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Efficacy and limits of sildenafil citrate in patients with arterial erectile dysfunction： role of peripheral arterial disease and cardiovascular comorbidities

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Asian Journal of Andrology 2008年第6期10卷 847-853页

作者： Enzo Vicari Mariano Malaguarnera sandro La Vignera Fabio Calzavara Carmelo Battiato Aldo E. Calogero Section of Endocrinology Andrology and Internal Medicine and Master in Andrological and Human Reproduction Sciences Department of Biomedical Sciences University of Catania Catania 95123 Italy Department of Senescence Urological and Neurological Sciences University of Catania Catania 95021 Italy

Aim： To evaluate whether the response to sildenafil administration in patients with arterial erectile dysfunction （ED） was related to their peak systolic velocity （PSV）, peripheral atherosclerosis, cardiovascular risk factors （RF） and/or comorbidities at low cardiovascular risk. Methods： We enrolled 97 patients with 1-2 RF and comorbidities, combined with arterial ED alone （group A, n = 27）, ED plus atherosclerotic carotid artery （group B, n = 23）, ED plus lower limb artery abnormalities （group C, n = 25）, and ED plus carotid and lower limb artery abnormalities （group D, n = 22）. Sildenafil efficacy （100 mg twice a week for 12 weeks） was also examined in patients with ≥ 3 RF, peripheral a（herosclerosis and no cardiovascular comorbidities （group E, n = 20）. Results： Median PSV was 24.1, 21.0, 19.3, 14.5 and 17.5 cm/s in groups A, B, C, D and E, respectively. Sildenafil response was higher in group A patients （77.8%）, intermediate in groups B and C （65.2% and 56%） and lowest in groups D （45.4%） and E （50%）, and the response in latter two groups was significantly lower than in the other three groups. In addition, sildenafil response was nega- tively influenced by：〉 3 RF, peripheral atherosclerosis and no systemic comorbidity, or presence of 1-2 RF associated with extended atherosclerosis and comorbidities. The number of comorbidifies was positively related to atherosclerosis localization or extension （25, 35, 38 and 47 in groups A, B, C and D, respectively）. Conclusion： Low sildenafil efficacy in patients with arterial ED was associated with extended atherosclerosis. These patients should undergo extensive ultrasonography and a full cardiovascular examination.

关键词： arterial erectile dysfunction cardiovascular comorbidities peripheral atherosclerosis sildenafil efficacy

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Comprehensive review on EUS-guided biliary drainage

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World Journal of Gastrointestinal Endoscopy 2019年第5期11卷 354-364页

作者： Raffaele Salerno Sophia Elizabeth Campbell Davies Nicolò Mezzina sandro Ardizzone Gastroenterology and Digestive Endoscopy Unit ASST Fatebenefratelli Sacco-Department of Biochemical and Clinical Sciences "L. Sacco"University of Milan Hospital Pharmacy ASST Fatebenefratelli SaccoPiazza Principessa Clotilde

Feasibility of endoscopic retrograde cholangiopancreatography(ERCP) for biliary drainage is not always applicable due to anatomical alterations or to inability to access the papilla. Percutaneous transhepatic biliary drainage has always been considered the only alternative for this indication. However,endoscopic ultrasonography-guided biliary drainage represents a valid option to replace percutaneous transhepatic biliary drainage when ERCP fails. According to the access site to the biliary tree,two kinds of approaches may be described: the intrahepatic and the extrahepatic. Endoscopic ultrasonography-guided rendezvous transpapillary drainage is performed where the second portion of the duodenum is easily reached but conventional ERCP fails. The recent introduction of self-expandable metal stents and lumen-apposing metal stents has improved this field. However,the role of the latter is still controversial. Echoendoscopic transmural biliary drainage can be challenging with potential severe adverse events. Therefore,trained endoscopists,in both ERCP and endoscopic ultrasonography are needed with surgical and radiological backup.

