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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 628-639页

作者： AndréMansinho Priscila Nejo Tito Leitão sandra casimiro Luís Costa Serviço de Oncologia Médica Centro Hospitalar Universitário Lisboa NorteHospital de Santa MariaLisboa 1649-035Portugal Luis Costa Laboratory Instituto de Medicina MolecularFaculdade de Medicina da Universidade de LisboaLisboa 1649-035Portugal Instituto Português de Oncologia Lisboa Francisco Gentil Lisboa 1649-035Portugal Urology Department Centro Hospitalar Universitário Lisboa NorteHospital de Santa MariaLisboa 1649-035Portugal

Metastatic renal cell carcinoma(mRCC)presents with bone metastases in around 20%-30%of patients enrolled in the most recent first-line clinical *** of several new agents in first line,in both monotherapy and combination,has significantly improved patient ***,the activity of such agents on bone metastases is unclear and management of these patients is complex,due to potential complications that can significantly impair quality of *** review addresses mRCC diagnosis and monitoring and summarizes the current evidence on systemic therapy,ablative therapies such as stereotactic ablative radiotherapy and surgery,and supportive therapy with bone-targeting agents for these patients,with the goal of improving their outcomes.

关键词： Bone metastases renal cell carcinoma bone targeted treatments radiotherapy systemic therapy

Evaluation of flow characteristics in an onshore horizontal separator using computational fluid dynamics

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Journal of Ocean Engineering and Science 2020年第3期5卷 261-268页

作者： Tathagata Acharya Lucio casimiro Department of Physics and Engineering California State UniversityBakersfield9001 Stockdale HighwayBakersfieldCA 93311United States

In the petrochemical industry,separation of oil from water is a very important *** produce mixtures of gas,oil,and water which undergo a primary stage of separation inside horizontal gravity *** performance of these vessels is evaluated by measuring mean residence time(MRT)and residence time distribution(RTD).Although many researchers studied flow characteristics in horizontal separators,limited number of articles exist that discuss separator MRT and RTD with varying *** this article,the authors study an experiment using a horizontal gravity separator by previous researchers and perform computational fluid dynamics(CFD)simulations on the same geometry under similar *** simulation results show qualitative agreement with the experiments by previous *** shown by experiments before,CFD results showed that MRT of the organic phase increased with increase in *** addition,the RTD characteristics show very similar trends between CFD and experimental results.

关键词： Multiphase separators Computational fluid dynamics Mean residence time Residence time distribution

Mainstreaming Disaster Risk Reduction and Climate Change Adaptation in Comprehensive Development Planning of the Cities in Nueva Ecija in the Philippines

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International Journal of Disaster Risk Science 2021年第3期12卷 367-380页

作者： Arneil G.Gabriel Patrick Neil M.Santiago Rosemarie R.casimiro Department of Public Administration Nueva Ecija University of Science and Technology3100 Cabanatuan CityPhilippines

Recent scientific consensus suggests that climate-related disasters are becoming more frequent and ***,increasing importance is given to disaster risk reduction(DRR)and climate change adaptation(CCA)in global *** projected global warming at 1.5℃and the climate variability that the Philippine archipelago experiences make DRR-CCA the key priorities of both the national and local government *** this study,we assessed and measured the degree of mainstreaming of DRR-CCA in the comprehensive development plans(CDPs)of the five component cities in the province of Nueva Ecija in the *** are among the areas in Central Luzon that are susceptible to hydrometeorological and geologic *** distributed survey questionnaires to 25 employees of the local government units in the five component cities in Nueva Ecija who are directly involved in planning *** triangulated their responses using archival data(review of written policies and plans).The main findings of the study indicate that in spite the presence of laws and policies on DRR-CCA,their implementation is only in the preliminary *** results also provide insights to policymakers and future researchers on the challenges and opportunities influencing the systemic mainstreaming of DRR-CCA in the province.

