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Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone:A pilot study

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Bioactive Materials 2023年第8期26卷 14-23页

作者： Jonathan Espiritu sandra Sefa Hanna Cwieka Imke Greving Silja Flenner Regine Willumeit-Römer Jan-Marten Seitz Berit Zeller-Plumhoff Syntellix AG HannoverGermany Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGeesthachtGermany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthachtGermany

An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market.A hierarchical analysis of bone remodelling after material implantation is necessary to better understand the relationship between implant and ***,which are housed and communicate through the lacuno-canalicular network(LCN),are integral to bone health and remodelling ***,it is essential to examine the framework of the LCN in response to implant materials or surface *** materials offer an alternative solution to permanent implants,which may require revision or removal *** alloys have resurfaced as promising materials due to their bone-like properties and safe degradation in *** further tailor their degradation capabilities,surface treatments such as plasma electrolytic oxidation(PEO)have demonstrated to slow *** the first time,the influence of a biodegradable material on the LCN is investigated by means of non-destructive 3D *** this pilot study,we hypothesize noticeable variations in the LCN caused by altered chemical stimuli introduced by the *** synchrotron-based transmission X-ray microscopy,we have characterised morphological LCN differences around uncoated and PEO-coated WE43 screws implanted into sheep *** specimens were explanted after 4,8,and 12 weeks and regions near the implant surface were prepared for *** from this investigation indicate that the slower degradation of PEO-coated WE43 induces healthier lacunar shapes within the ***,the stimuli perceived by the uncoated material with higher degradation rates induces a greater connected LCN better prepared for bone disturbance.

关键词： Nanotomography Lacuno-canalicular network Bone Magnesium Biodegradable implants

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

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Particuology 2019年第6期17卷 10-21页

作者： Ahmad Baroutaji sandra Lenihan Keith Bryan School of Engineering Faculty of Science and EngineeringUniversity of WolverhamptonTelfordUK School of Mechanical Electrical and Process EngineeringCork Institute of TechnologyCorkIreland

Capping failure,edge chipping,and non-uniform mechanical properties of convex-faced pharmaceutical tablets are common problems in the pharma *** this paper,the finite element method(FEM)and design of experiment techniques are used to determine the optimal shape of convex-faced(CF)pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping *** effects of different geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and *** FEM model of the tabletting process was generated using the implicit code ABAQUS and validated against experimental *** surface methodology was used to establish the relationship between the design variables,represented by the geometrical parameters and friction coefficient,and compaction responses of interest including residual die pressure,relative density variation within a tablet,and relative shear stress at the edge of a tablet.A statistical-based optimisation approach was then used to optimise the shape of CF *** obtained results demonstrated how the geometrical parameters and friction coefficient of CF pharmaceutical tablets strongly affect their compaction behaviour and quality.

关键词： Capping failure Edge chipping Tabletting FEM Optimisation Residual radial pressure

Neuroretinal dysfunction in patients affected by neurofibromatosis type 1

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 773-779页

作者： Antonietta Moramarco Luca Lucchino Fabiana Mallone Michela Marcelli Ludovico Alisi Vincenzo Roberti sandra Giustini Alessandro Lambiase Marcella Nebbioso Department of Sense Organs Sapienza University of RomePoliclinico Umberto IRome 00161Italy Department of Dermatology and Venereology Sapienza University of RomePoliclinico Umberto IRome 00161Italy

AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 patients(35 eyes)with NF1 and 30 healthy subjects(30 eyes)for the control *** subject underwent a complete ophthalmological examination including spectral domainoptical coherence tomography(SD-OCT)and mf *** 1.5-Tesla magnetic resonance imaging(MRI)scan of the brain was performed in NF1 patients to assess the presence of *** participants were recruited having a best corrected visual acuity(BCVA)of no less than 20/20 in each *** amplitude and implicit time of the P1 wave(first-order Kernel component)were evaluated on mf *** analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual ***:Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls,while the reduction was not significant in the 2 central degrees between the groups.A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group,with lower amplitudes detected in the nasal *** differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and ***:Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mf *** intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate(c AMP)generation,can be *** possible use of mf ERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.

关键词： neurofibromatosis type 1 multifocal electroretinography neuroretinal function optic pathway gliomas neurofibromin

The RXTE/PCA 35-Day X-Ray Lightcurve of Hercules X-1

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International Journal of Astronomy and Astrophysics 2023年第3期13卷 172-194页

作者： Denis Leahy sandra Gonzalez Enriquez Department of Physics and Astronomy University of Calgary Calgary Canada Division de Ciencias e Ingenierias Universidad de Guanajuato Guanajuato Mexico

The archival Rossi X-ray Timing Explorer (RXTE) Proportional Counter Array (PCA) observations of HZ Her/Her X-1 are analyzed here. The time periods for Anomalous Low States are refined. The 35-day X-ray lightcurve of Her X-1 is produced using 35-day phases determined with RXTE All-Sky Monitor (ASM) and Swift Burst Alert Telescope (BAT) data, with adjustments based on the RXTE/PCA data. As a result, we constructed the best-phased 35-day lightcurve of Her X-1 with the highest sensitivity. The RXTE/PCA data are separated into 8 different substates of the 35-day cycle: Main High (MH) turn-on, MH, MH decline, Low State (LS) 1, Short High (SH) turn-on, SH, SH decline, and LS2. Orbital lightcurves are created for each substate, and they are compared. Eclipse data are extracted for each substate to determine the changes in eclipse shape with 35-day phase. A scattering corona model is fit to the eclipses for the different 35-day substates: this shows that the corona is present with similar intensity at all 35-day phases. We search for previously reported dips without absorption but find none.