关键词： Endoscopic ultrasonography-guided biliary drainage EUS Percutaneous transhepatic biliary drainage Endoscopic ultrasonography-guided hepatogastric anastomosis Endoscopic ultrasonography-guided antegrade stent placement Endoscopic ultrasonography-guided choledochoduodenostomy Endoscopic ultrasonography-guided transgallbladder Endoscopic ultrasonography-guided rendezvous

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Clinical Management and Evaluation of White Spot Lesions: A Report of 11 Cases

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Open Journal of Stomatology 2020年第7期10卷 156-173页

作者： Domenico Aiello Riccardo Pulcini sandro Sestito Michele Mario Figliuzzi Sergio Paduano Department of Health Sciences “Magna Graecia” University of Catanzaro Catanzaro Italy Department of Medical Oral and Biotechnological Sciences University of Chieti Chieti Italy Privat Contractor Italy

Introduction: Today’s society is always more interested to the concept of aesthetics. The patients frequently ask to dentist to resolve unaesthetic problems of teeth, in particular that of the upper frontal group. The WSLs are enamel white alterations due to alteration during the demineralization and remineralization of enamel. This effect is caused by alteration of the pH in the oral cavity and buffer action of saliva. An alteration of this relationship leads to a progressive demineralization of enamel until the formation of a dental cavitation. Materials and Methods: For this study are selected 11 patients, of which 3 men and 8 women, with total of 17 WSLs. The inclusion criteria included WLSs with ICDAS = 2 and WLSs caused by hypomineralization of traumatic origin. These patients were subjected to treatment with infiltrating resin according to operative procedure. Discussion: The therapy with infiltrating resin gave great results in 12 lesions out of 17. In the lesions where there weren’t a complete remission we obtained a great aesthetic improvement and a good reduction of lesions. The follow up could improve the result after a better rehydration of hard tissue. Conclusions: With a correct selection of cases and good operative procedure, the use of the micro-infiltrative technique by low viscosity resin is a good procedure to resolve WSLs problems of non-orthodontic origins. Other studies with a larger sample are required to validate this clinical approach.

关键词： WSL Microinfiltration Demineralization Icon Enamel

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Monitoring Landslide-Induced Displacements with TerraSAR-X Persistent Scatterer Interferometry (PSI): Gimigliano Case Study in Calabria Region (Italy)

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International Journal of Geosciences 2013年第10期4卷 1467-1482页

作者： Bianchini Silvia Cigna Francesca Del Ventisette Chiara Moretti sandro Casagli Nicola British Geological Survey Nottingham UK Earth Sciences Department University of Firenze Florence Italy

This work provides a detailed detection of landslide-induced displacements at local scale on Gimigliano site (Italy), by means of PSI (Persistent Scatterers Interferometry) analysis, exploiting TerraSAR-X data acquired in November 2010-October 2011. In February-March 2010, several landslides affected Gimigliano, following high-intensity precipitation, and causing damages to structures and roads. In order to assess any spatial and temporal patterns of deformation, the present X-band PS data were compared with historical motion rates derived from ERS1/2 and ENVISAT satellites, and with geological and geomorphological evidences resulting from auxiliary data such as landslide databases and orthophotos referred to different dates, finally validated with recent field checks. The PSI analysis of the historical ground motion rates highlighted that the modern built-up area located downhill was already affected by surface ground deformation since 1993. A significant enlargement of the instability phenomena is detected across time. The recent PS data analysis and the in situ observations permitted us to accurately update the ground movements in the investigated site: their evidence allowed assessing a reactivation of the large deep-seated landslide zone on which the new urbanized area had built-up, with an average deformation rate of about 8 - 9 mm/yr. The higher instability phenomenon is affecting the eastern part of Gimigliano old village, with a mean displacement velocity reaching up values of -30 mm/yr, in the radar temporal acquisition of only 10 months. These outcomes can be taken into account for further hazard-reduction analysis and to support risk mitigation design within the investigated area.

