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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：陆红丽 sang don koh 上海交通大学医学院生理学教研室

Objectives:One of the prominent electrical and mechanical responses upon cessation of electrical field stimulation（EFS）in colonic smooth muscle is the rebound excitation（post-stimulus responses;PSR）.However,little is known about the mechanisms underlying the ***,we believe that EFS induces nitric oxide（NO）release from enteric motor neurons,increases cyclic GMP（c GMP）,activates protein kinase G and produces slow inhibitory junction potentials（s IJPs）.The s IJPs are mediated by interstitial cells of Cajal（ICC）.In the present study,we raised a new hypothesis that an increase in c GMP by NO in ICC inhibits phosphodiesterases,increases cyclic AMP and affects the ***,we investigated the role of various isoforms of c GMP-inhibited phosphodiesterases on PSR in murine colonic smooth ***:The proximal and distal colon was taken from C57/BL6（control）,W/Wv,Pde3a KO,Pde3b KO and Pde4b KO *** microelectrode recordings of circular muscle were employed to investigate the *** tissue was subjected to a series of EFS with exogenous applications of atropine,L-NNA and ***:Molecular data by deep sequencing and quantitative PCR analysis showed that Pde3a transcripts are highly expressed in ICC.W/Wv mice displayed a reduction of PSR with a decrease in amplitude of s *** slow wave activity in the proximal colon was augmented in Pde3a KO tissue compared with ***-evoked excitatory junction potentials（EJP）,s IJP and the PSR were significantly augmented in Pde3a KO *** pretreatment with atropine and MRS2500 did not affect PSR in both control and Pde3a KO *** additional application of L-NNA completely abolished the *** distal colon,Pde3a KO mice also showed a significant increase in ***3b and Pde4b KO mice had no significant phenotype in both proximal and distal *** was abolished by a protein kinase A（PKA）***:These data suggest that ICC have an important role in generating PS

关键词： ICC NO c GMP slow inhibitory junction potentials(s IJPs) cAMP/PKA

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Characterization of post-stimulus responses （3rd component） in murine colonic smooth muscle

Characterization of post-stimulus responses （3rd component...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：陆红丽 sang-don koh 上海交通大学医学院生理学教研室

Objectives:The firing of action potentials after IJPs has been described as rebound excitation（off-response）which increases with an increase in the frequency and train duration of electrical field stimulation（EFS）of enteric ***-stimulus responses（during stimulation）including EJP,fast IJP and slow IJP have been well characterized in previous *** little is known about the mechanisms underlying off（post-stimulus）responses（PSR）.In the present study,we will characterize the PSR in murine proximal and distal ***:C57/Bl6 mice were used for intracellular microelectrode recordings from the smooth muscle of the proximal and distal ***,L-NNA and MRS2500 were applied to investigate the responses to electrical field stimulation（EFS）.Results:In the proximal colon,EFS evoked excitatory junction potentials（EJP）followed by fast and slow inhibitory junction potentials（IJP）.Upon cessation of EFS,PSR showed slow depolarization with spike *** pretreatment did not affect PSR suggesting that PSR is not due to cholinergic ***2500 treatment inhibited fast IJP but had no effect on PSR.L-NNA inhibited slow IJP and significantly decreased *** the distal colon,EFS evoked mainly fast IJP with small amplitude of slow IJP.L-NNA treatment had minimum effect on slow IJP and negligible effect on ***,MRS2500significantly decreased fast IJP and almost abolished ***:The two regions of the colon display different EFS-induced on-responses and *** responses in the proximal colon and purinergic responses in the distal colon are main factor to evoke *** nitrergic IJP and purinergic IJP are mediated by ICC and PDGFRα+cells,respectively,the different regional responses may be due to the density of ICC or PDGFRα+cell in the proximal colon and distal colon.

