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Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan Kim Hyemi Eo sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

历史研究的大体与细节——抗日民族统一战线研究的取径

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史学集刊 2025年第1期 98-108页

作者：桑兵浙江大学历史学院浙江杭州310058

治史要在整体之下研究具体,所以既要把握大体,以免零碎,又须考究细节,以防空洞,使得二者相辅相成,相得益彰。抗日民族统一战线,是抗日战争成败及其学术研究的枢纽性关键所在,据此可以认识与把握和抗战相关的一系列中国革命的理论与实践... 详细信息

治史要在整体之下研究具体,所以既要把握大体,以免零碎,又须考究细节,以防空洞,使得二者相辅相成,相得益彰。抗日民族统一战线,是抗日战争成败及其学术研究的枢纽性关键所在,据此可以认识与把握和抗战相关的一系列中国革命的理论与实践的重大问题。要想坐实这一大体,应当放眼读书,梳理各种史料的多数之汇集,对相关人事具有了解与同情,将概念演变还原为事实衍化,呈现具体历史进程的全过程和各方面,进而深入认识抗日民族统一战线的渊源流变及其内外因缘。

关键词：抗日民族统一战线历史研究大体细节

Heuristic solution using decision tree model for enhanced XML schema matching of bridge structural calculation documents

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Frontiers of Structural and Civil Engineering 2020年第6期14卷 1403-1417页

作者： sang IPARK sang-Ho LEE Department of Civil Environmental and Architectural EngineeringUniversity of Colorado at BoulderBoulderco 80309USA Department of"Civil and Environmental Engineering Yonsei UniversitySeoul 03722Korea

Research on the quality of data in a structural calculation document(SCD)is lacking,although the SCD ofa bridge is used as an essential reference during the entire lifecycle of the *** Schema matching enables qualitative improvement of the stored *** study aimed to enhance the applicability of XML Schema matching,which improves the speed and quality of information stored in bridge ***,the authors proposed a method of reducing the computing time for the schema matching of bridge *** computing speed of schema matching was increased by 13 to 1800 times by reducing the checking process of the ***,the authors developed a heuristic solution for selecting the optimal weight factors used in the matching process to maintain a high accuracy by introducing a decision *** decision tree model was built using the content elements stored in the SCD,design companies,bridge types,and weight factors as input variables,and the matching accuracy as the target *** inverse-calculation method was applied to extract the weight factors from the decision tree model for high-accuracy schema matching results.

关键词： structural calculation document bridge structure XML Schema matching weight factor data mining decision tree model

根管填充联合奥硝唑合剂治疗老年牙体牙髓病的疗效评价

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临床研究 2025年第1期33卷 76-79页

作者：桑广宇平顶山市第一人民医院口腔科河南平顶山467000

目的探究在老年牙体牙髓病治疗过程中应用根管填充联合奥硝唑合剂的效果。方法选取平顶山市第一人民医院口腔科2022年1月至2023年12月期间收治的80例老年牙体牙髓病患者并随机分为对照组和观察组,每组患者40例。对照组患者予以根管填充... 详细信息

目的探究在老年牙体牙髓病治疗过程中应用根管填充联合奥硝唑合剂的效果。方法选取平顶山市第一人民医院口腔科2022年1月至2023年12月期间收治的80例老年牙体牙髓病患者并随机分为对照组和观察组,每组患者40例。对照组患者予以根管填充治疗,观察组先予以奥硝唑合剂治疗后再予以根管填充治疗。两组患者治疗后随访3个月,评估临床治疗效果并统计后3个月内各种不良反应的发生情况,同时对比两组患者治疗前后牙周指标[临床附着水平(CAL)、牙周袋探针深度(PD)和牙龈指数(GI)]以及咀嚼功能的变化。结果观察组患者临床治疗有效率(92.50%)高于对照组(72.50%),差异具有统计学意义(P0.05),治疗后,两组患者CAL、PD、GI均降低,且观察组低于对照组,两组咬合力和咀嚼效率均显著增加,且观察组高于对照组,差异均有统计学意义(P<0.05);治疗后3个月内,观察组患者不良反应发生率为7.50%,显著低于对照组(27.50%),差异具有统计学意义(P<0.05)。结论利用根管填充联合奥硝唑合剂治疗老年牙体牙髓病既有助于改善患者的牙周健康状况以及咀嚼功能,还能够降低不良反应发生率,临床效果较为理想,值得临床应用。

关键词：牙体牙髓病根管填充奥硝唑合剂牙周健康咀嚼功能

A Routing Protocol for Urban Vehicular Multi-hop Data Delivery

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Chinese Journal of Electronics 2016年第2期25卷 348-356页

作者： CHANG sang-woo LEE sang-sun Department of Electronic Engineering Hanyang University

Vehicular ad-hoc network(VANET) has distinctive environments such as highly dynamic topology, frequently disconnected network, hard delay constraints for safety-related application, and various communications environments based on highway or urban traffic scenarios. Therefore, development of a suitable routing protocol that considers these characteristics of VANET should be needed. In this paper we propose the improved distance-based VANET routing protocol in urban traffic environments. We apply approaches to multi-hop broadcast scheme for reliable packet dissemination in the intersection and stable route decision scheme based on the adaptive waiting time. The performance is evaluated under simulation which is implemented with the Manhattan urban traffic model. The results show the improved performance as compared with other protocols.

