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Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data

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World Journal of Clinical Cases 2021年第33期9卷 10198-10207页

作者： Hong Ki Min Se Hee Kim Jong Han Choi Kyomin Choi Hae-Rim Kim sang-heon lee Department of Internal Medicine Konkuk University Medical CenterSeoul KS013South Korea Department of Neurology Konkuk University Medical CenterSeoul KS013South Korea Division of Rheumatology Department of Internal MedicineKonkuk University School of MedicineSeoul KS013South Korea

BACKGROUND Neuropathy is a common chronic complication in type 2 diabetes mellitus(T2DM).Statin and metformin are commonly used medications in T2DM patients,and some studies showed statin-or metformin-induced *** To evaluate the incidence of neuropathy among patients with T2DM associated with statin and metformin *** Korean Health Insurance Review and Assessment national patient sample data from 2016 and 2017 were *** with T2DM and no complications were divided into statin/metformin/statin+metformin users and *** incidence was defined by International Statistical Classification of Diseases and Related Health Problems,10th revision codes and concomitant prescriptions for anticonvulsants or *** regression analyses were conducted to examine the associations between statin/metformin/statin+metformin therapies and the incidence of *** score(PS)matching was performed on the basis of age,sex and *** Overall,34964 and 35887 patients with T2DM and no complications were included in the Korean Health Insurance Review and Assessment national patient sample datasets from 2016 and 2017,*** therapy was associated with increased risks of neuropathy in 2016 and 2017[PS-matched odds ratio(OR)=1.22,95%confidence interval(CI):1.08-1.38;PS-matched OR=1.17,95%CI:1.03-1.33,respectively].Metformin therapy was associated with reduced risks of neuropathy in 2016 and 2017(PS-matched OR=0.30,95%CI:0.21-0.42;PSmatched OR=0.44,95%CI:0.32-0.60,respectively).Combined statin+metformin therapy was not significantly associated with neuropathy in 2016 or 2017(PSmatched OR=0.85,95%CI:0.61-1.19;PS-matched OR=0.95,95%CI:0.66-1.38,respectively).CONCLUSION Statin therapy was associated with enhanced risk of new-onset neuropathy in patients with T2DM,but metformin therapy showed the opposite association.

关键词： Diabetes mellitus Neuropathies Hydroxymethylglutaryl-CoA reductase inhibitors Metformin

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Integrated Production-and-Delivery Cycle Model for a Three-Echelon Supply Chain System

Integrated Production-and-Delivery Cycle Model for a Three-E...

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2011 International Conference on Mechanical, Industrial, and Manufacturing Engineering (MIME 2011)

作者： Hari Prasetyo lee Luong sang-heon lee School of Adv.Manufacturing and Mechanical Engineering University of South Australia Mawson Lakes Mawson Boulevard

This paper presents a model to determine the number of manufacturer's and buyers'shipments,production cycle length and production sequence simultaneously in a three-level supply chain *** system comprises of a number of distributors,single manufacturer/assembler and multiple part *** objective of the model is to find a set of the decision variables which minimize the average total relevant costs of the entire system.

关键词： production cycle,sequencing,inventory system

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Recent Advances in Patterning Strategies for Full‑Color Perovskite Light‑Emitting Diodes

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Nano-Micro Letters 2024年第3期16卷 99-137页

作者： Gwang heon lee Kiwook Kim Yunho Kim Jiwoong Yang Moon Kee Choi Graduate School of Semiconductor Materials and Devices Engineering Center for Future Semiconductor Technology(FUST)Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea

Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with remarkably narrow bandwidths,high quantum yield,and solution *** recent advances have pushed the luminance efficiency of monochromic perovskite light-emitting diodes(PeLEDs)to their theoretical limits,their current fabrication using the spincoating process poses limitations for fabrication of full-color *** integrate PeLEDs into full-color display panels,it is crucial to pattern red–green–blue(RGB)perovskite pixels,while mitigating issues such as cross-contamination and reductions in luminous ***,we present state-of-the-art patterning technologies for the development of full-color ***,we highlight recent advances in the development of efficient ***,we discuss various patterning techniques of MPHs(i.e.,photolithography,inkjet printing,electron beam lithography and laserassisted lithography,electrohydrodynamic jet printing,thermal evaporation,and transfer printing)for fabrication of RGB pixelated *** patterning techniques can be classified into two distinct approaches:in situ crystallization patterning using perovskite precursors and patterning of colloidal perovskite *** review highlights advancements and limitations in patterning techniques for PeLEDs,paving the way for integrating PeLEDs into full-color panels.