关键词： SAR Interferometry Persistent Scatterers Landslides

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Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia

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Asian Journal of Andrology 2008年第5期10卷 731-740页

作者： sandro La Vignera Aldo E. Calogero Alessandro Arancio Roberto Castiglione Gaetano De Grande Enzo Vicari Section of Endocrinology Andrology and Internal Medicine Department of Biomedical Sciences University of Catania 95123 Catania Italy Urology Unit Ospedale Umberto L 96100 Syracuse ltaly

Aim： To identify and define prostate and seminal vesicle abnormalities in patients with chronic male accessory gland infection （MAGI） who failed to respond to antibacterial treatment. Methods： We selected 67 consecutive patients with MAGI and persistently elevated bacteriospermia （≥ 10^6 colony forming units [CFU]/mL） after three antibiotic courses. Fourteen infertile patients with initial chronic microbial （≥ 10^6 CFU/mL） MAGI who responded to antibacterial treatment （〈 10^3 CFU/mL） served as a control group. All patients and controls underwent transrectal ultrasonography （TRUS） scans and semen analysis. Patients with low seminal plasma volume （〈 1.5 mL） underwent both preejaculatory and post-ejaculatory TRUS examination. Results： TRUS revealed multiple abnormalities indicative of：（i） bilaterally extended prostato-vesiculitis （group A： 52 cases, 77.6%）（nine of these patients also had micro-emphysematous prostate abscess）; and （ii） prostato-vesiculitis with unilateral or bilateral sub-obstruction of the ejaculatory ducts （group B： 15 cases, 22.4%）. Mean sperm concentration, total sperm number, ejaculate volume and pH value were significantly higher in group A than in group B. In addition, sperm forward motility and the percentage of normal forms were significantly worse than in controls, whereas leukocyte concentration was significantly higher in group A. Group B patients had all sperm parameters, but their pH values, significantly different from those of controls. Conclusion： Although antibiotic therapy is considered suitable when microbial MAGI is suspected, it is impossible to account for a poor response to antibiotics merely on the basis of conventional criteria （clinical history, physical and ejaculate signs）. Thus, TRUS may be helpful in the follow-up of these patients.

关键词： persistent bacteriospermia prostato-vesiculitis sub-obstruction of the ejaculatory ducts micro-emphysematous prostate abscess sperm parameters ultrasound features

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Landscapes—Structure, Functions, and Development Trends (On the Example of Landscapes of Georgia)

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Open Journal of Ecology 2022年第1期12卷 81-93页

作者： Nodar Elizbarashvili Giorgi Meladze Lado Grigolia Gela Sandodze sandro Gogoladze Miranda Gurgenidze Department of Regional Geography and Landscape Planning Tbilisi State University Tbilisi Georgia

The article discusses the peculiarities of landscape geography development, types of landscape structure and their types, the essence of cultural landscape and its types, landscape functions and peculiarities of their... 详细信息

关键词： Geography Landscape Structure Landscape Function Landscape Planning Climate Change

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Low Cycle Fatigue, Creep-Fatigue and Relaxation-Fatigue Tests on P91

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Journal of Physical Science and Application 2017年第2期7卷 18-26页

作者： Carlo Cristalli Pietro Agostini Davide Bemardi Nicola Bettocchi Luigi Masotti sandro Storai ENEA CR Brasimone Camugnano (BO) 40032 Italy

