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Multi-organ IgG4-related disease continues to mislead clinicians: A case report and literature review

World Journal of Clinical Cases 2020年第15期8卷 3267-3279页

作者： sandra Strainiene Lukas Sarlauskas Ilona Savlan Valentina Liakina Ieva Stundiene Jonas Valantinas Clinic of Gastroenterology Nephrourology and SurgeryCentre of HepatologyGastroenterology and DieteticsInstitute of Clinical MedicineVilnius UniversityVilnius 01513Lithuania Clinic of Internal Diseases Family Medicine and OncologyCentre of Internal DiseasesInstitute of Clinical MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a multisystemic mass forming immune-mediated disease that affects almost every organ and is a diagnostic challenge for every *** is a lack of adequate epidemiological data worldwide,and evidence-based treatment recommendations are not yet *** report the first case of IgG4-RD from Lithuania and the Baltic Sea region presented with thyroiditis,orbital myositis,orbitopathy,uveitis,scleritis,sialadenitis,autoimmune pancreatitis and *** SUMMARY A 54-year-old Caucasian male was admitted to our tertiary Centre complaining of severe weight loss,diarrhoea,abdominal pain,salivary gland swelling,sicca symptoms and *** examination,bilateral palpable masses in the projection of major salivary glands,severe protrusion of the left eyeball and cachexia were *** patient was previously diagnosed with autoimmune thyroiditis and endocrine *** magnetic resonance imaging(MRI)of the head revealed enlarged extraocular muscles indicating orbital *** biopsy from the salivary gland mass indicated *** MRI showed signs of autoimmune pancreatitis,and a serological test revealed the elevated serum IgG4 *** patient was then diagnosed with IgG4-RD and successfully treated with *** was a significant clinical,serological and radiological improvement after one month of treatment and no signs of relapse within twenty ***,it took almost 18 years and the efforts of eight different medical specialists to establish the correct *** A comprehensive approach to the patient is essential to improving the recognition of rare immune system conditions,such as IgG4-RD.

关键词： IgG4-related disease Autoimmune pancreatitis Sialadenitis Orbitopathy Autoimmune thyroiditis Case report Literature review

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The relationship between transport-to-school habits and physical activity in a sample of New Zealand adolescents

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Journal of Sport and Health Science 2019年第5期8卷 463-470页

作者： Chiew Ching Kek Enrique García Bengoechea John C.Spence sandra Mandic Active Living Laboratory School of Physical EducationSport and Exercise SciencesUniversity of OtagoDunedin 9054New Zealand Department of Physical Education and Sport Sciences Faculty of Education and Health SciencesUniversity of LimerickLimerickV94 T9PXIreland Institute for Health and Sport(IHES) Victoria UniversityMelbourneVIC 8001Australia Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada Centre for Sustainability University of OtagoDunedin 9054New Zealand

Objectives:Adolescents using active transport(AT)to school have higher levels of physical activity(PA)compared with motorized transport(MT)*** study compared school day and weekend day PA in adolescents using AT,MT,or combined AT and MT(AT + MT)to travel to ***:Adolescents(n= 314;age:14.7±1.4 years;32.8% boys)from Dunedin(New Zealand)wore an accelerometer for 7 days and completed a self-reported survey regarding mode of transport to school(73 AT,56 AT + MT,and 185 MT).Data were analyzed using t tests,analysis of variance,and χ2 ***:Although the proportion of adolescents meeting PA guidelines significantly differed among transport groups(AT,47.9%;AT + MT,46.4%;MT,33.5%;p=0.048;overall,39.2%),the observed differences were due mainly to *** with MT,AT and AT+MT engaged in more moderate-to-vigorous PA(MVPA)per day(AT:61.2 ± 23.2 min;AT+MT:59.6 ± 21.7 min;MT:52.5 ± 19.6 min;p = 0.004;p<0.001,adjusted for gender),per school day and before *** after school(15:00-16:00),AT engaged in significantly more MVPA compared with AT + MT and *** differences in MVPA between the groups were observed in the late afternoon/early evening period during school days or on weekend ***:Compared with MT users,adolescent girls using AT or AT + MT accumulated more MVPA during school commute *** + MT to school is also a plausible way to increase adolescent girls’ PA when AT only is not feasible.

