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Probing the upper band gap of atomic rhenium disulfide layers

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Light(Science & Applications) 2018年第1期7卷 163-173页

作者： Krishna P.Dhakal hyunmin Kim Seonwoo Lee Youngjae Kim JaeDong Lee Jong-hyun ahn School of Electrical and Electronic Engineering Yonsei UniversitySeoul 03722Republic of Korea Companion Diagnostics&Medical Technology Research Group DGISTDaegu 42988Republic of Korea Department of Emerging Materials Science DGISTDaegu 42988Republic of Korea

Here,we investigate the ultrafast carrier dynamics and electronic states of exfoliated ReS2 films using time-resolved second harmonic generation(TSHG)microscopy and density functional theory(DFT)*** second harmonic generation(SHG)of layers with various thicknesses is probed using a 1.19-eV *** to~13 nm,a gradual increment is observed,followed by a decrease caused by bulk interferometric light *** addition of a pump pulse tuned to the exciton band gap(1.57 eV)creates a decay-to-rise TSHG profile as a function of the probe *** power and thickness dependencies indicate that the electron–hole recombination is mediated by defects and *** two photon absorptions of 2.38 eV in the excited state that are induced by pumping from 1.57 to 1.72 eV are restricted because these transitions highly correlate with the forbidden d–d intrasubshell orbital ***,the combined usage of a frequency-doubled pump(2.38 eV)with wavelength-variant SHG probes(2.60–2.82 eV)allows us to vividly monitor the variations in TSHG profiles from decay-to-rise to rise-to-decay,which imply the existence of an additional electron absorption state(s-orbital)at an approximate distance of 5.05 eV from the highest occupied molecular orbital *** observation was critically examined by considering the allowance of each electronic transition and a small upper band gap(~0.5 eV)using modified DFT calculations.

关键词： pump pumping transitions

阿哈湖深层水中微生物和硫酸还原菌数量及群落结构空间变化

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生态学杂志 2007年第11期26卷 1898-1900页

作者：王明义梁小兵 Tae Seok ahn In Seon Kim Jong hyun Nam 魏中青张伟中国科学院地球化学研究所环境地球化学国家重点实验室 Department of Environmental Science Kangwon National University

采用荧光原位杂交法分析了贵州阿哈湖深层水环境中总微生物、真细菌和硫酸盐还原菌数量。结果表明:该湖水中微生物总量为1.6×107个.L-1,真细菌占微生物总量的52.9%,且微生物总量和真细菌数量垂直变化无明显差异。随着水体深度的增加,... 详细信息

采用荧光原位杂交法分析了贵州阿哈湖深层水环境中总微生物、真细菌和硫酸盐还原菌数量。结果表明:该湖水中微生物总量为1.6×107个.L-1,真细菌占微生物总量的52.9%,且微生物总量和真细菌数量垂直变化无明显差异。随着水体深度的增加,活性微生物数量增加,且微生物的群落结构更加复杂。阿哈湖深层水体中有一定数量的硫酸盐还原菌存在。

关键词：水环境荧光原位杂交真细菌硫酸盐还原菌空间变化

Radial growth response of Pinus densiflora and Quercus *** topographic and climatic factors in South Korea

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Journal of Plant Ecology 2013年第5期6卷 380-392页

作者： Jae Gyun Byun Woo Kyun Lee Moonil Kim Doo ahn Kwak Hanbin Kwak Taejin Park Woo Hyuk Byun Yowhan Son Jung Kee Choi Young Jin Lee Joachim Saborowski Dong Jun Chung Jin hyun Jung Institute for Environmental Research(Biology V) RWTH Aachen UniversityWorringerweg 152074 AachenGermany Division of Environmental Science and Ecological Engineering Korea UniversitySeoul136-701Korea GIS/RS Center for Environmental Resources Korea UniversitySeoul 136-173Korea Department of Forest Management Kangwon National UniversityChunchon 200-701Korea Department of Forest Resources Kongju National UniversityKongju 341-701Korea Institute of Forest Biometry and Informatics Georg-August-University Gottingen37077 GottingenGermany National Forestry Cooperative Federation Daejeon 306-808Korea

Aims This study aimed to develop radial growth models and to predict the potential spatial distribution of Pinus densiflora(Japanese red pine)and Quercus spp.(Oaks)in South Korea,considering topographic and climatic *** We used a dataset of diameter at breast height and radial growth estimates of individual trees,topographic and climatic factors in systematic sample plots distributed over the whole of South *** the basis that radial growth is attributed primarily to tree age,we developed a radial growth model employing tree age as an explanatory *** estimated standard growth(SG),defined as radial growth of the tree at age 30,to eliminate the influence of tree age on radial *** addition,SG estimates including the Topographic Wetness Index,temperature and precipitation were calculated by the Generalized Additive *** Findings As a result of variogram analysis of SG,we found spatial autocorrelation between SG,topographic and climatic *** temperature had negative impacts on radial growth of *** and positive impacts on that of Quercus *** was associated with positive effects on both tree *** on the model,we found that radial growth of *** would be more vulnerable than that of Quercus *** climatic *** simulation with the radial growth model,it was predicted that *** stands would be gradually replaced with Quercus *** in eastern coastal and southern regions of South Korea in the *** models developed in this study will be helpful for understanding the impact of climatic factors on tree growth and for predicting changes in distribution of *** and Quercus *** to climate change in South Korea.