关键词： Climate-related disasters Global warming Local development planning Philippines Southeast Asia

Hydrocarbons in particulate samples from wildfire events in central Portugal in summer 2010

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Journal of Environmental Sciences 2017年第3期29卷 122-131页

作者： Ana Vicente Ana Calvo Ana P.Fernandes Teresa Nunes Cristina Monteiro casimiro Pio Célia Alves Centre for Environmental and Marine Studies (CESAM) Department of EnvironmentUniversity of Aveiro Department of Physics IMARENABUniversity of León

In summer 2010, twenty eight （14 PM=2.5 samples plus 14 samples PM2.5-10） smoke samples were collected during wildfires that occurred in central Portugal. A portable high-volume sampler was used to perform the sampling, on quartz fibre filters of coarse （PM=2.5-10） and fine （PM2.5） smoke samples. The carbonaceous content （elemental and organic carbon） of particulate matter was analysed by a thermal-optical technique. Subsequently, the particulate samples were solvent extracted and fractionated by vacuum flash chromatog- raphy into three different classes of organic compounds （aliphatics, polycyclic aromatic hydrocarbons （PAHs） and carbonyl compounds）. The organic speciation was performed by gas chromatography-mass spectrometry （GC-MS）. Emissions were dominated by the fine particles, which represented around 92% of the PM10. A clear predominance of carbonaceous constituents was observed, with organic to elemental carbon （OC/EC） ratios ranging between 1.69 and 245 in both size fractions. The isoprenoid ketone 6,10,14-trimethyl-2-pentadecanone, a tracer for secondary organic aerosol formation, was one of the dominant constituents in both fine and coarse particles. Retene was the most abundant compound in all samples. Good correlations were obtained between OC and both aliphatic and PAH compounds. Pyrogenic processes, thermal release of biogenic com- pounds and secondary processing accounted for 97% of the apportioned PM2.5 levels.

关键词： WildfiresOrganic carbonOrganic compoundsBiomarkersParticulate matterPortugal

AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex

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Journal of Molecular Cell Biology 2017年第2期9卷 154-165页

作者： Anna de Polo Zhongling Luot casimiro Gerarduzzi Xiang Chen John B. Little Zhi-Min Yuan John B. Little Center for Radiation Sciences Harvard T.H. Chan School of Public Health Boston MA 02115 USA Department of Dermatology Xiangya Hospital Central South University Changsha 410008 China

Deregulation of the tyrosine kinase signalling is often associated with tumour progression and drug resistance, but its underlying mechanisms are only partly understood. In this study, we investigated the effects of the receptor tyrosine kinase AXL on the sta- biUty of the MDMX-MDM2 heterocomplex and the activity of p53 in melanoma cells. Our data demonstrated that AXL overexpres- sion or activation through growth arrest-specific 6 （Gas6） Ugand stimulation increases MDMX and MDM2 protein levels and decreases p53 activity. Upon activation, AXL stabilizes MDMX through a post-translational modification that involves phosphoryl- ation of MDMX on the phosphosite Ser314, leading to increased affinity between MDMX and MDM2 and favouring MDMX nuclear translocation. Ser314 phosphorylation can also protect MDMX from MDM2-mediated degradation, leading to stabilization of the MDMX-MDM2 complex. We identified CDK4/6 and p38 MAPK as the two kinases mediating AXL-induced modulation of the MDMX-MDM2 complex, and demonstrated that suppression of AXL, either through siRNA silencing or pharmacological inhibition, increases expression levels of p53 target genes P21, MDM2, and PUMA, improves p53 pathway response to chemotherapy, and sensitizes cells to both Cisplatin and Vemurafenib. Our findings offer an insight into a novel signalling axis linking AXL to p53 and provide a potentially druggable pathway to restore p53 function in melanoma.

