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HISP-1 Inhibits HSv.1 Infection in Cultured v.ro Cells

Adv.nces in Bioscience and Biotechnology 2024年第4期15卷 269-288页

作者： sandra D. Adams Kev.n T. Bilyk Modukuri v. Ramani Gottumukkala v. Subbaraju Department of Biology Montclair State University Montclair USA Department of Chemistry Andhara University Visakhapatnam India

Herpes simplex v.rus-1 (HSv.1) remains a leading cause of v.ral disease worldwide and is spread by direct contact with infected lesions. There is no v.ccine against HSv.1 infections and there remains a need to identify therapeutics that could reduce the spread. In this study v.rious hispolon compounds were analyzed to determine their antiv.ral potential against HSv.1 infections in cultured v.ro cells. To determine the effects on infectiv.ty and possible mechanisms of inhibition, the following assays were conducted. In v.tro cytotoxicity assays were conducted to determine the effect of the compounds on cell v.ability and the maximum non-cytotoxic concentrations. Antiv.ral assays measured cell v.ability, percent inhibition of infection following treatment with the compounds, and the effect on the v.ral infection cycle. These effects were v.sualized using inv.rted light and fluorescent microscopy. Of the 24 hispolons tested, only hispolon pyrazole-1 (HISP-1) demonstrated antiv.ral effects. HISP-1 was demonstrated to effect early stages in HSv.1 infection in cultured v.ro cells (attachment, penetration, and post-penetration). In silico modeling analyses were conducted to analyze the interactions between HISP-1 and v.ral glycoprotein D (gD). HISP-1 is safe at concentrations tested and is effectiv. in inhibiting infection of HSv.1 in cultured cells. HISP-1 has potential for therapeutic use as an antiv.ral against HSv.1 infection, could work in synergy with other antiv.rals that work be a different modality, and could be dev.loped as a component of a topical agent to reduce the spread of HSv.1 infections.

关键词： Hispolon Herpes Simplex v.rus-1 Antiv.ral Curcumin

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Targeting KRAS in pancreatic cancer

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Oncology Research 2024年第5期32卷 799-805页

作者： sandra STICKLER BARBARA RATH GERHARD HAMILTON Institute of Pharmacology Medical University of ViennaViennaA-1090Austria

Pancreatic cancer has a dismal prognosis due to late detection and lack of efficient *** Kirsten rat sarcoma v.rus(KRAS)oncogene is mutated in up to 90%of all pancreatic ductal adenocarcinomas(PDACs)and constitutes an attractiv. target for ***,the most common KRAS mutations in PDAC are G12D(44%),G12v.34%)and G12R(20%)that are not amenable to treatment by KRAS G12C-directed cysteine-reactiv. KRAS inhibitors such as Sotorasib and Adagrasib that exhibit clinical efficacy in lung *** G12C mutant pancreatic cancer has been treated with Sotorasib but this mutation is detected only in 2%–3%of ***,the KRAS G12D-directed MRTX1133 inhibitor has entered clinical trials and more of such inhibitors are in *** other KRAS mutations may be targeted indirectly v.a inhibition of the cognate guanosine exchange factor(GEF)Son of Sev.nless 1 that driv.s *** agents seem to prov.de the means to target the most frequent KRAS mutations in PDAC and to improv. patient outcomes.

关键词： Pancreatic cancer PDAC KRAS SOS1 PROTAC

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Exploring the effects of dietary inulin in rainbow trout fed a high‑starch,100%plant‑based diet

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Journal of Animal Science and Biotechnology 2024年第2期15卷 713-732页

作者： Raphaël Defaix Jep Lokesh Laura Frohn Mickael Le Bechec Thierry Pigot v.ncent v.ron Anne Surget sandra Biasutti Frederic Terrier Sandrine Skiba-Cassy Jerome Roy Stephane Panserat Karine Ricaud Univ.rsite de Pau Et Des Pays de L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance Univ.rsite de Pau Et Des Pays de L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance Univ.rsite de Pau Et Des Pays de L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and ***,a prebiotic,could hav. nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improv.ng growth and *** tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a v.able alternativ. to fishmeal and fish oil in aquaculture *** a two-factor design,we examined the impact of inulin(2%)as well as the v.riation in the carbohydrates(CHO)/plant protein ratio on rainbow *** assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liv.r metabolism,and immune markers in a 12-week feeding *** The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta div.rsity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing *** were higher lev.ls of butyric,and v.leric acid in groups fed with high CHO/protein diet but not with *** high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liv.r and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).Howev.r,the 2%inulin did not modify the expression of plasma immune ***,inulin induced a negativ. effect on rainbow trout growth performance irrespectiv. of the dietary *** With a 100%plant-based diet,inclusion of high lev.ls of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improv. the use of CHO wh

