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Clinicopathologic and molecular features associated with patient age in gastric cancer

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World Journal of Gastroenterology 2015年第22期21卷 6905-6913页

作者： Ji Yeon Seo Eun Hyo Jin Hyun Jin Jo hyuk Yoon Cheol Min Shin Young Soo park Nayoung Kim Hyun Chae Jung Dong Ho Lee Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam Center Seoul National University Hospital Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Seoul National University Bundang Hospital Seongnam-si

AIM: To compare characteristics and prognosis of gastric cancer based on ***: A retrospective study was conducted on clinical and molecular data from patients(n =1658) with confirmed cases of gastric cancer in Seoul National University Bundang Hospital(Seoul, South Korea) from 2003 to 2010 after exclusion of patients diagnosed with lymphoma, gastrointestinal stromal tumor, and metastatic cancer in the stomach. DNA was isolated from tumor and adjacent normal tissue,and a set of five markers was amplified by polymerase chain reaction to assess microsatellite instability(MSI). MSI was categorized as high, low, or stable if ≥ 2, 1, or 0 markers, respectively, had *** was performed on tissue sections to detect levels of expression of p53, human epidermal growth factor receptor(HER)-2, and epidermal growth factor receptor. Statistical analysis of clinical and molecular data was performed to assess prognosis based on the stratification of patients by age(≤ 45 and> 45 years).RESULTS: Among the 1658 gastric cancer patients, the number of patients with an age ≤ 45 years was 202(12.2%; 38.9 ± 0.4 years) and the number of patients> 45 years was 1456(87.8%; 64.1 ± 0.3 years).Analyses revealed that females were predominant inthe younger group(P < 0.001). Gastric cancers in the younger patients exhibited more aggressive features and were at a more advanced stage than those in older patients. Precancerous lesions, such as atrophic gastritis and intestinal metaplasia, were observed less frequently in the older than in the younger group(P < 0.001). Molecular characteristics, including overexpression of p53(P < 0.001), overexpression of HER-2(P = 0.006), and MSI(P = 0.006), were less frequent in gastric cancer of younger patients. Cancer related mortality was higher in younger patients(P= 0.048), but this difference was not significant after adjusting for the stage of ***: Gastric cancer is distinguishable between younger and older patien

关键词： Age Gastric cancer Microsatellite instability Molecular pathology Prognosis Stage

含有多壁碳纳米管(MWCNT)的丙烯酸类压敏胶的胶粘特性和粘弹性

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含有多壁碳纳米管(MWCNT)的丙烯酸类压敏胶的胶粘特性和粘弹性

'2007北京国际粘接技术研讨会暨第二届亚洲粘接技术研讨会

作者： Dong-hyuk Lim Young-Jun park Hyun-Joong Kim Laboratory of Adhesion and Bio-Composites Program in Environmental Materials ScienceSeoul National University

碳纳米管在聚合物复合材料领域的应用具有诱人的潜力。碳纳米管由排列成圆柱形的石墨片组成,作为一种新型材料它可以应用于不同的纳米技术领域如聚合物基填料、生物传感器等等。但纳米复合材料在有机溶剂和水溶液中的溶解性能很差。本...

碳纳米管在聚合物复合材料领域的应用具有诱人的潜力。碳纳米管由排列成圆柱形的石墨片组成,作为一种新型材料它可以应用于不同的纳米技术领域如聚合物基填料、生物传感器等等。但纳米复合材料在有机溶剂和水溶液中的溶解性能很差。本文通过溶液聚合法制备了含多壁碳纳米管(MWCNT)的压敏胶,通过剥离强度、探针粘着性、耐热性的测定对该压敏胶的特性进行了评价,并测定了它们的粘弹性。

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Optimal initiation of Helicobacter pylori eradication in patients with peptic ulcer bleeding

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World Journal of Gastroenterology 2015年第8期21卷 2497-2503页

作者： hyuk Yoon Dong Ho Lee Eun Sun Jang Jaihwan Kim Cheol Min Shin Young Soo park Jin-Hyeok Hwang Jin-Wook Kim Sook-Hayng Jeong Nayoung Kim Departments of Internal Medicine Seoul National University Bundang Hospital