关键词： Distance-based routing protocol Vehicle-to-vehicle communication Waiting time Urban traffic environments Vehicular ad-hoc network(VANET)

Effects of Flame Temperature and Absorption Coefficient on Premixed Flame Interactions with Radiation

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Journal of Thermal Science 2021年第3期30卷 1046-1056页

作者： KANG sang Hun Department of Aerospace System Engineering Sejong UniversitySeoul 05006Republic of Korea

The effects of the flame temperature and the absorption coefficient on interactions between radiative heat transfer and the flame behavior were numerically investigated using high-fidelity numerical code with the discrete ordinates *** study the effects of the flame temperature and the absorption coefficient,three different flame temperatures and four different absorption coefficient conditions were selected,so twelve test cases were studied in *** the numerical test results,radiation effects resulted in preheating of the reactant gases and heat loss from the product gases.A higher flame temperature resulted in stronger preheating effects in reactants near the *** to the preheating effects,with the appropriate absorption coefficient,the peak temperature appeared at the flame *** flame temperatures resulted in larger reabsorption effects in the product *** peak temperature at the flame front and the flame speed were influenced by the combined effects of preheating and radiative heat loss at the flame *** on the conditions,due to those effects,the peak temperature and the flame speed could increase or *** the absorption coefficient was sufficiently large,the temperature decrease was reduced in the product zone.

关键词： radiation high-fidelity numerical simulation discrete ordinates method premixed flame

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大语言模型驱动的多元关系知识图谱补全方法

计算机科学 2025年第1期52卷 94-101页

作者：刘畅成桑磊李炜张以文安徽大学计算机科学与技术学院合肥230601

知识图谱通过将复杂的互联网信息转化为易于理解的结构化形式,极大地提高了信息的可访问性。知识图谱补全技术进一步增强了知识图谱的信息完整性,显著提升了智能问答和推荐系统等通用领域应用的性能与用户体验。然而,现有的知识图谱补... 详细信息

知识图谱通过将复杂的互联网信息转化为易于理解的结构化形式,极大地提高了信息的可访问性。知识图谱补全技术进一步增强了知识图谱的信息完整性,显著提升了智能问答和推荐系统等通用领域应用的性能与用户体验。然而,现有的知识图谱补全方法大多专注于关系类型较少和简单语义情景下的三元组实例,未能充分利用知识图谱在处理多元关系和复杂语义方面的潜力。针对此问题,提出了一种由大语言模型(LLM)驱动的多元关系知识图谱补全方法。将LLM的深层语言理解能力与知识图谱的结构特性相结合,有效捕捉多元关系,理解复杂语义情景。此外,还引入了一种基于思维链的提示工程策略,旨在提高补全任务的准确性。该方法在两个公开知识图谱数据集上的实验结果都取得了显著的提升。

关键词：知识图谱大语言模型知识图谱补全多元关系候选集构建思维链提示

Transparent Supercapacitors: From Optical Theories to Optoelectronics Applications

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Energy & Environmental Materials 2020年第3期3卷 265-285页

作者： sang-Woo Kim sang-Young Lee Department of Energy Engineering School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 689-798Korea

The ever-increasing demand for smart optoelectronics spurs the relentless pursuit of transparent wireless devices as a game-changing technology that can provide unseen visual information behind the *** enable successful operation of the transparent wireless devices,their power sources should be highly transparent in addition to acquiring reliable electrochemical *** various transparent power sources,supercapacitors(SCs)have been extensively investigated as a promising candidate due to their exceptional cyclability,power capability,material diversity,and scalable/low-cost ***,we describe current status and challenges of transparent SCs,with a focus on their core materials,performance advancements,and integration with application devices.A special attention is devoted to transparent conductive electrodes(TCEs)which act as a keyenabling component in the transparent *** on fundamental understanding of optical theories and operating principles of transparent materials,we comprehensively discuss materials chemistry,structural design,and fabrication techniques of *** addition,noteworthy progresses of transparent SCs are briefly overviewed in terms of their architectural design,opto-electrochemical performance,flexibility,form factors,and integration compatibility with transparent flexible/wearable devices of ***,development direction and outlook of transparent SCs are explored along with their viable roles in future application fields.

关键词： energy storage flexibility optoelectronics transparent conductive electrodes transparent supercapacitors

Topological domains/domain walls and broken symmetries in multiferroics

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National Science Review 2019年第4期6卷 624-626页

作者： sang-Wook Cheong Rutgers Center for Emergent Materials Rutgers University

The magnetoelectric domains/domain walls in intrinsic multiferroics can exhibit intriguing topological nanoscale textures. These thermodynamically stabilized nano-textures are compared with nanoscale polar structures in nanostructured composite films. In addition,we show that the consideration of broken symmetries is essential to understand the macroscopic origin of multiferroicity and also to predict new ***, where ferroelectric and

关键词： Topological domains/domain walls and broken symmetries in multiferroics domain