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Neuroprotective effects of roasted licorice,not raw form,on neuronal injury in gerbil hippocampus after transient forebrain ischemia

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Acta Pharmacologica Sinica 2006年第8期27卷 959-965页

作者： In-koo HWANG Soon-sung LIM Kyu-hyun CHOI Ki-yeon YOO hyun-kyung shin Eun-ji KIM Jung-han YOONPARK Tae-cheon KANG Young-sup KIM Dae-young KWON Dong-woo KIM Won-kook MOON Moo-ho WON Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Silver Biotechnology Research Center Korea Silver Biotechnology Research Center Department of Food Science and Nutrition Hallym UniversityChunchon 200-702Korea Medical Science Division Korea Research Institute of Chemical TechnologyYuseong.Daejeon 305-343Korea Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Korea Silver Biotechnology Research Center

Aim:To observe neuroprotective effects of raw and roasted licorice against hy-poxia and ischemic ***:When elucidating the protective effects ofraw and roasted licorice,we analyzed the lactate dehydrogenase (LDH) releaseusing PC12 cells after hypoxia in an in vitro study and after transient forebrainischemia in an in vivo study on Mongolian ***:Raw and roastedlicorice significantly reduced LDH release from PC12 cells exposed to an hypoxicchamber for *** the roasted licorice-treated group,the decrease of LDH releasewas more pronounced compared to that of the raw licorice-treated *** licorice-treated animals,approximately 66%-71% of CA1 pyramidal cellsin the ischemic hippocampus were stained with cresyl violet compared to thecontrol ***,in the raw licorice-treated animals,no significantneuroprotection against ischemic damage was *** addition,ischemic ani-mals in roasted licorice-treated group maintained the Cu,Zn-superoxide dismutase(SOD1) activity and protein levels compared to the control group,while in rawlicorice-treated group SOD1 activity and protein levels were reduced *** pressure liquid chromatography analysis showed that non-polar compoundscontaining glycyrrhizin-degraded products,such as glycyrrhetinic acid (GA) andglycyrrhetinic acid monoglucuronide (GM),were increased in roasted ***:Roasted licorice had neuroprotective effects against ischemic dam-age by maintaining the SOD1 *** addition,the difference in protectiveability between raw and roasted licorice may be associated with non-polarcompounds,such as GA and GM.

关键词： transient ischemic attack roasted licorice raw licorice neurons PC12 cells hippocampus pyramidal cells Gerbillinae superoxide dismutase

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Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites

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World Journal of Gastroenterology 2008年第24期14卷 3884-3890页

作者： Soong Lee Seung-Cheol Son Moon-Jong Han Woo-Jin Kim Soo-hyun Kim Hye-Ran Kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun shin Department of Internal Medicine College of MedicineSeonam University and Seonam University Hospital Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National University Hwasun Hospital Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Medical School Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Korea Polymer Testing & Research Institute Ltd.

AIM： To determine intestinal permeability, the serum tumor necrosis factor （TNF）-α level and urine nitric oxide （NO） metabolites are altered in liver cirrhosis （LC） with or without ascites. METHODS： Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol （PEG） 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay （ELISA） and Greiss reaction method, respectively. RESULTS： The intestinal permeability index wassignificantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites （0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03, P 〈 0.05） and correlated with urine nitrite excretion （r = 0.98）. Interestingly, the serum TNF-α concentration was significantly higher in LC without ascites than in control subjects or in LC with ascites （198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL, P 〈 0.05）. Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites（ 1170.9± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L, P 〈 0.05）. COMCLUSIOM： Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites, but the serum TNF-α concentration was not related to LC with ascites.