AIM:To evaluate when Helicobacter pylori(***)eradication therapy(ET)should be started in patients with peptic ulcer bleeding(PUB).METHODS:Clinical data concerning adults hospitalizedwith PUB were retrospectively collected and ***,sex,type and stage of peptic ulcer,whether endoscopic therapy was performed or not,methods of *** detection,duration of hospitalization,and specialty of the attending physician were *** influencing the confirmation of *** infection prior to discharge were determined using multiple logistic regression *** *** eradication rates of patients who received ET during hospitalization and those who commenced ET as outpatients were ***:A total of 232 patients with PUB were evaluated for *** infection by histology and/or rapid urease *** these patients,53.7%(127/232)had confirmed results of *** infection prior to *** multivariate analysis,duration of hospitalization and ulcer stage were factors independently influencing whether *** infection was confirmed before or after *** the patients discharged before confirmation of *** infection,13.3%(14/105)were lost to *** the patients found to be ***-positive after discharge,41.4%(12/29)did not receive *** was no significant difference in the *** eradication rate between patients who received ET during hospitalization a n d t h o s e w h o c o m m e n c e d E T a s o u t p a t i e n t s[intention-to-treat:68.8%(53/77)vs 60%(12/20),P=0.594;per-protocol:82.8%(53/64)vs 80%(12/15),P=0.723].CONCLUSION:Because many patients with PUB who were discharged before *** infection status was confirmed lost an opportunity to receive ET,we should confirm *** infection and start ET prior to discharge.

关键词： Helicobacter pylori Peptic ulcer hemorrhage Diseas

In Vitro Assessment of Irritation Potential of an Anti-Melanogenic Agent, PF3758309, in a Reconstructed Human Epidermis Model

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In Vitro Assessment of Irritation Potential of an Anti-Melan...

作者： Ayeong Lee Yu Rim Lee Ji Yea Kim Jin hyuk Jung Young Kum park Yu-Jung Kim Sung-Nae Lee Sungkwan An Seunghee Bae Research Institute for Molecular-Targeted Drugs Department of Cosmetics Engineering Konkuk University

Purpose: This study was designed to determine whether a novel anti-melanogenic agent, PF3758309, has the potential to cause acute cutaneous irritation using a human skin equivalent model(HSEM). Methods: Human skin equivalent was constructed through incubation of normal human derived epidermal keratinocytes(HEKs) on collagen matrix insert with proliferation media. Using constructed human skin equivalent, the irritation potential of PF3758309 were investigated whether the viability of this agent-treated HESM is under 50%(irritant) or not(non-irritant) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay after applying the agent to the epidermal surface of the HSEM. Also, the PF3758309-mediated anti-pigmentation effects were analyzed using Fontana-Masson staining in the HSEM. Results: The integrity of the constructed HSEM was confirmed using immunohistochemical staining with differentiation markers of epidermis, and observed that Keratin 5, Keratin 1 and Involucrin were stained in basal, supra-basal and granular layers, respectively. In vitro irritation assay showed that the mean viabilities of the PF3758309 was 83.6%, 78.8% and 77.8% at the treatment doses of 0.2, 0.5 and 1 mg, respectively;however, the mean viability of the positive control(5% sodium dodecyl sulfate)-treated HESM was 2.8%. Also, in vitro corrosion assay showed that the mean viabilities of the PF3758309 was 95.3%, 95.0% and 94.2% at the treatment doses of 0.2, 0.5 and 1 mg, respectively. Furthermore, using a Fontana-Masson staining assay, the melanin levels in the PF3758309-treated HSEM was significantly decreased compared with the levels in control HSEM. Conclusion: The anti-melanogenic agent, PF3758309, has no skin irritation potential under the conditions used in this study.

关键词： Human skin equivalent PF3758309 Irritation Skin Anti-melanogenesis

Long term survivor of cerebellar glioblastoma multiforme:Case report

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Long term survivor of cerebellar glioblastoma multiforme:Cas...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Seung Hwan Lee Bong Jin park hyuk Jae Choi Seok Geun Choi Sung Bum Kim Tae Sung Kim Bong Arm Rhee Young-Jin Lim Department of Neurosurgery School of MedicineKyung Hee University Hospital

＜正＞Objective:It is well known that the glioblastoma multiforme（GBM） is hard to cure despite aggressive treatment application such as maximal surgical removal and concurrent chemoradiotherapy（CCRT）.Furthermore,w...

