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A New Method for Diagnosis of Leukemia Utilizing a Hybrid DL-ML Approach for Binary and Multi-class classification on a Limited-Sized Database

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computer Modeling in Engineering & Sciences 2024年第4期139卷 593-631页

作者： Nilkanth Mukund Deshpande Shilpa Gite Biswajeet Pradhan Abdullah Alamri chang-wook Lee Department of Electronics&Telecommunication LavaleSymbiosis Institute of TechnologySymbiosis International(Deemed University)PuneMaharashtra412115India Electronics&Telecommunication Dr.Vithalrao Vikhe Patil College of EngineeringAhmednagarMaharashtra414111India Artificial Intelligence and Machine Learning Department Symbiosis Institute of TechnologySymbiosis International(Deemed)UniversityPune412115India Symbiosis centre of Applied AI(ScAAI) Symbiosis International(Deemed)UniversityPune412115India centre for AdvancedModelling and Geospatial Information Systems(cAMGIS) School of Civil and Environmental EngineeringFaculty of Engineering&ITUniversity of Technology SydneySydneyAustralia Earth Observation centre Institute of Climate ChangeUniversiti Kebangsaan MalaysiaBangiSelangor43600Malaysia Department of Geology&Geophysics College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia Department of Science Education Kangwon National UniversityChuncheon-si24341Korea

Infection of leukemia in humans causes many complications in its later *** impairs bone marrow’s ability to produce *** diagnosis of human blood cells is a well-known and well-proven technique for diagnosis in this *** binary classification is employed to distinguish between normal and leukemiainfected *** addition,various subtypes of leukemia require different *** sub-classes must also be detected to obtain an accurate diagnosis of the type of *** entails using multi-class classification to determine the leukemia *** is usually done using a microscopic examination of these blood *** to the requirement of a trained pathologist,the decision process is critical,which leads to the development of an automated software framework for *** utilized state-of-the-art machine learning approaches,such as Support Vector Machine(SVM),Random Forest(RF),Na飗e Bayes,K-Nearest Neighbor(KNN),and others,to provide limited accuracies of *** advanced deep-learning methods are also *** to constrained dataset sizes,these approaches result in over-fitting,reducing their outstanding *** study introduces a deep learning-machine learning combined approach for leukemia *** uses deep transfer learning frameworks to extract and classify features using state-of-the-artmachine learning *** transfer learning frameworks such as VGGNet,Xception,InceptionResV2,Densenet,and ResNet are employed as feature *** extracted features are given to RF and XGBoost classifiers for the binary and multi-class classification of leukemia *** the experimentation,a very popular ALL-IDB dataset is used,approaching a maximum accuracy of 100%.A private real images dataset with three subclasses of leukemia images,including Acute Myloid Leukemia(AML),chronic Lymphocytic Leukemia(cLL),and chronic Myloid Leukemia(cML),is also employed to generalize the *** d

关键词： Leukemia diagnosis deep learning machine learning random forest XGBoost

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Synthesis of Planar-chiral[2.2]Paracyclophane-Based Oxazole-Pyrimidine Ligands and Application in Nickel-catalyzed 1,2-Reduction ofα,β-Unsaturated Ketones

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chinese Journal of chemistry 2024年第7期42卷 705-710页

作者： Juan wang Qing-Xian Xie Xiang Li chang-Bin Yu Yong-Gui Zhou School of chemistry Dalian University of Technology2 Linggong RoadDalianLiaoning 116024China State Key Laboratory of catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China

The planar-chiral ligands have been widely applied as a class of unique and significant ligands in asymmetric *** them,chiral[2.2]paracycyclophane has emerged as a privileged type of planar-chiral framework and has been utilized as an important toolbox due to their structural ***,we design and synthesize[2.2]paracyclophane-derived oxazole-pyrimidine ligands(abberviated as PYMcOX).These N,N-ligands with stable properties,rigid structure and large steric hindrance performed successfully in nickel-catalyzed asymmetric 1,2-reduction ofα,β-unsaturated ketones,affording the chiral allylic alcohols with up to 99%yield and 99%***,this reduction reaction could be conducted on gram-scale without loss of activity and enantioselectivity,and the chiral ligand could be conveniently recovered with high yield.