关键词： Perovskite Light-emitting diode Full-color display High-resolution patterning Electroluminescence

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Effect of music on colonoscopy performance: A propensity scorematched analysis

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 397-406页

作者： Eun Jeong Choi Sam Ryong Jee sang heon lee Jun Sik Yoon Seung Jung Yu Jong Hyun lee Han Byul lee sang Wook Yi Myeong Pyo Kim Byung Cheol Chung Hong Sub lee Department of Internal Medicine Inje University College of MedicineBusan Paik HospitalBusan 47392South Korea Department of Public Health Ajou University Graduate School of Public HealthSuwon 16499South Korea Department of Preventive Medicine and Public Health Catholic Kwandong University College of MedicineGangneung 25601South Korea

BACKGROUND Music has been used to reduce stress and improve task performance during medical *** To assess the effects of music on colonoscopy performance *** We retrospectively reviewed patients who underwent colonoscopy performed by four endoscopists with popular *** performance outcomes,such as insertion time,adenoma detection rate(ADR),and polyp detection rate(PDR),were compared between the music and non-music *** reduce selection bias,propensity score matching was *** After one-to-one propensity score matching,169 colonoscopies were selected from each *** significant differences in insertion time(4.97 vs 5.17 min,P=0.795)and ADR(39.1%vs 46.2%,P=0.226)were found between the two *** analysis showed that the insertion time(3.6 vs 3.8 min,P=0.852)and ADR(51.1%vs 44.7%,P=0.488)did not significantly differ between the two groups in ***,in trainees,PDR(46.9%vs 66.7%,P=0.016)and ADR(25.9%vs 47.6%,P=0.006)were significantly lower in the music than in the nonmusic *** The current study found that listening to music during colonoscopy did not affect procedure ***,it suggested that music may distract trainees from appropriately detecting adenomas and polyps.

关键词： Music Colonoscopy Performance Adenoma Colonic polyps Cecal insertion time

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Enhancement of Power Generation in Microbial Fuel Cells through Supplementation of <i>Platycodon grandiflorum</i>in Doraji Roots

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Journal of Sustainable Bioenergy Systems 2019年第4期9卷 169-178页

作者： Jung-In Park Hyunjin Kim Dae Kyung Go Peter S. Park sang heon lee Min Jung Koh Jonathan Jo Donghoon lee Seungshin lee Paul S. Chung Fuzbien Technology Institute Rockville MD USA Youth with Talents Fairfax VA USA St. Johnsbuury Academy Jeju Korea Department of Biology School of Arts and Sciences Cornell University Ithaca NY USA School of Arts and Sciences Johns Hopkins Baltimore MD USA

The current study reports the evidence of enhancement in power generation from cellulosic biomass in microbial fuel cell (MFC) systems by supplementing dried Doraji (Platycodon grandiflorum) roots powder. Mediator-less two chamber H-type MFCs were prepared using rumen fluid as anode inocula to convert finely ground pine tree (Avicel) at 2% (w/v) to electricity. Dried Doraji roots were ground to pass 1 mm sieve and added to the anode of MFC at 0.1% w/v dosage for treatment. MFC power and current across an external resistor were measured daily for 10 d. At the end of incubation on d10, collected gases were measured for total gas volume and analyzed for gas composition on gas chromatography. Supplementation of Doraji roots powder to MFC anode chamber increased power generation and CO2 production. Over the 10d experimental period, power density normalized to anode surface area were between 17.0 and 37.7 with average of 32.5 mW/m2 in Doraji MFCs, and between 16.8 and 19.8 with average of 18.2 mW/m2 in control group. CO2 production increased and methane to CO2 ratio decreased in Doraji root treatment comparing to control group. These observations imply that Doraji root components would inhibit methanogenesis and alter microbial fermentation of cellulose compounds favorable to produce bioenergy efficiently in MFC.

关键词： MFC Platycodon grandiflorum

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Is forceps more useful than visualization for measurement of colon polyp size?