Creep-fatigue is a damage mechanism where cyclic deformation damage （fatigue） is enhanced by creep damage and vice versa. Factors affecting the creep-fatigue damage are stress level （or, equivalently, strain range）, temperature, hold time period, material softening/hardening and number of cycles. Moreover, environmental effects can accelerate the creep-fatigue interaction （oxidation, hot corrosion, irradiation, etc.）. The activity described in this paper was planned to perform tests on 9Cr-lMo ferritic/martensitic steel （P91） combining fatigue cycles and constant tensile and compressive holding periods. A preliminary basic fatigue characterization campaign in the LCF （low cycle fatigue） regime was carried out by performing a series of strain controlled tests, each at the same temperature （550 ℃）, using two different values for the total strain range （1% and 0.6%） and the same total strain rate （2×10^-3 s^-1）. The tests were carried out with a strain ratio of-l, i.e., in fully reversed cyclic conditions. In this paper we illustrate the results obtained by testing in air P91 （9Cr-lMo） ferritic/martensitic steel, introducing different dwell periods （either in strain or load control） and obsetwing how these affect the fatigue life of the specimens. The final aim of the activity is to investigate how much detrimental is the effect of the holding periods on the fatigue life in order to validate the creep-fatigue interaction diagram presently adopted in RCC-MRx code for the P91 steel.

关键词： P91 creep-fatigue fatigue damage creep damage interaction diagram RCC-MRx softening.

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Systemic venous atrium stimulation in transvenous pacing after mustard procedure

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World Journal of Cardiology 2014年第9期6卷 1041-1044页

作者： Calogero Puntrello Fabiana Lucà Gaspare Rubino Carmelo Massimiliano Rao sandro Gelsomino Department of Cardiology Paolo Borsellino Hospital Department of Cardiology Melacrino Morelli Hospital Department of Heart and Vessels Careggi Hospital

We present the case of a young woman corrected with a Mustard procedure undergoing successful transvenous double chamber pacemaker implantation with the atrial lead placed in the systemic venous channel. The case presented demonstrates that, when the systemic venous atrium is separate from the left atrial appendage, the lead can be easily and safely placed in the systemic venous left atrium gaining satisfactory sensing and pacing thresholds despite consisting partially of pericardial tissue.

关键词： Cardiac pacing Mustard procedure Trans-position of great arteries

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The Effect of Electromagnetic Fields with the Mg²⁺ Cyclotron Frequency on Mouse Reproductive Performance

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Journal of Electromagnetic Analysis and Applications 2016年第7期8卷 115-123页

作者： Gabriele Gerardi Antonella De Ninno Vanni Ferrari sandro Mazzariol Daniele Bernardini Severino Segato Department of Animal Medicine Production and Health University of Padova Legnaro (PD) Italy ENEA C.R. Frascati Department Fusion and Nuclear Technologies Technologies for Safety and Health Division Frascati (Roma) Italy Department of Comparative Biomedicine and Food Science University of Padova Legnaro (PD) Italy

The present study is aimed to test whether exposure to electromagnetic fields of very weak intensity (≤1 mT) and low frequency (≤100 Hz) may influence reproductive performance and induce teratogenesis in mice. We speculate that a resonant effect occur when the applied frequency matches the cyclotron frequency of Mg2+ (≈60 Hz) involved in the cell duplication. Four groups of mice (four dams and one male each) were exposed to ?50 μT electromagnetic field continuous irradiation of for 100 days. A control group (four dams and one male) was also examined. The exposed dams exhibited a significantly lower number of offspring per birth than the control ones (11.0 vs. 11.6;P = 0.006). A significantly lower average daily gain of body weight per mouse was observed (0.74 vs. 0.77 g/d;P = 0.002), resulting in a reduction of the average body weight per nest at 11 days of age (404 vs. 463 g;P = 0.048). Post mortem examinations revealed a significant increase in mild chronic hepatic inflammatory findings (28 vs. 0%;P = 0.001) in the offspring and myocardial hypertrophy (25 vs. 0%;P = 0.023) in the dams. The exposure of mice to an electromagnetic field with the cyclotron frequency of Mg2+ during pregnancy caused a measurable effect on the reproductive performance in terms of offspring per birth. This finding may be considered as a warning about the environmental effects of the electromagnetic fields on the stability of individual species and ecosystems.