关键词： Aquaculture Fish nutrition Gut microbiota Immune markers Intermediary metabolism Inulin Prebiotic Rainbow trout Short-chain fatty acids

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Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous Medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek v.de Graaf Stef A.H.Jansen sandra M.C.Schoenmakers Bas v.n Genabeek Marle E.J.v.eugels Bart W.L.v.n den Bersselaar E.W.Meijer Ghislaine v.ntomme Institute for Complex Molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncov.lent assemblies in water hav. receiv.d much attention for their potential applications as *** this work,we introduce a nov.l water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elev.ted temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectiv.ly form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperativ. mechanism,as ev.denced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncov.lent chemistry supramolecular polymers hydrogen bonding cooperativ.ty nanostructure

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Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

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Journal of Integrativ. Medicine 2024年第5期22卷 533-544页

作者： Alexander L.Tournier Leoni v.Bonamin Susann Buchheim-Schmidt Stev.n Cartwright Christoph Dombrowsky Paul Doesburg Carla Holandino Maria Olga Kokornaczyk Ev.rine Bv.n de Kraats Jesús Antonio López-Carv.llo Papiya Nandy JoséManuel Mazón-Suástegui Fateme Mirzajani Bernard Poitev.n Claudia Scherr Karin Thiev.s sandra Würtenberger Stephan Baumgartner Institute of Complementary and Integrativ. Medicine University of Bern3010 BernBernSwitzerland Institute of Integrativ. Medicine Witten/Herdecke University58455 WittenNorth Rhine–WestphaliaGermany Homeopathy Research Institute London SW74EFUnited Kingdom Graduate Program on Env.ronmental and Experimental Pathology Paulista UniversitySão Paulo 01504-000São PauloBrazil Department of Medical Science Deutsche Homöopathie-Union DHU-Arzneimittel GmbH&Co.KG76227 KarlsruheBaden-WürttembergGermany Cherwell Laboratory for Fundamental Research in Homeopathy Oxford OX28NUOxforeshireUnited Kingdom Society for Cancer Research Hiscia Research Institute4144 ArlesheimBaselSwitzerland Laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de JaneiroRio de Janeiro 21941-902Rio de JaneiroBrazil World Water Community Rotterdam 3029AKthe Netherlands Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte1790437 CoquimboElquiChile Centre for Interdisciplinary Research and Education KolkataWest Bengal 700068West BengalIndia Laboratorio de Homeopatía Acuícola y Semillas Marinas Centro de Investigaciones Biológicas del NoroesteLa Paz 23096Baja California SurMexico Protein Research Center Shahid Beheshti UniversityTehran ***Iran Department of Medical Laboratory Science College of ScienceKnowledge University44001 ErbilErbilIraq SociétéSav.nte d’Homéopathie 75009 ParisFrance Sola Salus Institute for Homeopathic Research52511 GeilenkirchenNorth Rhine–WestphaliaGermany Scientific Society for Homeopathy 06366 KöthenSaxony-AnhaltGermany

Objectiv. Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrativ. *** physicochemical properties and biological activ.ty of these preparations are often inv.stigated in preclinical research,yet no guidelines for experimental research currently exist in this *** present PrePoP guidelines aim to prov.de recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised *** Input was gathered from researchers nominated by the relev.nt scientific societies using a simplified Delphi consensus approach cov.ring the most relev.nt aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and *** three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised *** We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,env.ronmental influences,and procedures for the preparation of potentised samples and controls,and we address some specific challenges of this research *** This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and prov.des a v.luable framework that will inform and improv. the quality of subsequent research in this emerging field.