关键词： IJPs ICC colonic smooth muscle EJP

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Establishment of a chicken intestinal organoid culture system to assess deoxynivalenol‑induced damage of the intestinal barrier function

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1119-1130页

作者： Tae Hong Kang sang In Lee Department of Animal Science and Biotechnology Kyungpook National UniversitySangjuGyeong‑Sangbuk‑Do 37224Republic of Korea Research Institute for Innovative Animal Science Kyungpook National University37224SangjuGyeong‑Sangbuk‑DoRepublic of Korea

Background Deoxynivalenol(don)is a mycotoxin that has received recognition worldwide because of its ability to cause growth delay,nutrient malabsorption,weight loss,emesis,and a reduction of feed intake in *** don-contaminated feedstuff is absorbed in the gastrointestinal tract,we used chicken organoids to assess the don-induced dysfunction of the small *** We established a culture system using chicken organoids and characterized the organoids at passages 1 and *** confirmed the mRNA expression levels of various cell markers in the organoids,such as KI67,leucine-rich repeat containing G protein-coupled receptor 5(Lgr5),mucin 2(MUC2),chromogranin A(CHGA),cytokeratin 19(CK19),lysozyme(LYZ),and microtubule-associated doublecortin-like kinase 1(DCLK1),and compared the results to those of the small *** results showed that the organoids displayed functional similarities in permeability compared to the small *** damaged the tight junctions of the organoids,which resulted in increased *** Our organoid culture displayed topological,genetic,and functional similarities with the small intes-tine *** on these similarities,we confirmed that don causes small intestine *** organoids offer a practical model for the research of harmful substances.

关键词： Barrier function Deoxynivalenol Organoids

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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya don Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

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Robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer

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Asian Journal of Urology 2024年第1期11卷 121-127页

作者： George McClintock Ahmed S.Goolam don Perera Ryan Downey Scott Leslie Peter Grimison Henry Woo Peter Ferguson Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaesthesia Chris O'Brien LifehouseSydneyNSWAustralia The University of Sydney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular ***:We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteristics,intraoperative and postoperative parameters,and functional and oncological *** statistics are ***:Nineteen patients were identified;18(94.7%)completed the procedure robotically and one was converted to open surgery;78.9%of patients had stage≥IIB and 12(63.2%)patients had undergone prior *** median operative time was 300(interquartile range[IQR]240-315)*** blood loss was 100(IQR 50-175)*** length of stay was 2(range 1-11)*** robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day *** median lymph node yield was 40.5(IQR 38-51)*** patients undergoing nerve-sparing procedures recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous ascites requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months,one patient developed retroperitoneal recurrence,which was successfully treated with second-line chemotherapy;no other patients have had ***:Robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients,offering low *** oncological outcomes are *** cohorts and longer follow-ups are required to validate our institution's findings.

关键词： Retroperitoneal lymph node dissection Robotic surgery Testicular cancer Retroperitoneal node dissection

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藏族英雄史诗格萨尔王传形式基础(续)

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中国藏学 2024年第1期 106-114,215页

作者：丹珠昂奔中央民族大学北京100081

形式基础是格萨尔研究的基本理论问题,涉及史诗产生、发展、传播的特定时代的社会文化基础,渊源深长。格萨尔的形式集中于“两‘仲’、三要素、一模式”。仲与德乌、苯都是青藏高原古老的文化形式,当格萨尔作为史诗萌芽时,艺人们借用了... 详细信息

形式基础是格萨尔研究的基本理论问题,涉及史诗产生、发展、传播的特定时代的社会文化基础,渊源深长。格萨尔的形式集中于“两‘仲’、三要素、一模式”。仲与德乌、苯都是青藏高原古老的文化形式,当格萨尔作为史诗萌芽时,艺人们借用了他们最熟悉的“仲”的形式,形成了格萨尔王传的形式基础。深刻认识把握这一形式基础,既是认识格萨尔光辉存在的一把钥匙,也是传承、弘扬格萨尔史诗,汲取其精神精华的桥梁,有利于我们传承、研究、弘扬、开发、利用格萨尔的既有成果,确立文化自信,构建各民族共有精神家园。

关键词：格萨尔形式仲仲肯音乐

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斯里兰卡初级汉语学习者语音偏误分析及教学对策 ——以凯拉尼亚大学为例

斯里兰卡初级汉语学习者语音偏误分析及教学对策 ——以凯拉尼亚...