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World Journal of Gastroenterology 2016年第11期22卷 3220-3226页

作者： Jae Hyun Kim Seun Ja Park Jong Hoon lee Tae Oh Kim Hyun Jin Kim Hyung Wook Kim sang heon lee Dong Hoon Baek Department of Gastroenterology Kosin University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Dong-A University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Haeundae Paik Hospital Inje University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Gyeongsang National University Hospital Jinju 660-702 South Korea Department of Gastroenterology Pusan National University Yangsan Hospital Yangsan 626-770 South Korea Department of Gastroenterology Inje University Busan Paik Hospital Inje University College of Medicine Busan 602-702 South Korea Department of Gastroenterology Pusan National University School of Medicine Busan 602-702 South Korea

AIM: To identify whether the forceps estimation is more useful than visual estimation in the measurement of colon polyp ***: We recorded colonoscopy video clips that included scenes visualizing the polyp and scenes using open biopsy forceps in association with the polyp, which were used for an exam. A total of 40 endoscopists from the Busan Ulsan Gyeongnam Intestinal Study Group Society(BIGS) participated in this study. Participants watched 40 pairs of video clips of the scenes for visual estimation and forceps estimation, and wrote down the estimated polyp size on the exam paper. When analyzing the results of the exam, we assessed interobserver differences, diagnostic accuracy, and error range in the measurement of the polyp size.R E S U LT S : The overall intra-class correlation coefficients(ICC) of inter-observer agreement for forceps estimation and visual estimation were 0.804(95%CI: 0.731-0.873, P < 0.001) and 0.743(95%CI: 0.656-0.828, P < 0.001), respectively. The ICCs of each group for forceps estimation were higher than those for visual estimation(Beginner group, 0.761 vs 0.693; Expert group, 0.887 vs 0.840, respectively). The overall diagnostic accuracy for visual estimation was 0.639 and for forceps estimation was 0.754(P < 0.001). In the beginner group and the expert group, the diagnostic accuracy for the forceps estimation was significantly higher than that of the visual estimation(Beginner group, 0.734 vs 0.613, P < 0.001; Expert group, 0.784 vs 0.680, P < 0.001, respectively). The overall error range for visual estimation and forceps estimation were 1.48 ± 1.18 and 1.20 ± 1.10, respectively(P < 0.001). The error ranges of each group for forceps estimation were significantly smaller than those for visual estimation(Beginner group, 1.38 ± 1.08 vs 1.68 ± 1.30, P < 0.001; Expert group, 1.12 ± 1.11 vs 1.42 ± 1.11, P < 0.001, respectively).CONCLUSION: Application of the open biopsy forceps method when measuring colon polyp size could help reduce int

关键词： Colon polyp Colonoscopy Measurement Endoscopy

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An Assessment of the Social, Cultural, and Economical Barriers to Option B+Retention and Their Solutions in Malawi: A Review

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World Journal of AIDS 2021年第1期11卷 15-24页

作者： Jamie Yoon David S. Chung Michelle Kim Kunmin Kim sang heon lee Tae Youn Kim Hark Joon lee Seog In Moon Jooheon Park Paul S. Chung Thomas Nyirenda School of Medical Boston University Boston USA Edward Via College of Osteopathic Medicine Blacksburg USA School of Medicine University of Virginia Charlottesville USA Youth with Talents Fairfax USA Department of Art & Science Biology Johns Hopkins University Baltimore USA Clinical Research Education and Management Service Lilongwe Malawi

Malawi has one of the highest rates of HIV prevalence in the world, and accounts for 4% of the total number of people living in sub-Saharan Africa with HIV. Approximately one million people in Malawi were living with HIV in 2016, with 24,000 HIV-related deaths. The Option B+ program, first implemented in Malawi, aimed to initiate ART for all pregnant women, regardless of their CD4 cell count or disease stage. This study serves to analyze and assess the effectiveness of Option B+ retention, in relation to the facilitation of how various social and cultural barriers were handled. A literature review of 29 publications was conducted. Careful evaluation of various studies indicates that although there is a myriad of reasons explaining low levels of retention, the women who were at the highest risk for low retention were young pregnant women who were treated on the same day of HIV-diagnosis. Solutions focused around women and their partners or communities showed promising evidence of success in increasing adherence, as these strategies likely provided women reliable social and emotional support to address major barriers to retention such as a lack of support from male partners, ineffective education from healthcare workers, or stigma towards their HIV disclosure statue.

