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mexican Guidelines for the Diagnosis and Treatment of chronic myeloid Leukaemia

Journal of cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo cervera Federico Godínez Rosa Sosa Ramón Rivas carlos Best Juan Hernández Adrián morales Hugo Zurita Ivette carrasco Jorge cruz álvaro Aguayo José Espinoza Juan Labardini Luis Valero Judith cruz Diana Arcos Diego Limón Omar López-Navarro Daniela Gordillo-Bastidas myrna candelaria Francisco Torres Juan Kassack Oscar de Jesús Pérez Ramírez Jorge Aquino Guillermo Díaz mariela cardiel margarita Rodríguez Patricia montoya Juan contreras maría chávez sandra chávez David Gómez Olga cantú Jorge Duque Luis Pita Eduardo Lobato Julio López Antonio López Pedro González Jorge cortés Haematology and Oncology Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology Deparment from Hospital Juárez Mexico City Mexico Haematology Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology Department General Hospital of Sonora State Sonora Mexico Haematology Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the Poblano child Puebla Mexico Internal medicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaemias clinic at ISSEmym Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los mochis General Hospital Sinaloa Mexico Renaissance clinic Morelia Mexico State council for AIDS Prevention and control Chihuahua Mexico Universidad Autónoma de Yucatán Mérida Mexico

Background: This document includes recommendations and guidelines issued by a group of mexican researchers and specialists gathered in the First National colloquium for the Diagnosis and management of chronic myeloid Leukaemia (cmL) by initiative of Instituto Nacional de cancerología and with the support of the Leukaemia Department of the mD Anderson cancer center. mexico lacks of updated information taken from its own reality on the diagnosis and treatment of cmL and other haematological disorders;besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of cmL adjusted to the national environment and overall characteristics. method: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. Results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of cmL in mexico. conclusions: Having consensus guidelines for the clinical management of cmL in our country will enable the consensual practice of mexican specialists regarding the clinical approach to cmL, as well as optimize the resources which allow the rational planning of the medical care strategies.

关键词： chronic myeloid Leukaemia management Guidelines Diagnosis Treatment.

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血管性因素对认知损害和痴呆的促成作用美国心脏协会／美国卒中协会对医疗卫生专业人员的声明

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国际脑血管病杂志 2012年第2期20卷 85-124页

作者：无无无无无曹雯炜（译）糜建华（译）宋叶平（译）余寿芬（译）王飞（译）李焰生（译）美国心脏协会卒中委员会流行病学与预防委员会心血管护理委员会心血管放射学和介入委员会心血管外科和麻醉学委员会上海交通大学医学院附属仁济医院神经科上海200127

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveimpairment）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveimpairment，VcI）的定义、神经病理... 详细信息

背景与目的本科学声明提供了血管性因素对认知损害（co,airiveimpairment）和痴呆促成作用证据的纵览。血管性因素在老年认知损害和痴呆中的作用十分普遍。本文对血管性认知损害（vascularcognitiveimpairment，VcI）的定义、神经病理学、基础科学和病理生理学研究、神经影像学的作用、血管性和其他相关危险因素的作用以及潜在的防治方法进行了回顾，旨在为临床医生提供一份总体指导，以进一步加深对VcI和痴呆及其防治的理解。方法写作组成员由写作组联合主席基于先前在相关领域的研究成果提名，并经美国心脏协会（AmericanHeartAssociation，AHA）卒中委员会科学声明监督委员会、流行病学和预防委员会以及文稿监督委员会批准。写作组采用系统文献回顾（主要涵盖1990年至2010年5月期间的文献）、以往公布的指南、个人资料以及专家观点总结现有证据，提出当前知识的不足，并对适当的问题根据AHA标准制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并认可了最终版本。经AHA的同行评议以及卒中委员会领导阶层、流行病学和预防委员会以及科学声明监督委员会审阅后，最终获得AHA科学咨询和协调委员会批准。结果VcI概念的提出涵盖了与所有类型脑血管性脑损害（而不仅仅是卒中）相关的整个认知障碍（cognitivedisorder）谱，其范围从轻度认知损害到完全痴呆。神经血管单元和脑血流调节机制障碍可能是VcI的潜在病理生理学过程的重要组成部分。脑淀粉样血管病已成为阿尔茨海默病（Alzheimerdisease，AD）、微梗死、微出血、脑出血以及VcI风险的一个重要标志。老年认知损害的神经病理学改变常常是AD与微血管性脑损害的混合状态，二者可叠加和协同增高认知损害风险。就此而言，mRI和其他神经影像学技术在VcI的确定和识别中起着重要作用，并提供证据说明以白质高信号和小的深部梗死为特征的皮质下型VcI很常见。在许多情况下，VcI的风险标志同样也是卒中的传统危险因素。这些危险因素包括但不仅限于心房颤动、高血压、糖尿病和高胆固醇血症。而且，这些血管危险因素也可能是AD的风险标志。颈动脉内膜一中膜厚度和动脉僵硬度是动脉老化的标记物，也可能成为VcI的风险标志。目前，美国食品药物管理局尚未批准任何VcI的特异性治疗方法。不过，对卒中和心血管病传统危险因素的评价和控制，可能对包括老年人群在内的VcI的预防具有作用。结论血管性因素在认知损害和痴呆中的促成作用很重要。近年来，在临床前、神经病理学、神经影像学、生理学和流行病学研究基础上，对VcI的认识得到了不断提高。推荐使用跨学科的、转化的以及交互的方法进一步加深对此领域的了解，并更好地掌握其神经心理学特征。需要开展前瞻性定量临床一病理学一神经影像学研究，以提高对神经影像学改变的病理学基础，以及血管病变和AD病变在VcI和AD临床演变中的复杂的丰互作用的认识。可能需要在中年期尽早肝始对血管危险标志进行长期干预，以预防或延迟VcI或AD发病的研究。住高危人群I}1强化控制血管危险因素则是另一个重要的研究方向。