关键词： MDMX MDM2 AXL CDK4/6 p53 melanoma

Trends in Maritime Spatial Planning in Europe: An Approach to Governance Models

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Journal of Environmental Protection 2019年第12期10卷 1677-1698页

作者： Daniela casimiro José Guerreiro Faculdade de Ciências da Universidade de Lisboa Lisboa Portugal MARE-Marine and Environmental Sciences Centre Faculdade de Ciências da Universidade de Lisboa Lisboa Portugal

Maritime spatial planning is considered a key instrument for the success of integrated maritime policy. MSP is therefore an integrated approach to address the conflicting and competing uses of ocean resources and spaces in order to achieve the sustainable development of seas. This paper aims to access how governance models have been evolving with the implementation of MSP in Europe. The study compares institutional and legal frameworks in a North-South context, based on the case studies of Norway, Netherlands, England, Germany and Portugal and concludes that, although there are similarities in the legal frameworks developed to implement MSP, more profound differences arise on marine governance models and institutional frameworks, reflecting different political approaches and regional contexts.

关键词： Maritime Spatial Planning Marine Governance Institutional Framework

Assessment of the exploitable biomass of thread herring(Opisthonema spp.)in northwestern Mexico

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Acta Oceanologica Sinica 2021年第9期40卷 53-65页

作者： Marcelino Ruiz-Dominguez casimiro Quinonez-Velazquez Dana Isela Arizmendi-Rodriguez Victor Manuel Gomez-Munoz Manuel Otilio Nevarez-Martinez Facultad de Ciencias del Mar Universidad Autonoma de SinaloaMazatlan 82000Mexico Instituto Politecnico Nacional Centro Interdisciplinario de Ciencias MarinasLa Paz 23000Mexico Instituto Nacional de Pesca y Acuacultura Centro Regional de Investigacion Pesquera Unidad GuaymasGuaymas 85400Mexico

In recent years,the small pelagic fishery on the Pacific northwest coast of Mexico has significantly increased fishing pressure on thread herring Opisthonema *** fishery is regulated using a precautionary approach(acceptable biological catch(ABC)and minimum catch size).However,due to fishing dynamics,fish aggregation habits and increased fishing mortality,periodic biomass assessments are necessary to estimate ABC and assess the resource *** Catch-MSY approach was used to analyze historical series of thread herring catches off the western Baja California Sur(BCS,1981–2018)and the Gulf of California(GC,1972–2018)to estimate exploitable biomass and target reference points in order to obtain catch *** to the results,in GC,the maximum biomass reached in 1972(at the beginning of fishery)and minimum biomass reached in 2015;the estimated exploitable biomass for 2019 was 42.2×10^(4) t;and the maximum sustainable yield(MSY)was 15.4×10^(4) *** the western BCS coast,the maximum biomass was reached in 1981(at the beginning of fishery)and minimum biomass was reached in 2017;the estimated exploitable biomass for 2019 was 3.2×10^(4) t;and the MSY was 1.2×10^(4) *** stocks showed a decrease in biomass over the past years and were currently near to point of full *** results suggest that the use of the Catch-MSY method is suitable to obtain annual biomass estimates,in order to establish an ABC,to know the current state of the resource,and to avoid overcoming the potential recovery of the stocks.

关键词： Catch-MSY thread herring exploitable biomass estimate

Computing Paradigms in Emerging Vehicular Environments:A Review

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 491-511页

作者： Lion Silva Naercio Magaia Breno Sousa Anna Kobusińska António casimiro Constandinos X.Mavromoustakis George Mastorakis Victor Hugo C.de Albuquerque Department of Computer Science Faculty of SciencesUniversity of LisbonLisbon 1749-016Portugal Laboratory of Computing Science PoznańUniversity of TechnologyPoznan 60-965Poland Department of Computer Science University of NicosiaNicosia CY-2417Cyprus Department of Management Science and Technology Hellenic Mediterranean UniversityAgios Nikolaos 72100Greece LAPISCO Federal Institute of EducationScience and Technology of CearáFortaleza 60750-740 ARMTEC Tecnologia em Robótica Fortaleza 60150000Brazil