关键词： X-Ray Binaries Light-Curves Accretion Disks

Fruit availability, frugivore satiation and seed removal in 2 primate-dispersed tree species

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Integrative Zoology 2011年第3期6卷 178-194页

作者： sandra RATIARISON Pierre-Michel FORGET Department of Ecology and Management of Biodiversity Museum of Natural History Museum(MNHN)BrunoyFrance and oological Society of London LibrevilleGabon

During a mast-fruiting event we investigated spatial variability in fruit availability,consumption,and seed removal at two sympatric tree species,Manilkara bidentata and ***(Sapotaceae)at Nouragues Natural Reserve,French *** addressed the question of how Manilkara density and fruits at the community level might be major causes of variability in feeding assemblages between tree *** thus explored how the frugivore assemblages differed between forest patches with contrasting relative Manilkara density and fruiting *** the daytime,Alouatta seniculus was more often observed in *** crowns at Petit Plateau(PP)with the greatest density of Manilkara *** the lowest fruit diversity and availability,whereas Cebus apella and Saguinus midas were more often observed in *** crowns at both Grand Plateau(GP),with a lowest density of *** and overall greater fruit supply,and ***,nearly 53%and 15%of the *** seed crop at GP and PP,respectively,and about 47%of the *** seed crop were removed,otherwise either spit out or defecated beneath trees,or dropped in ***-bodied primates concentrated fallen seeds beneath parent trees while large-bodied primate species removed and dispersed more seeds away from ***,among the latter,satiated *** wasted seeds under conspecific trees at *** in feeding assemblages,seed removal rates and fates possibly reflected interactions with extra-generic fruit species at the community level,according to feeding choice,habitat preferences and ranging patterns of primate species.

关键词： frugivores masting primates satiation seed dispersal

Crohn’s disease in human immunodeficiency virus-infected patient:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4202-4209页

作者： Ausra Vinikaite Benediktas Kurlinkus Dominyka Jasinskaite sandra Strainiene Audrone Buineviciute Goda Sadauskaite Vytautas Kiudelis Edita Kazenaite Lithuanian University of Health Sciences Faculty of MedicineKaunas 44307Lithuania Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Center of Hepatology Gastroenterology and DietologyVilnius University Hospital Santaros ClinicsVilnius 08661Lithuania Department of Internal Medicine and Surgery Antakalnis ClinicVilnius 10207Lithuania Department of Gastroenterology Lithuanian University of Health SciencesKaunas 44307Lithuania

BACKGROUND Inflammatory bowel disease(IBD)is an autoimmune condition treated with immunosuppressive ***,the need for immune system suppression becomes questionable when infection with the human immunodeficiency virus(HIV)occurs simultaneously and impacts the course of *** reported case represents the clinical course,prescribed treatment and its effect,as well as clinical challenges faced by physicians in a combination of such *** also present a comprehensive literature review of similar *** SUMMARY A 49-year-old woman suffering from a newly diagnosed Crohn’s disease was hospitalized due to exacerbated symptoms(abdominal pain,fever,and weight loss).During her hospital stay,she tested positive for *** conservative treatment,the patient improved and was *** the outpatient clinic,her HIV infection was confirmed as stage C3,and antiretroviral treatment was initiated *** notwithstanding,soon the patient was rehospitalized with pulmonary embolism and developed a series of complications because of the subsequent coexistence of IBD and *** intensive and meticulous treatment,the patient’s condition has improved and she remains in *** The paucity of studies and data on the coexistence of HIV and IBD leaves clinicians doubting the optimal treatment options.