关键词： ELF-EMF Cyclotron Frequency Mouse Birth-Rate Postnatal Growth Histological Findings

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First description of scleractinian corals from the Santa Marta and Snow Hill Island(Gamma Member) formations, Upper Cretaceous, James Ross Island, Antarctica

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Advances in Polar Science 2020年第3期31卷 205-214页

作者： Roberto VIDEIRA-SANTOS sandro Marcelo SCHEFFLER Luiza Corral Martins de Oliveira PONCIANO Luiz Carlos WEINSCHUTZ Rodrigo Giesta FIGUEIREDO Taissa RODRIGUES Juliana Manso SAYAO Douglas Santos RIFF Alexander Wilhelm Armin KELLNER Laboratorio de Paleoinvertebrados Departamento de Geologia e PaleontologiaMuseu NacionalUniversidade Federal do Rio de JaneiroQuinta da Boa Vistas/n20940-040Rio de JaneiroRJBrazil Universidade Federal Rural do Rio de Janeiro BR-465Km 07s/n23890-000SeropedicaRJBrazil Laboratorio de Tafonomia e Paleoecologia Aplicadas–LABTAPHO Departamento de Ciencias Naturais–DCNUniversidade Federal do Estado do Rio de Janeiro–UNIRIOAv.Pasteur45822290-250Rio de JaneiroRJBrasil Centro Paleontologico de Mafra–CENPALEO Universidade do ContestadoAv.Pres.Nereu Ramos107189300-000MafraSCBrazil Departamento de Biologia Universidade Federal do Espirito Santo–UFESAlto Universitario s/nGuararemaAlegreESBrazil Laboratorio de Paleontologia Departamento de Ciências BiologicasCentro de Ciencias Humanas e NaturaisUniversidade Federal do Espirito Santo–UFESAvenida Fernando Ferrari514Goiabeiras29075-910VitoriaESBrazil Laboratorio de Paleobiologia e Microestruturas Nucleo de BiologiaCentro Academico de VitoriaUniversidade Federal de Pernambuco–UFPERua do Alto do Reservatorios/n52050-480Vitoria de Santo AntaoPEBrazil Laboratory of Systematics and Taphonomy of Fossil Vertebrates Departamento de Geologia e PaleontologiaMuseu Nacional/Universidade Federal do Rio de JaneiroQuinta da Boa Vista s/nSao Cristovao20940-040 Rio de JaneiroRJBrazil Laboratorio de Paleontologia Instituto de BiologiaUniversidade Federal de Uberlandiacampus Umuarama38400-902UberlandiaMGBrazil

Antarctic corals are known from the Upper Cretaceous Santa Marta Formation(Santonian–early Campanian)and Gamma Member(late Campanian)of Snow Hill Island Formation(late Campanian–early Maastrichtian)but they have not so far been taxonomically *** describe three corals taxa based on 29 specimens collected in 2007 and 2016 on James Ross Island(northeast of the Antarctic Peninsula).They represent the first formal record of scleractinian corals from the Santa Marta Formation,identified as Caryophylliidae *** Gamma Member of Snow Hill Island Formation,identified as Astreopora *** Fungiacyathus *** family Caryophylliidae and the genus Astreopora were not restricted to the Weddellian Biogeographic Province but the species Fungiacyathus deltoidophorus was endemic to Antarctica during the *** genus Fungiacyathus and the family Caryophylliidae thrive in Antarctica until the present *** occurred in shallower environments during the late Campanian than *** specimens related to Astreopora have yet to be found in Antarctica after the late *** can be explained by the capacity of Fungiacyathus and Caryophyllidae to endure cold waters,since they are asymbiotic *** symbiotic Astreopora sp.,due to its sensitivity to low temperatures,became extinct in this continent as soon as the Antarctic waters began to cool,around the Campanian/*** presence of Astreopora *** Gamma Member of Snow Hill Island Formation may represents the first occurrence of this genus in Antarctica and the oldest record of this genus in the Southern Hemisphere.

关键词： scleractinia taxonomy Campanian James Ross Sub-Basin Antarctica

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