关键词： AHA科学声明血管性痴呆阿尔茨海默病危险因素预防治疗

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心肌梗死后肾功能不全与心血管预后的关系

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 10-11页

作者： Anavekar N.S. mcmurray J.J.V. Velazquez E.J. m.A. Pfeffer 王亭忠 cardiovascular Division Brigham and Women's Hospital 75 F rancis St. Boston MA 02115 United States Dr.

BAcKGROUND: The presence of coexisting conditions has a substantial effect on the outcome of acute myocardial infarction. Renal failure is associated with one of the highest risks, but the influence of milder degrees of renal impairment i s less well defined. mETHODS: As part of the Valsartan in Acute myocardial Infar ction Trial (VALIANT), we identified 14,527 patients with acute myocardial infar ction complicated by clinical or radiologic signs of heart failure, left ventric ular dysfunction, or both, and a documented serum creatinine measurement. Patien ts were randomly assigned to receive captopril, valsartan, or both. The glomerul ar filtration rate (GFR) was estimated by means of the four component modificat ion of Diet in Renal Disease equation, and the patients were grouped according t o their estimated GFR. We used a 70-candidate variable model to adjust and comp are overall mortality and composite cardiovascular events among four GFR groups. RESULTS: The distribution of estimated GFR was wide and normally shaped, with a mean (±SD) value of 70±21 ml per minute per 1.73 m2 of bodysurface area. The prevalence of co existing risk factors, prior cardiovascular disease, and a Kil lip class of more than I was greatest among patients with a reduced estimated GF R (less than 45.0 ml per minute per 1.73 m2), and the use of aspirin, beta bloc kers, statins, or coronary revascularization procedures was lowest in this group . The risk of death or the composite end point of death from cardiovascular caus es, reinfarction, congestive heart failure, stroke, or resuscitation after cardi ac arrest increased with declining estimated GFRs. Although the rate of renal ev ents increased with declining estimated GFRs, the adverse outcomes were predomin antly cardiovascular. Below 81.0 ml per minute per 1.73 m2, each reduction of th e estimated GFR by 10 units was associated with a hazard ratio for death and non fatal cardiovascular outcomes of 1.10(95 percent confidence interval,

关键词：肾功能不全左室功能不全随机入选复合终点心血管事件血运重建术再梗死 β-受体阻滞剂肾功能衰竭肾功能受损

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随机对照试验:评价吗啡对新生儿血浆肾上腺素/去甲肾上腺素浓度的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 24-25页

作者： Simons S. H. P. Van Dijk m. Van Lingen R. A. D. Tibboel 郭战宏 Departm ent of Paediatric Surgery Erasmus MC-Sophia Dr Molewaterplein 60 3015 GJ Rotterdam NetherlandsDr.

