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Sperm hyaluronidase is critical to mammals'fertilization for its ability to disperse cumulus-oocyte complex layer

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Asian Journal of Andrology 2022年第4期24卷 411-415页

作者： Dong-Won Seol Sang Hoon Joo Young-Hyun Kim Bong-Seok Song Bo-Woong Sim Sun-Uk Kim Soojin Park Gabbine Wee Ekyune Kim Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)Daegu 41061Korea College of Pharmacy Catholic University of DaeguGyeongbuk 38430Korea National Primate Research Center(NPCR) Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Department of Biochemistry and Molecular Biology Melvin and Bren Simon Comprehensive Cancer CenterIndiana University School of MedicineIndianapolisIN 46202USA

Glycosylphosphatidylinositol-anchored sperm hyaluronidases have long been believed to assist in sperm penetration through the cumulus-oocyte complex(COC);however,their role in mammalian fertilization remains unclear.Previously,we have shown that hyaluronidase 5(Hyal5)/Hyal7 double-knockout(dKO)mice produce significantly fewer offspring than their wild-type(WT)counterparts because of defective COC dispersal.Male infertility is mainly caused by a low sperm count.It can be further exacerbated by the deficiency of sperm hyaluronidase,which disperses the cumulus cells of the outer layer of the COC.In the current study,we evaluated the effects of a low count of Hyal-deficient sperm and conditions of ovulated oocytes on the fertilization rate using a mouse model.Our results demonstrated that a low sperm count further decreases the in vitro fertilization(IVF)rate of Hyal-deficient dKO spermatozoa.In addition,the dKO spermatozoa resulted in a fertilization rate of 12.5%upon fertilizing COCs with a thick cumulus layer,whereas the IVF rate was comparable to that of WT spermatozoa when oocytes with a thin or no cumulus layer were fertilized.Finally,we proved that the IVF rate of dKO spermatozoa could be recovered by adding rat spermatozoa as a source of sperm hyal.Our results suggest that a deficiency of proteins involved in fertilization,such as sperm hyal,has a vital role in fertilization.

关键词： HYAL5 HYAL7 cumulus-oocyte complex fertilization infertility sperm hyaluronidase

Endoscopic ultrasonography-guided trucut biopsy for the preoperative diagnosis of peripancreatic castleman's disease: A case report

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World Journal of Gastroenterology 2008年第13期14卷 2115-2117页

作者： Kyoung hoon Rhee sang Soo Lee joo Ryung Huh Department of Gastro-enterology University of Ulsan College of Medicine Asan Medical Center Seoul 138-736 South Korea Department of Pathology University of Ulsan College of Medicine Asan Medical Center Seoul 138-736 South Korea

Castleman's disease (CD) of the pancreas/peripancreas is extremely rare. The recently introduced, endoscopic ultrasonography (EUS)-guided trucut biopsy (TCB) is a useful diagnostic modality for obtaining tissue samples from peripancreatic lesions. However, its role in diagnosing CD remains unknown. We report a case of localized, peripancreatic, hyaline-vascular CD biopsied using EUS. The pathology results were initially interpreted as an extranodal, marginal-zone B-cell lymphoma. However, polymerase chain reaction (PCR) study for the IgH gene rearrangement revealed a polyclonal pattern. We also reviewed the relevant literature. To our knowledge, this is the first illustrated report on EUS-TCB findings of CD with its pathology results of EUS-TCB mimicked a B-cell lymphoma.

关键词： Castleman病内窥镜检查超声波检查法活组织切片检查淋巴瘤术前诊断

Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats

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Chinese Journal of Integrative Medicine 2018年第6期24卷 460-466页

作者： Kwon-Yeon Weon Min Gi Kim Soyoung Shin Tae Hwan Kim Sang Hoon Joo Eunsook Ma Seok Won Jeong Sun Dong Yoo Yu Seok Youn Beom Soo Shin College of Pharmacy Catholic University of Daegu School of Pharmacy Sungkyunkwan University College of Pharmacy Wonkwang University