关键词： Intestinal permeability Tumor necrosisfactor-R Nitric oxide Liver cirrhosis Ascites

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Multiplanar reformations and minimum intensity projections using multi-detector row CT for assessing anomalies and disorders of the pancreaticobiliary tree

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World Journal of Gastroenterology 2007年第31期13卷 4177-4184页

作者： hyun Cheol Kim Dal Mo Yang Wook Jin Chang Woo Ryu Jung Kyu Ryu Sung Il Park Seong Jin Park Hyeong Cheol shin Il Young Kim Department of Radiology East-West Neo Medical Center Kyung-Hee University Seoul Republic of Korea Department of Diagnostic Radiology Kwandong University Myongji Hospital Goyang Republic of Korea Department of Diagnostic Radiology Soonchunhyang University Bucheon Hospital Bucheon Republic of Korea Department of Diagnostic Radiology Soonchunhyang University Cheonan Hospital Cheonan Republic of Korea

CT scan is regarded as the imaging modality of choice in patients with pancreaticobiliary ductal abnormalities. However, the axial orientation of the CT images provides only limited anatomical view of pancreaticobiliary ductal abnormalities. The technological advances of multi-de-tector row CT and three-dimensional image processing in workstations allows rapid image acquisition and a short postprocessing time. In particular, multiplanar reforma-tions (MPR) and minimum intensity projections (MinIP) offer rapid and accurate images of the anatomy and ab-normalities of the pancreaticobiliary tree. Moreover, MPR and MinIP help determine the relationship between the pancreaticobiliary ductal anatomy and the surrounding structures. This pictorial review illustrates the wide spec-trum of images obtained by the MPR and MinIP of the anomalies and disorders of the pancreaticobiliary tree.

关键词： Multi-detector CT Bile Ducts Biliary System Pancreas Computer Applications-3D

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Smart Human Computer Interface with EMG and Vision Based on Multi-modal Information Fusion

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Journal of Measurement Science and Instrumentation 2011年第2期2卷 152-156页

作者： Hee-su KANG hyun-chool shin Dept.of Electronic Engineering School of ITSoongsil UniversitySeoul 156-743Korea

A smart Human Interface （HCI） replacing conventional mouse interface is proposed. The interface is able to control and command action with only hand. Four finger motions （left click, right dick, hold, drag） are used to command the interface. Also the authors materialiae cursor movement control using image processing The measure what they use for inference is entropy of Electromyogram （EMG） signal, Gaussian modeling and likelihood estimation. In image processing for cursor control, they use color recognition to get the center point of finger tip from marker, and map the point onto cursor. Accuracy of finger movement inference is over 95% and cursor control works naturally without delay. They materlalize whole system to check its performance and utility.

关键词： vision:HCI:interface:mouse

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Bedside index for severity in acute pancreatitis:comparison with other scoring systems in predicting severity and organ failure

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 645-650页

作者： Ji Young Park Tae Joo Jeon Tae Hwan Ha Jin Tae Hwang Dong hyun Sinn Tae-Hoon Oh Won Chang shin Won-Choong Division of Gastroenterology Department of Internal MedicineInje University Sanggye Paik Hospital

BACKGROUND:The early identification of severe acute pancreatitis is important for the management and for improving *** bedside index for severity in acute pancreatitis(BISAP)has been considered as an accurate method for risk stratification in patients with acute *** study aimed to evaluate the comparative usefulness of the ***:We retrospectively analyzed 303 patients with acute pancreatitis diagnosed at our hospital from March 2007to December ***,APACHE-II,Ranson criteria,and CT severity index(CTSI)of all patients were *** stratified the number of patiants with severe pancreatitis,pancreatic necrosis,and organ failure as well as the number of deaths by BISAP *** used the area under the receiveroperating curve(AUC)to compare BISAP with other scoring systems,C-reactive protein(CRP),hematocrit,and body mass index(BMI)with regard to prediction of severe acute pancreatitis,necrosis,organ failure,and ***:Of the 303 patiants,31(10.2%)were classified as having severe acute *** failure occurred in 23(7.6%)patients,pancreatic necrosis in 40(13.2%),and death in6(2.0%).A BISAP score of 2 was a statistically significant cutoff value for the diagnosis of severe acute pancreatitis,organ failure,and *** for BISAP predicting severe pancreatitis and death were 0.80 and 0.86,respectively,which were similar to those for APACHE-II(0.80,0.87)and Ranson criteria(0.74,0.74)and greater than AUCs for CTSI(0.67,0.42).The AUC for organ failure predicted by BISAP,APACHE-II,Ranson criteria,and CTSI was 0.93,0.95,0.84 and 0.57,*** for BISAP predicting severity,organ failure,and death were greater than those for CRP(0.69,0.80,0.72),hematocrit(0.45,0.35,0.14),and BMI(0.41,0.47,0.17).CONCLUSION:The BISAP predicts severity,death,and especially organ failure in acute pancreatitis as well as APACHE-II does and better than Ranson criteria,CTSI,CRP,hematocrit,and BMI.