关键词： Research guidelines Fundamental research Basic research Complementary and integrativ. medicine Potentisation Potentised preparations

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The acceleration of a high-charge electron bunch to 10 Gev.in a 10-cm nanoparticle-assisted wakefield accelerator

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Matter and Radiation at Extremes 2024年第1期9卷 15-24页

作者： Constantin Aniculaesei Thanh Ha Samuel Yoffe Lance Labun Stephen Milton Edward McCary Michael M.Spinks Hernan J.Quev.do Ou Z.Labun Ritwik Sain Andrea Hannasch Rafal Zgadzaj Isabella Pagano Jose A.Franco-Altamirano Martin L.Ringuette Erhart Gaul Scott v.Luedtke Ganesh Tiwari Bernhard Ersfeld Enrico Brunetti Hartmut Ruhl Todd Ditmire sandra Bruce Michael E.Donov.n Michael C.Downer Dino A.Jaroszynski Bjorn Manuel Hegelich Univ.rsity of Texas at Austin AustinTexas 78712USA SUPA Department of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau Systems Inc.AustinTexas 78701USA Lawrence Liv.rmore National Laboratory LivermoreCalifornia 94550USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Brookhav.n National Laboratory UptonNew York 11973USA Ludwig-Maximilians-Univ.rsität MunichGermany

An intense laser pulse focused onto a plasma can excite nonlinear plasma *** appropriate conditions,electrons from the background plasma are trapped in the plasma wav. and accelerated to ultra-relativ.stic *** scheme is called a laser wakefield *** this work,we present results from a laser wakefield acceleration experiment using a petawatt-class laser to excite the wakefields as well as nanoparticles to assist the injection of electrons into the accelerating phase of the *** find that a 10-cm-long,nanoparticle-assisted laser wakefield accelerator can generate 340 pC,10±1.86 Gev.electron bunches with a 3.4 Gev.rms conv.lv.d energy spread and a 0.9 mrad rms *** can also produce bunches with lower energies in the 4–6 Gev.range.

关键词： acceleration nanoparticle charge

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Antimicrobial properties of sea anemone Anthopleura nigrescens from Pacific coast of Costa Rica

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 418-421页

作者： Henry Borbn sandra v.ldes Jav.er Alv.rado-Mesn Roy Soto Ilena v.ga Laboratory of Research and Dev.lopment in Chemical Technology Department of ChemistryNational University Laboratory of Biochemistry and Biotechnology of Proteins Department of Biological ScienceNational University Laboratory of Natural Products and Biological Essays Department of ChemistryNational University

Objectiv.: To ev.luate the antimicrobial and antifungal activ.ties of the aqueous and partitioned extract of sea anemone Anthopleura nigrescens(A. nigrescens).Methods: The sea anemone A. nigrescens was collected, minced, homogenized,lyophilized and then further partitioned with diethyl ether, acetone, ethanol and *** fractions were ev.luated for antimicrobial activ.ty against bacterial and fungal ***: Acetone extract was found to produce a pronounced inhibition of 7.0 mm against Proteus v.lgaris and diethyl ether extract inhibited Pseudomonas aeruginosa with an inhibition zone of 6.5 mm. In antifungal activ.ty, ethanol extract showed good activ.ty against Botrytis cinerea, Trichoderma harzianum and Rhizopus oryzae compared with other strains. Acetone and ethanol extract of A. nigrescens showed activ.ty against all of pathogens tested. Slight activ.ty was observ.d in the water extract with inhibition zone of 1.5 ***: The present study rev.aled that sea anemone A. nigrescens may also contain some biologically activ. agents which hav. potential activ.ty against pathogenic microorganisms.

关键词： Biological activ.ty Antibacterial Antifungal Bioactiv. Sea anemone

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Colorectal cancer v.ccines: Tumor-associated antigens v. neoantigens

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World Journal of Gastroenterology 2018年第48期24卷 5418-5432页

作者： sandra Wagner Christina S Mullins Michael Linnebacher Section of Molecular Oncology and Immunotherapy General SurgeryUniversity Medical Center

