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Viral-host molecular interactions and metabolic modulation:Strategies to inhibit flaviviruses pathogenesis

World Journal of Virology 2024年第4期13卷 41-50页

作者： Zeeshan Ahmad Khan Mukesh Kumar Yadav dong-Woo Lim Hojun kim Jing-Hua Wang AbuZar Ansari Biohealth Products Research Center(BPRC) Research Center for Agedlife Redesign(RCAR)Department of Physical TherapyINJE UniversityGimhae 5084South Korea Department of Microbiology Central University of PunjabBathinda 151401India Department of Diagnostics College of Korean MedicineDongguk UniversityGoyang 10326South Korea Division of Rehabilitation Medicine of Korean Medicine Department of Oriental Rehabilitation MedicineDongguk UniversityIlsan HospitalGoyang 10326South Korea Institute of Oriental Medicine Dongguk UniversityGoyang 10326South Korea Department of Obstetrics and Gynecology Ewha Womans UniversitySeoul 07985South Korea

Flaviviruses,which include globally impactful pathogens,such as West Nile virus,yellow fever virus,Zika virus,Japanese encephalitis virus,and dengue virus,contribute significantly to human *** the ongoing emergence and resurgence of flavivirus-mediated pathogenesis,the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral *** the intricate processes of fusion,transcription,replication,and maturation,the complex interplay of viral and host metabolic interactions affects *** interactions involve metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,each playing a pivotal role in the replication and maturation of *** viral-host metabolic molecular interactions hijack and modulate the molecular mechanisms of host metabolism.A comprehensive understanding of these intricate metabolic pathways offers valuable insights,potentially unveiling novel targets for therapeutic interventions against flaviviral *** review emphasizes promising avenues for the development of therapeutic agents that target specific metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,which interact with flavivirus replication and are closely linked to the modulation of host *** clinical limitations of current drugs have prompted the development of new inhibitory strategies for flaviviruses based on an understanding of the molecular interactions between the virus and the host.

关键词： Flavivirus Nonstructural proteins Virus-host interaction Metabolism Inhibitors Vaccines

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Computational study of flow separation in truncated ideal contour nozzles under high-altitude conditions

International Journal of Fluid Engineering

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International Journal of Fluid Engineering 2024年第1期 21-30页

作者： Ijas Muhammed V V Shamsia Banu N Abhilash Suryan Vincent Lijo David Simurda Heuy dong kim College of Engineering Trivandrum Government Engineering College Thrissur Faculty of Mechanical Engineering Technical University of Liberec Andong National University

Flow separation in rocket nozzles has been studied mostly under sea-level conditions, which fail to take into account changes in ambient density and ambient pressure during the flight of a rocket. In the present study, numerical analysis is conducted of flow characteristics within a truncated ideal contour(TIC) nozzle to investigate the influence of ambient density and pressure on flow separation. Six different altitudes from a typical flight are considered, from a very low altitude to a high altitude. The flow is analyzed by varying the nozzle pressure ratios corresponding to these altitudes. Both cold flow and hot flow simulations are conducted. The locations of separation positions at various altitude conditions are accurately captured and are found to be in good agreement with experimental results. The results of the study establish that for a given nozzle pressure ratio, the flow separation point is shifted upstream with increasing altitude. This clearly points to a dependence of separation position on the altitude of operation for TIC rocket nozzles.

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Analysis of optical emission spectroscopy data during silicon etching in SF_(6)/O_(2)/Ar plasma

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Plasma Science and Technology 2021年第12期23卷 117-127页

作者： dong Hwan kim Jeong Eun CHOI sang Jeen HONG Department of Electronics Engineering Myongji University116 Myongji-roYongin-siGyeonggi-doRepublic of Korea

Silicon etching is an essential process in various applications,and a major challenge for etching process is anisotropic high aspect ratio etching *** etch profile is determined by the plasma parameters and process *** this study,the plasma state with each process parameters were analyzed through the optical emission spectroscopy(OES)plasma diagnostic sensor by both chemical and physical *** temperature and electron density were additionally acquired using the corona model with OES data that provides chemical species information,and the etch profile was evaluated through scanning electron microscope measurement *** results include changes in profile with gas ratio,bias power,and *** figure out that factors like ion energy and ion angular distribution as well as chemical reaction affect the anisotropic profile.