关键词： Accelerometer Adolescent Physical activity Schools Transportation Walking

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Binge eating and psychostimulant addiction

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World Journal of Psychiatry 2021年第9期11卷 517-529页

作者： M Carmen Blanco-Gandia sandra Montagud-Romero Marta Rodriguez-Arias Department of Psychology and Sociology University of ZaragozaTeruel 44003Spain Department of Psychobiology Facultad de PsicologiaUniversitat de ValenciaValencia 46010Spain

Many of the various factors,characteristics,and variables involved in the addictive process can determine an individual’s vulnerability to develop drug *** eating,based on pleasure rather than energy needs,modulates the same reward circuits,as do drugs of *** to the last report of the World Health Organization,the worldwide obesity rate has more than doubled since 1980,reaching especially critical levels in children and young people,who are overexposed to high-fat,high-sugar,energy-dense *** the past few decades,there has been an increase in the number of studies focused on how eating disorders can lead to the development of drug addiction and on the comorbidity that exists between the two ***,we review the most recent research on the subject,focusing especially on animal models of binge eating disorders and drug *** complex profile of patients with substance use and binge eating disorders requires an integrated response to dually diagnosed *** patterns should be considered an important variable in the treatment of substance use disorders,and future studies need to focus on specific treatments and interventions in individuals who show a special vulnerability to shift from one addiction to the other.

关键词： Binge eating Psychostimulant Dopamine Obesity Reward Addiction

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Vascularization mediated by mesenchymalstem cells from bone marrow and adiposetissue: a comparison

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Cell Regeneration 2015年第1期4卷 106-115页

作者： Karoline Pill sandra Hofmann Heinz Redl Wolfgang Holnthoner Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Donaueschingenstrasse 131200ViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Department of Biomedical Engineering Eindhoven University of Technology5600 MB EindhovenThe Netherlands Institute for Complex Molecular Systems Eindhoven University of TechnologyPO Box 5135600 MB EindhovenThe Netherlands Institute for Biomechanics Swiss Federal Institute of Technology ZürichVladimir-Prelog-Weg 38093 ZürichSwitzerland

Tissue-engineered constructs are promising to overcome shortage of organ donors and to reconstruct at least partsof injured or diseased tissues or organs. However, oxygen and nutrient supply are limiting factors in many tissues,especially after implantation into the host. Therefore, the development of a vascular system prior to implantationappears crucial. To develop a functional vascular system, different cell types that interact with each other need tobe co-cultured to simulate a physiological environment in vitro. This review provides an overview and a comparison ofthe current knowledge of co-cultures of human endothelial cells (ECs) with human adipose tissue-derived stem/stromal cells (ASCs) or bone marrow-mesenchymal stem cells (BMSCs) in three dimensional (3D) hydrogel *** stem cells (MSCs), BMSCs or ASCs, have been shown to enhance vascular tube formation of ECs and toprovide a stabilizing function in addition to growth factor delivery and permeability control for ECs. Althoughphenotypically similar, MSCs from different tissues promote tubulogenesis through distinct mechanisms. In this report,we describe differences and similarities regarding molecular interactions in order to investigate which of these two celltypes displays more favorable characteristics to be used in clinical applications. Our comparative study shows that ASCsas well as BMSCs are both promising cell types to induce vascularization with ECs in vitro and consequently arepromising candidates to support in vivo vascularization.

关键词： Vascularization Endothelial cells Mesenchymal stem cells Co-culture Molecular mechanisms

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Multidisciplinary diagnostic dilemma in differentiating Madelung’s disease—the value of superb microvascular imaging technique:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6145-6154页

作者： Goda Seskute Austeja Dapkute Dominyka Kausaite sandra Strainiene Andrius Talijunas Irena Butrimiene Clinic of Rheumatology Orthopaedics Traumatologyand Reconstructive SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Clinic of Neurology and Neurosurgery Institute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Institute of Dentistry Faculty of MedicineVilnius UniversityVilnius 01512Lithuania

BACKGROUND Madelung’s disease,also known as multiple symmetrical lipomatosis,is a rare,underrecognized disorder of fat metabolism that results in unusual accumulation of subcutaneous fat deposits around the neck,shoulders,upper arms,trunk,hips,and upper *** case demonstrates the importance of differential diagnosis and the value of a superb microvascular imaging technique for suspecting and confirming Madelung’s *** diagnosis and alcohol abstinence could prevent the progression of growing fatty masses and prevent *** SUMMARY A 62-year-old male was admitted to the Rheumatology center complaining of symmetric subcutaneous tumors in the area of the parotid and submandibular salivary glands,small soft masses in the occiput and upper third of the forearm,rashes on calves.A high titer of rheumatoid factor and low concentrations of serum complements were *** high-end ultrasound and magnetic resonance imaging examinations of all affected areas of the soft tissues showed predominantly adipose tissue(lipomas)without suspicion of *** biopsy from the small salivary gland revealed no *** evaluating the patient’s clinical presentation(symmetrical lipomatosis,cirrhosis,gynecomastia,anemia,hyperuricemia),Madelung’s disease,type I,along with the psoriatic rash and psoriatic arthritis and secondary liver cirrhosis were *** Madelung’s disease consists of many co-occurring disorders imitating and overlapping with other *** is the first choice for suspecting and confirming symmetrical lipomatosis.

