检索结果-南通市图书馆

Prediction models of hepatocellular carcinoma development in chronic hepatitis B patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第37期22卷 8314-8321页

作者： Hye Won Lee sang hoon ahn Department of Internal Medicine Yonsei University College of Medicine Seoul 03722 South Korea Institute of Gastroenterology Yonsei University College of Medicine Seoul 03722 South Korea Liver Cirrhosis Clinical Research Center Seoul 03722 South Korea Brain Korea 21 Project for Medical Science Seoul 03722 South Korea

Chronic hepatitis B virus(HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma(HCC). Applying the same strategies for antiviral therapy and HCC surveillance to all chronic hepatitis B(CHB) patients would be a burden worldwide. To properly manage CHB patients, it is necessary to identify and classify the risk for HCC development in such patients. Several HCC risk scores based on risk factors such as cirrhosis, age, male gender, and high viral load have been used, and have negative predictive values of ≥ 95%. Most of these have been derived from, and internally validated in, treatment-na?ve Asian CHB patients. Herein, we summarized various HCC prediction models, including IPM(Individual Prediction Model), CU-HCC(Chinese University-HCC), GAG-HCC(Guide with Age, Gender, HBV DNA, Core Promoter Mutations and Cirrhosis-HCC), NGM-HCC(NomogramHCC), REACH-B(Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B), and Page-B score. To develop a noninvasive test of liver fibrosis, we also introduced a new scoring system that uses liver stiffness values from transient elastography, including an LSM(Liver Stiffness Measurement)-based model, LSM-HCC, and mR EACH-B(modified REACH-B).

关键词： Chronic hepatitis B Hepatocellular carcinoma Development Prediction models

Transient elastography in chronic hepatitis B: An Asian perspective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第41期16卷 5173-5180页

作者： Seung Up Kim Kwang-Hyub Han sang hoon ahn Department of Internal Medicine Institute of Gastroenterology Yonsei University College of Medicine Seoul 120-752 South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752 South Korea Brain Korea 21 Project for Medical Science Seoul 120-752 South Kore

Transient elastography (TE) is a new non-invasive tool for assessing liver stiffness, which is correlated with the histologic stage of liver fibrosis. Many studies have reported a good accuracy of TE in predicting signif icant fibrosis and an optimal accuracy in predicting cirrhosis. Furthermore, the potential role of TE in screening the general population has also been proven. TE thus helps physicians to decide treatment strategies, predict prog-nosis, and monitor disease progression in patients with chronic liver disease and to screen the general popula-tion to identify high risk patients with potential liver disease. However, most data on the clinical roles of TE have been gathered in European patients with chronic hepatitis C (CHC), because TE was first developed in France. Accordingly, much data on the usefulness of TE in patients with CHC has accumulated. Recently, however, vigorous efforts have been made to apply TEto patients with chronic hepatitis B (CHB), and TE has also proved to have acceptable accuracy in diagnosing liver fibrosis and cirrhosis in these patients. Thus, we focused on TE in the Asian population with CHB in comparison with the European population with CHC and found that the diagnostic performance and cutoff values were different between the 2 populations possibly as a result of several different confounders between Asian and European populations (the etiology of chronic liver disease, histologic features, major fluctuation in alanine aminotransferase levels, and the prevalence of high body mass index and metabolic syndrome). Therefore, further studies tailored to the Asian population with CHB should be performed before the widespread application of TE in Asian populations with CHB.

关键词： Asia Chronic hepatitis B Fibroscan Hepatitis B virus Liver stiffness measurement Transient elas-tography

Non-invasive prediction of forthcoming cirrhosis-related complications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第10期20卷 2613-2623页

作者： Wonseok Kang Seung Up Kim sang hoon ahn Department of Internal Medicine Institute of Gastroenterology Yonsei University College of Medicine Seoul 120-752 South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752 South Korea

