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Effect of music therapy on short-term psychological and physiological outcomes in mechanically ventilated patients:A randomized clinical pilot study

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Journal of Intensive Medicine 2024年第4期4卷 515-525页

作者： Mark Ettenberger Rosangela Casanova-Libreros Josefina Chávez-Chávez Jose Gabriel Cordoba-Silva William Betancourt-Zapata Rafael Maya Lizeth Alexa Fandino-Vergara Mario Valderrama Ingrid Silva-Fajardo sandra milena hernández-zambrano SONO-Centro de Musicoterapia BogotáColombia Vice-Rectorate for Research Fundación Universitaria de Ciencias de la SaludBogotáColombia Department of Biomedical Engineering University of Los AndesBogotáColombia Department of Rehabilitation Sociedad de Cirugía de Bogotá Hospital de San JoséBogotáColombia Faculty of Nursing Fundación Universitaria de Ciencias de la SaludBogotáColombia

Background:Elevated anxiety levels are common in patients on mechanical ventilation(MV)and may challenge *** suggests music-based interventions may reduce anxiety during ***,studies inves-tigating specific music therapy techniques,addressing psychological and physiological well-being in patients on MV,are ***:This three-arm randomized clinical pilot study was conducted with MV patients admitted to the intensive care unit(ICU)of Hospital San Joséin Bogotá,Colombia between March 7,2022,and July 11,*** were divided into three groups:intervention group 1(IG1),music-assisted relaxation;intervention group 2(IG2),patient-preferred therapeutic music listening;and control group(CG),standard *** main outcome measure was the 6-item State-Anxiety *** outcomes were:pain(measured with a visual analog scale),resilience(measured with the Brief Resilience Scale),agitation/sedation(measured with the Richmond Agitation-Sedation Scale),vital signs(including heart rate,blood pressure,oxygen saturation,and respiratory rate),days of MV,extubation success,and days in the ***,three patients underwent electroencephalography during the ***:Data from 23 patients were analyzed in this *** age range of the patients was 24.0-84.0 years,with a median age of 66.0 years(interquartile range:57.0-74.0).Of the 23 patients,19 were female(82.6%).No statistically significant differences between the groups were observed for anxiety(P=0.330),pain(P=0.624),resilience(P=0.916),agitation/sedation(P=0.273),length of ICU stay(P=0.785),or vital signs.A statistically significant difference between the groups was found for days of MV(P=0.019).Electroencephalography mea-surements showed a trend toward delta and theta band power decrease for two patients and a power increase on both beta frequencies(slow and fast)in the frontal areas of the brain for one ***:In this pilot study,music therapy did not sig

关键词： Music therapy Mechanical ventilation Intensive care unit Anxiety Pain

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Transplacental transmission of dengue infection

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World Journal of Virology 2024年第3期13卷 1-6页

作者： Leonel Eslatkin Aguilar zambrano Victor Manuel Vasquez Zevallos Gita Vita Soraya Lola Ayu Istifiani Syafrizal Aji Pamungkas Zulvikar Syambani Ulhaq Department of Medicine Technical University of ManabiManabi 130101Ecuador Department of Pediatrics Verdi Cevallos Balda HospitalPortoviejo 130105Ecuador Department of Biochemistry Hasanuddin UniversityMakassar 90245Indonesia Department of Nutrition Faculty of Health SciencesBrawijaya UniversityMalang 65100Indonesia Clinic of Yayasan Dana Sosial Al Falah Malang 65100Indonesia Research Center for Preclinical and Clinical Medicine National Research and Innovation Agency Republic of IndonesiaCibinong 16911Indonesia

We specifically addressed the persistent challenge of dengue in endemic regions,highlighting the potential seriousness of dengue infection through vertical *** dengue transmission has been well documented,particularly in hyper-endemic regions,including ***,we present a neonate diagno-sed with congenital dengue and review similar cases from previously published *** congenital dengue is commonly infected with severe serotypes of DENV(DENV-1 and DENV-2)infections,favorable outcomes are generally observed.