关键词： Madelung’s disease Multiple symmetrical lipomatosis Cirrhosis Salivary gland tumors Superb microvascular imaging Case report

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Treatment of colorectal cancer in the elderly

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World Journal of Gastrointestinal Oncology 2015年第10期7卷 204-220页

作者： Monica Millan sandra Merino Aleidis Caro Francesc Feliu Jordi Escuder Tani Francesch Colorectal Surgery Unit Department of Surgery Joan XXIII University Hospital Department of Medical Oncology Joan XXIII University Hospital and St. Joan de Reus University Hospital Department of Geriatrics and Palliative Care Joan XXIII University Hospital (GiPSS)

Colorectal cancer has a high incidence, and approxi-mately 60% of colorectal cancer patients are older than 70, with this incidence likely increasing in the near future. Elderly patients(> 70-75 years of age) are a very heterogeneous group, ranging from the very fit to the very frail. Traditionally, these patients have often been under-treated and recruited less frequently to clinical trials than younger patients, and thus are underrepresented in publications about cancer treatment. Recent studies suggest that fit elderly patients can be treated in the same way as their younger counterparts, but the treatment of frail patients with comorbidities is still a matter of controversy. Many factors should be taken into account, including fitness for treatment, the wishes of the patient and family, and quality of life. This review will focus on the existing evidence for surgical, oncologic, and palliative treatment in patients over 70 years old with colorectal cancer. Careful patient assessment is necessary in order to individualize treatment approach, and this should rely on a multidisciplinary process. More well-designed controlled trials are needed in this patient population.

关键词： Colorectal cancer Surgery Chemotherapy Radiotherap

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A comparative study of the morphometry of sperm head components in cattle, sheep, and pigs with a computer-assisted fluorescence method

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Asian Journal of Andrology 2016年第6期18卷 840-843页

作者： Jesus L Yaniz Sara Capistros sandra Vicente-Fiel Carlos O Hidalgo Pilar Santolaria TECNOGAM research group Environmental Sciences Institute (IUCA) Department of Animal Production and Food Sciences University of Zaragoza Huesca Spain Animal Genetics and Reproduction Area Regional Agrifood Research and Development Service (SERIDA) 33394 Deva Gijan Spain

The aim of this study was to compare the sperm nuclear and acrosomal morphometry of three species of domestic artiodactyls; cattle （Bos taurus）, sheep （Ovis aries）, and pigs （Sus scrofa）. Semen smears of twenty ejaculates from each species were fixed and labeled with a propidium iodide-Pisum sativum agglutinin （PI/PSA） combination. Digital images of the sperm nucleus, acrosome, and whole sperm head were captured and analyzed. The use of the PI/PSA combination and CASA-Morph fluorescence-based method allowed the capture, morphometric analysis, and differentiation of most sperm nuclei, acrosomes and whole heads, and the assessment of acrosomal integrity with a high precision in the three species studied. For the size of the head and nuclear area, the relationship between the three species may be summarized as bull 〉 ram 〉 boar. However, for the other morphometric parameters （length, width, and perimeter）, there were differences in the relationships between species for sperm nuclei and whole sperm heads. Bull sperm acrosomes were clearly smaller than those in the other species studied and covered a smaller proportion of the sperm head. The acrosomal morphology, small in the bull, large and broad in the sheep, and large, long, and with a pronounced equatorial segment curve in the boar, was species-characteristic. It was concluded that there are clear variations in the size and shape of the sperm head components between the three species studied, the acrosome being the structure showing the most variability, allowing a clear distinction of the spermatozoa of each species.