Objectives: To determine the effects of continuous morphine infusion in ventil ated newborns on plasma concentrations of adrenaline (epinephrine) and noradrena line (norepinephrine)-and their relation to clinical outcome. Design: Blinded, randomised, placebo controlled trial. Setting: Level III neonatal intensive care units in two centres. Patients: A total of 126 ventilated neonates (inclusion c riteria: postnatal age catheter for clinical purposes; exclusion criteria: severe asphyxia, sev ere intraventricular haemorrhage, major congenital anomalies, neuromuscular bloc kers). Interventions: Plasma adrenaline and noradrenaline concentrations were de termined in patients during blinded morphine (n = 60) and placebo (n = 66) infus ion (100 μg/kg plus 10 μg/kg/h). Results: Plasma concentrations at baseline (n mol/l with interquartile range in parentheses) were comparable in infants treate d with morphine (adrenaline, 0.22 (0.31); noradrenaline, 2.52 (2.99)) or pla cebo (adrenaline, 0.29 (0.46); noradrenaline, 2.44 (3.14)). During infusion, median adrenaline concentrations were 0.12 (0.28) and 0.18 (0.35)-and medi an noradrenaline concentrations were 2.8 (3.7) and 3.8 (4.0) for the morphin e and placebo treated infants respectively. multivariate analyses showed that no radrenaline (p = 0.029), but not adrenaline (p = 0.18), concentrations were si gnificantly lower in the morphine group than the placebo group. Furthermore, nor adrenaline concentrations were related to the length of stay in the neonatal int ensive care unit. conclusions: continuous morphine infusion significantly decrea sed plasma noradrenaline concentrations in ventilated newborns compared with pla cebo treatment. The results of this study support the idea that routine morphine administration decreases stress responses in ventilated neonates.

关键词：随机对照试验去甲肾上腺素血浆肾上腺素神经肌肉阻断剂安慰剂对照脑室内出血应激反应机械通气连续静脉滴注剔除标准

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对非根治幽门螺杆菌感染患者的Hp标记物基因型和表型稳定性的9年随访研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 13-13页

作者： Gustavsson A Unemo m Blomberg B Danielsson D 徐小杰 Department of c linical microbiology rebro University Hospital SE-701 85 rebro Sweden.Dr

The cagA gene, alleles of the vacA gene, random amplified polymorphic DNA (RAP D), and neutrophil activating capacity (HpNAc) were used to examine paired H. py lori is- olates from 10 noneradicated individuals 9 years apart. Paired isolates from e ach patient were indistinguishable with regard to vacA alleles, RAPD, and HpNAc. Isolates fromnine patients showed concordance for the cagA gene, which was not detected in the recent isolate of the tenth patient. Antibodies to cagA were,how ever, demonstrated in the serum specimens 9 years apart and were also present in two other patients whose paired isolates were cagA-, indicating the existence of both cagA+and cagA-organisms, with the latter predominating in some patient *** present study suggests a greater stability of phenotypic and genotypic mar kers of H. pylori than previously regarded. This might be true for a community w ith low infection and transmission rates. complementary techniques like microarr ays might,however, disclose evolutionary changes not identified here.

关键词： Hp 随访研究 vacA 随机扩增基因芯片基因体分离菌 DNA 传播率补充性

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Nat Genet:科学家设计新方法找到抑制癌症发育的新基因

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现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： Jorge de la Rosa, mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, sandra Bernaldo de Quirós, Imran Noorani, Emmanouil metzakopian, Alexander Strong, meng Amy Li, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Allan Bradley Juan cadiñanos Jorge de la Rosa Juan cadiñanos Jorge de la Rosa carlos López-Otín Julia Weber Roland Rad Julia Weber Roland Rad Aurora Astudillo maría Teresa Fernández-García maría Soledad Fernández-García Gary J Hoffman carlos López-Otín The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton UK Instituto de medicina Oncológica y molecular de Asturias (ImOmA) Oviedo Spain Departamento de Bioquímica y Biología molecular Facultad de Medicina Instituto Universitario de Oncología (IUOPA) Universidad de Oviedo Oviedo Spain Department of Internal medicine II Klinikum rechts der Isar Technische Universität München München Germany German cancer consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Servicio de Anatomía Patológica Hospital Universitario Central de Asturias Oviedo Spain Unidad de Histopatología molecular Facultad de Medicina IUOPA Universidad de Oviedo Oviedo Spain School of medicine University of Western Australia Crawley Western Australia Australia centro de Investigación Biomédica en Red de cáncer Spain.

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在... 详细信息

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在国际学术期刊Nature Genetics上。该研究揭示了一些参与癌症发育的新途径，这些基因有望成为治疗PTEN突变癌症的新药物靶点。这项研究开发的一些方法也可以用于发现其他协同抑制癌症生长的基因。

关键词：新基因癌症发育 Nat 科学家设计肿瘤抑制基因国际学术期刊

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