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Surgical outcomes for vestibular schwannoma via retrosigmoid approach

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Surgical outcomes for vestibular schwannoma via retrosigmoid...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Seung Hwan Lee Bong Jin park hyuk Jae Choi Seok Keun Choi Seung Bum Kim Tae Sung Kim Bong Arm Rhee Young Jin Lim Department of Neurosurgery School of MedicineKyung Hee University Hospital

＜正＞Objective:The use of several approaches,involving different cerebello-pontine angles,has enabled vestibular schwannoma removal to be tailored to each patient’s pathology and physiological *** retrosigmoid appro...

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The result of long term follow up in Malignant Meningiomas

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The result of long term follow up in Malignant Meningiomas

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Seung Hwan Lee Bong Jin park hyuk Jae Choi Seok Keun Choi Sung Bum Kim Tae Sung Kim Bong Arm Rhee Young Jin Lim Department of Neurosurgery School of MedicineKyung Hee University Hospital

＜正＞Objective:Malignant meningiomas are rare and have worse prognosis than benign meningiomas. Moreover,postoperative radiation therapy is widely accepted to be requisite for treatment *** analyzed the therapeutic e...

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Multiple z-Score Based Method for Noninvasive Prenatal Test Using Cell-Free DNA in Maternal Plasma

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Open Journal of Genetics 2017年第1期7卷 1-8页

作者： hyuk Jung Kwon Amit Goyal Heesu Im Kichan Lee Seon Young Yun Yoon Hee Kim Sungjong Lee Mi-Gyeong Lee Hyuna Lee Reena Garg Boram park Soyoung Choi Joungsu Joo Jin-Sik Bae Min-Jeong Kim Min Seob Lee Sunghoon Lee EONE-DIAGNOMICS Genome Center Co. Ltd. Inchon Korea

Objective: To improve the detecting accuracy of chromosomal aneuploidy of fetus by non-invasive prenatal testing (NIPT) using next generation sequencing data of pregnant women’s cell-free DNA. Methods: We proposed the multi-Z method which uses 21 z-scores for each autosomal chromosome to detect aneuploidy of the chromosome, while the conventional NIPT method uses only one z-score. To do this, mapped read numbers of a certain chromosome were normalized by those of the other 21 chromosomes. Average and standard deviation (SD), which are used for calculating z-score of each sample, were obtained with normalized values between all autosomal chromosomes of control samples. In this way, multiple z-scores can be calculated for 21 autosomal chromosomes except oneself. Results: Multi-Z method showed 100% sensitivity and specificity for 187 samples sequenced to 3 M reads while the conventional NIPT method showed 95.1% specificity. Similarly, for 216 samples sequenced to 1 M reads, Multi-Z method showed 100% sensitivity and 95.6% specificity and the conventional NIPT method showed a result of 75.1% specificity. Conclusion: Multi-Z method showed higher accuracy and robust results than the conventional method even at low coverage reads.

关键词： Cell-Free DNA z-Score Multiple Thresholds Coefficient of Variance Noninvasive Prenatal Testing NIPT

Successful extracorporeal life support in sudden cardiac arrest due to coronary anomaly

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World Journal of Cardiology 2016年第6期8卷 379-382页

作者： Jung Wan park Jae hyuk Lee Ki-Sik Kim Duk Won Bang Min-Su Hyon Min-Ho Lee Byoung-Won park Department of Internal Medicine Division of CardiologySoon Chun Hyang University Hospital

Extracorporeal life support(ECLS) has recently been reported to have a survival benefit in patients with cardiac arrest. It is now used widely as a lifesaving modality. Here, we describe a case of sudden cardiac arrest(SCA) in a young athlete with an anomalous origin of the right coronary artery from the left coronary sinus. Resuscitation was successful using ECLS before curative bypass surgery. We highlight the efficacy of ECLS for a patient with SCA caused by a rare, unexpected aetiology. In conclusion, ECLS was a lifesaving modality for SCA due to an anomalous coronary artery in this young patient.

关键词： Coronary vessels anomalies Extracorporeal circulation Cardiac arrest