Determining how to structure vehicular network environments can be done in various ***,we highlight vehicle networks’evolution from vehicular ad-hoc networks(VANET)to the internet of vehicles(Io Vs),listing their benefits and *** also highlight the reasons in adopting wireless technologies,in particular,IEEE 802.11 p and 5 G vehicle-toeverything,as well as the use of paradigms able to store and analyze a vast amount of data to produce intelligence and their applications in vehicular *** also correlate the use of each of these paradigms with the desire to meet existing intelligent transportation systems’*** presentation of each paradigm is given from a historical and logical *** particular,vehicular fog computing improves on the deficiences of vehicular cloud computing,so both are not exclusive from the application point of *** also emphasize some security issues that are linked to the characteristics of these paradigms and vehicular networks,showing that they complement each other and share problems and *** these networks still have many opportunities to grow in both concept and application,we finally discuss concepts and technologies that we believe are *** this work,we emphasize the crucial role of these concepts for the well-being of humanity.

关键词： Computing paradigm cloud edge fog internet of vehicle(IoV) vehicular networks

Outcomes of abdominal surgery in patients with liver cirrhosis

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World Journal of Gastroenterology 2016年第9期22卷 2657-2667页

作者： Juan C Lopez-Delgado Josep Ballus Francisco Esteve Nelson L Betancur-Zambrano Vicente Corral-Velez Rafael Manez Antoni J Betbese Joan A Roncal casimiro Javierre Hospital Universitari de Bellvitge Intensive Care Department L'Hospitalet de Llobregat 08907 Barcelona Spain IDIBELL (Institut d'Investigacio Biomedica Bellvitge Biomedical Investigation Institute of Bellvitge) Research Team of Area of Innate Immunity and Pathology of the Critical Patient L'Hospitalet de Llobregat 08908 Barcelona Spain Hospital de la Santa Creu i Sant Pau Intensive Care Department 08041 Barcelona Spain Physiological Sciences II Department Universitat de Barcelona Campus Bellvitge 08907 Barcelona Spain

Patients suffering from liver cirrhosis(LC) frequently require non-hepatic abdominal surgery,even before liver *** is an important risk factor itself for surgery,due to the higher than average associated morbidity and *** high surgical risk occurs because of the pathophysiology of liver disease itself and to the presence of contributing factors,such as coagulopathy,poor nutritional status,adaptive immune dysfunction,cirrhotic cardiomyopathy,and renal and pulmonary dysfunction,which all lead to poor *** evaluation of these factors and the degree of liver disease can help to reduce the development of complications both during and after abdominal *** the emergency setting,with the presence of decompensated LC,alcoholic hepatitis,severe/advanced LC,and significant extrahepatic organ dysfunction conservative management is preferred.A multidisciplinary,individualized,and specialized approach can improve outcomes;preoperative optimization after risk stratification and careful management are mandatory before *** techniques can also improve *** review the impact of LC on surgical outcome in non-hepatic abdominal surgeries required in this cirrhotic population before,during,and after surgery.

关键词： Liver cirrhosis Outcomes Coagulopathy Nutritional status Abdominal surgery Adaptive immune dysfunction Cirrhotic cardiomyopathy

采用新型混合技术保证环境可持续性和提高生产效率 PARETO^(TM)湿部优化技术

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中华纸业 2008年第17期29卷 77-80页

作者： casimiro da Silva Santos 李晓巍纳尔科公司

造纸厂普遍使用清水配制和二次稀释湿部添加剂。以前曾试图用循环水代替清水,但有时效果很差。而且,湿部化学条件不稳定,化学助剂在进料管管壁沉积,导致纸机效率降低。PARETO是一种新的技术方案,采用循环水二次稀释助留剂,可以优化混合... 详细信息

造纸厂普遍使用清水配制和二次稀释湿部添加剂。以前曾试图用循环水代替清水,但有时效果很差。而且,湿部化学条件不稳定,化学助剂在进料管管壁沉积,导致纸机效率降低。PARETO是一种新的技术方案,采用循环水二次稀释助留剂,可以优化混合和进料效果,使造纸厂大幅度节水节能,并对改善环境具有显著的效果。本文介绍了PARETO在提高纸机效率和改善纸张品质方面的作用以及在节水节能方面的主要优点。

关键词： PARETO^TM 湿部优化技术节水节能纳尔科公司