Objective： To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib （Iressae） and the oriental medications Guipi Decoction （归脾汤, GPD, Guibi-tang in Korean） and Bawu Decoction （八物汤, BWD, Palmul-tang in Korean）. Methods： Methylceliulose （MC, control）, GPD （1,200 mg/kg）, or BWD （6,000 mg/kg） was orally administered to rats either as a single dose or multiple doses prior to gefitinib administration. To examine the effects of a single dose of the herbal medicines, gefitinib （10 mg/kg） was orally administered after 5 min or 1 h of MC or the herbal medicine pretreatments. To examine the effects of the multiple doses of the herbal medicines, gefltinib （10 mg/kg） was orally administered following 7 consecutive days of the administration of MC or each herbal medicine. The plasma concentrations of gefitinib were determined with liquid chromatography-tandem mass spectrometry assay. The plasma concentration-time profiles of gefitinib were analyzed with a noncompartmental analysis. Results： Gefitinib was rapidly absorbed and showed a mono- exponential decline with an elimination half-life of 3.7-4.1 h. The pharmacokinetics of gefitinib was not affected by GPD pretreatment. However, a significantly lower maximum plasma concentration （Crux, P〈0.05） and area under the curve （P〈0.05）, and a delayed time to reach Cmax （Tmax, P〈0.01） were observed in both single- and multiple- dose BWD-pretreated rats compared with the control rats. Conclusions： BWD and not GPD might delay and interfere with gefitinib absorption. Further evaluations of the clinical significance of these findings are needed.

关键词： herb-drug interaction pharmacokinetics gefitinib Guipi Decoction Bawu Decoction

Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

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Gastroenterology Report 2022年第1期10卷 440-450页

作者： sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung joo Cho Hye Jung Park Hye Won Lee Beom Kyung Kim Jun Yong Park Do Young Kim sang hoon Ahn Soo Han Bae Seung Up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of NAFLD.Methods NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/EZE.We also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 cells.Results Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle group.In the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

Mixed-dimensional stacked nanocomposite structures for a specific wavelength-selectable ambipolar photoresponse

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Nano Research 2024年第6期17卷 5549-5558页

作者： Young Jae Park Jaeho Shim joo Song Lee Kyu Seung Lee Ji-Yeon Kim Kang Bok Ko sang-Youp Yim Seongjun Kim hoon-Kyu Shin Donghee Park Yong Ju Yun Dong Ick Son Institute of Advanced Composite Materials Korea Institute of Science and TechnologyJeollabuk-do 55324Republic of Korea National Institute for Nanomaterials Technology Pohang University of Science and TechnologyGyeongsangbuk-do 37673Republic of Korea Department of Semiconductor Science and Technology Semiconductor Physics Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Republic of Korea KIST School Department of Nanomaterials and Nano ScienceUniversity of Science and Technology(UST)Daejeon 34113Republic of Korea

Mixed-dimensional composite structures using zero-dimensional(0D)quantum dots(QDs)and two-dimensional(2D)transition metal dichalcogenides(TMDs)materials are expected to attract great interest in optoelectronics due to the potential to generate new optical properties.Here,we report on the unique optical characteristics of a devices with mixed dimensional vertically stacked structures based on tungsten diselenide(WSe_(2))/CdSeS QDs monolayer/molybdenum disulfide(MoS_(2))(2D/0D/2D).Specifically,it exhibits an ambipolar photoresponse characteristic,with a negative photoresponse observed in the 400-600 nm wavelength range and a positive photoresponse appeared at 700 nm wavelength.It resulted in the high negative responsivity of up to 52.22 mA·W^(−1)under 400 nm,which is 163 times higher than that of the photodetector without CdSeS QDs.We also demonstrated the negative photoresponse,which could be due to increased carrier collision probability and non-radiative recombination.Device modeling and simulation reveal that Auger recombination among the types of non-radiative recombination is the main cause of negative photocurrent generation.Consequently,we discovered ambipolar photoresponse near a specific wavelength corresponding to the energy of quantum dots.Our study revealed interesting phenomenon in the mixed low-dimensional stacked structure and paved the way to exploit it for the development of innovative photodetection materials as well as for optoelectronic applications.

关键词： mixed-dimension quantum dot heterostructure photodetector ambipolar photoresponse

Chemical ablation of the gallbladder using alcohol in cholecystitis after palliative biliary stenting

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World Journal of Gastroenterology 2009年第16期15卷 2041-2043页

作者： Tae hoon Lee sang-Heum Park sang Pil Kim Ji-Young Park Chang Kyun Lee Il-Kwun Chung Hong Soo Kim Sun-joo Kim Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineCheonan Hospital

Chemical ablation of the gallbladder is effective in patients at high risk of complications after surgery. Percutaneous gallbladder drainage is an effective treatment for cholecystitis; however, when the drain tube cannot be removed because of recurrent symptoms, retaining it can cause problems. An 82-year-old woman presented with cholecystitis and cholangitis caused by biliary stent occlusion and suspected tumor invasion of the cystic duct. We present successful chemical ablation of the gallbladder using pure alcohol, through a percutaneous gallbladder drainage tube, in a patient who developed intractable cholecystitis with obstruction of the cystic duct after receiving a biliary stent. Our results suggest that chemical ablation therapy is an effective alternative to surgical therapy for intractable cholecystitis.