关键词： Crohn’s disease Inflammatory bowel disease Human immunodeficiency virus Immunocompromised patient Case report

Prevalence of posttraumatic stress disorder following acute coronary syndrome and clinical characteristics of patients referred to cardiac rehabilitation

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World Journal of Psychiatry 2023年第6期13卷 376-385页

作者： Ivana Sopek Merkaš Nenad Lakušić Zdenko Sonicki Barbara Koret sandra Vuk Pisk Igor Filipčić Department of Cardiology Special Hospital for Medical Rehabilitation Krapinske TopliceKrapinske Toplice 49217Croatia Department of Clinical Medicine Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Internal Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Medical Statistics Epidemiologyand Medical InformaticsSchool of Public Health Andrija StamparSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Psychiatry Clinic for Psychiatry“Sveti Ivan”Zagreb 10000Croatia Department of Psychiatry and Neurology Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Psychiatry and Psychological Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND Studies have demonstrated that patients who have experienced acute coronary syndrome(ACS)have an increased risk of developing posttraumatic stress disorder(PTSD)and experiencing worse survival outcomes than those who do not develop ***,the prevalence rates of PTSD following ACS vary widely across studies,and it is noteworthy that in most cases,the diagnosis of PTSD was based on self-report symptom questionnaires,rather than being established by ***,the individual characteristics of patients who develop PTSD after ACS can differ widely,making it difficult to identify any consistent patterns or predictors of the *** To investigate the prevalence of PTSD among a large sample of patients undergoing cardiac rehabilitation(CR)after ACS,as well as their characteristics in comparison to a control *** The participants of this study are patients who have experienced ACS with or without undergoing percutaneous coronary intervention and are enrolled in a 3-wk CR program at the largest CR center in Croatia,the Special Hospital for Medical Rehabilitation Krapinske *** recruitment for the study took place over the course of one year,from January 1,2022,to December 31,2022,with a total of 504 *** expected average follow-up period for patients included in the study is about 18 mo,and currently *** self-assessment questionnaire for PTSD criteria and clinical psychiatric interview,a group of patients with a PTSD diagnosis was *** the participants who do not have a PTSD diagnosis,patients who would match those with a PTSD diagnosis in terms of relevant clinical and medical stratification variables and during the same rehabilitation period were selected to enable comparability of the two *** A total of 507 patients who were enrolled in the CR program were approached to participate in the *** patients declined to participate in the *** screening PTSD

关键词： Cardiac rehabilitation Acute coronary syndrome Posttraumatic stress disorder Psychiatric interview Multidisciplinary team Cardiac biomarkers

Existence and Multiplicity Results for a Class of Nonlinear Schrödinger Equations with Magnetic Potential Involving Sign-Changing Nonlinearity

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Analysis in Theory and Applications 2022年第2期38卷 148-177页

作者： Francisco Odair de Paiva sandra Machado de Souza Lima Olimpio Hiroshi Miyagaki Departamento de Matematica UFSCarSao CarlosSP13560-970 Brazil Departamento de Ciencias Exatas Biologicas e da TerraINFES-UFFSanto Antonio de Padua-RJ28470-000Brazil

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈H_(A)^(1)(R^(N)),(P)with 2 详细信息

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈H_(A)^(1)(R^(N)),(P)with 2ely many solutions to the problem in question,varying the assumptions about the weight functions.

关键词： Magnetic potential sign-changing weight functions Nehari manifold Fibering map

Physicochemical Properties of Combustion Ashes of Some Trees(Urban Pruning)Present in the Neotropical Region

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Journal of Renewable Materials 2023年第10期11卷 3769-3787页

作者： John Freddy Gelves-Díaz Ludovic Dorkis Richard Monroy-Sepúlveda sandra Rozo-Rincón Yebrail Alexis Romero-Arcos Competitiveness and Sustainability for Development Research Group Faculty of EngineeringUniversidad Libre-Cúcuta SectionalCúcutaColombia Catalysis and Nanomaterials Research Group Faculty of MinesUniversidad Nacional de Colombia-Medellín SectionalMedellínColombia

Secondary lignocellulosic biomass has proved to be useful as an energy source through its oxidation by means of combustion *** accordance with the above,in this paper,we wanted to study the ash from urban pruning residues that are generated in cities in the *** such as Licania tomentosa,Azadirachta indica,Ficus benjamina,Terminalia catappa,Leucaena leucocephala,Prosopis juliflora and Pithecellobium dulce were selected because they have been previously studied and showed potential for thermal energy *** materials were calcined in an oxidizing atmosphere and characterized by X-ray diffraction and fluorescence,scanning electron microscopy with microchemistry,BET surface area,thermal gravimetric analysis,and differential scanning *** pH and apparent density were also *** results show high basicity materials(average pH 10),a behavior associated with the presence of chemical elements such as calcium,potassium,magnesium,chlorine,phosphorus,and ***,these materials have a very significant amorphous fraction(between 49%and 74.5%),the dominant crystalline phases are calcite,arcanite,sylvite,and *** ashes have low surface area and do not exceed 13 m^(2)/*** characteristic morphological aspects were observed in these ashes:a morphology of rounded grains where silicon content is highlighted,and lamellar morphologies where the presence of chlorine is ***,these ashes show four significant mass loss events(400℃,430℃,680℃,and 920℃),causing mass losses that vary between 25%and 40%.Through this study,it was possible to establish that,from a chemical point of view,these ashes are less dangerous in comparison with those of a mineral coal that was used as a ***,they require additional treatments for their disposal due to their high *** of their composition,these ashes have the potential to be used in the ceramic and cement industries,and in the manuf

关键词： Bottom ash chemical composition characterization mineralogy plant biomass pruning residues urban flora