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New insights into renal lipid dysmetabolism in diabetic kidney disease

World Journal of Diabetes 2021年第5期12卷 524-540页

作者： Alla Mitrofanova George Burke sandra merscher Alessia Fornoni Peggy and Harold Katz Family Drug Discovery Center University of MiamiMiller School of MedicineMiamiFL 33136United States Katz Family Division of Nephrology and Hypertension Department of MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136United States Department of Surgery University of MiamiMiller School of MedicineMiamiFL 33136United States Diabetes Research Institute University of MiamiMiller School of MedicineMiamiFL 33136United States

Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs,including the *** suggests that impaired cholesterol metabolism,increased lipid uptake or synthesis,increased fatty acid oxidation,lipid droplet accumulation and an imbalance in biologically active sphingolipids(such as ceramide,ceramide-1-phosphate and sphingosine-1-phosphate)contribute to the development of diabetic kidney disease(DKD).Currently,the literature suggests that both quality and quantity of lipids are associated with DKD and contribute to increased reactive oxygen species production,oxidative stress,inflammation,or cell ***,control of renal lipid dysmetabolism is a very important therapeutic goal,which needs to be *** article will review some of the recent advances leading to a better understanding of the mechanisms of dyslipidemia and the role of particular lipids and sphingolipids in DKD.

关键词： Diabetes Lipids Free fatty acids ATP-binding cassette transporters sub-class A Sterol-O-acyltransferase 1 CD36 Sphingolipids Sphingomyelin phosphodiesterase acid-like 3b Diabetic kidney disease

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Sphingomyelin phosphodiesterase acid like 3B(SMPDL3b)regulates Perilipin5(PLIN5)expression and mediates lipid droplet formation

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Genes & Diseases 2022年第6期9卷 1397-1400页

作者： Shamroop Kumar Mallela Mengyuan Ge Judith Molina Javier Varona Santos Jin-Ju Kim Alla Mitrofanova Hassan Al-Ali Brian Marples sandra merscher Alessia Fornoni Katz Family Division of Nephrology and Hypertension Department of MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136USA Peggy and Harold Katz Family Drug Discovery Center University of MiamiMiller School of MedicineMiamiFL 33136USA Department of Radiation Oncology University of RochesterRochesterNY 14627USA

Lipid droplets(LDs)are lipid storage organelles with a central hydrophobic core of neutral lipids that is enclosed in a monolayer of *** the storage of lipids,mainly cholesterol and triglycerides,was thought to be the primary function of LDs,studies have shown that they have important functions in maintaining lipid homeostasis and modulating various signaling *** lipid accumulation has been recognized as a key feature in several human diseases such as obesity,diabetes,cancer,neurological diseases,cardiovascular diseases,insulin resistance,liver diseases and kidney *** play an important role in innate immunity,in the fight against infections,and in the replication of *** a tight regulation of LD metabolism is essential for proper functioning of a cell.

关键词： metabolism immunity Lipid

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