焊接 LNG船绝缘膜优化工艺参数低温坦克不锈钢板最佳条件

Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway

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Neural Regeneration Research 2013年第35期8卷 3269-3274页

作者： Ji-Young kim Beom Seok Jeon Han-joon kim Tae-Beom Ahn Department of Neurology Inje University Seoul Paik Hospital Department of Neurology College of Medicine Seoul National University Hospital Department of Neurology Kyung Hee University Medical Center

Although alpha-synuclein is generally thought to have a pathological role in Parkinson＇s disease, accumulative evidence exists that alpha-synuclein has a neuroprotective effect. The aim of this study was to evaluate the effect of extracellular alpha-synuclein on dopaminergic cell survival. We assessed cell viability using the 3-（4,5-dimethyt-thiazol-2-yt）-2,5-diphenyltertazolium bromide （MTT） assay both in undifferentiated SH-SY5Y （SHSY） cells and neuronally-differentiated SH-SY5Y （ndSHSY） cells after 24 hour treatment with monomeric alpha-synuclein at various concentrations （0 [control], 50, 100 nmol/L, 1 IJmol/L）. To determine whether cell viability assessed by MTT assay was affected by cell proliferation, 5-bromo-2＇-deoxyuridine （BrdU） incorporation assay was per- formed. Level of both Akt and phosphorylated Akt was measured using western blot method in ndSHSY cells with or without 24 hour alpha-synuclein treatment. Cell viability was increased in ndSHSY cells at the nanomolar concentration of alpha-synuclein, but not in SHSY cells. Proportion of BrdU-positive ndSHSY cells was decreased in alpha-synuclein-treated group compared with control group. Level of phosphorylated Akt in alpha-synuclein-treated group was higher compared with the control group. Our study shows that extracellular alpha-synuclein at nanomolar concentra- tion benefits dopaminergic cell survival via Akt pathway.

关键词： neural regeneration alpha-synuclein neuronal survival nanomolar extracellular phosphorylatedAkt SH-SY5Y cell neuronal differentiation proliferation dopaminergic 5-bromo-2'-deoxyuridine grants-supported paper neuroregeneration

Ferroelectric composite-based piezoelectric energy harvester for selfpowered detection of obstructive sleep

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Journal of Materiomics 2023年第4期9卷 609-617页

作者： Swati Panda Hyoju Shin Sugato Hajra Yumi Oh Wonjeong Oh Jeonghyeon Lee P.M.Rajaitha Basanta Kumar Panigrahi Jyoti Shukla Alok Kumar Sahu Perumal Alagarsamy Hoe joon kim Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu42988South Korea Department of Electrical Engineering Siksha‘O’Anusandhan UniversityBhubaneswar751030India Department of Electrical Engineering Poornima College of EngineeringJaipur303903India Department of Physics Indian Institute of Technology-GuwahatiAssam781039India Robotics and Mechatronics Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu42988South Korea

Lead-free piezoelectric ceramic is a promising material for energy harvesters,as they have superior electromechanical,ferroelectric,and piezoelectric *** addition,piezoelectric ceramics can be blended with polymer to achieve high-flexibility polymer-ceramic composites,providing mechanical robustness and *** this context,a new lead-free ferroelectric material,having the chemical formula SrTi_(2)O_(5)(STO),was synthesized using a high-temperature solid-state *** analyses of the structural,morphological,and electrical properties of the synthesized material were *** crystallizes with orthorhombic symmetry and space group of *** frequency and temperature-dependent dielectric parameters were evaluated,and impedance spectroscopy shed light on the charge *** PDMS-STO composites at different mass fraction of the STO were prepared using a solvent casting route,and a corresponding piezoelectric nanogenerator(PENG)was *** electrical output of the different PENG by varying massfractions of STO in PDMS and varying force were *** 15%(in mass)PENG device delivered the highest peak-to-peak voltage,current,and power density of 25 V,92 nA,and 0.64 mW@500 MU,*** biomechanical energy harvesting using the PENG device by daily human motions,bending of the device,and attaching the device to laboratory equipment was *** the PENG device was attached to the human throat region,and snoring signals were recorded.A classification model was designed employing the convolutional neural network(CNN)*** have been laid to differentiate between normal and abnormal snores,which could help the patient with screening and early disease detection,contributing to self-powered healthcare applications.

关键词： Lead-free Ferroelectric Nanogenerator Sleepdisorder

The aspect of structural connectivity in relation toage-related gait performance

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Psychoradiology 2023年第1期3卷 11-12页

作者： Cheol-Woon kim Yechan kim Hyun-Ho kim joon Yul Choi Department of Physical Education Korea University02841SeoulRepublic of Korea Department of Biomedical Engineering Yonsei University26493WonjuRepublic of Korea

Fernandez et al.(2019).investigated the relationship between agerelated changes in attention control and gait performance in older *** study aimed to establish a more precise link between the influence of age on brain... 详细信息

关键词： gait connectivity performance

Study on frictional behavior of carbon nanotube thin films with respect to surface condition

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Friction 2018年第4期6卷 432-442页

作者： Youn-Hoo HWANG Byung-Soo MYUNG Hyun-joon kim Department of Precision Mechanical Engineering Kyungpook National University

In this work, tribological characteristics of thin films composed of entangled carbon nanotubes(CNTs) were investigated. The surface roughness of CNT thin films fabricated via a dip‐coating process was controlled by squeezing during the process with an applied normal force ranging from 0 to 5 kgf. Raman spectra and scanning electron microscopy(SEM) images of the thin films were obtained to estimate the influence of the squeezing process on the crystallinity of the CNTs. The analysis revealed that squeezing could reduce surface roughness, while preserving the crystallinity of the CNTs. Moreover, the surface energy of the cover glass used to press the CNT thin film was found to be the critical factor controlling surface roughness. A micro‐tribometer and macro‐tribometer were used to assess the tribological characteristics of the CNT thin film. The results of the tribotest exhibited a correlation between the friction coefficient and surface roughness. Dramatic changes in friction coefficient could be observed in the micro‐tribotest, while changes in friction coefficient in the macro‐tribotest were not significant.

关键词：碳纳米管薄膜摩擦学科学研究

High resolution impedance manometric findings in dysphagia of Huntington's disease

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World Journal of Gastroenterology 2012年第14期18卷 1695-1699页

作者： Tae Hee Lee joon Seong Lee Wan Jung kim Institute for Digestive Research Soon Chun Hyang College of MedicineSeoul 140-743South Korea

Conventional manometry presents significant challenges,especially in assessment of pharyngeal swallowing,because of the asymmetry and deglutitive movements of oropharyngeal *** only provides information about intraluminal pressure and thus it is difficult to study functional details of esophageal motility *** technology of solid high resolution impedance manometry(HRIM),with 32 pressure sensors and 6 impedance sensors,is likely to provide better assessment of pharyngeal swallowing as well as more information about esophageal motility ***,the clinical usefulness of application of HRIM in patients with oropharyngeal dysphagia or esophageal dysphagia is not *** experienced a case of Huntington's disease presenting with both oropharyngeal and esophageal dysphagia,in which HRIM revealed the mechanism of oropharyngeal dysphagia and provided comprehensive information about esophageal dysphagia.

关键词：高分辨率吞咽阻抗压力传感器压结运动障碍临床应用食管癌