关键词： Vertical transmission Transplacental Congenital dengue Infectious disease DENV

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In vitro Mutagenesis for the Improvement of Agave Genus

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Phyton-International Journal of Experimental Botany 2023年第7期92卷 2065-2078页

作者： Sugey Vásquez-hernández Joaquín Adolfo Montes-Molina Federico Antonio Gutiérrez-Miceli Sheila Jazmín Reyes-zambrano Carlos Alberto Lecona-Guzmán Laboratorio de Biotecnología Vegetal TecNM-Campus Tuxtla GutiérrezTuxtla Gutiérrez29050Mexico

Biotechnological techniques provide a viable alternative to help improve and increase the production of plant species of agricultural and economic importance,which have been affected over the years by climate change,increasing their susceptibility to pests and/or diseases,generating losses in production as well as a decrease in their regenerative and genetic *** application of biotechnological techniques such as in vitro mutagenesis offers a viable option for the generation of crops that are resistant to the different factors caused by abiotic and biotic *** vitro mutagenesis has been used in an efficient way to generate genetic changes in different plant ***,these methods have not been studied thoroughly in crops of agro-industrial interest,such as agave,which represents an economic resource of national importance and are considered as endemic species of ***,this literary review aimed to focus on the studies that have been used for the genetic improvement of this species via mutagenesis techniques in plants in the agave ***,the objective was to set a precedent for future genetic studies that aim to obtain more productive regenerants for various industries,such as food and *** is also of great interest to compile information from basic research that helps understand and elucidate a model of possible defense mechanisms that are activated in the Agave genus.

关键词： Biotechnology genetic variations stress mutations resistance

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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On the interaction of a donepezil-huprine hybrid with synthetic membrane models

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Neural Regeneration Research 2023年第2期18卷 333-334页

作者： Pablo zambrano Max Planck Institute of Biochemistry Cellular and Molecular BiophysicsMunichGermany

Alzheimer's disease is the most prevalent type of dementia today,discovered and described by Alois Alzheimer in *** to the World Alzheimer Report 2021,75%of people with dementia worldwide are undiagnosed,equivalent to 41 million people(Gauthier et al.,2021).With each passing year,the number of people affected by these diseases is increasing,and the estimates of suffering from them in the future are growing.

关键词： Alzheimer diseases

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Advancing and demonstrating the Impact Indices method to screen the sensitivity of building energy use to occupant behaviour

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Building Simulation 2023年第7期16卷 1257-1272页

作者： Juan Mahecha zambrano Isabella Gaetani Ulrich Filippi Oberegger Graziano Salvalai Zurich University of Applied Sciences Centre for Building Technologies and Processes8400 WinterthurSwitzerland Politecnico di Milano Department of ArchitectureBuilt Environment and Construction Engineering20133 MilanItaly Arup Smart BuildingsLondonW1T 4BQUK European Academy of Bolzano/Bozen Institute for Renewable Energy39100 Bolzano/BozenItaly

A critical gap between the occupant behaviour research field and the building engineering practice limits the integration of occupant-centric strategies into simulation-aided building design and *** this gap would contribute to the implementation of strategies that improve the occupants’well-being while reducing the buildings’environmental *** this view,it is urgent to develop guidelines,standardised methods,and supporting tools that facilitate the integration of advanced occupant behaviour models into the simulation *** important step that needs to be fully integrated into the simulation workflow is the identification of influential and non-influential occupant behaviour aspects for a given simulation ***,this article advances and demonstrates the application of the Impact Indices method,a fast and efficient method for screening the potential impact of occupant behaviour on the heating and cooling ***,the method now allows the calculation of Impact Indices quantifying the sensitivity of building energy use to occupancy,lighting use,plug-load appliances use,and blind operation at any spatial and temporal ***,users can apply it in more detailed heating and cooling scenarios without losing ***,they can identify which components in building design and operation require more sophisticated occupant behaviour *** office building is used as a real case study to illustrate the application of the method and asses its performance against a one-factor-at-a-time sensitivity *** Impact Indices method indicates that occupancy,lighting use and plug-load appliances have the greatest impact on the annual cooling demand of the studied office building;blind operation is influential only in the west and south façades of the ***,potential applications of the method in building design and operation practice are discussed.