关键词： standard radial growth general additive model climatic factors climate change forest-cover change

Expression of Genes Affecting Skin Coloration and Sugar Accumulation in Apple Fruits at Ripening Stages in High Temperatures

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World Journal of Engineering and Technology 2015年第3期3卷 7-12页

作者： Seon Ae Kim Soon Young ahn hyun Hee Han In Chang Son Hae Keun Yun Department of Horticulture and Life Science Yeungnam University Gyeongsan South Korea National Institute of Horticultural & Herbal Science Wanju South Korea

High temperature is one of the most important environmental factors that affect the successful cultivation of apple (Malus × domestica Borkh). The expression of genes related with anthocyanin synthesis and sugar accumulation by high temperature treatment was investigated in the fruits of “Fuji” apple at different developmental stages in different temperature conditions through real- time PCR. In the initial ripening stages in fruits, there was high expression of genes associated with fruit ripening, flavonoid compound accumulation, and coloration in high temperatures. Expression of phenylalanine ammonia-lyase, chalcone synthase, flavone 3-hydrogenase, and malate dehydrogenase genes increased gradually in initial ripening stages, while sharply reduced at 24 hr after treatment. In addition, there was no significant difference in the expression of all temperature treatments in late ripening stages. In the further work, investigation of expression levels of various genes could be conducted in the level of transcriptomes from fruits at the early stages to get meaningful information of ripening metabolism in apples in high temperatures.

关键词： Anthocyanin Apple High Temperature Skin Coloration Sugar Content

Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions

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Chinese Journal of Natural Medicines 2019年第6期17卷 424-434页

作者： Tae-Kyeong Lee Joon Ha Park Ji Hyeon ahn hyunjung Kim Minah Song Jae-Chul Lee Jong Dai Kim Yong Hwan Jeon Jung Hoon Choi Choong hyun Lee In Koo Hwang YAN Bing-Chun Moo-Ho Won Il Jun Kang Department of Neurobiology School of MedicineKangwon National UniversityChuncheon 24341Republic of Korea Department of Biomedical Science Research Institute of Bioscience and BiotechnologyHallym UniversityChuncheon 24252Republic of Korea Division of Food Biotechnology School of BiotechnologyKangwon National UniversityChuncheon 24341Republic of Korea Department of Radiology School of MedicineKangwon National UniversityChuncheon 24289Republic of Korea Department of Anatomy College of Veterinary MedicineKangwon National UniversityChuncheon 24341Republic of Korea Department of Pharmacy College of PharmacyDankook UniversityCheonan 31116Republic of Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National UniversitySeoul 08826Republic of Korea Jiangsu Key Laboratory of Integrated Traditional Chinese Western Medicine for Prevention and Treatment of Senile DiseasesYangzhou 225001China Department of Food Science and Nutrition Hallym UniversityChuncheon 24252Republic of Korea

To examine the effects of Populus tomentiglandulosa(PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1(CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia(TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries for 5 min. Before ischemic surgery, 200 mg·kg–1 PT extract was orally administrated once daily for 7 d. We performed neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B staining. Furthermore, we determined in situ production of superoxide anion radical, expression levels of SOD1 and SOD2 as antioxidant enzymes and brain-derived neurotrophic factor(BDNF) and insulin-like growth factor I(IGF-I) as neurotrophic factors. Pretreatment with 200 mg·kg–1 PT extract prevented neuronal death(loss). Furthermore, pretreatment with 200 mg·kg–1 PT extract significantly inhibited the production of superoxide anion radical, increased expressions of SODs and maintained expressions of BDNF and IGF-I. Such increased expressions of SODs were maintained in the neurons after IRI. In summary, pretreated PT extract can significantly increase levels of SODs and protect the neurons against TGCI, suggesting that PT can be a useful natural agent to protect against TGCI.

关键词： Transient global cerebral ischemia Populus tomentiglandulosa Neuroprotective effects Antioxidant enzymes

Clinical Pharmacokinetic and Bioequivalence Studies of Two Brands of Cephradine in Healthy Korean Using HPLC Method

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Pharmacology & Pharmacy 2018年第7期9卷 279-292页

作者： hyun-Jin Kim Shin-Hee Kim Semi Kim Jae-Sung ahn Ju-Seop Kang Department of Pharmacology Clinical Pharmacology Laboratory Division of Molecular Therapeutics Development Hanyang Biomedical Research Institute College of Medicine Hanyang University Seoul South Korea