关键词： silicon etching profile optical emission spectroscopy plasma in-formation corona model

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Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： H.T.Jeong S.W.Lee W.J.kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and associated deformation mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the HCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

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Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2

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National Science Review 2024年第3期11卷 108-118页

作者： Ning Tian Zhe Huang Bo Gyu Jang Shuaifei Guo Ya-Jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping Sun Zhongkai Liu dong-Lai Feng Xianhui Chen Sung-Kwan Mo Minjae kim Young-Woo Son Dawei Shen Wei Ruan Yuanbo Zhang State Key Laboratory of Surface Physics New Cornerstone Science Laboratory and Department of PhysicsFudan University Shanghai Qi Zhi Institute Shanghai Research Center for Quantum Sciences Institute for Nanoelectronic Devices and Quantum Computing Fudan University Zhangjiang Fudan International Innovation Center Fudan University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Korea Institute for Advanced Study School of Emerging Technology and Department of Physics University of Science and Technology of China Advanced Light Source Lawrence Berkeley National Laboratory ShanghaiTech Laboratory for Topological Physics Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of Sciences High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Collaborative Innovation Centre of Advanced Microstructures Nanjing University Department of Physics University of Science and Technology of China and Key Laboratory of Strongly Coupled Quantum Matter Physics Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional *** dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality,however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating *** dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.

关键词： two-dimensional materials 1T-TaSe2 dimensionality crossover metal to Mott insulator transition

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Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： Seon Yeong Ji EunJin Bang Hyun Hwangbo Min Yeong kim Da Hye kim Su Hyun Hong Shin-Hyung Park Chang-Young Kwon Gi-Young kim You-Jin Jeon Suengmok Cho Yung Hyun Choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

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Predicting moisture condensation risk on the radiant cooling floor of an office using integration of a genetic algorithm-back-propagation neural network with sensitivity analysis

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Energy and Built Environment 2024年第1期5卷 110-129页

作者： Meng Su Jiying Liu Moon Keun kim Xiaozhou Wu School of Thermal Engineering Shandong Jianzhu UniversityJinan 250101China Department of Civil Engineering and Energy Technology Oslo Metropolitan UniversityOslo N-0130Norway School of Civil Engineering Dalian University of TechnologyDalianChina

Pre-dehumidification time(τ_(pre))and pre-dehumidification energy consumption(E_(pre))play important roles in preventing the condensation of moisture on the floors of rooms that use a radiant floor cooling(RFC)***,there are few theoretical or experimental studies that focus on these two important *** this study,an artificial neural network(ANN)was used to predict condensation risk for the integration of RFC systems with mixed ventilation(MV),stratum ventilation(SV),and displacement ventilation(DV)systems.A genetic algorithm-back-propagation(GA-BP)neural network model was established to predict τ_(pre) and E_(pre).Both training data and validation data were obtained from tests in a computational fluid dynamics(CFD)*** results show that the established GA-BP model can predict τ_(pre) and E_(pre) *** coefficient of determination(R^(2))of τ_(pre) and of E_(pre) were,respectively,0.973 and *** an RFC system integrated with an MV,SV,or DV system,the lowest values of τ_(pre) and E_(pre) were with the DV system,23.1 s and 0.237 kWh,respectively,for a 67.5 m^(3) ***,the best pre-dehumidification effect was with integration of the DV and RFC *** study showed that an ANN-based method can be used for predictive control for condensation prevention in RFC *** also provides a novel and effective method by which to assess the pre-dehumidification control of radiant floor surfaces.

关键词： Condensation prevention Radiant floor cooling Ventilation system genetic algorithm BP neural network

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Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

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Food Science and Human Wellness 2024年第3期13卷 1698-1710页

作者： Young-Jin Choi Meiqi Fan Nishala Erandi Wedamulla Yujiao Tang Eun-Kyung kim Department of Food Science and Nutrition Dong-A UniversityBusan 49315Republic of Korea Center for Silver-targeted Biomaterials Brain Busan 21 Plus programDong-A UniversityBusan 49315Republic of Korea Department of Health Sciences the Graduate School of Dong-A UniversityBusan 49315Republic of Korea Division of Food Bioscience College of Biomedical and Health SciencesKonkuk UniversityChungju 27478Republic of Korea Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla 90000Sri Lanka School of Bio-Science and Food Engineering Changchun University of Science and TechnologyChangchun 130600China Nutritional Education Major Graduate School of EducationDong-A UniversityBusan 49315Republic of Korea Nutrinomics Lab.Co. Ltd.Busan 49315Republic of Korea