In patients with chronic liver diseases,identification of significant liver fibrosis and cirrhosis is essential for determining treatment strategies,assessing therapeutic response,and stratifying long-term *** liver biopsy remains the reference standard for evaluating the extent of liver fibrosis in patients with chronic liver diseases,several non-invasive methods have been developed as alternatives to liver *** of these non-invasive methods have demonstrated clinical accuracy for diagnosing significant fibrosis or cirrhosis in many cross-sectional studies with the histological fibrosis stage as a reference ***,non-invasive methods cannot be fully validated through cross-sectional studies since liver biopsy is not a perfect surrogate endpoint ***,recent studies have focused on assessing the performance of non-invasive methods through longterm,longitudinal,follow-up studies with solid clinical endpoints related to advanced stages of liver fibrosis and *** a result,current view is that these alternative methods can independently predict future cirrhosis-related complications,such as hepatic decompensation,liver failure,hepatocellular carcinoma,or liver-related *** clinical role of non-invasive models seems to be shifting from a simple tool for predicting the extent of fibrosis to a surveillance tool for predicting future liver-related *** this article,we will summarize recent longitudinal studies of non-invasive methods for predicting forthcoming complications related to liver cirrhosis and discuss the clinical value of currently available non-invasive methods based on evidence from the literature.

关键词： Non-invasive model Prediction Cirrhosis Complication Liver-related events

Length of negative resection margin does not affect local recurrence and survival in the patients with gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第30期20卷 10518-10524页

作者： Chang Min Lee Ye Seob Jee Ju-Hee Lee sang-Yong Son sang-hoon ahn Do Joong Park Hyung-Ho Kim Department of Surgery Seoul National University Bundang HospitalSeongnam 463-707South Korea Department of Surgery Dankook University HospitalCheonan 330-715South Korea Colledge of Medicine Dankook UniversityCheonan 330-715South Korea Department of Surgery Hanyang University Medical CenterSeoul 133-792South Korea Colledge of Medicine Seoul National UniversitySeoul 110-799South Korea

AIM: To investigate the influence of the resection margin on local recurrence and survival in gastric cancer patients.

关键词： Gastric cancer Survival Recurrence Resection Margin

Characterization of focal liver masses using acoustic radiation force impulse elastography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第2期19卷 219-226页

作者： Hana Park Jun Yong Park Do Young Kim sang hoon ahn Chae Yoon Chon Kwang-Hyub Han Seung Up Kim Division of Gastroenterology Department of Internal MedicineCHA Bundang Medical CenterCHA UniversityGyeonggi-do 463-712South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their ***:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November *** them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were *** a patient had multiple liver masses,only one mass of interest was *** masses were diagnosed by histological examination or clinical diagnostic *** ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver ***:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological *** mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in *** considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC

关键词： Acoustic radiation force impulse Focal liver mass Hepatocellular carcinoma Hemangioma Focal nodular hyperplasia Cholangiocellular carcinoma Liver metastasis

Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第43期19卷 7671-7679页

作者： Hana Park Jun Yong Park Seung Up Kim Do Young Kim Kwang-Hyub Han Chae Yoon Chon sang hoon ahn Department of Internal Medicine CHA Bundang Medical CenterCHA UniversitySeongnam-si 463-712South Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineLiver Cirrhosis Clinical Research CenterSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Brain Korea 21 Project for Medical Science Seoul 120-752South Korea