The goal of our research was to compare the pharmacokinetics and evaluate the bioequivalence of two brands of cephradine 500 mg capsules in 24 normal Korean volunteers. The plasma samples were acquired at 13 time points for 8 h after administration. The concentrations of cephradine in human plasma were measured by a high-performance liquid chromatography (HPLC). Isocratic mobile phase which consisted of acetonitrile, methanol, and 20 mM potassium phosphate (15/5/80, v/v/v, pH 3.48) was used to separate the analytical column cosmosil cholester (250 × 4.6 mm, 3 μm). Analytes were detected in ultraviolet (260 nm). The novel analytical method was described as simple sample preparation, a short retention time (less than 6 min) and making it suitable for use in clinical trials. Pharmacokinetic parameters, such as AUC0-t (20.54 vs 18.42 μg·h/mL), AUC0-infinity (21.22 vs 19.14 μg·h/mL), Cmax (12.69 vs 12.81 μg/mL), Tmax (1.22 vs 0.92 h), half-life (1.02 vs 1.13 h), extrapolation (3.22% vs 3.75%), and Ke (0.73 vs 0.69 h–1) were determined for the reference and test drugs in plasma. Pharmacokinetic parameters with a 90% confidence interval were 87% - 95% for AUC0-t and 91% - 115% for Cmax. They were satisfied within the bioequivalence range 80% - 125% of the KFDA guidelines. Therefore, our HPLC method was well applied in a bioequivalence and pharmacokinetic study of two formulations in normal subjects.

关键词： Bioequivalence Cephalosporin Antibiotic Cephradine Korean Volunteers Pharmacokinetics

SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF CKD- 501,A NOVEL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA/GAMMA DUAL AGONIST

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SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF CKD- 501,A NOV...

Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats

第十五届国际药理学大会

作者： Shin sang-Goo Kim Jung-Ryul Cho Joo-Youn Lim Kyoung Soo Kim JaeWoo Kim Bo-hyung Shin hyun Suk Yu Kyung-sang Shin Jae-Soo ahn Soon-Kil Jang In-Jin Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Chong Kun Dang Pharm. Korea. Chong Kun Dang Pharm. Korea. Department of Pharmacology Seoul National University College of Medicine Korea.

＜正＞ CKD-501 is a novel peroxisome proliferator-activated receptor α/γ dual agonist for the treatment of diabetes mellitus. This study aimed to investigate safety, tolerability, and pharmacokinetics of CKD-501 in healthy volunteers. A randomized, placebo-controlled, double-blind, parallel-group, dose-rising study was performed. Thirty-six healthy male subjects received single oral doses ranging from 0.5-8 mg CKD- 501 or placebo. In the multipledose study, 24 subjects received 1-4 mg once daily for 7 days. Serial blood and urine samples were collected. No serious adverse events （AEs） were observed and AEs reported were all of mild severity. In the single-dose study, mean Cmax and AUCinf increased linearly up to the 8 mg dose *** and t1/2 ranged from 0.5-4 h and 7.8-9.8 h. respectively. Less than 1 % CKD-501 was excreted in urine. After multiple dosing, accumulation index was around 1.2. Mean apparent clearance, Tmax and t1/2 in steady state were independent of dose and time. Single oral doses up to 8 mg CKD- 501 and multiple doses up to 4 mg were safe and well tolerated. Mean Cmax and AUCinf were dose proportional and there was no remarkable accumulation after multiple dosing.

关键词： PPAR clinical trial

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World Journal of Gastroenterology 2005年第47期11卷 7430-7435页

作者： Tae Young Oh Chang Yell Shin Yong Sung Sohn Dong Hwan Kim Byoung Ok ahn Eun Bang Lee Cho hyun Park Dong-A Pharmaceutical Research Institute YonginKorea Department of General Surgery Catholic University of MedicineSeoulKorea

AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD ***: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis.

关键词： DA-9601 Reflux gastritis Erosive gastritis Atrophic gastritis Sodium taurocholate

Impact loads generated by tandem cavitation bubble on solid wall

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Journal of Hydrodynamics 2022年第3期34卷 467-482页

作者： Nyo Me Thet Naing Jaehyun Park Seung-Ho hyun Rho-Taek Jung School of Naval Architecture and Ocean Engineering University of UlsanUlsanKorea School of Electrical Engineering University of UlsanUlsanKorea Foundation for Industry Cooperation University of UlsanUlsanKorea

Experiments on two cavitation bubbles,which are generated at the same instant,with three different sizes near solid wall are conducted and their impulses on the boundary are registered by polyvinylidene fluoride(PVDF)*** to being near the boundary,bubble interactions and deformed features are in contrast with those in infinite fluid *** this paper,five morphologies of bubble deformation during growth and collapse phases are observed by high-speed *** profiles are strongly influenced by inter-bubble distance(η),stand-off distance from boundary(γ),and bubble size *** of photographs coupled with sensor measurements enabled qualitative investigation of two bubble interactions on the *** sensor data acquisition,it is confirmed that lower bigger bubble with upper smaller bubble configuration produces highest impulses on the boundary compared with other vertical arrangements of the tandem cavitation bubble employed in this study.

关键词： Two bubbles spark-generated bubble impulse polyvinylidene fluoride(PVDF)