关键词： acute pancreatitis scoring system pancreatic necrosis organ failure

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Male metaplastic breast cancer with poor prognosis:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4964-4970页

作者： hyun Yul Kim Seungju Lee Dong-il Kim Chang shin Jung Jee Yeon Kim Kyung Jin Nam Ki Seok Choo Youn Joo Jung Department of Surgery Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Pathology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Radiology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea

BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast *** constitute less than 1%of breast cancer cases and are much rarer in *** are few reports of MBC because of its ***,an aggressive type of cancer,is refractory to common treatment modalities of breast cancer and has a poor *** SUMMARY We report a case of MBC in a 78-year-old *** visited our clinic with a palpable mass on the left breast with no masses in the axillary *** had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer,but there was no family history of *** breast mass was visible on ultrasonography,mammography,and magnetic resonance imaging,and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower *** patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung *** mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was ***,multiple metastases appeared 3 mo after surgery in the brain,chest,and abdomen,and the patient died 5 mo after the initial *** MBC is an aggressive and extremely rare breast cancer *** case reports are needed to determine the optimal treatment.

关键词： Breast neoplasm Male Triple-negative breast cancer Metaplastic breast cancer Adjuvant treatment Case report

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Olfactory Decoding Method Using Neural Spike Signals

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Journal of Measurement Science and Instrumentation 2010年第1期1卷 81-85页

作者： Kyung-jin YOU hyun-chool shin Dept.of Electronic Engineering Soongsil UniversitySeoul 156-743Korea

This paper presents a novel method for inferring the odor based on neural activities observed from rats' main olfactory ***-channel extra-cellular single unit recordings are done by micro-wire electrodes(Tungsten,50 μm,32 channels)implanted in the mitral/tufted cell layers of the main olfactory bulb of the anesthetized rats to obtain neural responses to various *** responses as a key feature are measured by subtraction firing rates before stimulus from *** odor inference,a decoding method is developed based on the ML *** results show that the average decoding accuracy is about 100.0%,96.0%,and 80.0% with three rats,*** work has profound implications for a novel brain-machine interface system for odor inference.

关键词： olfactory odoronts inference neural decoding neural signal processing neural activity

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Synthesis of Co/SiO2 hybrid nanocatalyst via twisted Co3Si2O5（OH）4 nanosheets for high-temperature Fischer- Tropsch reaction

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Nano Research 2017年第3期10卷 1044-1055页

作者： Ji Chan Park shin Wook Kang Jeong-Chul Kim Jae In Kwon Sanha Jang Geun Bae Rhim Mijong Kim Dong hyun Chun Ho-Tae Lee Heon Jung hyunjoon Song Jung-li Yang Clean Fuel Laboratory Korea Institute of Energy Research Daejeon 34129 Republic of Korea Advanced Energy Technology University of Science and Technology Daejeon 34713 Republic of Korea Center for Nanomaterials & Chemical Reactions Institute for Basic Science Daejeon 34141 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

A cobalt-silica hybrid nanocatalyst bearing small cobalt particles of diameter -5 nm was prepared through a hydrothermal reaction and hydrogen reduction. The resulting material showed very high CO conversion （〉82%） and high hydrocarbon productivity （-1.0gHC·gcat^-1·h^-1 ） with high activity （-8.5 × 10^-5 ***^-1.s-1） in the Fischer-Tropsch synthesis reaction.

关键词： hybrid nanostructure Fischer-Tropsch synthesis thermal stability metal silicate hydroxide cobalt catalyst

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SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF CKD- 501,A NOVEL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA/GAMMA DUAL AGONIST

SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF CKD- 501,A NOV...

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第十五届国际药理学大会

作者： shin sang-Goo Kim Jung-Ryul Cho Joo-Youn Lim Kyoung Soo Kim JaeWoo Kim Bo-hyung shin hyun Suk Yu Kyung-sang shin Jae-Soo Ahn Soon-Kil Jang In-Jin Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Chong Kun Dang Pharm. Korea. Chong Kun Dang Pharm. Korea. Department of Pharmacology Seoul National University College of Medicine Korea.