We evaluated the effect of isoquercetin(quercetin-O-3-glucoside-quercetin,IQ)as a functional component of Abeliophyllum disistichum Nakai ethanol extract(ADLE)on prostate cell proliferation and apoptosis and its effects on the IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia(BPH).Metabolites in ADLE were analyzed using UHPLC-qTOF-MS and *** was orally administered(1 or 10 mg/kg)to a testosterone propionate-induced BPH rat model,and its effects on the prostate weight were *** effect of IQ on androgen receptor(AR)signaling was analyzed in LNCaP *** IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also *** metabolites in ADLE were identified and quantified,which confirmed that ADLE contained abundant IQ(20.88 mg/g).IQ significantly reduced the prostate size in a concentration-dependent manner in a BPH rat model,and significantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent *** also inhibited the PI3K/AKT/mTOR pathway activated by IGF-1 treatment in BPH-1 *** BPH-1 cells,IQ led to G0/G1 arrest and suppressed the expression of proliferation factors while inducing ***,IQ shows potential for use as a pharmaceutical and nutraceutical for BPH.

关键词： Isoquercetin Benign prostatic hyperplasia Androgen receptor signaling PI3K/Akt/mtor pathway

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Huge encrusted ureteral stent forgotten for over 25 years:A case report

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World Journal of Clinical Cases 2020年第23期8卷 6043-6047页

作者： dong Soo kim sang Hyub Lee Department of Urology School of MedicineKyung Hee UniversitySeoul 02447South Korea

BACKGROUND Ureteral stent insertion is a relatively non-invasive procedure commonly used in the field of urology to resolve urinary ***,they are sometimes forgotten and the risk of complications increases with *** SUMMARY A 43-year-old woman with a history of recurrent urinary tract infections visited our hospital for evaluation of persistent left flank pain,and lower urinary tract symptoms despite anti-biotic *** had received urological surgery in her teens but did not know the details of her ***,ureter,and bladder X-ray and abdominopelvic computed tomography revealed a forgotten left ureteral stent with huge encrustation at both ends and a severely dilated left kidney with parenchymal *** order to remove the ureteral stent,a laparoscopic nephroureterectomy was *** ureteral stent was successfully removed,and she was discharged after *** patient was followed up for two years after surgery and did not show any signs of long-term *** Long indwelling stents can cause dire complications requiring radical *** registry systems,novel stent material development,and proper patient education is important for complication prevention.

关键词： Ureter Stent Calcification Endoscopy Nephroureterectomy Complications Case report

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Extrusion limit diagram of AZ91–0.9Ca–0.6Y–0.5MM alloy and effects of extrusion parameters on its microstructure and mechanical properties

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Journal of Magnesium and Alloys 2022年第12期10卷 3447-3458页

作者： dong HeeLee Ye Jin kim sang-Hoon kim Byoung Gi Moon Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Agency for Defense Development Daejeon 34186Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

An AZ91–0.9Ca–0.6Y–0.5MM(AZXWMM91100) alloy, which has higher corrosion resistance, ignition resistance, and extrudability than a commercial AZ91 alloy, has been developed recently. In this study, the AZXWMM91100 alloy is extruded at various temperatures(300–400 ℃) and ram speeds(1–14.5 mm/s), and the cracking behaviors, microstructure, and tensile properties of the extruded materials are systematically analyzed. On the basis of the pressure limit and surface and internal cracking limit, the extrusion limit diagram providing a safe extrusion processing zone is established. All of the materials extruded at temperatures and speeds within the safe extrusion processing zone have high surface quality and moderate tensile ductility with an elongation higher than 10%. Moreover, they have a fully recrystallized grain structure and contain undissolved particle stringers arranged parallel to the extrusion direction. The grain size of the extruded material does not show any relationship with the Zener–Hollomon parameter(Z). However, the yield strength(YS) of the extruded material is inversely proportional to the logarithm of the Z value, and their relationship is expressed as YS =-31.2·log(Z) + 536. These findings may broaden the understanding of the AZXWMM91100 alloy with excellent chemical and physical properties and provide valuable information for the development of high-performance extruded Mg products using this alloy.

关键词： Magnesium Extrudability Extrusion limit diagram Microstructure Tensile properties

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