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作者： JAYASINGHE don UMESHIKA SANU（吴美佳）贵州大学

学位级别：硕士

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Theory of phonon-modulated electron spin relaxation time based on the projection reduction method

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Chinese Physics B 2014年第8期23卷 436-443页

作者： Nam Lyong Kang sang don Choi Department of Applied Nanoscience Pusan National University Department of Physics Kyungpook National University

This paper introduces a new method for a formula for electron spin relaxation time of a system of electrons interacting with phonons through phonon-modulated spin-orbit coupling using the projection-reduction method. The phonon absorption and emission processes as well as the photon absorption and emission processes in all electron transition processes can be explained in an organized manner, and the result can be represented in a diagram that can provide intuition for the quantum dynamics of electrons in a solid. The temperature （T） dependence of electron spin relaxation times （T1） in silicon is T1 ∝ T-1.07 at low temperatures and T1 ∝ T-3.3 at high temperatures for acoustic deformation constant Pad = 1.4 × 10^7 eV and optical deformation constant Pod = 4.0 × 10^17 eV/m. This means that electrons are scattered by the acoustic deformation phonons at low temperatures and optical deformation phonons at high temperatures, respectively. The magnetic field （B） dependence of the relaxation times is T1 ∝ B-2.7 at 100 K and T1 ∝ B-2.3 at 150 K, which nearly agree with the result of Yafet, T1 ∝ B-3.0- B -2.5.

关键词： electron spin resonance spin-orbit coupling projection-reduction method phonon scattering

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五株昆虫病原真菌对草地贪夜蛾（Spodoptera frugiperda）生防潜力的评估及其培养基的优化

五株昆虫病原真菌对草地贪夜蛾（Spodoptera frugiperda）生防潜...

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作者： Wellabada Hewage don Piumalee Isurika Damithri 西北农林科技大学

学位级别：硕士

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Quasi-Static, Poiseuille Flow of Analgesics from an Elastomeric Pump: Theoretical Determination of Infusion Times and Toxicity Conditions

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Journal of Biosciences and Medicines 2024年第9期12卷 251-265页

作者： Clare B. Lipscombe Trevor C. Lipscombe don S. Lemons Division of General Surgery Vanderbilt University Medical Center Nashville TN USA Catholic University of America Press Washington DC USA Department of Physics Bethel College North Newton KS USA

Background: Elastomeric pumps (elastic balls into which analgesics or antibiotics can be inserted) push medicines through a catheter to a nerve or blood vessel. Since elastomeric pumps are small and need no power source, they fit easily into a pocket during infusion, allowing patient mobility. Elastomeric pumps are widely used and widely studied experimentally, but they have well-known problems, such as maintaining reliable flow rates and avoiding toxicity or other peak-and-trough effects. Objectives: Our research objective is to develop a realistic theoretical model of an elastomeric pump, analyze its flow rates, determine its toxicity conditions, and otherwise improve its operation. We believe this is the first such theoretical model of an elastomeric pump consisting of an elastic, medicine-filled ball attached to a horizontal catheter. Method: Our method is to model the system as a quasi-Poiseuille flow driven by the pressure drop generated by the elastic sphere. We construct an engineering model of the pressure exerted by an elastic sphere and match it to a solution of the one-dimensional radial Navier-Stokes equation that describes flow through a horizontal, cylindrical tube. Results: Our results are that the model accurately reproduces flow rates obtained in clinical studies. We also discover that the flow rate has an unavoidable maximum, which we call the “toxicity bump”, when the radius of the sphere approaches its terminal, unstretched value—an effect that has been observed experimentally. Conclusions: We conclude that by choosing the properties of an elastomeric pump, the toxicity bump can be restricted to less than 10% of the earlier, relatively constant flow rate. Our model also produces a relation between the length of time that the analgesic fluid infuses and the physical properties of the fluid, of the elastomeric sphere and the tube, and of the blood vessel into which the analgesic infuses. From these, we conclude that elastomeric pumps can be design

关键词： Elastomeric Pump Infusion Therapy Bio-Fluids Medical Devices Antibiotic Delivery Analgesic Delivery

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