＜正＞ CKD-501 is a novel peroxisome proliferator-activated receptor α/γ dual agonist for the treatment of diabetes mellitus. This study aimed to investigate safety, tolerability, and pharmacokinetics of CKD-501 in healthy volunteers. A randomized, placebo-controlled, double-blind, parallel-group, dose-rising study was performed. Thirty-six healthy male subjects received single oral doses ranging from 0.5-8 mg CKD- 501 or placebo. In the multipledose study, 24 subjects received 1-4 mg once daily for 7 days. Serial blood and urine samples were collected. No serious adverse events （AEs） were observed and AEs reported were all of mild severity. In the single-dose study, mean Cmax and AUCinf increased linearly up to the 8 mg dose *** and t1/2 ranged from 0.5-4 h and 7.8-9.8 h. respectively. Less than 1 % CKD-501 was excreted in urine. After multiple dosing, accumulation index was around 1.2. Mean apparent clearance, Tmax and t1/2 in steady state were independent of dose and time. Single oral doses up to 8 mg CKD- 501 and multiple doses up to 4 mg were safe and well tolerated. Mean Cmax and AUCinf were dose proportional and there was no remarkable accumulation after multiple dosing.

关键词： PPAR clinical trial

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Evaluation of SWAT sub-daily runoff estimation at small agricultural watershed in Korea

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Frontiers of Environmental Science & Engineering 2013年第1期7卷 109-119页

作者： Ganga Ram Maharjan Youn Shik Park Nam Won Kim Dong Seok shin Jae Wan Choi Geun Woo hyun Ji-Hong Jeon Yong Sik Ok Kyoung Jae Lim GIS Environmental System Laboratory Department of Regional Infrastructure Engineering Kangwon National University Chuncheon 200-701 R. O. Korea Department of Agricultural and Biological Engineering Purdue University West Lafayette IN 47907 USA Water-Resource Research Department Korea Institute of Construction Technology Goyang 411-712 R. O. Korea National Institute of Environmental Research Incheon 404-708 R. 0. Korea Department of Water Research Division Gangwon Institute of Health and Environment Chuncheon 200 822 R. O. Korea Department of Environmental Engineering Andong National University Andong 760-380 R. O. Korea Department of Biological Environ-ment Kangwon National University'Chuncheon 700-711 R. O. Korea

A study was undertaken for the prediction of runoff flow from 0.8 ha field-sized agricultural watershed in South Korea using Soil and Water Assessment Tool (SWAT) sub-daily. The SWAT model with sub-daily configuration predicted flow from the watershed within the range of acceptable accuracy. The SWAT sub-daily simulations were carried out for a total of 18 rainfall events, 9 each for calibration and validation. Overall trend and extent of matching simulated flow for the rainfall events in 2007-2008 with measured data during the calibration process were coefficient of determination ( ) value of 0.88 and Nash and Sutcliffe Efficiency ( ) value of 0.88. For validation, and values were 0.9 and 0.84, respectively. Whereas and values for simulation results using daily rainfall data were 0.79 and -0.01, respectively, that were observed to be out of acceptable limits for the model simulation. The importance of higher time resolution (hourly) precipitation records for flow simulation were evaluated by comparing and with 15 min, 2 h, 6 h and 12 h precipitation data, which resulted in lower statistics with increases in time resolution of precipitation data. The SWAT sub-daily sensitivity analysis was performed with the consideration of hydraulic parameter and was found as in the rank order of CN2 (curve number), ESCO (soil evaporation compensation factor), GW_DELAY (ground water delay time), ALPHA_BF ( base flow alpha factor), GWQMN ( a threshold minimum depth of water in the shallow aquifer required for return flow to occur) , REVAPMN (minimum depth of water in shallow aquifer for re-evaporation to occur) , LAT_TIME (lateral flow travel time) respectively. These sensitive parameters were evaluated at 10% higher and lower values of the parameters, corresponding to 70.5% higher and 23.2% lower in simulated flow out from the SWAT model. From the results obtained in this study, hourly precipitation record for SWAT sub-daily with Green-Ampt infiltration method was prov

关键词： Soil and Water Assessment Tool (SWAT) sub-daily simulation runoff rainfall

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