关键词： Oxazole-pyrimidine ligands Planar chirality Nickel Hydroboration Asymmetric synthesis

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Migration mechanism and risk assessment of perand polyfluoroalkyl substances in the Ya'Er Lake oxidation pond area,china

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Journal of Environmental Sciences 2024年第2期136卷 301-312页

作者： chang Li Huifang Zhong Jing wu Lingyi Meng Yingjun wang chunyang Liao Yawei wang Yujian He University of chinese Academy of Sciences Beijing 100049China Research center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China china National Environmental Monitoring centre Beijing 100012China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

The migration mechanisms,sources,and environmental risks of 29 legacy and emerging perfluorinated and polyfluoroalkyl species present in an oxidation pond(Ya'Er Lake)were investigated for treating sewage based on the analysis of their occurrence and *** concentration of per-and polyfluoroalkyl substances(PFAS)in pond area was between0.30 and 63.2 ng/g dw(dry weight),with the overall average concentration of 8.00 ng/g ***,the PFAS concentrations in the surface sediments near the sewage outlet in Pond-1(50.2 ng/g dw)and Pond-5(average 15.1 ng/g dw)were 1–2 orders of magnitude higher than those in other *** general,the legacy PFAS,i.e.,perfluorooctane sulfonic acid was considered to be the major pollutant in the polluted area,on average,accounting for 73.0%of the total concentration of PFAS *** evaluating the regional distribution of different PFAS homologs,the short-chain PFAS pollutants with lower K_(ow)were found to migrate farther in both horizontal and vertical *** sewage outlets in Pond-1 and Pond-5are the main pollution sources in polluted area and the emerging PFAS pollutants in Pond-5have replaced the legacy PFAS pollutants as the main *** on positive matrix factorization analysis,three main industrial sources of PFAS pollutants in the study area were identified:protective coating,fire-fighting,and food packaging ***,the environmental risk assessment results showed that most study areas exhibited medium environmental risk(0.01≤Risk quotient(RQ)cating that the ecological environment risks in this area need further attention.

关键词： Perfluoroalkyl substances Distribution Migration mechanism Risk assessment

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Roles of host proteases in the entry of SARS-coV-2

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Animal Diseases 2024年第1期4卷 27-39页

作者： Alexandria Zabiegalal Yunjeong Kim Kyeong-Ok chang Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State University1800 Denison Avenue ManhattanKS 66506USA

The spike protein(S)of SARS-coV-2 is responsible for viral attachment and entry,thus a major factor for host suscep-tibility,tissue tropism,virulence and *** S is divided with S1 and S2 region,and the S1 contains the receptor-binding domain(RBD),while the S2 contains the hydrophobic fusion domain for the entry into the host *** host proteases have been implicated in the activation of SARS-coV-2 S through various c leavage *** this article,we review host proteases including furin,trypsin,transmembrane protease serine 2(TMPRSS2)and cathepsins in the activation of SARS-coV-2 *** betacoronaviruses including SARS-coV-2 have polybasic residues at the S1/S2 site which is subjected to the cleavage by *** S1/S2 cleavage facilitates more assessable RBD to the receptor AcE2,and the binding triggers further conformational changes and exposure of the S2'site to proteases such as type Il transmembrane serine proteases(TTPRs)including *** the presence of TMPRSS2 on the target cells,SARS-coV-2 can utilize a direct entry route by fusion of the viral envelope to the cellular *** the absence of TMPRSS2,SARS-coV-2 enter target cells via endosomes where multiple cathepsins cleave the S for the successful *** host proteases involved in the cleavage of the S were *** article also includes roles of 3c-like protease inhibitors which have inhibitory activity against cathepsin L in the entry of SARS-coV-2,and discussed the dual roles of such inhibitors in virus replication.

关键词： SARS-coV-2 Spike protein(S) Host proteases cleavage site Virus entry

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An effective'salt in dimethyl sulfoxide/water'electrolyte enables high-voltage supercapacitor operated at-50℃

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Journal of Energy chemistry 2024年第6期93卷 361-367,I0009页

作者： Yingbin Liu chang Yu Xuedan Song Siyi Hou Shuqin Lan Jinhe Yu Yuanyang Xie Jieshan Qiu State Key Lab of Fine chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringLiaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina School of chemistry Frontier Science Center for Smart MaterialsLiaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina college of chemical Engineering State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing 100029China

compared with organic electrolytes,aqueous electrolytes exhibit significantly higher ionic conductivity and possess inherent safety features,showcasing unique advantages in ***,challenges remain for low-salt aqueous electrolytes operating at high voltage and low ***,we report a low-salt(0.87 m,m means mol kg^(-1))'salt in dimethyl sulfoxide/water'hybrid electrolyte with non-flammability via hybridizing aqueous electrolyte with an organic co-solvent of dimethyl sulfoxide(hydrogen bond acceptor).As a result,the 0.87 m hybrid electrolyte exhibits enhanced electrochemical stability,a freezing temperature below-50℃,and an outstanding ionic conductivity of 0.52mS cm~(-1)at-50℃.Dimethyl sulfoxide can anchor water molecules through intermolecular hydrogen bond interaction,effectively reinforcing the stability of water in the hybrid ***,the interaction between dimethyl sulfoxide and water molecules diminishes the involvement of water in the generation of ordered ice crystals,finally facilitating the low-temperature performance of the hybrid *** paired with the 0.87 m'salt in dimethyl sulfoxide/water'hybrid electrolyte,the symmetric supercapacitor presents a 2.0 V high operating voltage at 25℃,and can operate stably at-50℃.Importantly,the suppressed electrochemical reaction of water at-50℃further leads to the symmetric supercapacitor operated at a higher voltage of 2.6 *** modification strategy opens an effective avenue to develop low-salt electrolytes for high-voltage and low-temperature aqueous supercapacitors.

关键词： Dimethyl sulfoxide co-solvent High voltage Low temperature Supercapacitors

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Electrocatalytic cO2 reduction to syngas

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Green Energy & Environment 2024年第7期9卷 1085-1100页

作者： Bing chang Zhaojun Min Ning Liu Nan wang Maohong Fan Jing Fan Jianji wang School of Environment Key Laboratory of Yellow River and Huai River Water Environment and Pollution Control Ministry of Education Henan Normal University School of chemistry and chemical Engineering Key Laboratory of Green Chemical Media and Reactions Ministry of Education Henan Normal University college of Engineering and Physical Sciences and School of Energy Resources University of Wyoming college of Engineering Georgia Institute of Technology

while carbon dioxide （cO2） is a major greenhouse gas,it is also an important c1 *** the trend of energy conservation and emission reduction,electrocatalytic reduction has become a very promising strategy for cO2utilization because it can convert cO2directly to high-valued chemicals and fuels under mild *** particular,the product cO and by-product H2can be combined into syngas by an electrocatalytic cO2reduction reaction （cO2RR） in an aqueous *** molar ratios of cO and H2may be used to produce essential bulk chemicals or liquid fuels such as methanol,alkanes,and olefins through thermochemical catalysis,Fischer–Tropsch synthesis,microbial fermentation,and other *** work discusses the latest strategies in controlling the molar ratio of cO/H2and improving the yield of *** challenges of electrocatalytic syngas production are analyzed from an industrial application perspective,and the possible measures to overcome them are proposed in terms of new.c.talyst design,electrolyte innovation,flow reactor optimization,anodic reaction coupling,and operando technique application.

关键词： Electrocatalysis cO 2 reduction Syngas Electrolyte Electrolyzer

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complexity growth in a holographic QcD model

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chinese Physics c 2024年第3期48卷 142-147页

作者：常文彬侯德富 Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOS) Central China Normal UniversityWuhan 430079China

In this study,we utilize the complexity-action duality to study the evolution of complexity in a holographic QcD model at finite temperature and chemical *** inserting a fundamental string as a probe,we investigated the properties of complexity growth in this Einstein-Maxwell-scalar gravity system,which is affected by the string velocity,chemical potential,and *** results show that the complexity growth is maximized when the probe string is stationary,and it decreases as the velocity of the string *** the string approaches relativistic velocities,the complexity growth always increases monotonically with respect to the chemical ***,we find that the complexity growth can be used to identify phase transitions and crossovers in the model.

关键词： AdS/cFT holographic QcD model complexity growth

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An efficient molten-salt electro-deoxidation strategy enabling fast-kinetics and long-life aluminum-selenium batteries

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SusMat 2024年第1期4卷 126-139页

作者： Jiguo Tu Zheng Huang cheng chang Haiping Lei Shuai wang Shuqiang Jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijingChina School of chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingaporeSingapore School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijingChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore

Aluminum-selenium(Al-Se)batteries have been considered as one of the most promising energy storage systems owing to their high capacity,energy density,and cost effectiveness,but Se falls challenges in addressing the shuttle effect of soluble intermediate product and sluggish reaction kinetics in the solid-solid conversion process during ***,we propose an unprecedented design concept for fabricating uniform Se/c hollow microspheres with controllable morphologies through low-temperature electro-deoxidation in neutral Nacl-Alcl_(3) molten salt *** Se/c hollow microspheres are demonstrated to hold a favorable hollow structure for hosting Se,which can not only suppress the dissolution of soluble intermediate products into the electrolyte,thereby maintaining the structural integrity and maximizing Se utilization of the active material,but also promote the electrical/ionic conductivity,thus facilitating the rapid reaction kinetics during ***,the as-prepared Se/c hollow microspheres exhibit a high reversible capacity of 720.1 mAh g^(−1)at 500 mA g^(−1).Even at the high current density of 1000 mA g^(−1),Se/c delivers a high discharge capacity of 564.0 mAh g^(−1),long-term stability over 1100 cycles and high coulombic efficiency of 98.6%.This present work provides valuable insights into short-process recovery of advanced Se-containingmaterials and value-added utilization for energy storage.

关键词： aluminum-ion batteries hollow Se/c microspheres long-term cycling stability lowtemperature electro-deoxidation Nacl-Alcl_(3)molten salt

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Divergent total synthesis of marine meroterpenoids(+)-dysidavarones A–c

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chinese chemical Letters 2024年第3期35卷 234-238页

作者： Qunlong Zhang Yang Kuang Le chang Jingyi Kang Bingjian wang chuanke chong Zhaoyong Lu State Key Laboratory of Medicinal chemical Biology College of PharmacyNankai UniversityTianjin 300350China

Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A–c(1–3)using predysidavarone 6 as a key common *** highly strained and bridged eight-membered carbocycle of predysidavarone 6 was constructed by a one-pot intermolecular alkylation and intramolecular arylation of wieland–Miescher ketone derivative 11 and benzyl bromide *** total synthesis of(+)-dysidavarones A–c(1–3)was achieved from predysidavarone 6 in a divergent manner by a late-stage introduction of the ethoxy group,which reveals the possible source of the ethoxy group within(+)-dysidavarones A–c(1–3)and provides a late-stage modifiable route for the synthesis of dysidavarone analogs for further anti-cancer activity evaluation.

关键词： Total synthesis Natural product Dysidavarones A–c Sesquiterpene quinone Meroterpenoid

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One-step conversion of methane and formaldehyde to ethanol over SA-FLP dual-active-site catalysts: A DFT study

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chinese chemical Letters 2024年第4期35卷 544-548页

作者： Tao Ban Xi-Yang Yu Hai-Kuo Tian Zheng-Qing Huang chun-Ran chang Shaanxi Key Laboratory of Energy chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shaanxi Key Laboratory of Low Metamorphic coal clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

One-step conversion of methane and formaldehyde into ethanol is a 100% atom-efficient process for carbon resources utilization and environment protection but still faces eminent challenges due to the lacking of efficient catalysts. Therefore, developing active and stable catalysts is crucial for the co-conversion of methane and formaldehyde. Herein, twelve kinds of “Single-Atom”-“Frustrated Lewis Pair”(SA-FLP)dual-active-site catalysts are designed for the direct conversion of methane and formaldehyde to ethanol based on density functional theory(DFT) calculations and microkinetic simulations. The results show that the SA-FLP dual active sites can simultaneously activate methane at the SA site and activate formaldehyde at the FLP site. Among the twelve designed SA-FLP catalysts, Fe1-FLP shows the best performance in the co-conversion of methane and formaldehyde to ethanol with the rate-determining barrier of 1.15 e *** is proved as the main product with the turnover frequency of 1.32 × 10^(-4)s^(-1)at 573 K and 3 *** work provides a universal strategy to design dual active sites on metal oxide materials and offers new insights into the effective conversion of methane and formaldehyde to desired c_(2) chemicals.

关键词： Single-atom Frustrated Lewis pairs Methane conversion Dual active sites Ethanol synthesis

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