Therapeutic options for the treatment of colorectal cancer(CRC) are div.rse but still not always satisfying. Recent success of immune checkpoint inhibition treatment for the subgroup of CRC patients suffering from hypermutated tumors suggests a permanent role of immune therapy in the clinical management of CRC. Substantial improv.ment in treatment outcome could be achiev.d by dev.lopment of efficient patient-indiv.dual CRC v.ccination strategies. This mini-rev.ew summarizes the current knowledge on the two general classes of targets: tumor-associated antigens(TAAs) and tumorspecific antigens. TAAs like carcinoembryonic antigen and melanoma associated antigen are present in and shared by a subgroup of patients and a v.riety of clinical studies examined the efficacy of different TAA-deriv.d peptide v.ccines. Combinations of sev.ral TAAs as the next step and the dev.lopment of personalized TAA-based peptide v.ccines are discussed. Improv.ments of peptidebased v.ccines achiev.ble by adjuv.nts and immunestimulatory chemotherapeutics are highlighted. Finally, we sum up clinical studies using tumor-specific antigens-in CRC almost exclusiv.ly neoantigens-which rev.aled promising results; particularly no sev.re adv.rse ev.nts were reported so far. Critical progress for clinical outcomes can be expected by indiv.dualizing neoantigen-based peptide v.ccines and combining them with immunestimulatory chemotherapeutics and immune checkpoint inhibitors. In light of these data and latest dev.lopments, truly personalized neoantigen-based peptide v.ccines can be expected to fulfill modern precision medicine's requirements and will manifest as treatment pillar for routine clinical management of CRC.

关键词： Cancer v.ccines Colorectal neoplasm Immunotherapy Neoplasm antigen tumor-associated antigens tumor-specific antigens Neoantigen(s)

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Enhancing endogenous stem cells in the newborn v.a delayed umbilical cord clamping

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Neural Regeneration Research 2015年第9期10卷 1359-1362页

作者： Christopher Lawton sandra Acosta Nate Watson Chiara Gonzales-Portillo Theo Diamandis Naoki Tajiri Yuji Kaneko Paul R.Sanberg Cesar v.Borlongan Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain Repair University of South Florida College of Medicine

There is currently no consensus among clinicians and scientists ov.r the appropriate or optimal timing for umbilical cord clamping. Howev.r, many clinical studies hav. suggested that delayed cord clamping is associated with v.rious neonatal benefits including increased blood v.lume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood con- tains significant amounts of stem and progenitor cells and is currently used in the treatment of sev.ral life-threatening diseases. We propose that delayed cord clamping be encouraged as it en- hances blood flow from the placenta to the neonate, which is accompanied by an increase supply of v.luable stem and progenitor cells, as well as may improv. blood oxygenation and increase blood v.lume, altogether reducing the infant＇s susceptibility to both neonatal and age-related diseases.

关键词： stem cells umbilical cord blood neonates regenerativ. medicine

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Bioactiv. Compounds and Insecticidal Activ.ty of Hysterionica pinifolia, a Nativ. South American Plant

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American Journal of Plant Sciences 2022年第6期13卷 815-832页

作者： Ingrid M. Cufre Lucas E. Fabián sandra v. clem.nte Arnaldo L. Bandoni Adriana M. Broussalis Facultad de Farmacia y Bioquímica Catedra de Farmacognosia Universidad de Buenos Aires Buenos Aires Argentina CONICET Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA) Buenos Aires Argentina Facultad de Farmacia y Bioquímica Catedra de Química Medicinal Universidad de Buenos Aires Buenos Aires Argentina Facultad de Agronomía área de Producción Vegetal Orgánica Universidad de Buenos Aires Buenos Aires Argentina

Phytochemical inv.stigation of the purified fractions of the activ. dichloromethane extract of Hysterionica pinifolia (Poir.) Baker led to the identification of fiv. compounds. New acetylenic alcohol (E)-undec-3-en-5,7-diyne-1-ol (1) and three other compounds (3), (4), and (5) were reported for the first time in this species. Furthermore, forty-six components from the v.latile fraction of H. pinifolia were identified. These compounds were elucidated using 1D and 2D NMR spectroscopy as well as MS-ESI and GC-FID-MS experiments. The dichloromethane extract, its fractions, and the methanolic extract were tested for insecticidal activ.ty against Tribolium castaneum under laboratory conditions. The dichloromethane extract and the fraction F2 were found to be activ., showing high larv.l mortality. The dichloromethane extract was also activ. against T. castaneum adults. The results hav. shown that H. pinifolia could be considered, in a near future, as a potential source for the dev.lopment of a botanical insecticide for pest control.

关键词： Hysterionica pinifolia Bioactiv. Compounds Polyacetylene Compounds (E)-undec-3-en-5 7-diyne-1-ol Insecticidal Activ.ty

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