关键词： artiodactyls computer-assisted sperm morphometry analysis fluorescence microscopy image analysis sperm morphometry

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Nivolumab-induced tumour-like gastritis:A case report

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World Journal of Clinical Cases 2023年第18期11卷 4350-4359页

作者： Elena Cijauskaite Edita Kazenaite sandra Strainiene Goda Sadauskaite Benediktas Kurlinkus Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Vilnius University Hospital Santaros Clinics Center of HepatologyGastroenterology and DietologyVilnius 08661Lithuania Department of Internal Medicine and Surgery Antakalnis ClinicVilnius 10207Lithuania

BACKGROUND Immune checkpoint inhibitors are one of the modern treatment methods for advanced ***,this group of medications is also associated with various immune-related adverse events,such as colitis or *** checkpoint inhibitor-induced gastritis is a less common adverse *** SUMMARY We describe a 64-year-old woman presenting with diarrhea,nausea,and discomfort in the upper abdominal *** patient had a history of metastatic lung cancer,which was treated with *** the first endoscopy,an infiltrating gastric tumour was ***,based on endoscopic,histological and radiological findings,nivolumab-induced gastritis was *** patient was successfully treated with three courses of *** As a consequence of the increased use of immune checkpoint inhibitors,a growing number of reported immune-related adverse events could be *** diagnosis of immune checkpoint inhibitor-induced gastritis should be considered when assessing a patient treated with nivolumab with upper gastrointestinal distress.

关键词： Nivolumab Immune checkpoint inhibitors Tumour-like gastritis Proton pump inhibitors Case report

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Changes of protein expression during tumorosphere formation of small cell lung cancer circulating tumor cells

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Oncology Research 2023年第1期31卷 13-22页

作者： sandra STICKLER BARBARA RATH MAXIMILIAN HOCHMAIR CLEMENS LANG LUKAS WEIGL GERHARD HAMILTON Institute of Pharmacology Medical University of ViennaViennaAustria Karl Landsteiner Institute of Lung Research and Pulmonary Oncology Klinik FloridsdorfViennaAustria Department of Trauma Surgery Sozialmedizinisches Zentrum OstDonauspitalViennaAustria Division of Special Anesthesia and Pain Medicine Medical University of ViennaViennaAustria

Small cell lung cancer(SCLC)is frequently disseminated and has a dismal prognosis with survival times of approximately two *** cancer responds well to initial chemotherapy but recurs within a short time as a globally chemoresistant *** tumor cells(CTCs)are held responsible for metastasis,the extremely high numbers of these cells in advanced SCLC allowed us to establish several permanent CTC cell *** CTCs are distinguished by the spontaneous formation of large spheroids,termed tumorospheres,in regular tissue *** contain quiescent and hypoxic cells in their interior and are associated with high chemoresistance compared to single cell *** CTC lines were compared for their expression of 84 proteins associated with cancer either as single cells or in the form of tumorospheres in Western blot *** the exception of the UHGc5 line,all other CTC lines express EpCAM and lack a complete EpCAM-negative,vimentin-positive epithelial-mesenchymal transition(EMT)*** formation of tumorospheres the expression of EpCAM,that mediates cell-cell adhesion is markedly *** such as E-Cadherin,p27 KIP1,Progranulin,BXclx,Galectin-3,and Survivin showed variable changes for the distinct CTC cell *** conclusion,EpCAM presents the most critical marker for individual SCLC CTCs and the assembly of highly chemoresistant tumorospheres.

关键词： SCLC Spheroid Chemoresistance EpCAM Topotecan Epirubicin

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Transient elastography(Fibro Scan~?) with controlled attenuation parameter in the assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease- Where do we stand?

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World Journal of Gastroenterology 2016年第32期22卷 7236-7251页

作者： Ivana Mikolasevic Lidija Orlic Neven Franjic Goran Hauser Davor Stimac sandra Milic Department of Gastroenterology UHC Rijeka Department of Nephrology Dialysis and Kidney Transplantation UHC Rijeka

Non-alcoholic fatty liver disease(NAFLD) is the most common cause of chronic liver disease worldwide. Currently, the routinely used modalities are unable to adequately determine the levels of steatosis and fibrosis(laboratory tests and ultrasonography) or cannot be applied as a screening procedure(liver biopsy). Among the non-invasive tests, transient elastography(Fibro Scan?, TE) with controlled attenuation parameter(CAP) has demonstrated good accuracy in quantifying the levels of liver steatosis and fibrosis in patients with NAFLD, the factors associated with the diagnosis and NAFLD progression. The method is fast, reliable and reproducible, with good intra- and interobserver levels of agreement, thus allowing for population-wide screening and disease follow-up. The initial inability of the procedure to accurately determine fibrosis and steatosis in obese patients has been addressed with the development of the obese-specific XL probe. TE with CAP is a viable alternative to ultrasonography, both as an initial assessment and during follow-up of patients with NAFLD. Its ability to exclude patients with advanced fibrosis may be used to identify low-risk NAFLD patients in whom liver biopsy is not needed, therefore reducing the risk of complications and the financial costs.

关键词： Non-alcoholic fatty liver disease Transient elastography Controlled attenuation parameter

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