关键词： HIV Option B+ Malawi Retention CHTC PMTCT

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Development of CAD/CAM system and profile measuring device for CNC grinding machine to obtain an optimal grinding speed

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Journal of Central South University 2011年第1期18卷 146-152页

作者： LIM sang-heon KIM Jae-Hyun lee Choon-Man Agency of Promoting Technology Innovation Gyeongnam TechnoparkChangwon 641-465Korea School of Mechatronics Changwon National University

Cam mechanics is one of the most popular devices for generating irregular motions and is widely used in automatic equipment,such as textile machines,internal combustion engines,and other automatic *** order to obtain a positive motion from the follower using a rotating cam,its shape should be correctly designed and *** development of an adequate CAD/CAM system for a cam profile CNC grinding machine is necessary to manufacture high-precision *** purpose of this study is the development of a CAD/CAM system and profile measuring device for a CNC grinding machine to obtain an optimal grinding speed with a constant surface *** types of disk cams were manufactured using the proposed algorithm and procedures to verify effectiveness of the developed CAD/CAM system.

关键词： cam CAD/CAM system CNC grinding machine optimal grinding speed

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An advanced segmentation using area and boundary tracing technique in extraction of lungs region

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Journal of Central South University 2014年第10期21卷 3811-3820页

作者： Kiran THAPALIYA sang-Woong lee Jae-Young PYU heon JEONG Goo-Rak KWON Department of Information and Communication Engineering Chosun University School of Computer Engineering Chosun University Deparment of Fire Administration Chodang University

A new method is presented for the segmentation of pulmonary parenchyma. The proposed method is based on the area calculation of different objects in the image. The main purpose of the proposed algorithm is the segment of the lungs images from the computer tomography(CT) images. The original image is binarized using the bit-plane slicing technique and among the different images the best binarized image is chosen. After binarization, the labeling is done and the area of each label is calculated from which the next level of binarized image is obtained. Then, the boundary tracing algorithm is applied to get another level of binarized image. The proposed method is able to extract lung region from the original images. The experimental results show the significance of the proposed method.

关键词： bit-plane slicing technique connected component labeling area tracing boundary tracing

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Robot-assisted laparoscopic pyeloureterostomy for ureteropelvic junction rupture sustained in a traffic accident:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5802-5808页

作者： Si Hyun Kim Woong Bin Kim Jae heon Kim sang Wook lee Department of Urology Soonchunhyang University Cheonan HospitalCheonan 31151South Korea Department of Urology Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Urology Soonchunhyang University Seoul HospitalSoonchunhyang University Medical CollegeSeoul 04401South Korea Department of Urology Soonchunhyang University Bucheon HospitalSoonchunhyang University School of MedicineBucheon 14584South Korea

BACKGROUND Ureteral reconstruction is a highly technical type of laparoscopic or open *** incidence of ureteral injury is low;however,ureteral injuries tend to be *** surgery for urinary reconstructive surgery is growing in popularity,which has made procedures such as pyeloplasty,ureteroureterostomy,and ureteroneocystostomy possible,with minimal damage to the *** the best of our knowledge,this is the first report of robot-assisted laparoscopic pyeloureterostomy in Korea,in a 17-year-old female patient with a ureteral *** SUMMARY The patient,a 17-year-old girl without previous medical history,was presented at the emergency room and complained of abdominal and back *** in the right upper quadrant was observed on physical *** in the right perirenal space was observed without abdominal organ injuries on the initial enhanced abdomen computed tomography(CT)*** injury was not suspected at this *** patient was stabilized via conservative treatment,but complained of right flank pain 3 wk later and revisited the emergency *** enhanced abdominal CT scan revealed a huge urinoma in the right perirenal space with hydronephrosis of the right *** and antegrade pyelography were *** and discontinuity of the ureter were found.A rupture of the ureteropelvic junction was diagnosed and reconstructive surgery was *** 3 mo,the patient did not complain of any symptoms without any abnormal radiologic *** This case report discusses the safety and effectiveness of this minimal invasive procedure as an alternative to conventional open or laparoscopic surgery.

关键词： Robot surgical procedure Ureteral injuries Minimal invasive surgical procedures Reconstructive surgical procedures Urology Case report

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