AIM:To examine the efficacy of telbivudine(LdT)+adefovir(ADV)vs continuation of lamivudine(LAM)+ADV in patients with LAM-resistant chronic hepatitis B(CHB)who show a suboptimal response to LAM+***:This was a randomized,active-control,open-label,single-center,parallel *** eligible patients were enrolled in this study in Severance Hospital,Yonsei University College of Medicine,Seoul,South Korea,between March 2010 and March *** Be antigen(HBeAg)-positive CHB patients whose serum hepatitis B virus(HBV)DNA remained detectable despite at least 6 mo of LAM+ADV therapy were *** patients were randomized to either switching to LdT(600 mg/d orally)plus ADV(10 mg/d orally)(LdT+ADV group)or to continuation with LAM(100 mg/d orally)plus ADV(10 mg/d orally)(LAM+ADV group),and were followed for 48 *** hundred and six patients completed the 48-wk treatment *** HBV DNA,HBeAg status,liver biochemistry and safety were monitored at baseline and week 12,24,36 and ***:The duration of prior LAM+ADV treatment was 18.3(LdT+ADV)and 14.9 mo(LAM+ADV),respectively(P=0.131).No difference was seen in baseline serum HBV DNA between the two groups[3.66(LdT+ADV)vs 3.76(LAM+ADV)log10IU/mL,P=0.729].At week 48,although there was no significant difference in the mean reduction of serum HBV DNA from baseline between LdT+ADV group and LAM+ADV group(-0.81 vs-0.47 log10IU/mL,P=0.167),more patients in the LdT+ADV group had undetectable HBV DNA levels compared to those in the LAM+ADV group(30.2%vs 11.5%,P=0.019).Three patients with LdT+ADV treatment and 2 patients with LAM+ADV treatment achieved HBeAg *** patients in both groups tolerated the treatment well without serious adverse *** proportion of patients with estimated glomerular filtration rate≥90 mL/min per 1.73 m2in the LdT+ADV group increased from 49.1%(26/53)at baseline to 58.5%(31/53)at week 48,while that in the LAM+ADV group decreased from 37.7%(20/53)at baseline to 30.2%(16/53)at

关键词： Chronic hepatitis B Antiviral resistance Suboptimal response Telbivudine Lamivudine

Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第16期18卷 1946-1952页

作者： Hana Park Jin Young Yoon Kyeong Hye Park Do Young Kim sang hoon ahn Kwang-Hyub Han Chae Yoon Chon Jun Yong Park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Brain South Korea 21 Project for Medical Science Seoul 120-752South Korea

AIM:To evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and ***:We analyzed 67 patients with BCS between June 1988 and May *** diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or *** median follow-up period was 103 ± 156 [interquartile range(IQR)] ***:The median age of the patients was 47 ± 16(IQR) *** diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class *** the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).The survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 *** patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 ***:The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South *** HVPG is expected to provide additional information for predicting HCC development in BCS patients.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognosis

Factors associated with significant liver fibrosis assessed using transient elastography in general population

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第4期21卷 1158-1166页

作者： Seng Chan You Kwang Joon Kim Seung Up Kim Beom Kyung Kim Jun Yong Park Do Young Kim sang hoon ahn Won Jae Lee Kwang-Hyub Han Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Division of Endocrinology and Metabolism Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Seoul Gookgwain School Seoul 110-521South Korea

AIM: To investigate the prevalence of significant liver fibrosis assessed using transient elastography(TE) and its predictors in asymptomatic general ***: A total of 159 subjects without chronic viral hepatitis who underwent comprehensive medical health check-up between January 2012 and July 2012 were prospectively recruited. Significant liver fibrosis was defined as liver stiffness value > 7.0 k ***: The mean age and body mass index(BMI) of the study population(men 54.7%) was 56.0 years and 24.3 kg/m2. Among the study subjects, 11(6.9%) showed significant liver fibrosis. On univariate analysis, BMI, alanine aminotransferase(ALT), homeostasis model assessment of insulin resistance, carotid intimal media thickness(IMT), number of calcified plaques on carotid ultrasound, and visceral fat area on computed tomography were significantly higher in subjects with significant liver fibrosis than in those without(all P < 0.05). However, on multivariate analysis, BMI [odds ratio(OR) =1.487; P = 0.045], ALT(OR = 1.078; P = 0.014), carotid IMT(OR = 3.244; P = 0.027), and the number of calcified carotid plaques(OR = 1.787; P = 0.031) were independent predictors of significant liver fibrosis. CONCLUSION: The prevalence of significant liver fibrosis assessed using TE was 6.9% in apparently healthy subjects. High BMI, high ALT, thicker carotid IMT, and higher numbers of calcified carotid plaqueswere independently associated with the presence of significant liver fibrosis.

关键词： Transient elastography Healthy subjects Fibroscan

Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2022年第1期10卷 440-450页

作者： sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung Joo Cho Hye Jung Park Hye Won Lee Beom Kyung Kim Jun Yong Park Do Young Kim sang hoon ahn Soo Han Bae Seung Up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe