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Viral infections and implications for male reproductive health

Asian Journal of Andrology 2021年第4期23卷 335-347页

作者： Thiago A Teixeira Yasmin C Oliveira Felipe S Bernardes Esper G Kallas Amaro N Duarte-Neto sandro C Esteves Joël R Drevet Jorge Hallak Androscience Science and Innovation Center in Andrology and High-Complex Clinical and Research Andrology LaboratorySão Paulo 04534-011SPBrazil Division of Urology University of São PauloSão Paulo 05403-000SPBrazil Men's Health Study Group Institute for Advanced StudiesUniversity of São PauloSão Paulo 05508-060SPBrazil Division of Urology School of MedicineFederal University of AmapaMacapa 68903-419APBrazil Department of Infectious and Parasitic Diseases University of São PauloSão Paulo 05403-000SPBrazil BIAS–Brazilian Image Autopsy Study Group Department of PathologyUniversity of São PauloSão Paulo 05403-000SPBrazil ANDROFERT Andrology and Human Reproduction ClinicCampinas 13075-460SPBrazil Department of Surgery(Division of Urology) University of Campinas(UNICAMP)Campinas 13083-968SPBrazil Department of Clinical Medicine Faculty of HealthAarhus UniversityAarhus 8000Denmark GReD Institute CNRS-INSERM-UniversitéClermont AuvergneFaculty of MedicineClermont-Ferrand 63000France Reproductive Toxicology Unit Department of PathologyUniversity of São PauloSão Paulo 05403-000SPBrazil

Viral infections have haunted humankind since times ***,globalization,and extensive deforestation have created an ideal environment for a viral spread with unknown and multiple shedding *** viruses can infect the male reproductive tract,with potential adverse consequences to male reproductive health,including infertility and ***,some genital tract viral infections can be sexually transmitted,potentially impacting the resulting offspring's *** have summarized the evidence concerning the presence and adverse effects of the relevant viruses on the reproductive tract(mumps virus,human immunodeficiency virus,herpes virus,human papillomavirus,hepatitis B and C viruses,Ebola virus,Zika virus,influenza virus,and coronaviruses),their routes of infection,target organs and cells,prevalence and pattern of virus shedding in semen,as well as diagnosis/testing and treatment *** pathophysiological understanding in the male genital tract is essential to assess its clinical impact on male reproductive health and guide future research.

关键词： male genital tract reproduction semen sexual transmission sperm testis viral persistence viruses

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Thermal Analysis of Laser Chemical Machining: Part I: Static Irradiation

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Materials Sciences and Applications 2017年第10期8卷 685-707页

作者： Hamza Messaoudi sandro Eckert Frank Vollertsen BIAS—Bremer Institut für angewandte Strahltechnik Bremen Germany Faculty of Production Engineering-Mechanical Engineering & Process Engineering University of Bremen Bremen Germany

The laser chemical machining is a non-conventional substractive processing method. It is based on the laser-activation of a material dissolution of metals in electrolyte ambient via local-induced temperature gradients and allows a gentle and smooth processing of especially temperature-sensitive metals. However, the material removal is characterized by a narrow process window and is restricted by occurring disturbances, which are supposed to be related to the localized electrolyte boiling. In order to control the removal quality and avoid disturbances, the correlation between the laser-induced temperatures and the resulting removal geometry has to be better understood. In this work an analytical modeling of the laser-induced temperatures at the surface of titanium based on a Green-function approach is presented. The main influencing factors (laser, electrolyte, material) as well as possible heat transfer into the electrolyte are included and discussed. To verify the calculated temperatures, single spot experiments are performed and characterized for titanium in phosphoric acid solution within laser irradiation of 1 s. The correlation between the temperature distribution and the resulting removal geometry is investigated based on a spatial superposition. Thereby, the bottom limit temperature is found to range between 63°C and 70°C whereas the upper limit is related to the nucleate boiling regime. Based on the performed correlation an indicator is identified to predict the ruling removal regime and thereby to reduce the experimental expenditure.

关键词： Laser Micro Machining Laser Chemical Removal Modeling Temperature Process Stability Titanium

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Liver involvement in patients with COVID-19 infection:A comprehensive overview of diagnostic imaging features

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World Journal of Gastroenterology 2023年第5期29卷 834-850页

作者： Davide Ippolito Cesare Maino Federica Vernuccio Roberto Cannella Riccardo Inchingolo Michele Dezio Riccardo Faletti Pietro Andrea Bonaffini Marco Gatti sandro Sironi Milano Bicocca School of Medicine and Surgery Milano 20126Italy Fondazione IRCCS San Gerardo dei Tintori Monza 20900Italy Institute of Radiology(DIMED) University Hospital of PadovaPadova 35128Italy Section of Radiology-Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Department of Health Promotion Mother and Child CareInternal Medicine and Medical Specialties(PROMISE)University of PalermoPalermo 90127Italy Division of Interventional Radiology Department of RadiologyMadonna delle Grazie HospitalMatera 75100Italy Department of Surgical Sciences University of TurinTurin 10126Italy Department of Diagnostic Radiology Papa Giovanni XXIII HospitalBergamo 24127Italy Department of Diagnostic Radiology University of TurinTurin 10126Italy

During the first wave of the pandemic,coronavirus disease 2019(COVID-19)infection has been considered mainly as a pulmonary ***,different clinical and radiological manifestations were observed over time,including involvement of abdominal ***,the liver is considered one of the main affected abdominal *** involvement may be caused by either a direct damage by the virus or an indirect damage related to COVID-19 induced thrombosis or to the use of different *** clinical assessment,radiology plays a key role in the evaluation of liver ***(US),computed tomography(CT)and magnetic resonance imaging(MRI)may be used to evaluate liver *** is widely available and it is considered the first-line technique to assess liver involvement in COVID-19 infection,in particular liver steatosis and portal-vein *** and MRI are used as second-and third-line techniques,respectively,considering their higher sensitivity and specificity compared to US for assessment of both parenchyma and *** review aims to the spectrum of COVID-19 liver involvement and the most common imaging features of COVID-19 liver damage.

关键词： Liver Fatty liver Hepatomegaly Hepatic infarction Liver diseases Liver failure Biliary tract diseases COVID-19 SARS-CoV-2 Infection X-Ray computed tomography Magnetic resonance imaging Ultrasonography Adults Pediatrics

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Endoscopic retrograde cholangiopancreatography,lights and shadows:Handle with care

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World Journal of Gastrointestinal Endoscopy 2019年第3期11卷 219-230页

作者： Raffaele Salerno Nicolò Mezzina sandro Ardizzone Gastroenterology and Digestive Endoscopy Unit ASST Fatebenefratelli Sacco Gastrointestinal Unit ASST Fatebenefratelli Sacco-Department of Biochemical and Clinical Sciences "L. Sacco" University of Milan

The role of endoscopic retrograde cholangiopancreatography(ERCP) has dramatically changed in the last years, mainly into that of a therapeutic procedure. The treatment of benign biliary disease, like "difficult"choledocolithiasis, with endoscopic papillary large balloon dilation combined with endoscopic sphinterotomy has proven an effective and safe ***, safety in ERCP has improved as well, with the prevention of postERCP pancreatitis and patient-to-patient transmission of infections. The advent of self-expandable metal stenting has radically changed the management of biliopancreatic malignant strictures, while the role for therapy of benign strictures is still controversial. In addition, cholangioscopy(though the direct visualization of the biliopancreatic ductal system) has allowed for characterization of indeterminate biliary strictures and facilitated rescue therapy of large biliary stones deemed removable. Encouraging data from tissue ablation techniques, such as photodynamic therapy and radiofrequency ablation, need to be confirmed by large sample size clinical controlled trials. On the other hand, we have no drug-coated stents yet available to implant and evidence for the use of biodegradable stents is still weak. The competency and privileging of ERCP and endoscopic ultrasonography have been analyzed longer but the switch between the two procedures, at the same time, is becoming ordinary; as such, the endoscopist interested in this field should undergo parallel edification through training plans. Finally, the American Society for Gastrointestinal Endoscopy's statement on non-anesthesiologist administration of propofol for gastrointestinal endoscopy is not actually endorsed by the European Society of Anaesthesiology,having many medical-legal implications in some European countries.

关键词： Cholangiopancreatography Endoscopic papillary large balloon dilation Self-expandable metal stent Cholangioscopy Photodynamic therapy Radiofrequency ablation Competency Privileging Biodegradable stents Drug-coated stents

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Re： Sperm retrieval rates and intracytoplasmic sperm injection outcomes for men with non-obstructive azoospermia and the health of resulting offspring

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Asian Journal of Andrology 2014年第4期16卷 642-642页

作者： sandro C Esteve Ashok Agarwal ANDROFERT Center for Male Reproduction Campinas Brazil Center for Reproductive Medicine The Cleveland Clinic Foundation Cleveland USA.

We are thankful to Dr. Drobnis for her insights and balanced comments with regard to our article titled ＇comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructi... 详细信息

关键词： @@

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An Innovative Approach for Attribute Reduction in Rough Set Theory

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Intelligent Information Management 2014年第5期6卷 223-239页

作者： Alex sandro Aguiar Pessoa Stephan Stephany National Institute for Space Research (INPE) Sao Jose dos Campos Brazil

The Rough Sets Theory is used in data mining with emphasis on the treatment of uncertain or vague information. In the case of classification, this theory implicitly calculates reducts of the full set of attributes, eliminating those that are redundant or meaningless. Such reducts may even serve as input to other classifiers other than Rough Sets. The typical high dimensionality of current databases precludes the use of greedy methods to find optimal or suboptimal reducts in the search space and requires the use of stochastic methods. In this context, the calculation of reducts is typically performed by a genetic algorithm, but other metaheuristics have been proposed with better performance. This work proposes the innovative use of two known metaheuristics for this calculation, the Variable Neighborhood Search, the Variable Neighborhood Descent, besides a third heuristic called Decrescent Cardinality Search. The last one is a new heuristic specifically proposed for reduct calculation. Considering some databases commonly found in the literature of the area, the reducts that have been obtained present lower cardinality, i.e., a lower number of attributes.

关键词： Rough Set Theory Reducts Attribute Reduction Metaheuristics

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全球电离层对2000年4月6-7日磁暴事件的响应

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空间科学学报 2005年第3期25卷 173-180页

作者：张满莲 sandro M. Radicella 中国科学院空间科学与应用研究中心北京100080 The Abdus Salam International Center for Theoretical Physics Trieste Italy

利用分布于全球的电离层台站的测高仪观测数据,对扰动期间,f0F2值与其宁静期间参考值进行比较,研究了2000年4月6-7日磁暴期间全球不同区域电离层的响应形态,并通过对比磁扰期间NmF2的变化与由MSISE90经验模式估算的中性大气浓度比(no/n... 详细信息

利用分布于全球的电离层台站的测高仪观测数据,对扰动期间,f0F2值与其宁静期间参考值进行比较,研究了2000年4月6-7日磁暴期间全球不同区域电离层的响应形态,并通过对比磁扰期间NmF2的变化与由MSISE90经验模式估算的中性大气浓度比(no/nN2)的变化,探讨了本次事件期间的电离层暴扰动机制.结果表明,在磁暴主相和恢复相早期,出现了全球性的电离层F2层负相暴效应.最大负相暴效应出现在磁暴恢复相早期,即电离层暴恢复相开始时间滞后于磁暴恢复相开始时间.在磁暴恢复相后期,一些台站出现正相扰动.研究结果表明,本次事件期间的电离层暴主要是由磁暴活动而诱发的热层暴环流引起的.

关键词： 2000年磁暴事件响应电离层暴观测数据经验模式开始时间时间滞后研究结果复相测高仪扰动参考值浓度比 F2层全球性台站早期效应大气磁扰环流

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Therapeutic strategies for gastroenteropancreatic neuroendocrine neoplasms: State-of-the-art and future perspectives

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World Journal of Gastrointestinal Surgery 2022年第2期14卷 78-106页

作者： Elettra Merola Andrea Michielan Umberto Rozzanigo Marco Erini sandro Sferrazza Stefano Marcucci Chiara Sartori Chiara Trentin Giovanni de Pretis Franca Chierichetti Department of Gastroenterology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Radiology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Nuclear Medicine Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Surgery Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Pathology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Department of Medical Oncology Santa Chiara HospitalAzienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy

Although gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)have always been considered rare tumors,their incidence has risen over the past few *** represent a highly heterogeneous group of neoplasms with several prognostic factors,including disease stage,proliferative index(Ki67),and tumor *** of these neoplasms express somatostatin receptors on the cell surface,a feature that has important implications in terms of prognosis,diagnosis,and *** International Guidelines propose algorithms aimed at guiding therapeutic strategies,GEP-NEN patients are still very different from one another,and the need for personalized treatment continues to *** surgery is always the best option when feasible;however,up to 80%of cases are metastatic upon *** medical treatments,as GEP-NENs are characterized by relatively long overall survival,multiple therapy lines are adopted during the lifetime of these patients,but the optimum sequence to be followed has never been clearly ***,although new molecular markers aimed at predicting the response to therapy,as well as prognostic scores,are currently being studied,their application is still far from being part of daily clinical *** they represent a complex disease,with therapeutic protocols that are not completely standardized,GEP-NENs require a multidisciplinary *** review will provide an overview of the available therapeutic options for GEP-NENs and attempts to clarify the possible approaches for the management of these patients and to discuss future perspectives in this field.

关键词： Gastroenteropancreatic neuroendocrine neoplasms Therapeutic strategies Radical surgery Medical treatments Overview Future perspectives

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The Effect of Familiarization on the Reliability of Isokinetic Assessment in Breast Cancer Survivors

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Journal of Science in Sport and Exercise 2020年第3期2卷 220-225页

作者： Filipe D.de Lima Claudio L.Battaglini sandro N.Chaves Lucas Ugliara Jonathan Sarandy Martim Bottaro College of Health Sciences University of BrasiliaBrasiliaBrazil College of Education and Health Sciences University Center of BrasiliaBrasiliaBrazil Department of Exercise and Sport Science and Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillUSA College of Physical Education University of BrasiliaBrasiliaDFBrazil Integrated College IESGO FormosaBrazil

Purpose To determine the amount of familiarization sessions required by breast cancer survivors to achieve a reliable meas-urement of muscle function assessed using isokinetic *** Twenty-six breast cancer survivors performed three isokinetic knee extension tests separated by,at least,48 *** isokinetic testing protocol included one warm-up set of 10 submaximal knee extensions at 120°/s,followed by two sets of four maximal knee extensions at 60°/s,with 2-min rest interval between *** torque(PT),time to peak torque(TPT),angle of peak torque(APT),and average power(AP)of each trial was used for the assessment of testing *** change in the mean,typical error,coefficient of variation and intraclass correlation coefficients(ICC2.1)were calculated to determine test-retest *** For PT,change in mean was lower between trials 2 and 3 than between trials 1 and 2(4.18% and 13.18%,respec-tively),and ICC was greater between trials 2 and 3 than between trials 1 and 2(0.962 and 0.818,respectively).For TPT and APT,ICC was clinically acceptable only between trials 2 and 3(0.757 and 0.803,respectively).For AP,change in mean was clinically acceptable between trials 2 and 3(9.84%),while ICC met acceptable reliability between both,trials 1 and 2 and,trials 2 and 3(0.756 and 0.891,respectively).Conclusion At least one familiarization session is adequate to achieve reliable measurements of muscle function using isokinetic dynamometry,while avoiding the impact of learning effect of the measurements in breast cancer survivors.

关键词： Muscle strength Breast cancer Isokinetic testing Resistance exercise Motor learning effect

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Georeferencing Brazilian Highway Addresses

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Journal of Geographic Information System 2016年第5期8卷 547-557页

作者： sandro Laudares Mateus Pereira Libório Marianna Petrovna Ekel Pontifícia Universidade Católica de Minas Gerais (PUC-MG) Belo Horizonte Brazil

The usage of georeferencing as a search tool has suffered a massification after the diffusion of technologies developed by Google and Microsoft. In this context, problems related to the location of properties situated on highways are becoming quite usual in Brazil, because properties registration in highway is permitted in the country and this invalidates the dynamics of the georeferencing process. Therefore, a growing number of geotechnology users which desire to localize properties on highways, find inaccurate or amiss geographical information. This research focus is to present an enumeration method for highway properties and, consequently, the possibility of a precise georeferencing. The presented method contributes to turning possible the precision of this georeferencing process and it will also be relevant for geotechnology diffusion considering its integration to geographic information systems which include geocoding tools.

关键词： Geoprocessing Georeferencing Highways Geographic Precision

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