关键词： occupant behaviour building simulation occupant-centric building design building performance

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Photoinactivation of Escherichia coli using five photosensitizers and the same number of photons

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Journal of Innovative Optical Health Sciences 2022年第6期15卷 53-67页

作者： Daniel Ortega-zambrano Denisse Fuentes-López Hilda Mercado-Uribe CINVESTAV-Monterrey Parque PIITAutopista al Aeropuerto km.9.5ApodacaNL 66600Mexico

Bacterial resistance is today a matter of great medical concern,so it is urgent to investigate alternatives to alleviate *** inactivation(PDI)is a method that has been endorsed to inactivate diferent pathogens,including bacteria,fungi and *** is achieved by using a photosensitizer(PS)molecule which generates reactive oxygen species under visible or UV *** use visible light and UV-A radiation to excite four commercial PSs(methylene blue,rose bengal,riboflavin and curcumin),and nanopartides synthesized in our *** these PSs having been thoroughly studied in the past by other research groups,in order to compare their effects in an appropriate way,we matched the number of photons they *** found that methylene blue leads to the major inactivation of Escherichia ***,we evaluated the production of singlet axygen and hydroxyl radicals in the photoinactivation process.

关键词： Photodynamic inactivation E.coli ROS photons

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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

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Punctual mutations in 23S rRNA gene of clarithromycinresistant Helicobacter pylori in Colombian populations

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World Journal of Gastroenterology 2018年第14期24卷 1531-1539页

作者： Andrés Jenuer Matta Diana Carolina zambrano Alvaro Jairo Pazos Registro Poblacional de Cáncer de Cali Department of Pathology School of Medicine Universidad del Valle Faculty of Education and Sports Sciences Institución Universitaria Escuela Nacional del Deporte Department of Biology Universidad de Nari?o

AIM To characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori(H. pylori) and determine their association with therapeutic *** PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin(29 from a low-risk gastric cancer(GC) population: TumacoColombia, and 5 from a high-risk population: TuquerresColombia) and 40 from a susceptible population(28 from Tumaco and 12 from Túquerres) were sequenced using capillary electrophoresis. The concordance between mutations of V domain 23S rRNA gene of H. pylori and therapeutic failure was determined using the Kappa coefficient and Mc Nemar's test was performed to determine the relationship between H. pylori mutationsand clarithromycin ***23S rRNA gene from H. pylori was amplified in 56/74 isolates, of which 25 were resistant to clarithromycin(20 from Tumaco and 5 from Túquerres, respectively). In 17 resistant isolates(13 from Tumaco and 4 from Túquerres) the following mutations were found: A1593 T1, A1653 G2, C1770 T, C1954 T1, and G1827 C in isolates from Tumaco, and A2144 G from Túquerres. The mutations T2183 C, A2144 G and C2196 T in H. pylori isolates resistant to clarithromycin from Colombia are reported for the first time. No association between the H. pylori mutations and in vitro clarithromycin resistance was found. However, therapeutic failure of eradication treatment was associated with mutations of 23S rRNA gene in clarithromycin-resistant H. pylori(κ = 0.71).CONCLUSION The therapeutic failure of eradication treatment in the two populations from Colombia was associated with mutations of the 23S rRNA gene in clarithromycinresistant H. pylori.

关键词： Clarithromycin In vitro resistance Point mutation Helicobacter pylori Gastric cancer 23S rRNA

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Nest composition and worker relatedness in three slave-making ants of the genus Rossomyrmex Arnoldi and their Proformica Ruzsky hosts （Hymenoptera, Formicidae）

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Insect Science 2010年第4期17卷 361-368页

作者： Alberto Tinaut Francisca Ruano Olivia Sanllorente Alejandra Fernandez-zambrano Celal Karaman Yelimbek Kaz Department of Animal Biology Faculty of Sciences University of Granada Granada Spain Department of Biology Faculty of Arts and Sciences Trakya University Edirne Turkey Department of Biology Faculty of Sciences L.N. Gumilev Eurasian National University Astana Kazakhstan

In this paper, we analyze and compare nest composition and architecture as well as worker relatedness in three related species of slave-making ants： Rossomyrmex anatolicus, R. minuchae, and R. quandratinodum. Colony structure within nests is an important trait in ants, especially in the case of mixed societies, when host and parasite coexist in the same nest. Data for their respective free-living hosts, Proformica korbi, P.. longiseta and P. sp., are also provided. For our study, we integrated a meticulous excava- tion procedure with a genetic method. We conclude that the average number of parasites, as well as of slaves, is species-specific, whereas nest depth depends on the nest archi- tecture of the host. The genus Rossomyrmex seems to be monogynous and monandrous, whereas Proformica shows differences in the number of queens and mating frequency. R. quandratinodum shows different traits in nest composition （host/parasite ratio： P/R） and architecture. The difference in traits may account for some differences in parasitism： raid process or avoidance of parasitism.

关键词： nest architecture nest composition Proformica relatedness Rossomyrmex,slave-making ants

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