关键词：化学消融治疗胆道内支架置入术胆囊炎纯酒精姑息胆道支架胆囊引流术高危患者

Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

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The Journal of Biomedical Research 2018年第4期32卷 257-263页

作者： sang-Yong Eom Dong-Hyuk Yim Dae-hoon Kim Hyo-Yung Yun Young-Jin Song Sei-Jin Youn Taisun Hyun joo-Seung Park Byung Sik Kim Yong-Dae Kim Heon Kim Departments of Preventive Medicine and Medical Research Institute College of Medicine Departments of Preventive Medicine and Surgery College of Medicine Departments of Preventive Medicine and Internal Medicine College of Medicine Dartment of Food and Nutrition Chungbuk National UniversityCheongju 28644Korea Department of Surgery College of MedicineEulji UniversityDaejon 301746Korea Department of Surgery Asan Medical CenterCollege of MedicineUlsan UniversitySeoul 138736Korea

There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations,but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway.The effects of vitamin D intake,vitamin D related genetic polymorphisms,and their association with the incidence of gastric cancer were investigated in a hospital case-control study,including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex.Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects.No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls,nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses.Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels,but not with the active form of the vitamin,1,25-dihydroxyvitamin D.There were no statistically significant interactions between vitamin D intake,and VDR or TXNIP polymorphisms.This study suggests that dietary vitamin D intake is not associated with gastric cancer risk,and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.

关键词： gastric cancer vitamin D vitamin D receptor gene-environment interaction

Cholecystoduodenal fistula presenting with upper gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第2期9卷 410-415页

作者： Jin Myung Park Chang Don Kang Ji Hyun Kim sang hoon Lee Seung-joo Nam Sung Chul Park Sung joonLee Seungkoo Lee Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Kangwon DoSouth Korea Department of Gastroenterology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea Anatomy and Pathology Kangwon National University School of MedicineChuncheon 200947Kangwon DoSouth Korea Department of Pathology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea

BACKGROUND Cholecystoduodenal fistula is a rare complication of cholelithiasis.Symptoms are usually non-specific and often indistinguishable from those of etiologic diseases,but it rarely presents as severe gastrointestinal bleeding.Bleeding associated with cholecystoduodenal fistula usually requires surgery because significant bleeding from the cystic artery is unlikely to be resolved by conservative management or endoscopic hemostasis.CASE SUMMARY We report a case of cholecystoduodenal fistula that presented with hematemesis which was diagnosed by endoscopy and computed tomography.Endoscopic hemostasis could not be achieved,but surgical treatment was successful.Additionally,we have presented a literature review.CONCLUSION Cholecystoduodenal fistula should be considered as differential diagnosis when a patient with history of gallstone disease presents with gastrointestinal bleeding.

关键词： Biliary fistula Hematemesis Cholecystitis Gallstones Cholecystectomy Case report

Modified rendezvous intrahepatic bile duct cannulation technique to pass a PTBD catheter in ERCP

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World Journal of Gastroenterology 2010年第42期16卷 5388-5390页

作者： Tae hoon Lee sang-Heum Park Sae Hwan Lee Chang-Kyun Lee Suck-Ho Lee Il-Kwun Chung Hong Soo Kim Sun-joo Kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University College of MedicineCheonan Hospital23-20 Bongmyung-dongCheonan-siChungcheongnam-do330-721South Korea

The rendezvous procedure combines an endoscopic technique with percutaneous transhepatic biliary drainage(PTBD).When a selective common bile duct cannulation fails,PTBD allows successful drainage and retrograde access for subsequent rendezvous techniques.Traditionally,rendezvous procedures such as the PTBDassisted over-the-wire cannulation method,or the parallel cannulation technique,may be available when a bile duct cannot be selectively cannulated.When selective intrahepatic bile duct(IHD) cannulation fails,this modified rendezvous technique may be a feasible alternative.We report the case of a modified rendezvous technique,in which the guidewire was retrogradely passed into the IHD through the C2 catheter after end-to-end contact between the tips of the sphincterotome and the C2 catheter at the ampulla's orifice,in a 39-year-old man who had been diagnosed with gallbladder carcinoma with a metastatic right IHD obstruction.Clinically this procedure may be a feasible and timesaving technique.

关键词： Endoscopic retrograde cholangiopancreatography Intrahepatic bile duct Rendezvous technique